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The map label for this gene is mcpA [H]

Identifier: 99081842

GI number: 99081842

Start: 2106428

End: 2108020

Strand: Direct

Name: mcpA [H]

Synonym: TM1040_2002

Alternate gene names: 99081842

Gene position: 2106428-2108020 (Clockwise)

Preceding gene: 99081841

Following gene: 99081843

Centisome position: 65.81

GC content: 62.08

Gene sequence:

>1593_bases
ATGCAAAAGCTAAGAGAGCCGCACGCGGACACCTCAGCCATTGATAGCCCTGCTCGCCCCATTGCAAAGGCGGCGAACAA
GCGACGAATTCAGCGGGTCACCAGTTGGCTGCTGGTCCCCCTGCCTGCCGCGGCCGCGTATTTTGTCAACGGGCTCCCCC
TCTGGTGGGCCTTTGCCGCGCTGAGCCTTGTGCTCGGTGCCATGGCCTGGGTCTCCCGCAAACTGCCGGAGTCGACGCGC
GATTACCTGCTGAGTTTCTGCTTCATCGCCCACTGTATCTTGCTCACCGCCTCGCTCAGCGGTCACGCGTGGCAGCTTGA
TACGCATATGATGTTCTTTGCCGCCCTGGCCATCGTATCGACCCTTTCAAGTCCGCGCGCGCTGATCTTTGCAACGGTTC
TGATCGCGCTGCACCACATTTCATTCAGCGTCCTGATGCCCTCTCTCGTCTATCCGGGTGGCGGCATTGCCGAGAACCTG
CAACGCACTGTGATGCATGCGGTGATCGTGCTTCTGGAAGCCGGTGTTCTGCTGCTCAGCATGCTCAGGAGCCTTGCCGC
CGACACGGAGCTGAAAACCCAGCAGAGCGCGGCCGAACATCAGGCGCAAGCGGCAGAACGCGCCGAAGCCCTCGCGATGC
AAAGCCACAAGAACGCCGAGCGCGTCGTCAGCATCGTCGGCGATCATCTGCGTGAACTCGCCGCCGGGCGGCTGGATTGC
AAGATCGACACCTCTTTCCCACAGGAATATGCGCAGCTTCAGGAGAGCTTCAATTCCACCGTCGATACGCTGAAAGGCAC
CATCGAACAGGTCAAAGACGCCACCTATCGCCTCAGCAAAGGCGCGACGGACATCGATCAGGCCTCTGAAAATCTCTCCA
ACCGCACCGAAAGCCAGGCCGCGACGCTGGAGCAATCCGTGGCCGCCCTCGAAGAACTGACCACTTCCGTCAAATCTTCG
GCCGAAGGCGCGCTCAGCGTTCAGCGCACGATGGATGATGCCCGCTCCGAAGCCGTAAGCAGCGGTGGCGTCGTGAAGGA
TGCGGTCTCCGCCATGAGCGCGATCGAGGACTCCTCCTCCCAGATTGCGCGCAACATCAGCGTGATCGACGACATCGCCT
TCCAGACCAACCTGCTGGCGCTCAATGCCGGGGTCGAGGCCGCCCGTGCGGGCGAGGCCGGCAAAGGCTTTGCCGTGGTC
GCCGCCGAGGTGCAGGCGCTTGCGCAGCGGTCGGCTGATGCCGCAACCGAGATCAAGAGCCTGATCTCGCAGAGTTCCCA
GCACGTTGATCACGGGGTTGATCTGGTGGGTCAGGCTGGCGAGGCGATCGAGAAGATCGTTGAACGCGTCGAGCAGATCT
CTGAACTTGTGTCGGGCATCGCCACCAGCGCGGCAGAGCAGTCTTCCGGGCTGGGCGAGATCAACACCGGGATGAGCCAG
CTGGATCAGGTGACCCAGCAGAATGCGGCCATGGTGGAACAGGTCAGCGCAGCCAGTCATCTGCTGCATTCGGACTCAAA
GCGGCTTGCACAGTTGATGGCGCATTTCGAGACGGGCGCCGCCGACCAGACCCAAAGCGCCGCTGCGGCCTGA

Upstream 100 bases:

>100_bases
CCATTGGTGCTCTTGTTTTGCTCGAGACGCCAGACAGCATTGACCGGCTTTATCGTGAAGGGGCCTGGTTGATTACAGAC
GGAAAGAAAGTTTTGGAACT

Downstream 100 bases:

>100_bases
GGTCTCTCGTCCTTGTGCAAGGGGCGCGCCGTGCGCCTCCCGGCACCTGTCCATCAAGCGAATTCAAAAGAAGGGGCCAA
CAGGCCCCTTCTTTTGATCT

Product: methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: Methyl-accepting chemotaxis protein [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MQKLREPHADTSAIDSPARPIAKAANKRRIQRVTSWLLVPLPAAAAYFVNGLPLWWAFAALSLVLGAMAWVSRKLPESTR
DYLLSFCFIAHCILLTASLSGHAWQLDTHMMFFAALAIVSTLSSPRALIFATVLIALHHISFSVLMPSLVYPGGGIAENL
QRTVMHAVIVLLEAGVLLLSMLRSLAADTELKTQQSAAEHQAQAAERAEALAMQSHKNAERVVSIVGDHLRELAAGRLDC
KIDTSFPQEYAQLQESFNSTVDTLKGTIEQVKDATYRLSKGATDIDQASENLSNRTESQAATLEQSVAALEELTTSVKSS
AEGALSVQRTMDDARSEAVSSGGVVKDAVSAMSAIEDSSSQIARNISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVV
AAEVQALAQRSADAATEIKSLISQSSQHVDHGVDLVGQAGEAIEKIVERVEQISELVSGIATSAAEQSSGLGEINTGMSQ
LDQVTQQNAAMVEQVSAASHLLHSDSKRLAQLMAHFETGAADQTQSAAAA

Sequences:

>Translated_530_residues
MQKLREPHADTSAIDSPARPIAKAANKRRIQRVTSWLLVPLPAAAAYFVNGLPLWWAFAALSLVLGAMAWVSRKLPESTR
DYLLSFCFIAHCILLTASLSGHAWQLDTHMMFFAALAIVSTLSSPRALIFATVLIALHHISFSVLMPSLVYPGGGIAENL
QRTVMHAVIVLLEAGVLLLSMLRSLAADTELKTQQSAAEHQAQAAERAEALAMQSHKNAERVVSIVGDHLRELAAGRLDC
KIDTSFPQEYAQLQESFNSTVDTLKGTIEQVKDATYRLSKGATDIDQASENLSNRTESQAATLEQSVAALEELTTSVKSS
AEGALSVQRTMDDARSEAVSSGGVVKDAVSAMSAIEDSSSQIARNISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVV
AAEVQALAQRSADAATEIKSLISQSSQHVDHGVDLVGQAGEAIEKIVERVEQISELVSGIATSAAEQSSGLGEINTGMSQ
LDQVTQQNAAMVEQVSAASHLLHSDSKRLAQLMAHFETGAADQTQSAAAA
>Mature_530_residues
MQKLREPHADTSAIDSPARPIAKAANKRRIQRVTSWLLVPLPAAAAYFVNGLPLWWAFAALSLVLGAMAWVSRKLPESTR
DYLLSFCFIAHCILLTASLSGHAWQLDTHMMFFAALAIVSTLSSPRALIFATVLIALHHISFSVLMPSLVYPGGGIAENL
QRTVMHAVIVLLEAGVLLLSMLRSLAADTELKTQQSAAEHQAQAAERAEALAMQSHKNAERVVSIVGDHLRELAAGRLDC
KIDTSFPQEYAQLQESFNSTVDTLKGTIEQVKDATYRLSKGATDIDQASENLSNRTESQAATLEQSVAALEELTTSVKSS
AEGALSVQRTMDDARSEAVSSGGVVKDAVSAMSAIEDSSSQIARNISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVV
AAEVQALAQRSADAATEIKSLISQSSQHVDHGVDLVGQAGEAIEKIVERVEQISELVSGIATSAAEQSSGLGEINTGMSQ
LDQVTQQNAAMVEQVSAASHLLHSDSKRLAQLMAHFETGAADQTQSAAAA

Specific function: Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein. Note=Localized at the flagellum-bearing pole of the swarmer cell [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 methyl-accepting transducer domain [H]

Homologues:

Organism=Escherichia coli, GI1788195, Length=293, Percent_Identity=42.320819112628, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI2367378, Length=289, Percent_Identity=44.9826989619377, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1787690, Length=265, Percent_Identity=43.7735849056604, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1788194, Length=294, Percent_Identity=40.1360544217687, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789453, Length=249, Percent_Identity=36.5461847389558, Blast_Score=153, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal [H]

EC number: NA

Molecular weight: Translated: 56244; Mature: 56244

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50885 HAMP ; PS00639 THIOL_PROTEASE_HIS ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKLREPHADTSAIDSPARPIAKAANKRRIQRVTSWLLVPLPAAAAYFVNGLPLWWAFAA
CCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSLVLGAMAWVSRKLPESTRDYLLSFCFIAHCILLTASLSGHAWQLDTHMMFFAALAIVS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
TLSSPRALIFATVLIALHHISFSVLMPSLVYPGGGIAENLQRTVMHAVIVLLEAGVLLLS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MLRSLAADTELKTQQSAAEHQAQAAERAEALAMQSHKNAERVVSIVGDHLRELAAGRLDC
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCE
KIDTSFPQEYAQLQESFNSTVDTLKGTIEQVKDATYRLSKGATDIDQASENLSNRTESQA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ATLEQSVAALEELTTSVKSSAEGALSVQRTMDDARSEAVSSGGVVKDAVSAMSAIEDSSS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHH
QIARNISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVVAAEVQALAQRSADAATEIKS
HHHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LISQSSQHVDHGVDLVGQAGEAIEKIVERVEQISELVSGIATSAAEQSSGLGEINTGMSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LDQVTQQNAAMVEQVSAASHLLHSDSKRLAQLMAHFETGAADQTQSAAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MQKLREPHADTSAIDSPARPIAKAANKRRIQRVTSWLLVPLPAAAAYFVNGLPLWWAFAA
CCCCCCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
LSLVLGAMAWVSRKLPESTRDYLLSFCFIAHCILLTASLSGHAWQLDTHMMFFAALAIVS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHH
TLSSPRALIFATVLIALHHISFSVLMPSLVYPGGGIAENLQRTVMHAVIVLLEAGVLLLS
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
MLRSLAADTELKTQQSAAEHQAQAAERAEALAMQSHKNAERVVSIVGDHLRELAAGRLDC
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCE
KIDTSFPQEYAQLQESFNSTVDTLKGTIEQVKDATYRLSKGATDIDQASENLSNRTESQA
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
ATLEQSVAALEELTTSVKSSAEGALSVQRTMDDARSEAVSSGGVVKDAVSAMSAIEDSSS
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHH
QIARNISVIDDIAFQTNLLALNAGVEAARAGEAGKGFAVVAAEVQALAQRSADAATEIKS
HHHHHHHHHHHHHHHHHHHEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LISQSSQHVDHGVDLVGQAGEAIEKIVERVEQISELVSGIATSAAEQSSGLGEINTGMSQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LDQVTQQNAAMVEQVSAASHLLHSDSKRLAQLMAHFETGAADQTQSAAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1577276; 11259647 [H]