Click here to switch to the map view.

The map label for this gene is hisQ [H]

Identifier: 99081554

GI number: 99081554

Start: 1810884

End: 1811792

Strand: Direct

Name: hisQ [H]

Synonym: TM1040_1713

Alternate gene names: 99081554

Gene position: 1810884-1811792 (Clockwise)

Preceding gene: 99081553

Following gene: 99081555

Centisome position: 56.57

GC content: 61.06

Gene sequence:

>909_bases
ATGACGAGGCCCGCCATTTTTTCCTATTGCTCTGATCCGGCCACGCTCGAGGGCTTGCAGTGGCTGAGTTGCTACCTCAC
TACCGGCAAGCATTGGGCCTTTTACATGTCCTTTGGGACGGTTCTGTTGCTGCTGGCGGTCACCGCCCCGATGGCGCTGG
CCTTTGGTTTCTTTGGCGCCAGCGCCGCACGTTCGCGTGTCCTGCCGCTGGCTTGGTTCGGCAAAGGCTACATCGCCGTG
GTGCGGGGTGTGCCCGATATTGCCTTCTTCCTGTTCTTTGTGATCGCGCTCGATCAGGGGATAGAATGGCTGCGCCATCA
GGTGAAATGTCCGGACTGGGATGAGCCGATCCGGCAGGGCAACGACTTTATCGTCTGCCAGGCCGCCAAGATGCCGCTCA
ATACCGACCCGCAGTGGTTCCATGAGATCTATGGCTTCAGCCTCGCGGTCCTGACCTTTGCGATCGTGTTTGGCGCCTTT
GCCGCCAACGTGTTGTTTGGGGCCATGCGCGCGGTGCCGCGTGCGCAGATTGAAACCGCCGAAGCCTATGGGATGACGCC
CCGCCAGACCTTCTGGCGCGTGCTGGTGCCGCAGATGTGGGTTTATGCTCTGCCCGGGCTCTCGAACCTCTGGATGGTTC
TGATAAAGGCGACGCCGCTTCTGTTCCTGCTCGGCGTCGAAGACATCGTCTATTGGGCCCGCGAGCTGGGCGGGTCAAAA
ACCACCCGCTTCACCGACTACCCCCACGGCGACTGGCGCATGTGGTACTTCCTTGGGCTTCTGGTGTTCTACCTCGCCTT
TACCAAGGTCTCTGAAATCGTCCTGGCCCGTATTTCCCGCCGCCTGTCCCATGGGCAGGCCACCCTCGCCGGCGAAGCCC
AACGCAAAGCCGAAGGAGCCGCAACATGA

Upstream 100 bases:

>100_bases
GTTCTGATCGCCCTGATCCCTGACTGAAACACGGGAGGGGGGCATCGGCCCCCTTTCCACTTTTGCCACCGCGCATGCGG
TCGCGCCCGTTCCCCATCAG

Downstream 100 bases:

>100_bases
GCTGCTTTGAAACCTTTCAGGCCTATGCGCTGCGCTCAATCGGGATTGGCGAACGGTTGCTGCCGCGCAGTGACTTTACG
CTCTGCGATCAATTTGTCCT

Product: binding-protein-dependent transport systems inner membrane component

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MTRPAIFSYCSDPATLEGLQWLSCYLTTGKHWAFYMSFGTVLLLLAVTAPMALAFGFFGASAARSRVLPLAWFGKGYIAV
VRGVPDIAFFLFFVIALDQGIEWLRHQVKCPDWDEPIRQGNDFIVCQAAKMPLNTDPQWFHEIYGFSLAVLTFAIVFGAF
AANVLFGAMRAVPRAQIETAEAYGMTPRQTFWRVLVPQMWVYALPGLSNLWMVLIKATPLLFLLGVEDIVYWARELGGSK
TTRFTDYPHGDWRMWYFLGLLVFYLAFTKVSEIVLARISRRLSHGQATLAGEAQRKAEGAAT

Sequences:

>Translated_302_residues
MTRPAIFSYCSDPATLEGLQWLSCYLTTGKHWAFYMSFGTVLLLLAVTAPMALAFGFFGASAARSRVLPLAWFGKGYIAV
VRGVPDIAFFLFFVIALDQGIEWLRHQVKCPDWDEPIRQGNDFIVCQAAKMPLNTDPQWFHEIYGFSLAVLTFAIVFGAF
AANVLFGAMRAVPRAQIETAEAYGMTPRQTFWRVLVPQMWVYALPGLSNLWMVLIKATPLLFLLGVEDIVYWARELGGSK
TTRFTDYPHGDWRMWYFLGLLVFYLAFTKVSEIVLARISRRLSHGQATLAGEAQRKAEGAAT
>Mature_301_residues
TRPAIFSYCSDPATLEGLQWLSCYLTTGKHWAFYMSFGTVLLLLAVTAPMALAFGFFGASAARSRVLPLAWFGKGYIAVV
RGVPDIAFFLFFVIALDQGIEWLRHQVKCPDWDEPIRQGNDFIVCQAAKMPLNTDPQWFHEIYGFSLAVLTFAIVFGAFA
ANVLFGAMRAVPRAQIETAEAYGMTPRQTFWRVLVPQMWVYALPGLSNLWMVLIKATPLLFLLGVEDIVYWARELGGSKT
TRFTDYPHGDWRMWYFLGLLVFYLAFTKVSEIVLARISRRLSHGQATLAGEAQRKAEGAAT

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4215

COG function: function code E; ABC-type arginine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788646, Length=247, Percent_Identity=31.9838056680162, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1787087, Length=232, Percent_Identity=28.8793103448276, Blast_Score=102, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 33966; Mature: 33835

Theoretical pI: Translated: 8.83; Mature: 8.83

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPAIFSYCSDPATLEGLQWLSCYLTTGKHWAFYMSFGTVLLLLAVTAPMALAFGFFGA
CCCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAARSRVLPLAWFGKGYIAVVRGVPDIAFFLFFVIALDQGIEWLRHQVKCPDWDEPIRQG
HHHHCCCCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
NDFIVCQAAKMPLNTDPQWFHEIYGFSLAVLTFAIVFGAFAANVLFGAMRAVPRAQIETA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EAYGMTPRQTFWRVLVPQMWVYALPGLSNLWMVLIKATPLLFLLGVEDIVYWARELGGSK
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTRFTDYPHGDWRMWYFLGLLVFYLAFTKVSEIVLARISRRLSHGQATLAGEAQRKAEGA
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AT
CC
>Mature Secondary Structure 
TRPAIFSYCSDPATLEGLQWLSCYLTTGKHWAFYMSFGTVLLLLAVTAPMALAFGFFGA
CCCHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAARSRVLPLAWFGKGYIAVVRGVPDIAFFLFFVIALDQGIEWLRHQVKCPDWDEPIRQG
HHHHCCCCCCEECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCC
NDFIVCQAAKMPLNTDPQWFHEIYGFSLAVLTFAIVFGAFAANVLFGAMRAVPRAQIETA
CCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
EAYGMTPRQTFWRVLVPQMWVYALPGLSNLWMVLIKATPLLFLLGVEDIVYWARELGGSK
HHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
TTRFTDYPHGDWRMWYFLGLLVFYLAFTKVSEIVLARISRRLSHGQATLAGEAQRKAEGA
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AT
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]