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The map label for this gene is bhbA [H]

Identifier: 99081706

GI number: 99081706

Start: 1964662

End: 1966647

Strand: Reverse

Name: bhbA [H]

Synonym: TM1040_1865

Alternate gene names: 99081706

Gene position: 1966647-1964662 (Counterclockwise)

Preceding gene: 99081707

Following gene: 99081705

Centisome position: 61.44

GC content: 61.73

Gene sequence:

>1986_bases
ATGGGCACACTGCCGGGCTTTGGCCCGTTCACCCGTGGGGTGAAGGCCACCATGTATGCAGGCCGCCGCTGGACCATCCG
CCAATACGCGGGCTTCTCCACGGCCGAAGAATCCAACGCCTTTTACCGCCGCAACCTTGCCGCTGGTCAGCAGGGGGTCT
CGGTGGCTTTCGATCTCGCCACCCACCGCGGCTATGACAGCGATCACGAGCGCGTCGTCGGTGATGTCGGCAAGGCGGGC
GTTGCCATCGACAGTGTCGAGGATATGAAGATCCTGTTTGACGGCATCCCGCTCGATCAGGTTTCGGTCTCCATGACCAT
GAATGGCGCGGTGATCCCGATCCTGGCGAGCTTCATCGTCGCAGGTGAAGAACAGGGCCACGACAAGGCGCTCCTCTCCG
GGACCATCCAGAACGACATCCTCAAGGAGTTCATGGTCCGCAACACCTATATCTATCCGCCAGAACCCTCGATGCGGATC
ATCGCGGACATCATTGAATACACCTCGAACGAGATGCCGAAGTTCAACTCCATCTCGATCTCCGGCTACCACATGCAGGA
GGCGGGCGCGAACCTCGTTCAGGAACTCGCCTATACGCTGGCGGATGGGCGCGAATACGTCAAAGCCGCCATCGAGGCGG
GCATGGACGTGGACAAATTCGCAGGCCGTTTGTCGTTCTTCTTTGCCATTGGCATGAACTTCTTCATGGAGGCGGCCAAG
CTGCGCGCCGCGCGTACGCTCTGGCATCGGGTGATGACGGAATTCGGCGCCAAATCCGACCGCTCCAAGATGCTGCGCAC
CCATTGCCAGACCTCGGGCGTGAGCCTGCAGGAGCAGGATCCTTACAACAACGTGATCCGCACCGCCTATGAGGCGATGA
GCGCGGTTCTGGGCGGCACGCAAAGTCTGCACACCAACGCTTTGGATGAGGCGATTGCGCTGCCCACCGATTTCTCTGCC
CGAATTGCGCGCAATACCCAGTTGATCTTGCAAGAAGAAACCGGCGTCACCAATGTCGTCGATCCGCTTGCCGGCAGCTA
TTATGTCGAGAGCCTCACCGCAGAGCTCGTCGACAAGGCCTGGGCGATGATGCAGGAAGTGGAGGAGATGGGCGGCATGA
CCAAGGCCGTGGCCTCCGGCATGCCGAAACTGCGCATCGAGGAAACTGCCGCCCGCCGTCAGGCGATGATCGACCGCGGC
GAAGAGGTGATCGTCGGCGTCAACAAATACCGCAAGGACAAGGAAGACCCCATCGACATCCTCGATGTGGACAACGTCAA
GGTGCGCGAGAGTCAGATCGCCCGGCTTGAACAGATCCGCGCCAGCCGCGATGCGGCGGCCTGCGAGGCGGCGCTGGCCG
AACTCACCCGCCGCGCGTCTGAGGGCGGCAATCTTCTGGAAGCAGCCGTCGAGGCCGCCCGCGCGCGCGCCACTGTGGGG
GAAATCAGCATGGCAATGGAAAAAGAATTCGGTCGTCACCGCGCCGAGGTCAAAACCCTCGCAGGCGTCTACGGCGCCGC
ATACGAGGGCGACGAGGGCTTTGCCGCGATCCAGAAATCCATCGAGTCCTTTGCCGAGGAAGAGGGCCGCCGCCCGCGTC
TTCTGGTGGTCAAGATGGGGCAGGACGGTCACGACCGGGGCGCCAAGGTGATCGCCACCGCCTTTGCTGACATTGGCTTT
GACGTGGATGTGGGACCGCTGTTCCAGACCCCGGCAGAGGCCGCGCAGGATGCCATCGACAATGATGTGCATGTGGTCGG
TATCTCCAGCCAGGCGGCGGGTCACAAGACGCTCGCCCCCCAGCTGATCGCCGAACTCAAAGCCGCCGGGGCGGAGGACA
TCATCGTGATCTGTGGCGGGGTGATCCCGCAGCAGGATTATGACTTCCTCTACAAGGCGGGTGTCAAAGCGATCTTTGGT
CCCGGCACCAATATCTCCACCGCGGCACAGGATATTCTCGAACTCATCCGCGAAGCGCGCAGCTAA

Upstream 100 bases:

>100_bases
ACTGCGCGGACGCCCGCTCGAGGATCTCACCTGGCAGACCCTCGAGGGCATTGACGTCAAACCGCTTTATACGGCCGAGG
ACACCGCAGAGCTTGGCCAT

Downstream 100 bases:

>100_bases
GGCGAGGGCCGCAAGATGCGCGATCCAGCCTTCAAAGGCCGCGTGTACCTCTCGGGTCACCTCTTCTGCGCTTCGGCGCA
GGAGCAGGCCCTGGTGGAGC

Product: methylmalonyl-CoA mutase

Products: NA

Alternate protein names: MCM [H]

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MGTLPGFGPFTRGVKATMYAGRRWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHERVVGDVGKAG
VAIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIVAGEEQGHDKALLSGTIQNDILKEFMVRNTYIYPPEPSMRI
IADIIEYTSNEMPKFNSISISGYHMQEAGANLVQELAYTLADGREYVKAAIEAGMDVDKFAGRLSFFFAIGMNFFMEAAK
LRAARTLWHRVMTEFGAKSDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTDFSA
RIARNTQLILQEETGVTNVVDPLAGSYYVESLTAELVDKAWAMMQEVEEMGGMTKAVASGMPKLRIEETAARRQAMIDRG
EEVIVGVNKYRKDKEDPIDILDVDNVKVRESQIARLEQIRASRDAAACEAALAELTRRASEGGNLLEAAVEAARARATVG
EISMAMEKEFGRHRAEVKTLAGVYGAAYEGDEGFAAIQKSIESFAEEEGRRPRLLVVKMGQDGHDRGAKVIATAFADIGF
DVDVGPLFQTPAEAAQDAIDNDVHVVGISSQAAGHKTLAPQLIAELKAAGAEDIIVICGGVIPQQDYDFLYKAGVKAIFG
PGTNISTAAQDILELIREARS

Sequences:

>Translated_661_residues
MGTLPGFGPFTRGVKATMYAGRRWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHERVVGDVGKAG
VAIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIVAGEEQGHDKALLSGTIQNDILKEFMVRNTYIYPPEPSMRI
IADIIEYTSNEMPKFNSISISGYHMQEAGANLVQELAYTLADGREYVKAAIEAGMDVDKFAGRLSFFFAIGMNFFMEAAK
LRAARTLWHRVMTEFGAKSDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTDFSA
RIARNTQLILQEETGVTNVVDPLAGSYYVESLTAELVDKAWAMMQEVEEMGGMTKAVASGMPKLRIEETAARRQAMIDRG
EEVIVGVNKYRKDKEDPIDILDVDNVKVRESQIARLEQIRASRDAAACEAALAELTRRASEGGNLLEAAVEAARARATVG
EISMAMEKEFGRHRAEVKTLAGVYGAAYEGDEGFAAIQKSIESFAEEEGRRPRLLVVKMGQDGHDRGAKVIATAFADIGF
DVDVGPLFQTPAEAAQDAIDNDVHVVGISSQAAGHKTLAPQLIAELKAAGAEDIIVICGGVIPQQDYDFLYKAGVKAIFG
PGTNISTAAQDILELIREARS
>Mature_660_residues
GTLPGFGPFTRGVKATMYAGRRWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLATHRGYDSDHERVVGDVGKAGV
AIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIVAGEEQGHDKALLSGTIQNDILKEFMVRNTYIYPPEPSMRII
ADIIEYTSNEMPKFNSISISGYHMQEAGANLVQELAYTLADGREYVKAAIEAGMDVDKFAGRLSFFFAIGMNFFMEAAKL
RAARTLWHRVMTEFGAKSDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGTQSLHTNALDEAIALPTDFSAR
IARNTQLILQEETGVTNVVDPLAGSYYVESLTAELVDKAWAMMQEVEEMGGMTKAVASGMPKLRIEETAARRQAMIDRGE
EVIVGVNKYRKDKEDPIDILDVDNVKVRESQIARLEQIRASRDAAACEAALAELTRRASEGGNLLEAAVEAARARATVGE
ISMAMEKEFGRHRAEVKTLAGVYGAAYEGDEGFAAIQKSIESFAEEEGRRPRLLVVKMGQDGHDRGAKVIATAFADIGFD
VDVGPLFQTPAEAAQDAIDNDVHVVGISSQAAGHKTLAPQLIAELKAAGAEDIIVICGGVIPQQDYDFLYKAGVKAIFGP
GTNISTAAQDILELIREARS

Specific function: Catalyzes the interconversion of succinyl-CoA and methylmalonyl-CoA during the polyhydroxyalkanoate degradation pathway [H]

COG id: COG1884

COG function: function code I; Methylmalonyl-CoA mutase, N-terminal domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=658, Percent_Identity=65.1975683890577, Blast_Score=893, Evalue=0.0,
Organism=Escherichia coli, GI1789284, Length=661, Percent_Identity=64.5990922844176, Blast_Score=860, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144500, Length=652, Percent_Identity=65.4907975460123, Blast_Score=886, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: =5.4.99.2 [H]

Molecular weight: Translated: 71800; Mature: 71669

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: PS00544 METMALONYL_COA_MUTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTLPGFGPFTRGVKATMYAGRRWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLA
CCCCCCCCHHHHCCHHHHCCCCCEEHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHH
THRGYDSDHERVVGDVGKAGVAIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIV
HHCCCCCCHHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
AGEEQGHDKALLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIEYTSNEMPKFNSISI
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEE
SGYHMQEAGANLVQELAYTLADGREYVKAAIEAGMDVDKFAGRLSFFFAIGMNFFMEAAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LRAARTLWHRVMTEFGAKSDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
QSLHTNALDEAIALPTDFSARIARNTQLILQEETGVTNVVDPLAGSYYVESLTAELVDKA
HHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHH
WAMMQEVEEMGGMTKAVASGMPKLRIEETAARRQAMIDRGEEVIVGVNKYRKDKEDPIDI
HHHHHHHHHHCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCCCCE
LDVDNVKVRESQIARLEQIRASRDAAACEAALAELTRRASEGGNLLEAAVEAARARATVG
EECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EISMAMEKEFGRHRAEVKTLAGVYGAAYEGDEGFAAIQKSIESFAEEEGRRPRLLVVKMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
QDGHDRGAKVIATAFADIGFDVDVGPLFQTPAEAAQDAIDNDVHVVGISSQAAGHKTLAP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
QLIAELKAAGAEDIIVICGGVIPQQDYDFLYKAGVKAIFGPGTNISTAAQDILELIREAR
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHC
S
C
>Mature Secondary Structure 
GTLPGFGPFTRGVKATMYAGRRWTIRQYAGFSTAEESNAFYRRNLAAGQQGVSVAFDLA
CCCCCCCHHHHCCHHHHCCCCCEEHHHHCCCCCCHHCCHHHHHHHHCCCCCCEEEEEHH
THRGYDSDHERVVGDVGKAGVAIDSVEDMKILFDGIPLDQVSVSMTMNGAVIPILASFIV
HHCCCCCCHHHHHHHCCCCCEEECCHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHH
AGEEQGHDKALLSGTIQNDILKEFMVRNTYIYPPEPSMRIIADIIEYTSNEMPKFNSISI
HCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHCCCCCCCCEEEE
SGYHMQEAGANLVQELAYTLADGREYVKAAIEAGMDVDKFAGRLSFFFAIGMNFFMEAAK
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LRAARTLWHRVMTEFGAKSDRSKMLRTHCQTSGVSLQEQDPYNNVIRTAYEAMSAVLGGT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
QSLHTNALDEAIALPTDFSARIARNTQLILQEETGVTNVVDPLAGSYYVESLTAELVDKA
HHHHHHHHHHHHCCCCCCHHHHHCCCEEEEECCCCCHHHHHHHCCHHHHHHHHHHHHHHH
WAMMQEVEEMGGMTKAVASGMPKLRIEETAARRQAMIDRGEEVIVGVNKYRKDKEDPIDI
HHHHHHHHHHCCHHHHHHCCCCCEEHHHHHHHHHHHHHCCCEEEEECHHHCCCCCCCCCE
LDVDNVKVRESQIARLEQIRASRDAAACEAALAELTRRASEGGNLLEAAVEAARARATVG
EECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EISMAMEKEFGRHRAEVKTLAGVYGAAYEGDEGFAAIQKSIESFAEEEGRRPRLLVVKMG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEEC
QDGHDRGAKVIATAFADIGFDVDVGPLFQTPAEAAQDAIDNDVHVVGISSQAAGHKTLAP
CCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHH
QLIAELKAAGAEDIIVICGGVIPQQDYDFLYKAGVKAIFGPGTNISTAAQDILELIREAR
HHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHC
S
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9889346; 11481431 [H]