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The map label for this gene is hisC [H]

Identifier: 99081821

GI number: 99081821

Start: 2084941

End: 2086053

Strand: Direct

Name: hisC [H]

Synonym: TM1040_1981

Alternate gene names: 99081821

Gene position: 2084941-2086053 (Clockwise)

Preceding gene: 99081818

Following gene: 99081822

Centisome position: 65.14

GC content: 63.61

Gene sequence:

>1113_bases
ATGACAGACAGCCGCCAAACCCCGCTCGCCCAATCCCTGCCCGCTTCGGTGCCCTTTGTTGGCCCCGAGACCCATGAACG
CCAGCGCGGCGCGCCTTTTGTGGCGCGGCTCGGTGCAAATGAGAACCTCTTTGGCGTCTCCCCCAAGGCGATTGCCGCCA
TGCAGGCCTCAGCGGCAGAGATCTGGAAATACGGCGATGCAGAGAGCTACGAGCTGCGCGCGGCCCTCTCGGCGTTGCAT
GGCATTGCACCCGAACACATCATGGTTGGCGAGGGCATCGACGGCCTCCTGGGCAATCTGGTGCGGCTTTATGTCGGCGC
CGGCGATGCTGTGGTGACATCGCTGGGGGCCTATCCGACCTTCAACTATCATGTGGCCGGTTTTGGCGGCGACCTTCACA
CTGTGCCCTACAAGGACGACCACGAAGACATCAAAGCCCTGATGGCCAAGGCACATGAGGTGGGCGCAAAGCTGGTCTAT
CTCGCCAATCCTGACAATCCGATGGGCAGTTGGCATCGCGGTGCAGATATTGTCGCCGCACTTGACGACCTGCCCGAAGG
CAGCCTCTTGGTGCTGGATGAGGCCTATGTGGAATGCGCGCCCAAAGGCACCGCCGCCCCGGTCGATGTGACCGACCCGC
GCGTGATCCGCATGCGCACCCTCTCCAAGGCCTATGGCATGGCGGGGGCACGCGTCGGCTATGCCATGGGGGCGGTTGAA
GTCATCTCCGCCTTTCACAAGGTCCGCAATCACTTTGGCATGAACCGCTGCGCACAGATCGGCGCAACCGAGGCCATCAA
GGATCAGGCATGGCTGGCTCATGTGCAGGCCGAGATCGCCACCGCACGCGAAGAGATCTCGCGCATCGCTCGCGAAAACG
GCCTCACACCGCTGCCTTCCGCGACCAACTTCGTCGCCATAGACTGCGGTCGCGATGGCGCCTTTGCCAAGGCGGTCTTG
GAGGCGCTGGTGGCGCGGGACATCTTTGTGCGCATGCCATTTGCAGCCCCGCAAAACCGCTGCATCCGCGTCAGCTGCGG
CCCCGAAAGAGAGCGCCGCGCCTTTGCCGAGGCCCTGCCGCTGGCCCTCAAAGACGCGCAGAACGGCGCCTAA

Upstream 100 bases:

>100_bases
TGACGCGAGGGCACGCCGGACCGGATCCTTCCCGGACCGCGACCTGATCTCGCCCGATCTGCCCTTGCCCGCCTGCGCGC
GCGCCGCTAGGTCTTGGGCC

Downstream 100 bases:

>100_bases
AGCGCAAGGCAAACGGTAAATCCTGCCAAAAGAGACCCTGTTTTACCGCCGGTTTACCCCTTTCAGGCTAGGCTGTTTCA
ACATTGCCTGCCTGGAGGGG

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTDSRQTPLAQSLPASVPFVGPETHERQRGAPFVARLGANENLFGVSPKAIAAMQASAAEIWKYGDAESYELRAALSALH
GIAPEHIMVGEGIDGLLGNLVRLYVGAGDAVVTSLGAYPTFNYHVAGFGGDLHTVPYKDDHEDIKALMAKAHEVGAKLVY
LANPDNPMGSWHRGADIVAALDDLPEGSLLVLDEAYVECAPKGTAAPVDVTDPRVIRMRTLSKAYGMAGARVGYAMGAVE
VISAFHKVRNHFGMNRCAQIGATEAIKDQAWLAHVQAEIATAREEISRIARENGLTPLPSATNFVAIDCGRDGAFAKAVL
EALVARDIFVRMPFAAPQNRCIRVSCGPERERRAFAEALPLALKDAQNGA

Sequences:

>Translated_370_residues
MTDSRQTPLAQSLPASVPFVGPETHERQRGAPFVARLGANENLFGVSPKAIAAMQASAAEIWKYGDAESYELRAALSALH
GIAPEHIMVGEGIDGLLGNLVRLYVGAGDAVVTSLGAYPTFNYHVAGFGGDLHTVPYKDDHEDIKALMAKAHEVGAKLVY
LANPDNPMGSWHRGADIVAALDDLPEGSLLVLDEAYVECAPKGTAAPVDVTDPRVIRMRTLSKAYGMAGARVGYAMGAVE
VISAFHKVRNHFGMNRCAQIGATEAIKDQAWLAHVQAEIATAREEISRIARENGLTPLPSATNFVAIDCGRDGAFAKAVL
EALVARDIFVRMPFAAPQNRCIRVSCGPERERRAFAEALPLALKDAQNGA
>Mature_369_residues
TDSRQTPLAQSLPASVPFVGPETHERQRGAPFVARLGANENLFGVSPKAIAAMQASAAEIWKYGDAESYELRAALSALHG
IAPEHIMVGEGIDGLLGNLVRLYVGAGDAVVTSLGAYPTFNYHVAGFGGDLHTVPYKDDHEDIKALMAKAHEVGAKLVYL
ANPDNPMGSWHRGADIVAALDDLPEGSLLVLDEAYVECAPKGTAAPVDVTDPRVIRMRTLSKAYGMAGARVGYAMGAVEV
ISAFHKVRNHFGMNRCAQIGATEAIKDQAWLAHVQAEIATAREEISRIARENGLTPLPSATNFVAIDCGRDGAFAKAVLE
ALVARDIFVRMPFAAPQNRCIRVSCGPERERRAFAEALPLALKDAQNGA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=334, Percent_Identity=26.0479041916168, Blast_Score=96, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322075, Length=365, Percent_Identity=24.1095890410959, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 39477; Mature: 39346

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSRQTPLAQSLPASVPFVGPETHERQRGAPFVARLGANENLFGVSPKAIAAMQASAAE
CCCCCCCCCHHHCCCCCCCCCCCCHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHH
IWKYGDAESYELRAALSALHGIAPEHIMVGEGIDGLLGNLVRLYVGAGDAVVTSLGAYPT
HHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCC
FNYHVAGFGGDLHTVPYKDDHEDIKALMAKAHEVGAKLVYLANPDNPMGSWHRGADIVAA
CCEEEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHH
LDDLPEGSLLVLDEAYVECAPKGTAAPVDVTDPRVIRMRTLSKAYGMAGARVGYAMGAVE
HHCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHH
VISAFHKVRNHFGMNRCAQIGATEAIKDQAWLAHVQAEIATAREEISRIARENGLTPLPS
HHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATNFVAIDCGRDGAFAKAVLEALVARDIFVRMPFAAPQNRCIRVSCGPERERRAFAEALP
CCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
LALKDAQNGA
HHHHCCCCCC
>Mature Secondary Structure 
TDSRQTPLAQSLPASVPFVGPETHERQRGAPFVARLGANENLFGVSPKAIAAMQASAAE
CCCCCCCCHHHCCCCCCCCCCCCHHHHCCCCEEEEECCCCCEECCCHHHHHHHHHHHHH
IWKYGDAESYELRAALSALHGIAPEHIMVGEGIDGLLGNLVRLYVGAGDAVVTSLGAYPT
HHHCCCCCCHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHCCCHHHHHHHCCCCC
FNYHVAGFGGDLHTVPYKDDHEDIKALMAKAHEVGAKLVYLANPDNPMGSWHRGADIVAA
CCEEEEEECCCEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCHHHHH
LDDLPEGSLLVLDEAYVECAPKGTAAPVDVTDPRVIRMRTLSKAYGMAGARVGYAMGAVE
HHCCCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCEEHHHHHHHHHCCCHHHHHHHHHHHH
VISAFHKVRNHFGMNRCAQIGATEAIKDQAWLAHVQAEIATAREEISRIARENGLTPLPS
HHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
ATNFVAIDCGRDGAFAKAVLEALVARDIFVRMPFAAPQNRCIRVSCGPERERRAFAEALP
CCCEEEEECCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEEEEECCCCHHHHHHHHHHH
LALKDAQNGA
HHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA