Click here to switch to the map view.

The map label for this gene is nqo1 [H]

Identifier: 99080589

GI number: 99080589

Start: 804573

End: 805871

Strand: Direct

Name: nqo1 [H]

Synonym: TM1040_0748

Alternate gene names: 99080589

Gene position: 804573-805871 (Clockwise)

Preceding gene: 99080588

Following gene: 99080590

Centisome position: 25.14

GC content: 60.51

Gene sequence:

>1299_bases
ATGCTGAAGGATCAGGACCGGATCTTTACCAACCTTTACGGGATGCACGAACGCACGTTGGCGGGCGCACAAAAGCGCGG
CCACTGGGACGGTACGGCGGGCCTCATTGAAAAAGGGCGCGACTGGATCATCCAGACCATGAAGGATTCCGGCCTGCGCG
GGCGTGGCGGTGCGGGCTTCCCCACCGGCCTCAAATGGTCCTTCATGCCCAAGGAAAGCGACGGGCGTCCCGCCTATCTG
GTCATCAATGCTGATGAGTCCGAGCCCGGCACCTGCAAAGACCGCGAAATCATGCGTCACGATCCGCATACGCTGATCGA
GGGCGCGCTGATCGCTTCCTTCGCGATGAACGCGCACACCTGCTACATCTATCTGCGCGGCGAATATATCCGCGAGCGCG
AGGCGCTGCAGGCCGCCATCGACGAATGCTACGACAAGGGTCTTCTGGGCAAGAACGCTGCAGGCTCGGGCTGGGATTTC
GATCTTTTCCTGCACCACGGGGCAGGGGCTTATATCTGCGGCGAGGAAACCGCCCTGATCGAGAGCCTTGAGGGCAAAAA
AGGCATGCCGCGCATGAAGCCGCCATTCCCGGCAGGCGCGGGGCTTTATGGCTGCCCGACCACGGTGAACAATGTCGAAT
CCATCGCCGTGGTGCCCACCATCCTGCGGCGCGGTGCGGAGTGGTTTGCCGGCTTTGGCCGTCAGAACAACGCGGGCACC
AAGCTTTTTGCGATCTCCGGTCACGTCAACAACCCCTGCGTTGTTGAAGAGGCCATGTCGATCAGCTTTGAAGAGCTGAT
TGAAAAACACTGCGGTGGCATTCGCGGCGGCTGGGACAATCTTCTGGCGGTGATCCCAGGCGGCTCTTCAGTGCCCTGTG
TGCGCGGCGAGAAGATGCGCGATGCGATCATGGATTTTGATTACCTGCGCGGCGAGTTGGGCTCTGGCCTTGGCACTGCG
GCGGTGATCGTGATGGACAAGCAGACCGATATCGTCAAAGCGATCTGGCGCCTCTCGAAGTTCTACAAGCACGAAAGCTG
CGGCCAGTGCACGCCCTGCCGTGAAGGCACCGGCTGGATGATGCGCGTGATGGATCGTCTGGTGCGCGGTGAGGCGGAGC
TTGAAGAGATCGACATGCTCTGGGATGTCACCAAGCAGGTCGAAGGCCACACCATCTGTGCACTGGGCGATGCGGCCGCA
TGGCCCATTCAGGGTCTCATTCGCAACTTCCGTGAAGAGATCGAAGATCGCATCAAGGCGCAGAAATCTGGCCGTATGGG
CGCGATGGCAGCGGAATAA

Upstream 100 bases:

>100_bases
GCTGCTGTTCGATTTTGCGGCTCTGGCCGCGATGATCTACGCGGGCGTCAACATCATTCAACTCTGGCGTATGCGTCAGA
ACAGTCAAAGGTAGGCACAC

Downstream 100 bases:

>100_bases
TCTGAAAGATGATGATGAACTCCCGTTTTCCTTTGTCACTGATGCTCGTGGCCTCGCTGGGGCTGGTGGCTTGTGGCCAA
TCGCGCGACGACAAGCGTAT

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 1; NDH-1, chain 1 [H]

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MLKDQDRIFTNLYGMHERTLAGAQKRGHWDGTAGLIEKGRDWIIQTMKDSGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VINADESEPGTCKDREIMRHDPHTLIEGALIASFAMNAHTCYIYLRGEYIREREALQAAIDECYDKGLLGKNAAGSGWDF
DLFLHHGAGAYICGEETALIESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRQNNAGT
KLFAISGHVNNPCVVEEAMSISFEELIEKHCGGIRGGWDNLLAVIPGGSSVPCVRGEKMRDAIMDFDYLRGELGSGLGTA
AVIVMDKQTDIVKAIWRLSKFYKHESCGQCTPCREGTGWMMRVMDRLVRGEAELEEIDMLWDVTKQVEGHTICALGDAAA
WPIQGLIRNFREEIEDRIKAQKSGRMGAMAAE

Sequences:

>Translated_432_residues
MLKDQDRIFTNLYGMHERTLAGAQKRGHWDGTAGLIEKGRDWIIQTMKDSGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VINADESEPGTCKDREIMRHDPHTLIEGALIASFAMNAHTCYIYLRGEYIREREALQAAIDECYDKGLLGKNAAGSGWDF
DLFLHHGAGAYICGEETALIESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRQNNAGT
KLFAISGHVNNPCVVEEAMSISFEELIEKHCGGIRGGWDNLLAVIPGGSSVPCVRGEKMRDAIMDFDYLRGELGSGLGTA
AVIVMDKQTDIVKAIWRLSKFYKHESCGQCTPCREGTGWMMRVMDRLVRGEAELEEIDMLWDVTKQVEGHTICALGDAAA
WPIQGLIRNFREEIEDRIKAQKSGRMGAMAAE
>Mature_432_residues
MLKDQDRIFTNLYGMHERTLAGAQKRGHWDGTAGLIEKGRDWIIQTMKDSGLRGRGGAGFPTGLKWSFMPKESDGRPAYL
VINADESEPGTCKDREIMRHDPHTLIEGALIASFAMNAHTCYIYLRGEYIREREALQAAIDECYDKGLLGKNAAGSGWDF
DLFLHHGAGAYICGEETALIESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRQNNAGT
KLFAISGHVNNPCVVEEAMSISFEELIEKHCGGIRGGWDNLLAVIPGGSSVPCVRGEKMRDAIMDFDYLRGELGSGLGTA
AVIVMDKQTDIVKAIWRLSKFYKHESCGQCTPCREGTGWMMRVMDRLVRGEAELEEIDMLWDVTKQVEGHTICALGDAAA
WPIQGLIRNFREEIEDRIKAQKSGRMGAMAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=418, Percent_Identity=67.7033492822967, Blast_Score=598, Evalue=1e-171,
Organism=Homo sapiens, GI260656005, Length=418, Percent_Identity=67.7033492822967, Blast_Score=597, Evalue=1e-171,
Organism=Escherichia coli, GI1788620, Length=397, Percent_Identity=46.095717884131, Blast_Score=342, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI17531727, Length=417, Percent_Identity=67.3860911270983, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI19920794, Length=418, Percent_Identity=67.9425837320574, Blast_Score=606, Evalue=1e-173,
Organism=Drosophila melanogaster, GI45550452, Length=434, Percent_Identity=64.9769585253456, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24653819, Length=425, Percent_Identity=46.8235294117647, Blast_Score=388, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24653817, Length=425, Percent_Identity=43.5294117647059, Blast_Score=352, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 47584; Mature: 47584

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDQDRIFTNLYGMHERTLAGAQKRGHWDGTAGLIEKGRDWIIQTMKDSGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGLKWSFMPKESDGRPAYLVINADESEPGTCKDREIMRHDPHTLIEGALIASFAMNAHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCEE
CYIYLRGEYIREREALQAAIDECYDKGLLGKNAAGSGWDFDLFLHHGAGAYICGEETALI
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRQNNAGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCC
KLFAISGHVNNPCVVEEAMSISFEELIEKHCGGIRGGWDNLLAVIPGGSSVPCVRGEKMR
EEEEEECCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHH
DAIMDFDYLRGELGSGLGTAAVIVMDKQTDIVKAIWRLSKFYKHESCGQCTPCREGTGWM
HHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
MRVMDRLVRGEAELEEIDMLWDVTKQVEGHTICALGDAAAWPIQGLIRNFREEIEDRIKA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QKSGRMGAMAAE
HHCCCCCCCCCC
>Mature Secondary Structure
MLKDQDRIFTNLYGMHERTLAGAQKRGHWDGTAGLIEKGRDWIIQTMKDSGLRGRGGAGF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCCCCC
PTGLKWSFMPKESDGRPAYLVINADESEPGTCKDREIMRHDPHTLIEGALIASFAMNAHT
CCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCEE
CYIYLRGEYIREREALQAAIDECYDKGLLGKNAAGSGWDFDLFLHHGAGAYICGEETALI
EEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGMPRMKPPFPAGAGLYGCPTTVNNVESIAVVPTILRRGAEWFAGFGRQNNAGT
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCC
KLFAISGHVNNPCVVEEAMSISFEELIEKHCGGIRGGWDNLLAVIPGGSSVPCVRGEKMR
EEEEEECCCCCCHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCHHHH
DAIMDFDYLRGELGSGLGTAAVIVMDKQTDIVKAIWRLSKFYKHESCGQCTPCREGTGWM
HHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHH
MRVMDRLVRGEAELEEIDMLWDVTKQVEGHTICALGDAAAWPIQGLIRNFREEIEDRIKA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHH
QKSGRMGAMAAE
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1905152; 1909571; 1605643 [H]