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The map label for this gene is folE2

Identifier: 99081778

GI number: 99081778

Start: 2040105

End: 2041208

Strand: Reverse

Name: folE2

Synonym: TM1040_1937

Alternate gene names: 99081778

Gene position: 2041208-2040105 (Counterclockwise)

Preceding gene: 99081779

Following gene: 99081777

Centisome position: 63.77

GC content: 59.33

Gene sequence:

>1104_bases
ATGAATATTCATTCTCGTGATGTAAACGAAACGCCAGATCGCTCGGACGCGGAACAAGCGCTTGCGGTGCTGCGGCGCTG
GGCGGGCGAAGCAAGCGAGACCGAAGTGGCGCAGCTCGACCCTGCGATTGCGCGCCTGCTGCCCGGGCAGGAATTGCAGA
ATTACCCCGACCTCAAGCGCCAGTACCCGGACGACTTTGATGCAAACGAGTCCTACCGCGCCACGCTCCCGGATCTTCAG
AACGGCCCTTCCAGCCTGATCCGCGGCGCCAAGGAGCAGATCCAGCATGTCGGTATCTCCAATTTCCGCCTGCCGATCCG
GTTTCATACGCGGGACAACGGTGATCTGACGCTCGAGACCAGCGTAACCGGCACCGTCAGCTTGGATGCGGAGAAAAAAG
GCATCAACATGTCGCGCATCATGCGCAGCTTTTACAAACATGCTGAGAAGGTCTTTTCTTTCGACGTGATGGAAGCAGCT
CTTGAGGATTATCTGAGCGATCTTGAGAGTGGCGACGCGCGGCTGCAGATGCGGTTTTCCTTCCCTGTGAAGGTGCAGAG
CCTGCGCTCGGGTCTTTCGGGCTATCAGTATTACGACGTGGCGCTGGAACTGGTGCAGATGGCTGGGCAACGCCATCGCA
TCGTGCATCTGGACTATGTCTATTCTTCGACCTGCCCGTGCTCGCTTGAGCTTTCGGAACATGCCCGTCAGGCGCGTGGA
CAGCTGGCGACCCCGCACTCGCAGCGCTCTGTTGCGCGGATTTCCGTGCAGATGGAACAGGATGGCGGCTGTTTGTGGTT
CGAGGATCTGATCGACCATTGCCGTCGCGCGGTGCCGACCGAGACGCAGGTGATGGTGAAGCGCGAAGACGAACAGGCAT
TTGCGGAGTTGAACGCGGCCAATCCGATCTTTGTGGAAGATGCGGCGCGCCTCTTTTGTGAAGCGCTTCAGAGCGATGCG
CGGGTGGGGGATTTTCGGGTTGTGGCGAGCCATCAGGAAAGCCTGCACAGCCATGACGCGGTCTCTGTGCTGACGCAGGG
CACGATGTTTGCGGCGCCGAGCCTCGACCCGCAGCTATTCTCGACTTTGATCCATCGCGGTTAG

Upstream 100 bases:

>100_bases
ACCTTTTGGGGCGTTTTTTGGTGATCTACTTTGTGTTTATTGACGTACTACCCTAGATGATTGTGAACAGGCATTTGCTG
CTGGGACAGGAGTACGGGTT

Downstream 100 bases:

>100_bases
GGTCGGATGCGAGGGGCGCTGCCCCTCGCGCTCCCCGAGGTATTTTCAAAAAGATGAAAGCATAGGCCCTCCCGGGAGGA
TGGGCTTGTTTTTGCCGCGG

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MNIHSRDVNETPDRSDAEQALAVLRRWAGEASETEVAQLDPAIARLLPGQELQNYPDLKRQYPDDFDANESYRATLPDLQ
NGPSSLIRGAKEQIQHVGISNFRLPIRFHTRDNGDLTLETSVTGTVSLDAEKKGINMSRIMRSFYKHAEKVFSFDVMEAA
LEDYLSDLESGDARLQMRFSFPVKVQSLRSGLSGYQYYDVALELVQMAGQRHRIVHLDYVYSSTCPCSLELSEHARQARG
QLATPHSQRSVARISVQMEQDGGCLWFEDLIDHCRRAVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFCEALQSDA
RVGDFRVVASHQESLHSHDAVSVLTQGTMFAAPSLDPQLFSTLIHRG

Sequences:

>Translated_367_residues
MNIHSRDVNETPDRSDAEQALAVLRRWAGEASETEVAQLDPAIARLLPGQELQNYPDLKRQYPDDFDANESYRATLPDLQ
NGPSSLIRGAKEQIQHVGISNFRLPIRFHTRDNGDLTLETSVTGTVSLDAEKKGINMSRIMRSFYKHAEKVFSFDVMEAA
LEDYLSDLESGDARLQMRFSFPVKVQSLRSGLSGYQYYDVALELVQMAGQRHRIVHLDYVYSSTCPCSLELSEHARQARG
QLATPHSQRSVARISVQMEQDGGCLWFEDLIDHCRRAVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFCEALQSDA
RVGDFRVVASHQESLHSHDAVSVLTQGTMFAAPSLDPQLFSTLIHRG
>Mature_367_residues
MNIHSRDVNETPDRSDAEQALAVLRRWAGEASETEVAQLDPAIARLLPGQELQNYPDLKRQYPDDFDANESYRATLPDLQ
NGPSSLIRGAKEQIQHVGISNFRLPIRFHTRDNGDLTLETSVTGTVSLDAEKKGINMSRIMRSFYKHAEKVFSFDVMEAA
LEDYLSDLESGDARLQMRFSFPVKVQSLRSGLSGYQYYDVALELVQMAGQRHRIVHLDYVYSSTCPCSLELSEHARQARG
QLATPHSQRSVARISVQMEQDGGCLWFEDLIDHCRRAVPTETQVMVKREDEQAFAELNAANPIFVEDAARLFCEALQSDA
RVGDFRVVASHQESLHSHDAVSVLTQGTMFAAPSLDPQLFSTLIHRG

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_SILST (Q1GF96)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613932.1
- ProteinModelPortal:   Q1GF96
- SMR:   Q1GF96
- STRING:   Q1GF96
- GeneID:   4076888
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1937
- NMPDR:   fig|292414.1.peg.324
- eggNOG:   COG1469
- HOGENOM:   HBG466315
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   SSP292414:TM1040_1937-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 41243; Mature: 41243

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIHSRDVNETPDRSDAEQALAVLRRWAGEASETEVAQLDPAIARLLPGQELQNYPDLKR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHCCCHHHHCCCCHHH
QYPDDFDANESYRATLPDLQNGPSSLIRGAKEQIQHVGISNFRLPIRFHTRDNGDLTLET
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEE
SVTGTVSLDAEKKGINMSRIMRSFYKHAEKVFSFDVMEAALEDYLSDLESGDARLQMRFS
ECEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
FPVKVQSLRSGLSGYQYYDVALELVQMAGQRHRIVHLDYVYSSTCPCSLELSEHARQARG
CCEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHCC
QLATPHSQRSVARISVQMEQDGGCLWFEDLIDHCRRAVPTETQVMVKREDEQAFAELNAA
CCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCC
NPIFVEDAARLFCEALQSDARVGDFRVVASHQESLHSHDAVSVLTQGTMFAAPSLDPQLF
CCEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEECCCCCHHHH
STLIHRG
HHHHHCC
>Mature Secondary Structure
MNIHSRDVNETPDRSDAEQALAVLRRWAGEASETEVAQLDPAIARLLPGQELQNYPDLKR
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCHHHHHHCCCHHHHCCCCHHH
QYPDDFDANESYRATLPDLQNGPSSLIRGAKEQIQHVGISNFRLPIRFHTRDNGDLTLET
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCEEEEE
SVTGTVSLDAEKKGINMSRIMRSFYKHAEKVFSFDVMEAALEDYLSDLESGDARLQMRFS
ECEEEEEECCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
FPVKVQSLRSGLSGYQYYDVALELVQMAGQRHRIVHLDYVYSSTCPCSLELSEHARQARG
CCEEHHHHHCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHCC
QLATPHSQRSVARISVQMEQDGGCLWFEDLIDHCRRAVPTETQVMVKREDEQAFAELNAA
CCCCCCCCCCEEEEEEEEECCCCEEEHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHCCC
NPIFVEDAARLFCEALQSDARVGDFRVVASHQESLHSHDAVSVLTQGTMFAAPSLDPQLF
CCEEHHHHHHHHHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHCCCEEECCCCCHHHH
STLIHRG
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA