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The map label for this gene is uppS [H]

Identifier: 99081253

GI number: 99081253

Start: 1505764

End: 1506534

Strand: Reverse

Name: uppS [H]

Synonym: TM1040_1412

Alternate gene names: 99081253

Gene position: 1506534-1505764 (Counterclockwise)

Preceding gene: 99081254

Following gene: 99081252

Centisome position: 47.07

GC content: 60.57

Gene sequence:

>771_bases
ATGTCACTCGTCACAGATAGCGCAACGCCGCGTGCGGCTGGTGCGGGAGATCCTGCACCGGGCGTTGGTGACGGGCCGAA
ACATGTAGCGATCATCATGGATGGCAACGGCCGCTGGGCGCAGGCGCGCGGGCGGCCACGGCTGTTCGGGCATCATGCGG
GCGCGCGGCGCGTGCGCGAAGTGGTGGAATGCTGTCCGTCGCTTGGGATCAAGTATCTCACGATTTTTGCCTTCTCGACT
GAAAACTGGAAACGCACACAGGTCGAGGTCGCAGGCCTGATGAGCTTGTTCCGGCGCTATATCTCCAAGGAAATGAAGGC
GCTGGCGGCAAAGAATGTGCGCGTTCGTTTCATCGGAGACCGCGTGCGGCTCGACACCAAACTGGTGCAGCTGATGGATG
CGCTCGAGCTCGAGACCGCAGGCAATGACGGCACTCACCTCACCATTGCGCTGAATTACGGCGGGCGGGATGAGGTGGCA
CGCGCAACTCAGCGTCTGGCACAGGATGTTGCGGATGGGCGGCTGGACCCCAGGGACGTCGATGAAGAAACCCTGCCGCG
CTATCTCGACACCCATGTGCTGCCGGATCCGGATCTGGTGATCCGTACCTCAGGTGAGGCGCGGATCTCGAATTTCTTGC
TGTGGCAGTCCGCCTATTCTGAATACGAGTTCATCGACACGCTGTGGCCCGATTTTTCATCCGAAGAACTGGCGCGCCTG
TGTCGTAACTTCGGCAATCGAGACAGACGGTTCGGGGCCACCAAGAAATGA

Upstream 100 bases:

>100_bases
GGAGACCGAGGTTCAGGAACTGACCGACAAGATGATCAAGGCCGTGGACGCTGCGCTGGAGACCAAGCAAGCCGAAATCA
TGCAGGTTTGATCAGCTCAG

Downstream 100 bases:

>100_bases
AAACACCTCTTAGCGCGCATGCCTCCAAGGCGAACCGTTGGGCCGATCTCGGACCGCGCACTGCCTCTGCGGTTGTGCTG
GCCCTGTTGGGCGGCGCTGC

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 256; Mature: 255

Protein sequence:

>256_residues
MSLVTDSATPRAAGAGDPAPGVGDGPKHVAIIMDGNGRWAQARGRPRLFGHHAGARRVREVVECCPSLGIKYLTIFAFST
ENWKRTQVEVAGLMSLFRRYISKEMKALAAKNVRVRFIGDRVRLDTKLVQLMDALELETAGNDGTHLTIALNYGGRDEVA
RATQRLAQDVADGRLDPRDVDEETLPRYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFSSEELARL
CRNFGNRDRRFGATKK

Sequences:

>Translated_256_residues
MSLVTDSATPRAAGAGDPAPGVGDGPKHVAIIMDGNGRWAQARGRPRLFGHHAGARRVREVVECCPSLGIKYLTIFAFST
ENWKRTQVEVAGLMSLFRRYISKEMKALAAKNVRVRFIGDRVRLDTKLVQLMDALELETAGNDGTHLTIALNYGGRDEVA
RATQRLAQDVADGRLDPRDVDEETLPRYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFSSEELARL
CRNFGNRDRRFGATKK
>Mature_255_residues
SLVTDSATPRAAGAGDPAPGVGDGPKHVAIIMDGNGRWAQARGRPRLFGHHAGARRVREVVECCPSLGIKYLTIFAFSTE
NWKRTQVEVAGLMSLFRRYISKEMKALAAKNVRVRFIGDRVRLDTKLVQLMDALELETAGNDGTHLTIALNYGGRDEVAR
ATQRLAQDVADGRLDPRDVDEETLPRYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFSSEELARLC
RNFGNRDRRFGATKK

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=214, Percent_Identity=39.2523364485981, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI45580742, Length=214, Percent_Identity=39.2523364485981, Blast_Score=155, Evalue=2e-38,
Organism=Escherichia coli, GI1786371, Length=231, Percent_Identity=49.7835497835498, Blast_Score=231, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI71993029, Length=227, Percent_Identity=36.1233480176211, Blast_Score=156, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6319474, Length=225, Percent_Identity=36.8888888888889, Blast_Score=122, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323748, Length=220, Percent_Identity=32.7272727272727, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI18857969, Length=220, Percent_Identity=35.9090909090909, Blast_Score=136, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28634; Mature: 28503

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVTDSATPRAAGAGDPAPGVGDGPKHVAIIMDGNGRWAQARGRPRLFGHHAGARRVRE
CCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCEECCCHHHHHHHH
VVECCPSLGIKYLTIFAFSTENWKRTQVEVAGLMSLFRRYISKEMKALAAKNVRVRFIGD
HHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RVRLDTKLVQLMDALELETAGNDGTHLTIALNYGGRDEVARATQRLAQDVADGRLDPRDV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCC
DEETLPRYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFSSEELARL
CHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
CRNFGNRDRRFGATKK
HHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SLVTDSATPRAAGAGDPAPGVGDGPKHVAIIMDGNGRWAQARGRPRLFGHHAGARRVRE
CCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCCCEECCCHHHHHHHH
VVECCPSLGIKYLTIFAFSTENWKRTQVEVAGLMSLFRRYISKEMKALAAKNVRVRFIGD
HHHHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RVRLDTKLVQLMDALELETAGNDGTHLTIALNYGGRDEVARATQRLAQDVADGRLDPRDV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCC
DEETLPRYLDTHVLPDPDLVIRTSGEARISNFLLWQSAYSEYEFIDTLWPDFSSEELARL
CHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
CRNFGNRDRRFGATKK
HHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]