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The map label for this gene is glpD [H]

Identifier: 99082046

GI number: 99082046

Start: 2316535

End: 2318115

Strand: Direct

Name: glpD [H]

Synonym: TM1040_2206

Alternate gene names: 99082046

Gene position: 2316535-2318115 (Clockwise)

Preceding gene: 99082045

Following gene: 99082048

Centisome position: 72.37

GC content: 60.97

Gene sequence:

>1581_bases
ATGACTGATTCCTCGCAAAGCACCGAGATCACCGATCTCTTCATCATTGGCGGCGGCATCAATGGCTGTGGCATCGCGCG
CGACGCAGCAGGCCGTGGGCTTTCCGTGACCCTCGCGGAAAAGAACGATCTCGCGTCCGCGACATCCTCGGCCTCGACCA
AGCTCTTTCACGGCGGGCTGCGCTATCTTGAATATTTCGAGTTCCGCCTCGTCCAGGAAGCCCTGATCGAACGTGAAGTA
CTGCTGCGTGCGATGCCGCATATCTCCTGGCCAATGCGCTTTGTGCTGCCCTTTCACAAAGACATGCGGTTCGACAACAC
CACACCAACCTCCAAACTGCTCACCACCTTCATGCCATGGATGAAAGGCCGCCGCCCTGCGTGGCTGATCCGGCTGGGCC
TTTTCATGTACGATACGCTTGGCAAACGCGGCATCCTGCCCGGCACCACGACGGTGGATCTGACCCGTGACGAGGCAGGC
AAGCCGCTGCAATCAAAATTCAAAAAGGCCTTTGAATATTCCGACTGCTGGGTCGAGGACGCTCGCCTCGTGGTGCTCAA
TGCGCGCGACGCCGAAAGCCGCGGCACAGAGATCCTGACCCGCACCGAAGTCATCAACGCCACCCGCCACGCCGATCACT
GGGAGATCCGCCTCAGGGATCTTGCCACCGGCGAGGAAGAAACGCGCCGCGCCAAGATGCTCGTCAATGCCGGTGGCCCA
TGGGTTGCAGATGTGCTGCGCCAGAAGCTGGGCCAGAACAGCCGCGAAAACGTACGCCTCGTGCGCGGCAGCCATATCGT
CGTGCCCAAGCTATATGATCATGGGCGCTGCTATTTCTTCCAGGGTCAGGATGGGCGCATCATCTTTGCCATCCCCTACG
AGGAAGACTTCACCCTCATCGGCACCACGGATGCAGATCACCCAGATCCCGAAACAAAACCCGTCTGCACCGAGGAAGAG
CAGGATTATCTGGTGCGCTTTGCCTCGAACTACTTCGAGCGCCCCGTCACGCGCGAGCAGATCGTCTGGACCTACTCGGG
CGTGCGCCCGCTCTATGACGATGGCGCCAGCTCGGCGTCGGCAGCGACGCGTGAATATGTGCTGACACTCGACACCGCCC
AAGCCCCTTTGCTCAACGTCTTTGGCGGCAAGATCACCACCTATCGCAAACTCGCCGAAGCCGCGCTCGAGAAGATCAAC
GAAGTCTTTCCAGAGCTGCCTGAGAAATGGACGGCCGGTGTCGCTCTGCCCGGTGGCGACTTCCCCGTCGAGGGCGTGAC
GGAACTGGGTGCCAAACTCGCGCAAGACTATCCGTTCCTCACCCCCTATGCCGTGCGCCGCCTGATCCGCGCCTATGGCA
CCGAGGCTTGGGATGTTCTGGGCGATGCGACCACGCCGTCGGATCTCGGGGAGGATTTTGGCGCGACCATCACCGCGCGC
GAATTGGACTGGACCATTCAAAACGAATGGGTGCGCTCCGGAGAGGACTACCTCTGGCGCCGAACCAAACTCGGCCTGCG
TCTCGATGCAGACGCTCGCGGTGCCGTCAACCGCTACATCGAGGCGCGCATCACCGGCTAA

Upstream 100 bases:

>100_bases
ACCGACCGCCCCGTTCCCGCGGAATTTGCCGAGGCCGCAGAGGCCGCTGGCACACGAATCCTCATCGCAGACGGCGGCGC
AGAAAACGAAAGCAGCGCAA

Downstream 100 bases:

>100_bases
AAGCTCAACGGAAAACAAAAATGAGGGGCCCGCGGCCCCTCTTCTTCTAACGAAAAATATCCCGGAGCGCGAGGCAGCGC
CTCGCATCCCCACCCCGCGC

Product: glycerol-3-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MTDSSQSTEITDLFIIGGGINGCGIARDAAGRGLSVTLAEKNDLASATSSASTKLFHGGLRYLEYFEFRLVQEALIEREV
LLRAMPHISWPMRFVLPFHKDMRFDNTTPTSKLLTTFMPWMKGRRPAWLIRLGLFMYDTLGKRGILPGTTTVDLTRDEAG
KPLQSKFKKAFEYSDCWVEDARLVVLNARDAESRGTEILTRTEVINATRHADHWEIRLRDLATGEEETRRAKMLVNAGGP
WVADVLRQKLGQNSRENVRLVRGSHIVVPKLYDHGRCYFFQGQDGRIIFAIPYEEDFTLIGTTDADHPDPETKPVCTEEE
QDYLVRFASNYFERPVTREQIVWTYSGVRPLYDDGASSASAATREYVLTLDTAQAPLLNVFGGKITTYRKLAEAALEKIN
EVFPELPEKWTAGVALPGGDFPVEGVTELGAKLAQDYPFLTPYAVRRLIRAYGTEAWDVLGDATTPSDLGEDFGATITAR
ELDWTIQNEWVRSGEDYLWRRTKLGLRLDADARGAVNRYIEARITG

Sequences:

>Translated_526_residues
MTDSSQSTEITDLFIIGGGINGCGIARDAAGRGLSVTLAEKNDLASATSSASTKLFHGGLRYLEYFEFRLVQEALIEREV
LLRAMPHISWPMRFVLPFHKDMRFDNTTPTSKLLTTFMPWMKGRRPAWLIRLGLFMYDTLGKRGILPGTTTVDLTRDEAG
KPLQSKFKKAFEYSDCWVEDARLVVLNARDAESRGTEILTRTEVINATRHADHWEIRLRDLATGEEETRRAKMLVNAGGP
WVADVLRQKLGQNSRENVRLVRGSHIVVPKLYDHGRCYFFQGQDGRIIFAIPYEEDFTLIGTTDADHPDPETKPVCTEEE
QDYLVRFASNYFERPVTREQIVWTYSGVRPLYDDGASSASAATREYVLTLDTAQAPLLNVFGGKITTYRKLAEAALEKIN
EVFPELPEKWTAGVALPGGDFPVEGVTELGAKLAQDYPFLTPYAVRRLIRAYGTEAWDVLGDATTPSDLGEDFGATITAR
ELDWTIQNEWVRSGEDYLWRRTKLGLRLDADARGAVNRYIEARITG
>Mature_525_residues
TDSSQSTEITDLFIIGGGINGCGIARDAAGRGLSVTLAEKNDLASATSSASTKLFHGGLRYLEYFEFRLVQEALIEREVL
LRAMPHISWPMRFVLPFHKDMRFDNTTPTSKLLTTFMPWMKGRRPAWLIRLGLFMYDTLGKRGILPGTTTVDLTRDEAGK
PLQSKFKKAFEYSDCWVEDARLVVLNARDAESRGTEILTRTEVINATRHADHWEIRLRDLATGEEETRRAKMLVNAGGPW
VADVLRQKLGQNSRENVRLVRGSHIVVPKLYDHGRCYFFQGQDGRIIFAIPYEEDFTLIGTTDADHPDPETKPVCTEEEQ
DYLVRFASNYFERPVTREQIVWTYSGVRPLYDDGASSASAATREYVLTLDTAQAPLLNVFGGKITTYRKLAEAALEKINE
VFPELPEKWTAGVALPGGDFPVEGVTELGAKLAQDYPFLTPYAVRRLIRAYGTEAWDVLGDATTPSDLGEDFGATITARE
LDWTIQNEWVRSGEDYLWRRTKLGLRLDADARGAVNRYIEARITG

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses molecular oxygen or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=547, Percent_Identity=29.6160877513711, Blast_Score=181, Evalue=1e-45,
Organism=Homo sapiens, GI285002231, Length=547, Percent_Identity=29.6160877513711, Blast_Score=181, Evalue=1e-45,
Organism=Escherichia coli, GI2367226, Length=491, Percent_Identity=46.0285132382892, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1788574, Length=496, Percent_Identity=28.4274193548387, Blast_Score=96, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI115534726, Length=541, Percent_Identity=28.6506469500924, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17509253, Length=481, Percent_Identity=29.3139293139293, Blast_Score=144, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6322036, Length=562, Percent_Identity=28.2918149466192, Blast_Score=157, Evalue=3e-39,
Organism=Drosophila melanogaster, GI161077125, Length=483, Percent_Identity=29.6066252587992, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24653942, Length=483, Percent_Identity=29.6066252587992, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24653944, Length=483, Percent_Identity=29.6066252587992, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI20130025, Length=483, Percent_Identity=29.6066252587992, Blast_Score=145, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24586295, Length=403, Percent_Identity=28.7841191066998, Blast_Score=106, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 59226; Mature: 59094

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSSQSTEITDLFIIGGGINGCGIARDAAGRGLSVTLAEKNDLASATSSASTKLFHGGL
CCCCCCCCEEEEEEEECCCCCCCCCCHHCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHH
RYLEYFEFRLVQEALIEREVLLRAMPHISWPMRFVLPFHKDMRFDNTTPTSKLLTTFMPW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECHHCCCCCCCCCHHHHHHHHHHH
MKGRRPAWLIRLGLFMYDTLGKRGILPGTTTVDLTRDEAGKPLQSKFKKAFEYSDCWVED
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEECC
ARLVVLNARDAESRGTEILTRTEVINATRHADHWEIRLRDLATGEEETRRAKMLVNAGGP
CEEEEEECCCCCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCHHHHHHEEEEEECCCC
WVADVLRQKLGQNSRENVRLVRGSHIVVPKLYDHGRCYFFQGQDGRIIFAIPYEEDFTLI
HHHHHHHHHHCCCCCCCEEEEECCEEEEECEECCCEEEEEECCCCEEEEEECCCCCEEEE
GTTDADHPDPETKPVCTEEEQDYLVRFASNYFERPVTREQIVWTYSGVRPLYDDGASSAS
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCHH
AATREYVLTLDTAQAPLLNVFGGKITTYRKLAEAALEKINEVFPELPEKWTAGVALPGGD
HCCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEECCCCC
FPVEGVTELGAKLAQDYPFLTPYAVRRLIRAYGTEAWDVLGDATTPSDLGEDFGATITAR
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCEEEEE
ELDWTIQNEWVRSGEDYLWRRTKLGLRLDADARGAVNRYIEARITG
ECCEEEHHHHHHCCCHHHHHHHCCCEEECCCCCHHHHHEEEEEECC
>Mature Secondary Structure 
TDSSQSTEITDLFIIGGGINGCGIARDAAGRGLSVTLAEKNDLASATSSASTKLFHGGL
CCCCCCCEEEEEEEECCCCCCCCCCHHCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHH
RYLEYFEFRLVQEALIEREVLLRAMPHISWPMRFVLPFHKDMRFDNTTPTSKLLTTFMPW
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEEEECHHCCCCCCCCCHHHHHHHHHHH
MKGRRPAWLIRLGLFMYDTLGKRGILPGTTTVDLTRDEAGKPLQSKFKKAFEYSDCWVED
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCCCCEECC
ARLVVLNARDAESRGTEILTRTEVINATRHADHWEIRLRDLATGEEETRRAKMLVNAGGP
CEEEEEECCCCCCCCCEEEEHHHHHHHHCCCCCEEEEEEECCCCHHHHHHEEEEEECCCC
WVADVLRQKLGQNSRENVRLVRGSHIVVPKLYDHGRCYFFQGQDGRIIFAIPYEEDFTLI
HHHHHHHHHHCCCCCCCEEEEECCEEEEECEECCCEEEEEECCCCEEEEEECCCCCEEEE
GTTDADHPDPETKPVCTEEEQDYLVRFASNYFERPVTREQIVWTYSGVRPLYDDGASSAS
ECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHEEEEEECCCCCCCCCCCCCHH
AATREYVLTLDTAQAPLLNVFGGKITTYRKLAEAALEKINEVFPELPEKWTAGVALPGGD
HCCEEEEEEEECCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCEECCCCC
FPVEGVTELGAKLAQDYPFLTPYAVRRLIRAYGTEAWDVLGDATTPSDLGEDFGATITAR
CCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHCCCCCCCHHHHHHHCCEEEEE
ELDWTIQNEWVRSGEDYLWRRTKLGLRLDADARGAVNRYIEARITG
ECCEEEHHHHHHCCCHHHHHHHCCCEEECCCCCHHHHHEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1987111; 9278503; 3045087; 3045764 [H]