Click here to switch to the map view.

The map label for this gene is accC [H]

Identifier: 99081359

GI number: 99081359

Start: 1624175

End: 1625524

Strand: Direct

Name: accC [H]

Synonym: TM1040_1518

Alternate gene names: 99081359

Gene position: 1624175-1625524 (Clockwise)

Preceding gene: 99081358

Following gene: 99081360

Centisome position: 50.74

GC content: 60.52

Gene sequence:

>1350_bases
ATGTTTGACAAAATCTTAATTGCCAACCGGGGTGAGATCGCGCTGCGCGTGATCCGTGCCTGCCGCGAGATGGGCATCCA
ATCCGTTGCGGTGCACTCCACCGCCGACGCCGATGCCATGCATGTGCGCATGGCCGATGAGTCGATCTGCATTGGCCCAC
CGTCAGGCGCCCAGAGCTATCTGTCGATCCCCGCGATCATCTCCGCCTGCGAAATTTCGGGCGCTCAGGCGATCCACCCG
GGCTACGGGTTTCTCTCCGAGAACGCCAATTTTGTGCAGATCGTCGAGGACCACGGGCTGACCTTCATCGGCCCCTCCGC
AGAACATATTCGCCAGATGGGCGACAAGATCACCGCAAAAGACACCGCAAAAGCGCTCGGCATTCCTTGTGTGCCGGGAT
CTGACGGCGGTGTGCCCGATGTGGAGACCGCAAAAAAGGTCGCCGCCGAAATGGGCTATCCGGTGATCATCAAGGCCACC
GCCGGTGGCGGCGGGCGCGGCATGAAAGTGGCCCAGACCGAAGCAGATCTGGTTCAAGCGTTCCAGACCGCGCGCTCAGA
AGCCAAAGCGGCCTTTGGCAACGACGAAGTCTACATGGAGAAATACCTCCAGCGTCCGCGCCACATCGAGATCCAGGTCT
TTGGTGATGGCAAAGGCGGCGGCGTACACCTGGGCGAGCGCGACTGCTCCTTGCAGCGGCGCCACCAGAAGGTCTTTGAA
GAGGCTCCCGGCCCCTGCATCACCGAGGAAGAGCGTGCCAAGATCGGCAAGATCTGCGCGGATGCGATCGGCAAGATGGG
CTACTCCGGTGCGGGTACCGTCGAATTCCTCTATGAGGATGGCGAGTTCTACTTCATCGAGATGAACACCCGCCTGCAGG
TGGAACACCCTGTGACCGAAGCCATCTTTGGCGTCGACCTGGTGCGTGAACAGATCCGCGTTGCCTCTGGCCTGCCGCTC
TCGTTCACGCAGGATGATCTGATCATCAACGGTCACGCCATCGAAGTGCGCATCAATGCCGAAAAGCTGCCGAATTTCTC
GCCCTGCCCGGGTAAGATCACCGCATATCATGCCCCCGGCGGCCTTGGCGTGCGGATGGATTCGGCGCTTTATGACGGCT
ACTCGATCCCGCCGTACTACGACAGCCTGATCGGCAAGCTGATCGTCCACGGGCGCGACCGGGAAGAGGCCCTTGCGCGT
CTCAGCCGCTCGCTGGGCGAGCTCATTGTGGACGGGATCGATACCACGGTGCCGCTGTTCCACGCGCTCTTGCAGGAAAA
AGACATCCACACCGGTGAGTACAACATTCACTGGCTGGAAAAATGGCTTGAAGCCAACCTTCAGGCCTGA

Upstream 100 bases:

>100_bases
CCCGGCCCCCAAATCGGGCACCGTGAAGCGCATCCTTGTTGAAGATGGCGCCGCGGTCGAGTTTGGTCATCCGCTCGTCA
TCGTCGAGTAAGGCCCTGCC

Downstream 100 bases:

>100_bases
GACATCTTTCTGGGGGCGGCGGTTTAAAACCTCCGCCCCTCTGCTACCCCGTGCTAGGCTAATCTATGACGCTCAGCGCT
GATCTCCTGCTTCATGCTTA

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MFDKILIANRGEIALRVIRACREMGIQSVAVHSTADADAMHVRMADESICIGPPSGAQSYLSIPAIISACEISGAQAIHP
GYGFLSENANFVQIVEDHGLTFIGPSAEHIRQMGDKITAKDTAKALGIPCVPGSDGGVPDVETAKKVAAEMGYPVIIKAT
AGGGGRGMKVAQTEADLVQAFQTARSEAKAAFGNDEVYMEKYLQRPRHIEIQVFGDGKGGGVHLGERDCSLQRRHQKVFE
EAPGPCITEEERAKIGKICADAIGKMGYSGAGTVEFLYEDGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGLPL
SFTQDDLIINGHAIEVRINAEKLPNFSPCPGKITAYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDREEALAR
LSRSLGELIVDGIDTTVPLFHALLQEKDIHTGEYNIHWLEKWLEANLQA

Sequences:

>Translated_449_residues
MFDKILIANRGEIALRVIRACREMGIQSVAVHSTADADAMHVRMADESICIGPPSGAQSYLSIPAIISACEISGAQAIHP
GYGFLSENANFVQIVEDHGLTFIGPSAEHIRQMGDKITAKDTAKALGIPCVPGSDGGVPDVETAKKVAAEMGYPVIIKAT
AGGGGRGMKVAQTEADLVQAFQTARSEAKAAFGNDEVYMEKYLQRPRHIEIQVFGDGKGGGVHLGERDCSLQRRHQKVFE
EAPGPCITEEERAKIGKICADAIGKMGYSGAGTVEFLYEDGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGLPL
SFTQDDLIINGHAIEVRINAEKLPNFSPCPGKITAYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDREEALAR
LSRSLGELIVDGIDTTVPLFHALLQEKDIHTGEYNIHWLEKWLEANLQA
>Mature_449_residues
MFDKILIANRGEIALRVIRACREMGIQSVAVHSTADADAMHVRMADESICIGPPSGAQSYLSIPAIISACEISGAQAIHP
GYGFLSENANFVQIVEDHGLTFIGPSAEHIRQMGDKITAKDTAKALGIPCVPGSDGGVPDVETAKKVAAEMGYPVIIKAT
AGGGGRGMKVAQTEADLVQAFQTARSEAKAAFGNDEVYMEKYLQRPRHIEIQVFGDGKGGGVHLGERDCSLQRRHQKVFE
EAPGPCITEEERAKIGKICADAIGKMGYSGAGTVEFLYEDGEFYFIEMNTRLQVEHPVTEAIFGVDLVREQIRVASGLPL
SFTQDDLIINGHAIEVRINAEKLPNFSPCPGKITAYHAPGGLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDREEALAR
LSRSLGELIVDGIDTTVPLFHALLQEKDIHTGEYNIHWLEKWLEANLQA

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI189095269, Length=442, Percent_Identity=47.737556561086, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=47.8555304740406, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=47.737556561086, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI116805327, Length=437, Percent_Identity=45.3089244851259, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=445, Percent_Identity=44.4943820224719, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049295, Length=445, Percent_Identity=44.4943820224719, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI106049292, Length=445, Percent_Identity=44.4943820224719, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI38679960, Length=519, Percent_Identity=29.8651252408478, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679977, Length=519, Percent_Identity=29.8651252408478, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679967, Length=519, Percent_Identity=29.8651252408478, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679974, Length=519, Percent_Identity=29.8651252408478, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI38679971, Length=519, Percent_Identity=29.8651252408478, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI134142062, Length=520, Percent_Identity=30, Blast_Score=225, Evalue=8e-59,
Organism=Escherichia coli, GI1789654, Length=444, Percent_Identity=61.036036036036, Blast_Score=550, Evalue=1e-158,
Organism=Escherichia coli, GI1786216, Length=281, Percent_Identity=25.2669039145907, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.0588235294118, Blast_Score=405, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI71987519, Length=432, Percent_Identity=46.9907407407407, Blast_Score=385, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17562816, Length=455, Percent_Identity=42.1978021978022, Blast_Score=337, Evalue=1e-92,
Organism=Caenorhabditis elegans, GI133931226, Length=486, Percent_Identity=29.8353909465021, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI71997168, Length=504, Percent_Identity=26.5873015873016, Blast_Score=187, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI71997163, Length=504, Percent_Identity=26.5873015873016, Blast_Score=187, Evalue=8e-48,
Organism=Saccharomyces cerevisiae, GI6319685, Length=428, Percent_Identity=44.6261682242991, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=456, Percent_Identity=41.6666666666667, Blast_Score=321, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6321376, Length=449, Percent_Identity=43.2071269487751, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=30.5182341650672, Blast_Score=222, Evalue=1e-58,
Organism=Saccharomyces cerevisiae, GI6323863, Length=482, Percent_Identity=30.7053941908714, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=47.7578475336323, Blast_Score=389, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24651757, Length=439, Percent_Identity=44.6469248291572, Blast_Score=380, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24651759, Length=403, Percent_Identity=43.424317617866, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI161076409, Length=513, Percent_Identity=28.4600389863548, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI161076407, Length=513, Percent_Identity=28.4600389863548, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24586460, Length=513, Percent_Identity=28.4600389863548, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24586458, Length=513, Percent_Identity=28.4600389863548, Blast_Score=209, Evalue=4e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48715; Mature: 48715

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDKILIANRGEIALRVIRACREMGIQSVAVHSTADADAMHVRMADESICIGPPSGAQSY
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCHHH
LSIPAIISACEISGAQAIHPGYGFLSENANFVQIVEDHGLTFIGPSAEHIRQMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCHH
DTAKALGIPCVPGSDGGVPDVETAKKVAAEMGYPVIIKATAGGGGRGMKVAQTEADLVQA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHH
FQTARSEAKAAFGNDEVYMEKYLQRPRHIEIQVFGDGKGGGVHLGERDCSLQRRHQKVFE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCCHHHHHHHHHHHH
EAPGPCITEEERAKIGKICADAIGKMGYSGAGTVEFLYEDGEFYFIEMNTRLQVEHPVTE
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIFGVDLVREQIRVASGLPLSFTQDDLIINGHAIEVRINAEKLPNFSPCPGKITAYHAPG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECCEEEEEEEEHHHCCCCCCCCCCEEEEECCC
GLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDREEALARLSRSLGELIVDGIDTTVPLF
CCCEEECHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
HALLQEKDIHTGEYNIHWLEKWLEANLQA
HHHHHHCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MFDKILIANRGEIALRVIRACREMGIQSVAVHSTADADAMHVRMADESICIGPPSGAQSY
CCCCEEEECCCHHHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCCCCHHH
LSIPAIISACEISGAQAIHPGYGFLSENANFVQIVEDHGLTFIGPSAEHIRQMGDKITAK
HHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEECCCEEEECCCHHHHHHHCCCCCHH
DTAKALGIPCVPGSDGGVPDVETAKKVAAEMGYPVIIKATAGGGGRGMKVAQTEADLVQA
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEHHHHHHHHH
FQTARSEAKAAFGNDEVYMEKYLQRPRHIEIQVFGDGKGGGVHLGERDCSLQRRHQKVFE
HHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCCEECCCCCHHHHHHHHHHHH
EAPGPCITEEERAKIGKICADAIGKMGYSGAGTVEFLYEDGEFYFIEMNTRLQVEHPVTE
HCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCHHH
AIFGVDLVREQIRVASGLPLSFTQDDLIINGHAIEVRINAEKLPNFSPCPGKITAYHAPG
HHHHHHHHHHHHHHHCCCCCEECCCCEEECCEEEEEEEEHHHCCCCCCCCCCEEEEECCC
GLGVRMDSALYDGYSIPPYYDSLIGKLIVHGRDREEALARLSRSLGELIVDGIDTTVPLF
CCCEEECHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHH
HALLQEKDIHTGEYNIHWLEKWLEANLQA
HHHHHHCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]