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The map label for this gene is Hgd [H]

Identifier: 99081843

GI number: 99081843

Start: 2108344

End: 2109321

Strand: Direct

Name: Hgd [H]

Synonym: TM1040_2003

Alternate gene names: 99081843

Gene position: 2108344-2109321 (Clockwise)

Preceding gene: 99081842

Following gene: 99081844

Centisome position: 65.87

GC content: 62.17

Gene sequence:

>978_bases
ATGAAAATCGGCTTTATCGGCCTCGGCAATGTGGGGGGCAAGCTTGCTGGCAGCCTGCTGCGCAACGGCTTTGATCTCAC
GGTCTATGATCTCAACCCTGATCTGGTTGCGGAATACGTCGAAAAAGGCGCGCAGCCCGGCACCGGGCCCTTGGCGATCA
TGCGGGCCTGCGACGCCGTCATCACCTGCCTGCCCTCGCCCGCCGCCTGCGCCACCGTGGTCGAGGAGATGCTGCCCGCA
GTGGACAGCTCCAAGATCTGGATGGAGATGTCGACCACCGACGCCGCCGAGGTCAAACGGCTGGCGGCCCTTGTCTCTGA
ACGGGGCGGCAGTGCGATGGAATGCCCCGTGTCTGGTGGCTGTCATCGCGCCGACACCGGCAATATCTCGATTTTTGCAG
GCTGCGACCGCGCGACATTCGAACGCATGCTGCCGACCCTGACGACCCTCGGGCGACGCGTGCTGCACACCGGCGACATC
GGCAGCGCCTCCATTCTCAAGGTGATGACCAACTATCTTGCGACGGCGAACCTGCTGACCTGTTGCGAGGCGCTGGTGAC
GATGAAGGCCGCGGGCATTGATCTCAATACCACCTATGAAGCGATGAAGATCTCCTCCGGGACCTCCTTCGTGCATGAAA
CCGAAAGCCAGGTGATCCTGAACGGGTCGCGCGACATCTCATTCACGATGGATCTGGTGAAAAAGGACATCAGCCTGTTC
CAGACCATCGCCGACGCCCATGGGGTGCCACTGGAAATCAGCCCGCTGCTGGTGGAGATCTTCACCGATGGGATCGCCAG
GTTTGGCGAACGCGAGCTCTCCCCAAATATCATCCGCCGCCTCGAAGAGGCCACGGGGCTGTCGATCACCGCACCGGGCT
TTCCTGCGGAAATGGTCGATGATGAGCCCGAAGAACCGGGGTATGAGGTTGTGCCAACCGGACTCTCCGCCCCGCTCGCC
AAGGCGCCAGCCGGGTAG

Upstream 100 bases:

>100_bases
GCTGCAACGCCAGCCCCCCCTTAGGCCCAACAGCCGTTGTTTCACCCCAGCGCGCGCCCCGGGCAATGTGAGGCAAAGAG
CCCTCAAAAGGACACGCGAT

Downstream 100 bases:

>100_bases
CGCACCTCTCTGTTGGGGCTCAACCCATCCATCGTGGCGCGTGTCTGAAAACGTGCGGAGCCCTCCCGGCACGCCCTTCT
AAAGTCCTCGCGCGTGATCC

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MKIGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAVITCLPSPAACATVVEEMLPA
VDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSGGCHRADTGNISIFAGCDRATFERMLPTLTTLGRRVLHTGDI
GSASILKVMTNYLATANLLTCCEALVTMKAAGIDLNTTYEAMKISSGTSFVHETESQVILNGSRDISFTMDLVKKDISLF
QTIADAHGVPLEISPLLVEIFTDGIARFGERELSPNIIRRLEEATGLSITAPGFPAEMVDDEPEEPGYEVVPTGLSAPLA
KAPAG

Sequences:

>Translated_325_residues
MKIGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAVITCLPSPAACATVVEEMLPA
VDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSGGCHRADTGNISIFAGCDRATFERMLPTLTTLGRRVLHTGDI
GSASILKVMTNYLATANLLTCCEALVTMKAAGIDLNTTYEAMKISSGTSFVHETESQVILNGSRDISFTMDLVKKDISLF
QTIADAHGVPLEISPLLVEIFTDGIARFGERELSPNIIRRLEEATGLSITAPGFPAEMVDDEPEEPGYEVVPTGLSAPLA
KAPAG
>Mature_325_residues
MKIGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAVITCLPSPAACATVVEEMLPA
VDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSGGCHRADTGNISIFAGCDRATFERMLPTLTTLGRRVLHTGDI
GSASILKVMTNYLATANLLTCCEALVTMKAAGIDLNTTYEAMKISSGTSFVHETESQVILNGSRDISFTMDLVKKDISLF
QTIADAHGVPLEISPLLVEIFTDGIARFGERELSPNIIRRLEEATGLSITAPGFPAEMVDDEPEEPGYEVVPTGLSAPLA
KAPAG

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=263, Percent_Identity=26.615969581749, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=26.8041237113402, Blast_Score=108, Evalue=7e-24,
Organism=Escherichia coli, GI145693186, Length=252, Percent_Identity=28.1746031746032, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790315, Length=294, Percent_Identity=27.891156462585, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=29.0657439446367, Blast_Score=98, Evalue=7e-22,
Organism=Escherichia coli, GI1789092, Length=271, Percent_Identity=25.0922509225092, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=272, Percent_Identity=28.3088235294118, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24655230, Length=268, Percent_Identity=26.4925373134328, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922568, Length=268, Percent_Identity=26.4925373134328, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574115, Length=263, Percent_Identity=22.4334600760456, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 34287; Mature: 34287

Theoretical pI: Translated: 4.41; Mature: 4.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAV
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ITCLPSPAACATVVEEMLPAVDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSGG
HHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCC
CHRADTGNISIFAGCDRATFERMLPTLTTLGRRVLHTGDIGSASILKVMTNYLATANLLT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
CCEALVTMKAAGIDLNTTYEAMKISSGTSFVHETESQVILNGSRDISFTMDLVKKDISLF
HHHHHHHHHHCCCCCCCCHHHEEECCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
QTIADAHGVPLEISPLLVEIFTDGIARFGERELSPNIIRRLEEATGLSITAPGFPAEMVD
HHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCHHHCC
DEPEEPGYEVVPTGLSAPLAKAPAG
CCCCCCCCEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKIGFIGLGNVGGKLAGSLLRNGFDLTVYDLNPDLVAEYVEKGAQPGTGPLAIMRACDAV
CEEEEEEECCCCHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCCCCCHHHHHHHHHHH
ITCLPSPAACATVVEEMLPAVDSSKIWMEMSTTDAAEVKRLAALVSERGGSAMECPVSGG
HHHCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEECCCCCC
CHRADTGNISIFAGCDRATFERMLPTLTTLGRRVLHTGDIGSASILKVMTNYLATANLLT
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHH
CCEALVTMKAAGIDLNTTYEAMKISSGTSFVHETESQVILNGSRDISFTMDLVKKDISLF
HHHHHHHHHHCCCCCCCCHHHEEECCCCCHHHCCCCEEEEECCCCHHHHHHHHHHHHHHH
QTIADAHGVPLEISPLLVEIFTDGIARFGERELSPNIIRRLEEATGLSITAPGFPAEMVD
HHHHHCCCCCEEHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEEECCCCCHHHCC
DEPEEPGYEVVPTGLSAPLAKAPAG
CCCCCCCCEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA