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The map label for this gene is dxr

Identifier: 99081251

GI number: 99081251

Start: 1503751

End: 1504938

Strand: Reverse

Name: dxr

Synonym: TM1040_1410

Alternate gene names: 99081251

Gene position: 1504938-1503751 (Counterclockwise)

Preceding gene: 99081252

Following gene: 99081250

Centisome position: 47.02

GC content: 62.04

Gene sequence:

>1188_bases
ATGCATGGGGTCACTATGAAAAAGATATCGATTTTTGGGGCAACGGGATCAATCGGGCAGAGCACCATTGACCTGATCCG
CCGCGCCCCCGACGCCTATGACGTGGTGGCGCTCAGCGGTGGGCATAATGTGGCGCAGCTGGCGCGGGACGCCATAGAAC
TGCAAGCAGATATAGCGATCACGGCGCATGACGCCCGGCTTGAGGAGCTGCGCTCCGCGCTTGCGGGCAGTGGCGTTGAA
GCGGCCTCGGGCGCGGCGGCCCTGGTGGAGGCCGCAAGCCGTCCTGCGGATTGGATCATGTCGGCCATCGTGGGCGCTGC
GGGTCTTGCGCCGGGCCTCAAAGCGCTGGAGCAGGGCACGACGCTGGCGCTGGCCAACAAGGAATCCCTCGTCTGTGCGG
GCGCGCTTTTGATGCAGACCGCTGCAGATCACGGCGCGCGGATTTTGCCCGTGGACAGTGAGCACTCAGCTGTGTTTCAG
GCGCTTGTCGGCGAACGTATCGAAGAGGTCGAGCGTATCATCATCACTGCGTCGGGCGGTGCCTTTCGGGACTGGCCGCT
GGAACGGTTAAAAACGGCATCATTGGCCGAGGCCTCTTCTCATCCCAATTGGGACATGGGGCAGCGGATCACGATCGACA
GTGCGTCGATGTTCAACAAGGCGCTTGAAGTCATTGAAACCAGAGAATTCTTTGGTGTTGCGCCTGAGCAGATCGAGGTA
TTGGTGCATCCCCAGTCGCTGGTTCATGCGCTGGTCGGATTTCGCGATGGTGCGCTCATGAGCCACCTTGGCGCGCCGGA
TATGCGCCATGCCATCGGCTATGCGTTGCACTGGCCGGACCGCAATGCGCTGCCGGTGGCGCGGCTCGATCTGGCCGCAA
TCGGCCAGCTGGAATTTCGCGCGCCCGATCTTCAGCGCTATCCGGCGCTGAGGCTTGCGCAAGAGGTCATGCGGCGTGGC
GGGCTGAGCGGGGCGGCCTTCAACGGCGCCAAGGAACGCGCGCTCGATCACTTTATCGCGGGGCGCATTGGTTTTCTGGA
CATGGCCAGCCTAACTGAAGAAGGACTGGCGACGCTCGAGGCCCAACCGGGCCTTATTGATGCCTCAATGACACTTGAAA
ACGTCACCCGAGTTGACGATCTGGCGCGTAGGGCGGTGGATCAGGTCGTGACGCAACGAACAGGATAG

Upstream 100 bases:

>100_bases
TTTGACCGTTTTGATGGCATGCTGGGCGCTGGGGCACTCTGTTTCTTGATCGCCATCATCTGGGGATGAACCTGCCCCAA
CGCGGGGCGCGGGGCGGGTG

Downstream 100 bases:

>100_bases
AGTTTTGGACGCAGTATTTTTGGTCTCGCAACTGGGCGGGCTCCTTTACACGATCGGCAGCTTTGTCGTGGTGCTTTCGA
TCATCGTGTTCGTGCATGAA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MHGVTMKKISIFGATGSIGQSTIDLIRRAPDAYDVVALSGGHNVAQLARDAIELQADIAITAHDARLEELRSALAGSGVE
AASGAAALVEAASRPADWIMSAIVGAAGLAPGLKALEQGTTLALANKESLVCAGALLMQTAADHGARILPVDSEHSAVFQ
ALVGERIEEVERIIITASGGAFRDWPLERLKTASLAEASSHPNWDMGQRITIDSASMFNKALEVIETREFFGVAPEQIEV
LVHPQSLVHALVGFRDGALMSHLGAPDMRHAIGYALHWPDRNALPVARLDLAAIGQLEFRAPDLQRYPALRLAQEVMRRG
GLSGAAFNGAKERALDHFIAGRIGFLDMASLTEEGLATLEAQPGLIDASMTLENVTRVDDLARRAVDQVVTQRTG

Sequences:

>Translated_395_residues
MHGVTMKKISIFGATGSIGQSTIDLIRRAPDAYDVVALSGGHNVAQLARDAIELQADIAITAHDARLEELRSALAGSGVE
AASGAAALVEAASRPADWIMSAIVGAAGLAPGLKALEQGTTLALANKESLVCAGALLMQTAADHGARILPVDSEHSAVFQ
ALVGERIEEVERIIITASGGAFRDWPLERLKTASLAEASSHPNWDMGQRITIDSASMFNKALEVIETREFFGVAPEQIEV
LVHPQSLVHALVGFRDGALMSHLGAPDMRHAIGYALHWPDRNALPVARLDLAAIGQLEFRAPDLQRYPALRLAQEVMRRG
GLSGAAFNGAKERALDHFIAGRIGFLDMASLTEEGLATLEAQPGLIDASMTLENVTRVDDLARRAVDQVVTQRTG
>Mature_395_residues
MHGVTMKKISIFGATGSIGQSTIDLIRRAPDAYDVVALSGGHNVAQLARDAIELQADIAITAHDARLEELRSALAGSGVE
AASGAAALVEAASRPADWIMSAIVGAAGLAPGLKALEQGTTLALANKESLVCAGALLMQTAADHGARILPVDSEHSAVFQ
ALVGERIEEVERIIITASGGAFRDWPLERLKTASLAEASSHPNWDMGQRITIDSASMFNKALEVIETREFFGVAPEQIEV
LVHPQSLVHALVGFRDGALMSHLGAPDMRHAIGYALHWPDRNALPVARLDLAAIGQLEFRAPDLQRYPALRLAQEVMRRG
GLSGAAFNGAKERALDHFIAGRIGFLDMASLTEEGLATLEAQPGLIDASMTLENVTRVDDLARRAVDQVVTQRTG

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=40.6565656565657, Blast_Score=286, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_SILST (Q1GGS3)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_613405.1
- ProteinModelPortal:   Q1GGS3
- SMR:   Q1GGS3
- STRING:   Q1GGS3
- GeneID:   4078040
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_1410
- NMPDR:   fig|292414.1.peg.3486
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   LYDIPFD
- PhylomeDB:   Q1GGS3
- ProtClustDB:   PRK05447
- BioCyc:   SSP292414:TM1040_1410-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41944; Mature: 41944

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: BINDING 127-127 BINDING 154-154 BINDING 178-178 BINDING 201-201 BINDING 223-223

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGVTMKKISIFGATGSIGQSTIDLIRRAPDAYDVVALSGGHNVAQLARDAIELQADIAI
CCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCEEE
TAHDARLEELRSALAGSGVEAASGAAALVEAASRPADWIMSAIVGAAGLAPGLKALEQGT
EECHHHHHHHHHHHCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCC
TLALANKESLVCAGALLMQTAADHGARILPVDSEHSAVFQALVGERIEEVERIIITASGG
EEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEEEEECCC
AFRDWPLERLKTASLAEASSHPNWDMGQRITIDSASMFNKALEVIETREFFGVAPEQIEV
CCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEEE
LVHPQSLVHALVGFRDGALMSHLGAPDMRHAIGYALHWPDRNALPVARLDLAAIGQLEFR
EECCHHHHHHHHCCCCCHHHHHCCCCHHHHHHCEEEECCCCCCCCHHHHHHHHHCCEECC
APDLQRYPALRLAQEVMRRGGLSGAAFNGAKERALDHFIAGRIGFLDMASLTEEGLATLE
CCCHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
AQPGLIDASMTLENVTRVDDLARRAVDQVVTQRTG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHGVTMKKISIFGATGSIGQSTIDLIRRAPDAYDVVALSGGHNVAQLARDAIELQADIAI
CCCCEEEEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHCEEE
TAHDARLEELRSALAGSGVEAASGAAALVEAASRPADWIMSAIVGAAGLAPGLKALEQGT
EECHHHHHHHHHHHCCCCCCHHCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHHHHHCCC
TLALANKESLVCAGALLMQTAADHGARILPVDSEHSAVFQALVGERIEEVERIIITASGG
EEEEECCCCHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHEEEEEECCC
AFRDWPLERLKTASLAEASSHPNWDMGQRITIDSASMFNKALEVIETREFFGVAPEQIEV
CCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCCHHHEEE
LVHPQSLVHALVGFRDGALMSHLGAPDMRHAIGYALHWPDRNALPVARLDLAAIGQLEFR
EECCHHHHHHHHCCCCCHHHHHCCCCHHHHHHCEEEECCCCCCCCHHHHHHHHHCCEECC
APDLQRYPALRLAQEVMRRGGLSGAAFNGAKERALDHFIAGRIGFLDMASLTEEGLATLE
CCCHHHCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEC
AQPGLIDASMTLENVTRVDDLARRAVDQVVTQRTG
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA