Click here to switch to the map view.

The map label for this gene is mepA [H]

Identifier: 99081995

GI number: 99081995

Start: 2262375

End: 2263757

Strand: Reverse

Name: mepA [H]

Synonym: TM1040_2155

Alternate gene names: 99081995

Gene position: 2263757-2262375 (Counterclockwise)

Preceding gene: 99081997

Following gene: 99081994

Centisome position: 70.72

GC content: 61.75

Gene sequence:

>1383_bases
ATGTCTACCTCCCCTCCAAATCGATTTTTGACCGCCCGCTTGGGGCCGGTTTATGCAAAAACTGCGTTGCCCATCATCTT
TGTGATGGGGATGAACGGCTTTTTGACCGTGGCGGACGCGCTGTTTCTGGGGCATTTCGTCGGGCCCGAGGCTTTGGCCG
CTGTGACGCTGATGTTTCCCGGCTACATGTTGGTTGTGGCTCTGGCAACGCTGGTGGCCAGCGGCATGTCCAGTCGGCTG
GCCCGTCATCTCGGTGCGGGCGATACCGAGGCGGCGCAGGCCGATTTTGCGGCGGCGCATGGTCTGGCGCTCTCGGTCGC
GGTGGGCCTCATGGCGGCTTTTGCGCTCTGGGGGAGCGCTGTGGCGCATGCCGCCGCCGGGGGCGACCGCCTCCTTGCTG
ACATGGGGCACACCTATCTGCGGATCACTGTGGGGTGTACGCCGCTCCTGTTCGTGCTCTCGGTGAATTCCGACGCCTTG
CGTAACGAGGGCCGGGCCGGACTGATGGCCCTCATGAGCCTTGTCGTCTCGCTGTCGAATATTGCGTTCAACTATCTGCT
GATCGCCCAAGCGGGATTGGGCGTGGCGGGATCGGCGTTGGGAACGGCTTTGGCACAGGTTCTGGCGCTCTCGCTGATCG
TGGCGTTTCGCCTGCGTGGCGATACAGTTTTGCGGCCAAGCTGTCTTTGGCGACAGAGCCTTTGGGGCGGCTGGGGGCGG
ATGCTTGCGCTGGGCGCGCCGCAGAGTCTCAACTTTATCGGCATCGCCTTGGGGTCGGCGGTGATTATGTTTGCACTGCA
ATGGGTTGATGTCTCTGATTATGCAACAACGGTGAGCGCCTATGGGGTCATCACACGACTTTTGACCTTCACGTTCCTGC
CGCTTTTGGGGCTGTCGCATGCGATGCAGAGCATCACCGGGAACCTGTATGGGGCAGGTCAAATCCTTAGAGTGGGGCAA
AGCCTCCGGTTCGCGGTCGTGAGTGCCTTGATCTATTGCGCGGTGATGCAGGCCGGTCTGACGTGGGGCGCTGCATGGAT
TGCAGCGTGGTTTGTGGACGATCAGGGCGTTATCGAAGACGTTGCGCGCATCCTGCCCATTCTTGGCGCTCTTTTTGTGC
TCGCGGGGCCGCTCATGATGGTGGCAATGCATTTTCAGGCGATAGGAGATGCCCCGCGGGCTGCGCTTCTGGGGCTCTCC
AAACCCTATCTGTTCTCGATCCCACTGACCTTTATGCTTGCTGCGCTTTGGGGGGAGCCCGGGATCTGGCTTGCTGCGCC
CGTTGCCGAGGCGGGGCTCCTTGTGCTGACGGGGCTGGTTCTGCTGGACCTTCGTCGCCGGCGTGACCAAGTGACCTCCA
AAGTGCAGGAGCGCCGCGCATGA

Upstream 100 bases:

>100_bases
TACGGATATGTCTTTTGATCATCCTCCACGCCTGTCGCGCGGGTGGTAATGCGGGTCCCATCCAGTTCTTGCGCGATACC
TGCAAGAGGAGATCGGGGAT

Downstream 100 bases:

>100_bases
CCGAGAATTTGCCAACGATTGCACAGGCCAAAGCCATGGCTAGAGAGTGGCGCGCAGCCCGCCAGCAGGCGGGCGAGAGC
CTGCGCCACGGCGCGGCGCT

Product: multi anti extrusion protein MatE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSTSPPNRFLTARLGPVYAKTALPIIFVMGMNGFLTVADALFLGHFVGPEALAAVTLMFPGYMLVVALATLVASGMSSRL
ARHLGAGDTEAAQADFAAAHGLALSVAVGLMAAFALWGSAVAHAAAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSDAL
RNEGRAGLMALMSLVVSLSNIAFNYLLIAQAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPSCLWRQSLWGGWGR
MLALGAPQSLNFIGIALGSAVIMFALQWVDVSDYATTVSAYGVITRLLTFTFLPLLGLSHAMQSITGNLYGAGQILRVGQ
SLRFAVVSALIYCAVMQAGLTWGAAWIAAWFVDDQGVIEDVARILPILGALFVLAGPLMMVAMHFQAIGDAPRAALLGLS
KPYLFSIPLTFMLAALWGEPGIWLAAPVAEAGLLVLTGLVLLDLRRRRDQVTSKVQERRA

Sequences:

>Translated_460_residues
MSTSPPNRFLTARLGPVYAKTALPIIFVMGMNGFLTVADALFLGHFVGPEALAAVTLMFPGYMLVVALATLVASGMSSRL
ARHLGAGDTEAAQADFAAAHGLALSVAVGLMAAFALWGSAVAHAAAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSDAL
RNEGRAGLMALMSLVVSLSNIAFNYLLIAQAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPSCLWRQSLWGGWGR
MLALGAPQSLNFIGIALGSAVIMFALQWVDVSDYATTVSAYGVITRLLTFTFLPLLGLSHAMQSITGNLYGAGQILRVGQ
SLRFAVVSALIYCAVMQAGLTWGAAWIAAWFVDDQGVIEDVARILPILGALFVLAGPLMMVAMHFQAIGDAPRAALLGLS
KPYLFSIPLTFMLAALWGEPGIWLAAPVAEAGLLVLTGLVLLDLRRRRDQVTSKVQERRA
>Mature_459_residues
STSPPNRFLTARLGPVYAKTALPIIFVMGMNGFLTVADALFLGHFVGPEALAAVTLMFPGYMLVVALATLVASGMSSRLA
RHLGAGDTEAAQADFAAAHGLALSVAVGLMAAFALWGSAVAHAAAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSDALR
NEGRAGLMALMSLVVSLSNIAFNYLLIAQAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPSCLWRQSLWGGWGRM
LALGAPQSLNFIGIALGSAVIMFALQWVDVSDYATTVSAYGVITRLLTFTFLPLLGLSHAMQSITGNLYGAGQILRVGQS
LRFAVVSALIYCAVMQAGLTWGAAWIAAWFVDDQGVIEDVARILPILGALFVLAGPLMMVAMHFQAIGDAPRAALLGLSK
PYLFSIPLTFMLAALWGEPGIWLAAPVAEAGLLVLTGLVLLDLRRRRDQVTSKVQERRA

Specific function: Multidrug resistance efflux protein [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48381; Mature: 48250

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSPPNRFLTARLGPVYAKTALPIIFVMGMNGFLTVADALFLGHFVGPEALAAVTLMFP
CCCCCCCCEEEECCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
GYMLVVALATLVASGMSSRLARHLGAGDTEAAQADFAAAHGLALSVAVGLMAAFALWGSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHAAAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSDALRNEGRAGLMALMSLVVSLSN
HHHHHCCCHHHHHHCCCEEEEEEECCCEEEHEEECCCHHHHCCCCHHHHHHHHHHHHHHH
IAFNYLLIAQAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPSCLWRQSLWGGWGR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCHHH
MLALGAPQSLNFIGIALGSAVIMFALQWVDVSDYATTVSAYGVITRLLTFTFLPLLGLSH
HHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMQSITGNLYGAGQILRVGQSLRFAVVSALIYCAVMQAGLTWGAAWIAAWFVDDQGVIED
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VARILPILGALFVLAGPLMMVAMHFQAIGDAPRAALLGLSKPYLFSIPLTFMLAALWGEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCHHHHHHHHHCCC
GIWLAAPVAEAGLLVLTGLVLLDLRRRRDQVTSKVQERRA
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STSPPNRFLTARLGPVYAKTALPIIFVMGMNGFLTVADALFLGHFVGPEALAAVTLMFP
CCCCCCCEEEECCCHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHH
GYMLVVALATLVASGMSSRLARHLGAGDTEAAQADFAAAHGLALSVAVGLMAAFALWGSA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAHAAAGGDRLLADMGHTYLRITVGCTPLLFVLSVNSDALRNEGRAGLMALMSLVVSLSN
HHHHHCCCHHHHHHCCCEEEEEEECCCEEEHEEECCCHHHHCCCCHHHHHHHHHHHHHHH
IAFNYLLIAQAGLGVAGSALGTALAQVLALSLIVAFRLRGDTVLRPSCLWRQSLWGGWGR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHCCHHH
MLALGAPQSLNFIGIALGSAVIMFALQWVDVSDYATTVSAYGVITRLLTFTFLPLLGLSH
HHEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMQSITGNLYGAGQILRVGQSLRFAVVSALIYCAVMQAGLTWGAAWIAAWFVDDQGVIED
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
VARILPILGALFVLAGPLMMVAMHFQAIGDAPRAALLGLSKPYLFSIPLTFMLAALWGEP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCEECCCHHHHHHHHHCCC
GIWLAAPVAEAGLLVLTGLVLLDLRRRRDQVTSKVQERRA
CCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA