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The map label for this gene is lpxD [H]

Identifier: 99081060

GI number: 99081060

Start: 1309957

End: 1311030

Strand: Direct

Name: lpxD [H]

Synonym: TM1040_1219

Alternate gene names: 99081060

Gene position: 1309957-1311030 (Clockwise)

Preceding gene: 99081059

Following gene: 99081061

Centisome position: 40.92

GC content: 60.99

Gene sequence:

>1074_bases
ATGTTCACCGTTCGTGAAATTGCCACGGCACTTGGCGCGCAGGCGGCGGGTGATCTAGACCTCAAGATCACACATGCCTC
AGAGCCCCAGGATGCGGGCGCTGAGGCGCTCGCGATGGCGATGTCGCCGCAATATGGTGAGGCCCTGACGCAGGGCAATG
CACGCGCCGCCCTTGTCTGGGAGGGCGCAGACTGGCAGGCTCTGGGTCTAGACGCTGCTATTTTTGTTGTCCGTCCGCGC
CTCGCCATGAGCGGTGTCACCCGCATGATGGACCGAGGTCAGCGCTTAGCTGCGGGAATCCATCCTTCTGCCGTCATCGA
CCCCTCAGCCGAGATCGGCGCGGATGTCACGATCGGGCCTCTCTCCGTGGTTGGACCGGACGCCAAGATTGGGGCGGGTT
CGCTTATCGGGGCGCATTGTTTCATCGGCGCGGATGTCACAATTGGTCCAGAGGCCAACCTGAGGGAAATGGTGTCGATT
GGTGCGCGCGTCACCATTGGTGCGCGGTTTCGCGCCCAGCCGGGCGCGCGGATTGCTGCGGATGGGTTTTCCTATGTGAC
GCCCGAGACGTCTGGCGTCGAGAATGCCCGGAAAACGCTCGGAGATCAGGGCGACACCTCCGCCCAGTCCTGGGTTCGGA
TTCATTCGCTTGGATCGGTGCGGATCGGCGACGATGTGGAGATCGGCGCAAACTGCACCATCGACAATGGCACCATTCGG
GACACCGTGATCGGCAATGGAACCAAGCTCGACAACCAGGTGCATGTGGGCCACAACTGCCGCATTGGCAATGATTGCCT
GCTCTGCGGCCAGACGGGCCTCTCTGGTTCGGTTGATATTGGCAACAACGTTGTCCTTGGCGGGCAATGTGGCGTCGCCG
ACAACCTCTTTATCGGTGACCGCGTGATTGCGGGAGGAGGCACCAAAATCCTCTCGAATGTTCCGGCCGGGCGAGTGATG
ATGGGCTATCCGGCGGTCAAGATGGACACCCACACAGAGATGTACAAAGCCCAGCGCCGTTTGCCGCGCCTGATGCGCGA
TCTCGATGCGTTGAAAAAGGCTGTTTTCAAATAG

Upstream 100 bases:

>100_bases
GACGCAAAGATCTGGTCCGCTTTGGAGCGGGCAGGGGTGGCACTTCCCGGCGTTCAAGGCTAAGTCTCAGGCCAAGATCC
GCATTTGGAGGGATGGCCTG

Downstream 100 bases:

>100_bases
CGGCGCAGTCAGTAAACCACAGGCAATCTTATCTCCCGCAGGAGCCGCCCTATGAGCACGCAGGACAAGGTCATCGCAAT
CATCGCAGAGCAGGCGGTGT

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MFTVREIATALGAQAAGDLDLKITHASEPQDAGAEALAMAMSPQYGEALTQGNARAALVWEGADWQALGLDAAIFVVRPR
LAMSGVTRMMDRGQRLAAGIHPSAVIDPSAEIGADVTIGPLSVVGPDAKIGAGSLIGAHCFIGADVTIGPEANLREMVSI
GARVTIGARFRAQPGARIAADGFSYVTPETSGVENARKTLGDQGDTSAQSWVRIHSLGSVRIGDDVEIGANCTIDNGTIR
DTVIGNGTKLDNQVHVGHNCRIGNDCLLCGQTGLSGSVDIGNNVVLGGQCGVADNLFIGDRVIAGGGTKILSNVPAGRVM
MGYPAVKMDTHTEMYKAQRRLPRLMRDLDALKKAVFK

Sequences:

>Translated_357_residues
MFTVREIATALGAQAAGDLDLKITHASEPQDAGAEALAMAMSPQYGEALTQGNARAALVWEGADWQALGLDAAIFVVRPR
LAMSGVTRMMDRGQRLAAGIHPSAVIDPSAEIGADVTIGPLSVVGPDAKIGAGSLIGAHCFIGADVTIGPEANLREMVSI
GARVTIGARFRAQPGARIAADGFSYVTPETSGVENARKTLGDQGDTSAQSWVRIHSLGSVRIGDDVEIGANCTIDNGTIR
DTVIGNGTKLDNQVHVGHNCRIGNDCLLCGQTGLSGSVDIGNNVVLGGQCGVADNLFIGDRVIAGGGTKILSNVPAGRVM
MGYPAVKMDTHTEMYKAQRRLPRLMRDLDALKKAVFK
>Mature_357_residues
MFTVREIATALGAQAAGDLDLKITHASEPQDAGAEALAMAMSPQYGEALTQGNARAALVWEGADWQALGLDAAIFVVRPR
LAMSGVTRMMDRGQRLAAGIHPSAVIDPSAEIGADVTIGPLSVVGPDAKIGAGSLIGAHCFIGADVTIGPEANLREMVSI
GARVTIGARFRAQPGARIAADGFSYVTPETSGVENARKTLGDQGDTSAQSWVRIHSLGSVRIGDDVEIGANCTIDNGTIR
DTVIGNGTKLDNQVHVGHNCRIGNDCLLCGQTGLSGSVDIGNNVVLGGQCGVADNLFIGDRVIAGGGTKILSNVPAGRVM
MGYPAVKMDTHTEMYKAQRRLPRLMRDLDALKKAVFK

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786376, Length=349, Percent_Identity=31.8051575931232, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI1786378, Length=251, Percent_Identity=25.0996015936255, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001451
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573 [H]

Pfam domain/function: PF00132 Hexapep; PF04613 LpxD [H]

EC number: 2.3.1.-

Molecular weight: Translated: 37168; Mature: 37168

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTVREIATALGAQAAGDLDLKITHASEPQDAGAEALAMAMSPQYGEALTQGNARAALVW
CCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHCCCCEEEEEE
EGADWQALGLDAAIFVVRPRLAMSGVTRMMDRGQRLAAGIHPSAVIDPSAEIGADVTIGP
CCCCCEEECCCEEEEEECCHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHCCCEEECC
LSVVGPDAKIGAGSLIGAHCFIGADVTIGPEANLREMVSIGARVTIGARFRAQPGARIAA
EEEECCCCCCCCCCEEEEEEEEECCEEECCCCCHHHHHHCCCEEEEEEEEECCCCCEEEE
DGFSYVTPETSGVENARKTLGDQGDTSAQSWVRIHSLGSVRIGDDVEIGANCTIDNGTIR
CCCEEECCCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCEEECCCEEECCEEEECCCCEE
DTVIGNGTKLDNQVHVGHNCRIGNDCLLCGQTGLSGSVDIGNNVVLGGQCGVADNLFIGD
EEEECCCCCCCCEEECCCCCEECCCEEEECCCCCCCCEECCCCEEECCCCCCCCCEEECC
RVIAGGGTKILSNVPAGRVMMGYPAVKMDTHTEMYKAQRRLPRLMRDLDALKKAVFK
EEEECCCHHHHHCCCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFTVREIATALGAQAAGDLDLKITHASEPQDAGAEALAMAMSPQYGEALTQGNARAALVW
CCCHHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHCCCCEEEEEE
EGADWQALGLDAAIFVVRPRLAMSGVTRMMDRGQRLAAGIHPSAVIDPSAEIGADVTIGP
CCCCCEEECCCEEEEEECCHHHHHHHHHHHHCCCCEECCCCCCEEECCCHHHCCCEEECC
LSVVGPDAKIGAGSLIGAHCFIGADVTIGPEANLREMVSIGARVTIGARFRAQPGARIAA
EEEECCCCCCCCCCEEEEEEEEECCEEECCCCCHHHHHHCCCEEEEEEEEECCCCCEEEE
DGFSYVTPETSGVENARKTLGDQGDTSAQSWVRIHSLGSVRIGDDVEIGANCTIDNGTIR
CCCEEECCCCCCHHHHHHHCCCCCCCCHHHEEEEECCCCEEECCCEEECCEEEECCCCEE
DTVIGNGTKLDNQVHVGHNCRIGNDCLLCGQTGLSGSVDIGNNVVLGGQCGVADNLFIGD
EEEECCCCCCCCEEECCCCCEECCCEEEECCCCCCCCEECCCCEEECCCCCCCCCEEECC
RVIAGGGTKILSNVPAGRVMMGYPAVKMDTHTEMYKAQRRLPRLMRDLDALKKAVFK
EEEECCCHHHHHCCCCCCEEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA