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The map label for this gene is apxIIIA [H]

Identifier: 99080972

GI number: 99080972

Start: 1215643

End: 1216653

Strand: Reverse

Name: apxIIIA [H]

Synonym: TM1040_1131

Alternate gene names: 99080972

Gene position: 1216653-1215643 (Counterclockwise)

Preceding gene: 99080973

Following gene: 99080960

Centisome position: 38.01

GC content: 61.23

Gene sequence:

>1011_bases
ATGTTGATGCTTGCACTTATTGGCTCGATTGCGGTCATCGGCGCGTTTGTTGCGCTCGATGATGACGACGACACCGAAGA
CACGATCCCCGACAACACCGAAACCGGAACCCCAGGTTCAGATCAGCTTGATGGCACCGATGGCCGTGATCTGATCACGC
TTGGCGACGGGGATGACAGCAGCTTTGGCGGCGATGGGGATGACACCATTCACGGGGATGCCGGCGCAGATGTGCTCGGC
GGCCAGATTGGGGGCGATGATCTCTACGGTGGCGATGGTAACGATAATCTCTACGGCGGCGCGGGCGATGATTTCCTCTC
GGGCGGCGCGGATGCAGACATCCTCGAGGGAGGGGGCAGCGACGACCGCATGACCGGCGGCGGTGGCCTTGACGTTCTGC
TCGGCGGGAACGGCGAGGACACCCTGAATGGCAGCCTTGGTCAGGACTTGCTCTACGGTGGCAACGACGACGATGTCCTG
AATGGGGGCTATGGTGCAGACGGGCTGCACGGCGGCAACGGAGAGGACACGGTCTCCGGCGGCGACGGCGATGATGTGAT
CAACGGGGGCGAACTGCTTGTTGATACCTCTCTCACCTCGGCGTCCGCCCTGCGCGAGGCCTTCCTTGATGGTGAAAACA
GCCCAGCCAACCTGGACTTCCTCTTTGAGGATGACAAAGAGAGCGACGTTTTGAATGGCGACGCGGGCAGTGATCTCTTG
GTGGGGGGCGCGGGTGACGTCCTCAATGGCGGCACCGGCGACGACACGTTCCTGGTCGGAGACTGGCTGCAAGCCGGCGA
ACAGGTGATCATTCGCGATTTCGACGTGGAAGACGAAGTCGTGCTCTACCGCTACTCCGGCGCTGCACCAGATCTCGACT
ACAACACGGTCGTCAATTCTGATGGATCTTCCGATATCGAGGTCACCGTGAACGGCGAGGTGGTCGCCTATCTCGAGAAC
GCGGGCGATGGGTTCGACCTTGCGTCAAACGTGGCCCTGGTCTCTGCGTGA

Upstream 100 bases:

>100_bases
TCATGAATTTGTCAAACGTGCCGCAATTCTCGCGGCGTCTTGCTGACAGCGATTAACCCGATCCCGGCCCGATTTTCGTG
GTGGCCAGAGGAGTATTTTT

Downstream 100 bases:

>100_bases
TCTTCGGTCTTTGAGCAAACAAAAGCCGCCCTCAATCGGGGGCGGCTTTTTCGTGGGATCATAACAAGTGGGGCCTCAGC
GCCCCTCGAAATCCGGTTTG

Product: hemolysin-type calcium-binding region

Products: NA

Alternate protein names: APX-IIIA; Cytolysin IIIA; CLY-IIIA [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MLMLALIGSIAVIGAFVALDDDDDTEDTIPDNTETGTPGSDQLDGTDGRDLITLGDGDDSSFGGDGDDTIHGDAGADVLG
GQIGGDDLYGGDGNDNLYGGAGDDFLSGGADADILEGGGSDDRMTGGGGLDVLLGGNGEDTLNGSLGQDLLYGGNDDDVL
NGGYGADGLHGGNGEDTVSGGDGDDVINGGELLVDTSLTSASALREAFLDGENSPANLDFLFEDDKESDVLNGDAGSDLL
VGGAGDVLNGGTGDDTFLVGDWLQAGEQVIIRDFDVEDEVVLYRYSGAAPDLDYNTVVNSDGSSDIEVTVNGEVVAYLEN
AGDGFDLASNVALVSA

Sequences:

>Translated_336_residues
MLMLALIGSIAVIGAFVALDDDDDTEDTIPDNTETGTPGSDQLDGTDGRDLITLGDGDDSSFGGDGDDTIHGDAGADVLG
GQIGGDDLYGGDGNDNLYGGAGDDFLSGGADADILEGGGSDDRMTGGGGLDVLLGGNGEDTLNGSLGQDLLYGGNDDDVL
NGGYGADGLHGGNGEDTVSGGDGDDVINGGELLVDTSLTSASALREAFLDGENSPANLDFLFEDDKESDVLNGDAGSDLL
VGGAGDVLNGGTGDDTFLVGDWLQAGEQVIIRDFDVEDEVVLYRYSGAAPDLDYNTVVNSDGSSDIEVTVNGEVVAYLEN
AGDGFDLASNVALVSA
>Mature_336_residues
MLMLALIGSIAVIGAFVALDDDDDTEDTIPDNTETGTPGSDQLDGTDGRDLITLGDGDDSSFGGDGDDTIHGDAGADVLG
GQIGGDDLYGGDGNDNLYGGAGDDFLSGGADADILEGGGSDDRMTGGGGLDVLLGGNGEDTLNGSLGQDLLYGGNDDDVL
NGGYGADGLHGGNGEDTVSGGDGDDVINGGELLVDTSLTSASALREAFLDGENSPANLDFLFEDDKESDVLNGDAGSDLL
VGGAGDVLNGGTGDDTFLVGDWLQAGEQVIIRDFDVEDEVVLYRYSGAAPDLDYNTVVNSDGSSDIEVTVNGEVVAYLEN
AGDGFDLASNVALVSA

Specific function: Does not have hemolytic activity but shows a strong cytotoxicity towards alveolar macrophages and neutrophils [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 6 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR013550
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX; PF08339 RTX_C [H]

EC number: NA

Molecular weight: Translated: 33720; Mature: 33720

Theoretical pI: Translated: 3.05; Mature: 3.05

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLMLALIGSIAVIGAFVALDDDDDTEDTIPDNTETGTPGSDQLDGTDGRDLITLGDGDDS
CCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SFGGDGDDTIHGDAGADVLGGQIGGDDLYGGDGNDNLYGGAGDDFLSGGADADILEGGGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEECCCCC
DDRMTGGGGLDVLLGGNGEDTLNGSLGQDLLYGGNDDDVLNGGYGADGLHGGNGEDTVSG
CCCEECCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCC
GDGDDVINGGELLVDTSLTSASALREAFLDGENSPANLDFLFEDDKESDVLNGDAGSDLL
CCCCCEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEE
VGGAGDVLNGGTGDDTFLVGDWLQAGEQVIIRDFDVEDEVVLYRYSGAAPDLDYNTVVNS
EECCCCCCCCCCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCCEEECC
DGSSDIEVTVNGEVVAYLENAGDGFDLASNVALVSA
CCCCEEEEEECCEEEEEEECCCCCCCHHCCEEEEEC
>Mature Secondary Structure
MLMLALIGSIAVIGAFVALDDDDDTEDTIPDNTETGTPGSDQLDGTDGRDLITLGDGDDS
CCHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCC
SFGGDGDDTIHGDAGADVLGGQIGGDDLYGGDGNDNLYGGAGDDFLSGGADADILEGGGS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCEECCCCC
DDRMTGGGGLDVLLGGNGEDTLNGSLGQDLLYGGNDDDVLNGGYGADGLHGGNGEDTVSG
CCCEECCCCEEEEECCCCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCCCCCCCC
GDGDDVINGGELLVDTSLTSASALREAFLDGENSPANLDFLFEDDKESDVLNGDAGSDLL
CCCCCEECCCEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCCCEE
VGGAGDVLNGGTGDDTFLVGDWLQAGEQVIIRDFDVEDEVVLYRYSGAAPDLDYNTVVNS
EECCCCCCCCCCCCCCEEEEHHHHCCCEEEEEECCCCCCEEEEEECCCCCCCCCCEEECC
DGSSDIEVTVNGEVVAYLENAGDGFDLASNVALVSA
CCCCEEEEEECCEEEEEEECCCCCCCHHCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7927703; 8432615 [H]