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The map label for this gene is hom [H]

Identifier: 99082004

GI number: 99082004

Start: 2273080

End: 2274366

Strand: Direct

Name: hom [H]

Synonym: TM1040_2164

Alternate gene names: 99082004

Gene position: 2273080-2274366 (Clockwise)

Preceding gene: 99082003

Following gene: 99082005

Centisome position: 71.01

GC content: 63.79

Gene sequence:

>1287_bases
ATGACTGAACCGCTTCGACTGGGGATTGCAGGTTTGGGCACGGTCGGCATTGGCGTGGTGAAGATCATTCGCCGCCATGC
TGCCCTGTTGGAGGCGCGAACTGGCCGCCCGGTGGTGATCACTGCCGTTTCGGCCCGCGACGCCACCAAGGATCGCGGCG
TGTCGCTCAAGGACTATGCGTGGGAAACCGATCCAGTCGCCCTTGCCACGCGCGATGATGTCGATGTGTTTGTCGAACTG
ATGGGCGGGCACGAAGGCCCGGCCCGGCTTGCAACGGAGGCTGCGCTGGCAGCCGGCAAGGATGTGGTCACCGCAAACAA
GGCGCTCCTGGCGATCCACGGCCAGGATCTGGCCGAACGCGCAGAGGCCAATGGCAGCGTCATCCGCTTTGAGGCGGCGG
TTGCAGGTGGCATCCCCGTGATCAAATCCATGACCGAGAGCCTTGCAGGCAATGAAATCACCCGCGTCATGGGCGTGATG
AACGGCACCTGCAACTATATCCTCACGCAGATGGAAGCCACAGGCCGGGGTTATAACGCTCTCTTTGAGGAATGCGGCAA
GCTTGGCTACCTGGAGGCCGACCCGCTGCTGGACGTGGGCGGTATTGATGCCGGCCACAAGCTGGCGCTCCTGGCCTCTA
TCGCGTTTGGGACCAAACCGGCCTTTGACGATGTCAAACTCGAAGGCATTCAGCGCATCGCCATTGAAGACATCCGCCAC
GCCGCCGATATGGGCTATCGGATCAAGCTTCTGGGCGTTGCACAGCGTTCGGCGCGCGGGCTTGAGCAGCGCATGACCCC
CTGCCTGGTGCCCGCGAATTCTCCGCTCGGGCAGCTTGAGGGCGGCACCAACATGGTGGTGATCGAGGGCGACGCCATCG
AACAAGTGGTGCTGCGCGGCCCCGGCGCGGGCGAAGGCCCCACCGCCAGTGCGGTGATGGGCGATGTGCTCGACATTGCG
CGCGGCCTGCGGATCTCGACCTTTGGCCAGCCGGCCACGACGCTCTCGAAAGAACCAGCCGCACAAACCGGCCTGCCTGC
GCCCTATTATGTGCGTATGGCGCTGCAGGACAAACCCGGCGCGCTGGCCAAAGTCGCCGCAGCATTGGGGGATGCGGGGG
TCTCTATCCACCGGATGCGCCAGTATGATCACGCCACCACAGTGGCTCCGGTGTTGATCGTGACTCACAAATGCACGTCT
GCCATGCTGGAACAGGCCCTTGAGGCGCTGGCCGCAACAGGCGTGGTTGAAGGCGCCCCCGTGGCGCTGCGCATCGAAGA
GCTGTGA

Upstream 100 bases:

>100_bases
TCTGACCCCCCGCTCACCCTGTTGAGCGTTGCACCAAAGGGCCAGAGCCGCTAAGGCGGCATCGAACCCATAGATCGTCA
AGACAATAAGGACCTCCACT

Downstream 100 bases:

>100_bases
GGCAGAACCTCTGAAACGCGCCGCGTGCGCGCGCTCGGGTGCAAATGCCCAAGGGCGCGCTCAAGGCGCAAAATATATGT
TGTTAGCGACATCAGCCGCG

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MTEPLRLGIAGLGTVGIGVVKIIRRHAALLEARTGRPVVITAVSARDATKDRGVSLKDYAWETDPVALATRDDVDVFVEL
MGGHEGPARLATEAALAAGKDVVTANKALLAIHGQDLAERAEANGSVIRFEAAVAGGIPVIKSMTESLAGNEITRVMGVM
NGTCNYILTQMEATGRGYNALFEECGKLGYLEADPLLDVGGIDAGHKLALLASIAFGTKPAFDDVKLEGIQRIAIEDIRH
AADMGYRIKLLGVAQRSARGLEQRMTPCLVPANSPLGQLEGGTNMVVIEGDAIEQVVLRGPGAGEGPTASAVMGDVLDIA
RGLRISTFGQPATTLSKEPAAQTGLPAPYYVRMALQDKPGALAKVAAALGDAGVSIHRMRQYDHATTVAPVLIVTHKCTS
AMLEQALEALAATGVVEGAPVALRIEEL

Sequences:

>Translated_428_residues
MTEPLRLGIAGLGTVGIGVVKIIRRHAALLEARTGRPVVITAVSARDATKDRGVSLKDYAWETDPVALATRDDVDVFVEL
MGGHEGPARLATEAALAAGKDVVTANKALLAIHGQDLAERAEANGSVIRFEAAVAGGIPVIKSMTESLAGNEITRVMGVM
NGTCNYILTQMEATGRGYNALFEECGKLGYLEADPLLDVGGIDAGHKLALLASIAFGTKPAFDDVKLEGIQRIAIEDIRH
AADMGYRIKLLGVAQRSARGLEQRMTPCLVPANSPLGQLEGGTNMVVIEGDAIEQVVLRGPGAGEGPTASAVMGDVLDIA
RGLRISTFGQPATTLSKEPAAQTGLPAPYYVRMALQDKPGALAKVAAALGDAGVSIHRMRQYDHATTVAPVLIVTHKCTS
AMLEQALEALAATGVVEGAPVALRIEEL
>Mature_427_residues
TEPLRLGIAGLGTVGIGVVKIIRRHAALLEARTGRPVVITAVSARDATKDRGVSLKDYAWETDPVALATRDDVDVFVELM
GGHEGPARLATEAALAAGKDVVTANKALLAIHGQDLAERAEANGSVIRFEAAVAGGIPVIKSMTESLAGNEITRVMGVMN
GTCNYILTQMEATGRGYNALFEECGKLGYLEADPLLDVGGIDAGHKLALLASIAFGTKPAFDDVKLEGIQRIAIEDIRHA
ADMGYRIKLLGVAQRSARGLEQRMTPCLVPANSPLGQLEGGTNMVVIEGDAIEQVVLRGPGAGEGPTASAVMGDVLDIAR
GLRISTFGQPATTLSKEPAAQTGLPAPYYVRMALQDKPGALAKVAAALGDAGVSIHRMRQYDHATTVAPVLIVTHKCTSA
MLEQALEALAATGVVEGAPVALRIEEL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 44674; Mature: 44543

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPLRLGIAGLGTVGIGVVKIIRRHAALLEARTGRPVVITAVSARDATKDRGVSLKDYA
CCCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHCC
WETDPVALATRDDVDVFVELMGGHEGPARLATEAALAAGKDVVTANKALLAIHGQDLAER
CCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEECCHHHHH
AEANGSVIRFEAAVAGGIPVIKSMTESLAGNEITRVMGVMNGTCNYILTQMEATGRGYNA
HCCCCCEEEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEHHHCCCCHHH
LFEECGKLGYLEADPLLDVGGIDAGHKLALLASIAFGTKPAFDDVKLEGIQRIAIEDIRH
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AADMGYRIKLLGVAQRSARGLEQRMTPCLVPANSPLGQLEGGTNMVVIEGDAIEQVVLRG
HHCCCCEEEEEEEHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHEEC
PGAGEGPTASAVMGDVLDIARGLRISTFGQPATTLSKEPAAQTGLPAPYYVRMALQDKPG
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHCCCCCCEEEEEEECCCCC
ALAKVAAALGDAGVSIHRMRQYDHATTVAPVLIVTHKCTSAMLEQALEALAATGVVEGAP
HHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCC
VALRIEEL
EEEEEECC
>Mature Secondary Structure 
TEPLRLGIAGLGTVGIGVVKIIRRHAALLEARTGRPVVITAVSARDATKDRGVSLKDYA
CCCCEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHCCCCCHHCC
WETDPVALATRDDVDVFVELMGGHEGPARLATEAALAAGKDVVTANKALLAIHGQDLAER
CCCCCEEEEECCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCEEEEEECCHHHHH
AEANGSVIRFEAAVAGGIPVIKSMTESLAGNEITRVMGVMNGTCNYILTQMEATGRGYNA
HCCCCCEEEEEEHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCHHHEEEEHHHCCCCHHH
LFEECGKLGYLEADPLLDVGGIDAGHKLALLASIAFGTKPAFDDVKLEGIQRIAIEDIRH
HHHHHCCCCCCCCCCCEECCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
AADMGYRIKLLGVAQRSARGLEQRMTPCLVPANSPLGQLEGGTNMVVIEGDAIEQVVLRG
HHCCCCEEEEEEEHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCHHHHHHEEC
PGAGEGPTASAVMGDVLDIARGLRISTFGQPATTLSKEPAAQTGLPAPYYVRMALQDKPG
CCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHCCCCCCHHCCCCCCEEEEEEECCCCC
ALAKVAAALGDAGVSIHRMRQYDHATTVAPVLIVTHKCTSAMLEQALEALAATGVVEGAP
HHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCC
VALRIEEL
EEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1333566; 10984043 [H]