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The map label for this gene is gbpR [H]

Identifier: 99081437

GI number: 99081437

Start: 1706570

End: 1707535

Strand: Direct

Name: gbpR [H]

Synonym: TM1040_1596

Alternate gene names: 99081437

Gene position: 1706570-1707535 (Clockwise)

Preceding gene: 99081436

Following gene: 99081438

Centisome position: 53.31

GC content: 60.56

Gene sequence:

>966_bases
ATGGCCACTCGCCACACCCGTATCGTTGAACGCGCTCTGACCCGGCTCAAGCTGCGCCAACTGAGGTTGCTTGTCGCCGT
GGGCCAGCATGGAAGCATTCAGAACGCGGCGCGCGATCTCAACATCTCGCAACCAGCAGCGACAAAGATGATCCAGGATC
TCGAAGTGGATTTTGAGGTCAAACTGTTCGAGCGCACCAATCGCGGCGTGGTCCCCACGGTCTTTGGAGACTCGCTGATC
CGACATGGCAAACTGATATTCGCGCAGGTGTCCAACGCCGCACAGGAGCTCGATGATCTCAATGAAGGCAACAGTGGCCG
AGTCGTGGTGGGTACGCTCTTGGCCGCATCGCCTTCGCTCTTGCCGATGGCGGTCGAGCGTGTGCTACAGGACCGTCCAA
AGGTCGCGATCAAGATCGTCGAAGGCACACATGAGGTGCTGATGCCCGGTCTTCTGTCGGGGGAAATCGACATGGTCGTC
GGGCGCCTGCCCAGCCATCGCCACCGCGAGAATATCACGCAGGAAAAGTTCTTTGATGAGAGGATCTTGGCAGTCGCCGG
CCCGCAACACCCCCTTGCCTGTGAAAGCAACCTGACATTCGACGATATCCGGCCTCATGGCTGGATTCTTCCCCCCATCG
AGACCACGCTCCGGCGGCAGACCGATCAGTTTTTTATCCGTCAGGATCAGTACATGCCGCAAACCGCGATCGAGTCAGTA
TCGTATCTGGCCAATCGCGCGCTTCTGCGCAGCCATGATTTCATCGGCTTGATGCCCGCACATGTTGCGGCCCTCGACAT
TGAAAACGGGCTCCTGAAGCCGCTGGATTGGGTGGTGCCCTTCGGGGCTGGTCCGGTGGGCGTCTCGTTTCGCGGCCAGC
AGAGCCTCTCGCCGGCGGGAGGTGCGCTCTTGGCGGCGCTTCATGCGGCGGCGGCAGAGATTGCGCGTCTCACCCCCGCG
TCCTGA

Upstream 100 bases:

>100_bases
TGCCCTGCCCGACAATCCGCGCAGCTCGGCGCTGGCCGCCATGAGCGCGGTCGCCGCCATCGAGCGCGCCTGCGCCGCAA
TCATCACCTGAGGACCACCT

Downstream 100 bases:

>100_bases
TATCGCTGATTGTGATACCTGTATTTGTTCAATTCGGTTGAGGTGATGCCACGCGCGCGAAAGAGTTGCCCTATCGCGAC
TGACACCAATGAGGCCGAAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Galactose-binding protein regulator; GBP regulator [H]

Number of amino acids: Translated: 321; Mature: 320

Protein sequence:

>321_residues
MATRHTRIVERALTRLKLRQLRLLVAVGQHGSIQNAARDLNISQPAATKMIQDLEVDFEVKLFERTNRGVVPTVFGDSLI
RHGKLIFAQVSNAAQELDDLNEGNSGRVVVGTLLAASPSLLPMAVERVLQDRPKVAIKIVEGTHEVLMPGLLSGEIDMVV
GRLPSHRHRENITQEKFFDERILAVAGPQHPLACESNLTFDDIRPHGWILPPIETTLRRQTDQFFIRQDQYMPQTAIESV
SYLANRALLRSHDFIGLMPAHVAALDIENGLLKPLDWVVPFGAGPVGVSFRGQQSLSPAGGALLAALHAAAAEIARLTPA
S

Sequences:

>Translated_321_residues
MATRHTRIVERALTRLKLRQLRLLVAVGQHGSIQNAARDLNISQPAATKMIQDLEVDFEVKLFERTNRGVVPTVFGDSLI
RHGKLIFAQVSNAAQELDDLNEGNSGRVVVGTLLAASPSLLPMAVERVLQDRPKVAIKIVEGTHEVLMPGLLSGEIDMVV
GRLPSHRHRENITQEKFFDERILAVAGPQHPLACESNLTFDDIRPHGWILPPIETTLRRQTDQFFIRQDQYMPQTAIESV
SYLANRALLRSHDFIGLMPAHVAALDIENGLLKPLDWVVPFGAGPVGVSFRGQQSLSPAGGALLAALHAAAAEIARLTPA
S
>Mature_320_residues
ATRHTRIVERALTRLKLRQLRLLVAVGQHGSIQNAARDLNISQPAATKMIQDLEVDFEVKLFERTNRGVVPTVFGDSLIR
HGKLIFAQVSNAAQELDDLNEGNSGRVVVGTLLAASPSLLPMAVERVLQDRPKVAIKIVEGTHEVLMPGLLSGEIDMVVG
RLPSHRHRENITQEKFFDERILAVAGPQHPLACESNLTFDDIRPHGWILPPIETTLRRQTDQFFIRQDQYMPQTAIESVS
YLANRALLRSHDFIGLMPAHVAALDIENGLLKPLDWVVPFGAGPVGVSFRGQQSLSPAGGALLAALHAAAAEIARLTPAS

Specific function: Does not seem to be required for sbpA expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081904, Length=297, Percent_Identity=27.9461279461279, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1787601, Length=271, Percent_Identity=26.5682656826568, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789506, Length=249, Percent_Identity=22.0883534136546, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790399, Length=249, Percent_Identity=26.1044176706827, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI145693105, Length=177, Percent_Identity=27.1186440677966, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787879, Length=191, Percent_Identity=30.8900523560209, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI157672245, Length=249, Percent_Identity=23.6947791164659, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788297, Length=212, Percent_Identity=26.4150943396226, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=301, Percent_Identity=24.2524916943522, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1790262, Length=201, Percent_Identity=25.8706467661692, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=198, Percent_Identity=25.2525252525253, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788887, Length=184, Percent_Identity=28.804347826087, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789204, Length=239, Percent_Identity=26.3598326359833, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787530, Length=214, Percent_Identity=21.4953271028037, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35196; Mature: 35065

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATRHTRIVERALTRLKLRQLRLLVAVGQHGSIQNAARDLNISQPAATKMIQDLEVDFEV
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEE
KLFERTNRGVVPTVFGDSLIRHGKLIFAQVSNAAQELDDLNEGNSGRVVVGTLLAASPSL
EEEECCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCH
LPMAVERVLQDRPKVAIKIVEGTHEVLMPGLLSGEIDMVVGRLPSHRHRENITQEKFFDE
HHHHHHHHHCCCCCEEEEEECCCHHHHCCHHCCCCHHHHHHCCCCHHHHHCCHHHHHHHH
RILAVAGPQHPLACESNLTFDDIRPHGWILPPIETTLRRQTDQFFIRQDQYMPQTAIESV
HHHEEECCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SYLANRALLRSHDFIGLMPAHVAALDIENGLLKPLDWVVPFGAGPVGVSFRGQQSLSPAG
HHHHHHHHHHCCCCEEECHHHHEEEECCCCCCCCHHHEECCCCCCCCEEECCCCCCCCCH
GALLAALHAAAAEIARLTPAS
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ATRHTRIVERALTRLKLRQLRLLVAVGQHGSIQNAARDLNISQPAATKMIQDLEVDFEV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCCHHHHHHHHHCCCCEEE
KLFERTNRGVVPTVFGDSLIRHGKLIFAQVSNAAQELDDLNEGNSGRVVVGTLLAASPSL
EEEECCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCH
LPMAVERVLQDRPKVAIKIVEGTHEVLMPGLLSGEIDMVVGRLPSHRHRENITQEKFFDE
HHHHHHHHHCCCCCEEEEEECCCHHHHCCHHCCCCHHHHHHCCCCHHHHHCCHHHHHHHH
RILAVAGPQHPLACESNLTFDDIRPHGWILPPIETTLRRQTDQFFIRQDQYMPQTAIESV
HHHEEECCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHH
SYLANRALLRSHDFIGLMPAHVAALDIENGLLKPLDWVVPFGAGPVGVSFRGQQSLSPAG
HHHHHHHHHHCCCCEEECHHHHEEEECCCCCCCCHHHEECCCCCCCCEEECCCCCCCCCH
GALLAALHAAAAEIARLTPAS
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10361275 [H]