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The map label for this gene is dmdA [H]

Identifier: 99081285

GI number: 99081285

Start: 1542571

End: 1543728

Strand: Reverse

Name: dmdA [H]

Synonym: TM1040_1444

Alternate gene names: 99081285

Gene position: 1543728-1542571 (Counterclockwise)

Preceding gene: 99081286

Following gene: 99081284

Centisome position: 48.23

GC content: 60.19

Gene sequence:

>1158_bases
ATGCGCCGCTCGCCCTCAACTCATGGTATGAAAGGGTTTGCCATGACCGTTCTGAAACCTGCCATTTCCCTCTCTCGGCG
CCTGCGTCGAACCCCTTTTTCGGAGGGCGTCGAAGCCGCTGGAGTCAAAGGCTACACCGTCTACAATCACATGCTGCTGC
CCACGGTGTTTGAGAGTGTCGAAGCCGACTACCACCACCTCAAGCGTCATGTGCAAGTCTGGGACGTCGCCTGCGAACGC
CAGGTGGAACTGCGCGGCCCCGACGCCGGACGCCTGATGCAGATGCTGACCCCGCGCGATCTGCGTGGCATGATGCCCGG
TCAATGTTACTATGTCCCCATCGTCGATGAGACCGGCGGGATGCTCAATGATCCCGTAGCCGTAAAGCTCGCAGAGGATC
GTTGGTGGATCTCCATTGCGGACAGTGATCTGTTGTACTGGGTCAAGGGGATCGCAAACGGCTGGCGCCTTGATGTGCTG
GTGGATGAACCGGATGTTTCGCCGCTTGCGGTGCAGGGCCCCAAGGCAGAGGACTTGATGGCGCGTGTCTTCGGCGAGAC
TGTGCGCGCGATCCGGTTTTTCCGCTTTGGCGTCTACCAGTTCGAAGGACGCGATCTGGTGGTGGCAAGGTCGGGCTACT
CAAAGCAGGGTGGGTTCGAGATCTACGTCGAAGGCGGCGATCTTGGCATGCCGCTCTGGAACCGTCTGTTTGAGGCTGGC
GCAGATCTCGAGGTGCGTGCGGGCTGTCCCAACCTCATTGAGCGGATCGAGAGCGGTCTTCTGAGCTACGGCAATGATAT
GACCGACGACAACACACCGCACGAATGCGGCCTTGGGCGGTTCTGTAACACCCACACGGCCATTGGGTGTATCGGGCGTG
ATGCGCTGCTGCGGGTGGCCAAGGAAGGCCCGGTGCAGCAGATCCGCCCGATCGAGATTTCCGGCGAAGCGGTGCCGCCC
TGTGATCAATTCTGGCCGCTCGTTGCAAATGGGCGTCGTGTCGGTCGGGTCTCCTCGGCCACCTGGTCGCCGGATCATGC
CACGAATGTTGCGATCGGCATGGTCAAGATGACGCATTGGGATGCGGGGACGCAGCTAGAGGTGGAGACACCGGATGGAA
TGCGTACTGCTCTGGTGCGCGAAAATTTCTGGAATTAA

Upstream 100 bases:

>100_bases
CTGGGATTTTGACGGCCGCTCTGCCGAGATCTGCCAGATCGATTGGAAGGGGCCGCGCTGACGCGCAGCACCTACGTGAC
CGAGCGGCGGTCGCGTCGTG

Downstream 100 bases:

>100_bases
TGGGAGAGATCAACATGTTCAAAGCCCTTGTTATGACGCAAGACAGCGAGAGCGGCAAAGCCGCTGCTGAAATTCAGGAT
CTGACCCTTGAGGATCTGCC

Product: putative dimethyl sulfoniopropionate demethylase

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MRRSPSTHGMKGFAMTVLKPAISLSRRLRRTPFSEGVEAAGVKGYTVYNHMLLPTVFESVEADYHHLKRHVQVWDVACER
QVELRGPDAGRLMQMLTPRDLRGMMPGQCYYVPIVDETGGMLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVL
VDEPDVSPLAVQGPKAEDLMARVFGETVRAIRFFRFGVYQFEGRDLVVARSGYSKQGGFEIYVEGGDLGMPLWNRLFEAG
ADLEVRAGCPNLIERIESGLLSYGNDMTDDNTPHECGLGRFCNTHTAIGCIGRDALLRVAKEGPVQQIRPIEISGEAVPP
CDQFWPLVANGRRVGRVSSATWSPDHATNVAIGMVKMTHWDAGTQLEVETPDGMRTALVRENFWN

Sequences:

>Translated_385_residues
MRRSPSTHGMKGFAMTVLKPAISLSRRLRRTPFSEGVEAAGVKGYTVYNHMLLPTVFESVEADYHHLKRHVQVWDVACER
QVELRGPDAGRLMQMLTPRDLRGMMPGQCYYVPIVDETGGMLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVL
VDEPDVSPLAVQGPKAEDLMARVFGETVRAIRFFRFGVYQFEGRDLVVARSGYSKQGGFEIYVEGGDLGMPLWNRLFEAG
ADLEVRAGCPNLIERIESGLLSYGNDMTDDNTPHECGLGRFCNTHTAIGCIGRDALLRVAKEGPVQQIRPIEISGEAVPP
CDQFWPLVANGRRVGRVSSATWSPDHATNVAIGMVKMTHWDAGTQLEVETPDGMRTALVRENFWN
>Mature_385_residues
MRRSPSTHGMKGFAMTVLKPAISLSRRLRRTPFSEGVEAAGVKGYTVYNHMLLPTVFESVEADYHHLKRHVQVWDVACER
QVELRGPDAGRLMQMLTPRDLRGMMPGQCYYVPIVDETGGMLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVL
VDEPDVSPLAVQGPKAEDLMARVFGETVRAIRFFRFGVYQFEGRDLVVARSGYSKQGGFEIYVEGGDLGMPLWNRLFEAG
ADLEVRAGCPNLIERIESGLLSYGNDMTDDNTPHECGLGRFCNTHTAIGCIGRDALLRVAKEGPVQQIRPIEISGEAVPP
CDQFWPLVANGRRVGRVSSATWSPDHATNVAIGMVKMTHWDAGTQLEVETPDGMRTALVRENFWN

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI257796258, Length=394, Percent_Identity=28.4263959390863, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI44662838, Length=402, Percent_Identity=27.8606965174129, Blast_Score=95, Evalue=8e-20,
Organism=Homo sapiens, GI257796256, Length=316, Percent_Identity=28.1645569620253, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1789272, Length=338, Percent_Identity=24.2603550295858, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=220, Percent_Identity=24.5454545454545, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129441, Length=348, Percent_Identity=25.2873563218391, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 42952; Mature: 42952

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRSPSTHGMKGFAMTVLKPAISLSRRLRRTPFSEGVEAAGVKGYTVYNHMLLPTVFESV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
EADYHHLKRHVQVWDVACERQVELRGPDAGRLMQMLTPRDLRGMMPGQCYYVPIVDETGG
HHHHHHHHHHHHHEEHHHCCEEEECCCCHHHHHHHCCCHHHCCCCCCCEEEEEEECCCCC
MLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVLVDEPDVSPLAVQGPKAEDLM
CCCCCEEEEEECCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHHH
ARVFGETVRAIRFFRFGVYQFEGRDLVVARSGYSKQGGFEIYVEGGDLGMPLWNRLFEAG
HHHHHHHHHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHCC
ADLEVRAGCPNLIERIESGLLSYGNDMTDDNTPHECGLGRFCNTHTAIGCIGRDALLRVA
CCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEEECCHHHHHHHH
KEGPVQQIRPIEISGEAVPPCDQFWPLVANGRRVGRVSSATWSPDHATNVAIGMVKMTHW
HCCCHHHCCCEEECCCCCCCHHHCCCHHCCCCEECEECCCCCCCCCCCCEEEEEEEEEEC
DAGTQLEVETPDGMRTALVRENFWN
CCCCEEEEECCCCHHHHHHHHCCCC
>Mature Secondary Structure
MRRSPSTHGMKGFAMTVLKPAISLSRRLRRTPFSEGVEAAGVKGYTVYNHMLLPTVFESV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHH
EADYHHLKRHVQVWDVACERQVELRGPDAGRLMQMLTPRDLRGMMPGQCYYVPIVDETGG
HHHHHHHHHHHHHEEHHHCCEEEECCCCHHHHHHHCCCHHHCCCCCCCEEEEEEECCCCC
MLNDPVAVKLAEDRWWISIADSDLLYWVKGIANGWRLDVLVDEPDVSPLAVQGPKAEDLM
CCCCCEEEEEECCEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCCCEEECCCCHHHHH
ARVFGETVRAIRFFRFGVYQFEGRDLVVARSGYSKQGGFEIYVEGGDLGMPLWNRLFEAG
HHHHHHHHHHHHHHHHCEEEECCCEEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHHCC
ADLEVRAGCPNLIERIESGLLSYGNDMTDDNTPHECGLGRFCNTHTAIGCIGRDALLRVA
CCEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHEEECCHHHHHHHH
KEGPVQQIRPIEISGEAVPPCDQFWPLVANGRRVGRVSSATWSPDHATNVAIGMVKMTHW
HCCCHHHCCCEEECCCCCCCHHHCCCHHCCCCEECEECCCCCCCCCCCCEEEEEEEEEEC
DAGTQLEVETPDGMRTALVRENFWN
CCCCEEEEECCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]