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The map label for this gene is pyrD [H]

Identifier: 99081391

GI number: 99081391

Start: 1656807

End: 1657865

Strand: Direct

Name: pyrD [H]

Synonym: TM1040_1550

Alternate gene names: 99081391

Gene position: 1656807-1657865 (Clockwise)

Preceding gene: 99081390

Following gene: 99081395

Centisome position: 51.76

GC content: 64.12

Gene sequence:

>1059_bases
ATGAAGCTGAGCGAGAAACTTGCCCTCGGGCTGATGCATCGCCTTGATCCCGAAACCGCGCATGGTCTGTCGATCAAGGC
GCTCAGAGCGGGGCTGACGCCACGCCCTGGTCCGGTGACATCACCGCGCCTGCGCACGGATGTGGCGGGTCTTTCGCTGC
CGAACCCGGTGGGGCTTGCAGCCGGGTTTGACAAGAACGCCGAAGCGCTTGCTCCGCTTTCAGAGGCTGGCTTTGGATTT
ATCGAAGTGGGGGCCGCCACGCCGCGCCCGCAACCGGGCAACCCCAAGCCGCGCCTTTTTCGTCTGAGCGAAGATCGCGC
CGCCATCAACCGCTTTGGCTTTAACAATGAGGGCATGGACACGATCGGGAAGCGCCTCGCGCAGCGTCCAAAGTCGGGCG
TGATCGGCCTCAACCTCGGGGCCAACAAGGACAGCGAGGACCGCGCGCAGGATTTCGCCCGCGTGCTCAGCCATTGCGGC
GCGCATCTGGATTTTGCCACCGTGAACGTGTCGTCGCCCAACACAGAGAAACTGCGCGATCTGCAGGGCAAGGATGCTCT
TGCTTCACTGCTGGCAGGGGTCATTGACGCCCGAGAGGCCCTGCAGCGCCCCATCCCGGTCTTTCTCAAGATTGCGCCGG
ATCTCGACATATCCGGGCTTGATGACATTGCCGAGGTCGCGCGTGACAGCGGCATTGATGCGGTGATCGCCACCAACACG
ACGCTTTCGCGCGACGGCCTGAAAAGCACGCACCGGGACGAGATGGGCGGCCTCTCGGGCGCGCCCCTATTTGAGCGCTC
GACACGGGTGCTGGCGCAGCTTTCGCAACGTCTGGATGGGGCGGTGCCGATCATCGGCGTCGGGGGCATCTCCACGGCTG
AAGGCGCCTATGCCAAGATCCGCGCTGGAGCCTCGGCGGTGCAGCTTTATACGGCGCTGGTCTACGGCGGGCTGTCGCTG
GCCTCTGAGGTCGCTTCGGGTCTTGATGCATTGCTCGCGCGAGACGGGTTTTCAAATGTCGCGGAAGCGGTTGGCACAGG
GCGTGCGGACTGGCTCTGA

Upstream 100 bases:

>100_bases
CGAAGGCACCCATCGCTTCCCTCAAGAGATGGTCTGAAGACCCTCAGACCCCACCCCGCGGCGCGCACGCCTGCGCCGCA
TCCGCTAGGAGGCCCTGCCC

Downstream 100 bases:

>100_bases
GCCAGAGAGTACAGTAGTCGCGATCCGCCTCCGGACCGCTCCCGCCCGTCAGGTTGGCTTTTGAGAAAAGCCCCTTCCCG
TTGGGCCCGGCAGGCCGCGC

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MKLSEKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTSPRLRTDVAGLSLPNPVGLAAGFDKNAEALAPLSEAGFGF
IEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDTIGKRLAQRPKSGVIGLNLGANKDSEDRAQDFARVLSHCG
AHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNT
TLSRDGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAKIRAGASAVQLYTALVYGGLSL
ASEVASGLDALLARDGFSNVAEAVGTGRADWL

Sequences:

>Translated_352_residues
MKLSEKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTSPRLRTDVAGLSLPNPVGLAAGFDKNAEALAPLSEAGFGF
IEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDTIGKRLAQRPKSGVIGLNLGANKDSEDRAQDFARVLSHCG
AHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNT
TLSRDGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAKIRAGASAVQLYTALVYGGLSL
ASEVASGLDALLARDGFSNVAEAVGTGRADWL
>Mature_352_residues
MKLSEKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTSPRLRTDVAGLSLPNPVGLAAGFDKNAEALAPLSEAGFGF
IEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMDTIGKRLAQRPKSGVIGLNLGANKDSEDRAQDFARVLSHCG
AHLDFATVNVSSPNTEKLRDLQGKDALASLLAGVIDAREALQRPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNT
TLSRDGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAKIRAGASAVQLYTALVYGGLSL
ASEVASGLDALLARDGFSNVAEAVGTGRADWL

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=353, Percent_Identity=47.0254957507082, Blast_Score=291, Evalue=9e-79,
Organism=Escherichia coli, GI1787177, Length=329, Percent_Identity=42.2492401215805, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI87082059, Length=335, Percent_Identity=25.3731343283582, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17509475, Length=358, Percent_Identity=43.854748603352, Blast_Score=281, Evalue=5e-76,
Organism=Caenorhabditis elegans, GI71984108, Length=142, Percent_Identity=33.8028169014084, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281361352, Length=349, Percent_Identity=45.5587392550143, Blast_Score=291, Evalue=5e-79,
Organism=Drosophila melanogaster, GI17137316, Length=349, Percent_Identity=45.5587392550143, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 36778; Mature: 36778

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLSEKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTSPRLRTDVAGLSLPNPVGLA
CCCHHHHHHHHHHHCCCCHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCC
AGFDKNAEALAPLSEAGFGFIEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMD
CCCCCCCHHHCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCHH
TIGKRLAQRPKSGVIGLNLGANKDSEDRAQDFARVLSHCGAHLDFATVNVSSPNTEKLRD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
LQGKDALASLLAGVIDAREALQRPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNT
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCC
TLSRDGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAKI
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHH
RAGASAVQLYTALVYGGLSLASEVASGLDALLARDGFSNVAEAVGTGRADWL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKLSEKLALGLMHRLDPETAHGLSIKALRAGLTPRPGPVTSPRLRTDVAGLSLPNPVGLA
CCCHHHHHHHHHHHCCCCHHCCCCHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCC
AGFDKNAEALAPLSEAGFGFIEVGAATPRPQPGNPKPRLFRLSEDRAAINRFGFNNEGMD
CCCCCCCHHHCCHHHCCCCEEEECCCCCCCCCCCCCCCEEEECHHHHHHHHCCCCCCCHH
TIGKRLAQRPKSGVIGLNLGANKDSEDRAQDFARVLSHCGAHLDFATVNVSSPNTEKLRD
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHH
LQGKDALASLLAGVIDAREALQRPIPVFLKIAPDLDISGLDDIAEVARDSGIDAVIATNT
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCEEEECCC
TLSRDGLKSTHRDEMGGLSGAPLFERSTRVLAQLSQRLDGAVPIIGVGGISTAEGAYAKI
CCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCHHHH
RAGASAVQLYTALVYGGLSLASEVASGLDALLARDGFSNVAEAVGTGRADWL
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA