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The map label for this gene is nqo2 [H]

Identifier: 99080587

GI number: 99080587

Start: 803081

End: 804277

Strand: Direct

Name: nqo2 [H]

Synonym: TM1040_0746

Alternate gene names: 99080587

Gene position: 803081-804277 (Clockwise)

Preceding gene: 99080586

Following gene: 99080588

Centisome position: 25.09

GC content: 60.65

Gene sequence:

>1197_bases
ATGCTGCGTCGTCTTCATCACGAACAGCCTGACAGCTTTGCGTTCACCCCGGCCAATCAGGCCTGGGCCGAAGCTCAGAT
GACCAAATACCCCGAAGGCCGTCAGGCCTCGGCGGTCATTCCGATTCTGTGGCGCGCTCAGGAGCAAGAGGGCTGGATTT
CCAAACCCGCGATCGAATATGTGGCCGATATGCTCGGCATGGCCTACATCCGCGTGCTGGAAGTGGCCTCTTTCTATTTC
ATGTTCCAGCTGCAGCCCACGGGTTCGGTTGCGCATATCCAGATCTGTGGCACCACGTCCTGCATGATCTGTGGTGCCGA
GGATCTGGTCGCGATCTGCAAGGACAAGATCTCTGCCAAGCCGCATACGCTGTCCGAGGACGGCAAGTTCTCTTGGGAAG
AGGTAGAATGCCTTGGCTCCTGCGCCAATGCGCCGATGGCGCAGATCGGCAAGGATTATTACGAGGATCTGACCGCGGCA
TCTTTTACCAAGCTGCTCGATGATCTGGCGGCGGGTAAACCCGTCGTACCCGGCCCGCAAAACGGTCGCTACGCTGCAGA
GCCAAAGGCGGGCCTGACCTCGCTCACCGAATATGAAGCAGGCAAGCCGCAGTATAATGCCTCGGCGGAGCTTGCGACCG
AAATCGGTGACGGTGTGAAGCGTATTCAGGGCGATGAAGTTCCGCTCCTGACCCCATGGGTCGGCAAGGATGGCGTGGTT
GCAGGGCGTGCCGCTGCAGATCCGACGCCGCCCGCGCCAGAGCGTCCGCAACCCGCGGCCAAGCAGGCTGAGACCGCCAA
GAAGAAGGCTCCGGCCAAGCCTGCGGTCAAGAAATCGGATGCGGCAACGCCTGCACAGCCCGAAGCCGCCGCCGCAAAGG
TGACGGAACCCAAGGCGGACTTGGAAGAACAAGCACCCGAGACGCTGACAGCGGCGCGCGAGGGCGGGGCGGACGATCTC
AAGCTCCTCAAAGGTGTGGGGCCAAAGCTCGAACAGACGCTCAATGAGCTGGGCTTTTTCCACTTTGACCAGATTGCCAA
ATGGACCGAGGCCGAGGTGGCCTGGGTGGATGCGCGCCTGAAGTTCAAAGGCCGCATCGAGCGCGACGGCTGGATCGAGC
AAGCCAAGCAACTGGCAGCCGGTGAAGAAACCGAGTTTGCCAAATCGGCCAAGAAAGACGGCCGCTACAAAGACTAA

Upstream 100 bases:

>100_bases
ATGCGAGCGATGCCGCATTCGATGCCAAGGCCGCAGGTCAGGAGATCCCCGCAGGATCGCTTACCTCGACTTGCATTCTG
CTTGAGGAGTTCGACAAGTA

Downstream 100 bases:

>100_bases
ACTCTCCGCTGCGTGCGGCCTCAATGGCCTACGCCGTGGTCAAGGATGACTGGACCGGATGACGCAGGACGAACAGGATA
AGGCCATCGCTGCCAAAGGG

Product: NADH dehydrogenase subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I, chain 2; NDH-1, chain 2 [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MLRRLHHEQPDSFAFTPANQAWAEAQMTKYPEGRQASAVIPILWRAQEQEGWISKPAIEYVADMLGMAYIRVLEVASFYF
MFQLQPTGSVAHIQICGTTSCMICGAEDLVAICKDKISAKPHTLSEDGKFSWEEVECLGSCANAPMAQIGKDYYEDLTAA
SFTKLLDDLAAGKPVVPGPQNGRYAAEPKAGLTSLTEYEAGKPQYNASAELATEIGDGVKRIQGDEVPLLTPWVGKDGVV
AGRAAADPTPPAPERPQPAAKQAETAKKKAPAKPAVKKSDAATPAQPEAAAAKVTEPKADLEEQAPETLTAAREGGADDL
KLLKGVGPKLEQTLNELGFFHFDQIAKWTEAEVAWVDARLKFKGRIERDGWIEQAKQLAAGEETEFAKSAKKDGRYKD

Sequences:

>Translated_398_residues
MLRRLHHEQPDSFAFTPANQAWAEAQMTKYPEGRQASAVIPILWRAQEQEGWISKPAIEYVADMLGMAYIRVLEVASFYF
MFQLQPTGSVAHIQICGTTSCMICGAEDLVAICKDKISAKPHTLSEDGKFSWEEVECLGSCANAPMAQIGKDYYEDLTAA
SFTKLLDDLAAGKPVVPGPQNGRYAAEPKAGLTSLTEYEAGKPQYNASAELATEIGDGVKRIQGDEVPLLTPWVGKDGVV
AGRAAADPTPPAPERPQPAAKQAETAKKKAPAKPAVKKSDAATPAQPEAAAAKVTEPKADLEEQAPETLTAAREGGADDL
KLLKGVGPKLEQTLNELGFFHFDQIAKWTEAEVAWVDARLKFKGRIERDGWIEQAKQLAAGEETEFAKSAKKDGRYKD
>Mature_398_residues
MLRRLHHEQPDSFAFTPANQAWAEAQMTKYPEGRQASAVIPILWRAQEQEGWISKPAIEYVADMLGMAYIRVLEVASFYF
MFQLQPTGSVAHIQICGTTSCMICGAEDLVAICKDKISAKPHTLSEDGKFSWEEVECLGSCANAPMAQIGKDYYEDLTAA
SFTKLLDDLAAGKPVVPGPQNGRYAAEPKAGLTSLTEYEAGKPQYNASAELATEIGDGVKRIQGDEVPLLTPWVGKDGVV
AGRAAADPTPPAPERPQPAAKQAETAKKKAPAKPAVKKSDAATPAQPEAAAAKVTEPKADLEEQAPETLTAAREGGADDL
KLLKGVGPKLEQTLNELGFFHFDQIAKWTEAEVAWVDARLKFKGRIERDGWIEQAKQLAAGEETEFAKSAKKDGRYKD

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=205, Percent_Identity=44.8780487804878, Blast_Score=178, Evalue=8e-45,
Organism=Escherichia coli, GI1788621, Length=159, Percent_Identity=32.7044025157233, Blast_Score=83, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17561328, Length=199, Percent_Identity=45.7286432160804, Blast_Score=172, Evalue=2e-43,
Organism=Drosophila melanogaster, GI18859877, Length=202, Percent_Identity=44.5544554455446, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI21355353, Length=183, Percent_Identity=35.5191256830601, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 43130; Mature: 43130

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRRLHHEQPDSFAFTPANQAWAEAQMTKYPEGRQASAVIPILWRAQEQEGWISKPAIEY
CCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHH
VADMLGMAYIRVLEVASFYFMFQLQPTGSVAHIQICGTTSCMICGAEDLVAICKDKISAK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHCCC
PHTLSEDGKFSWEEVECLGSCANAPMAQIGKDYYEDLTAASFTKLLDDLAAGKPVVPGPQ
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NGRYAAEPKAGLTSLTEYEAGKPQYNASAELATEIGDGVKRIQGDEVPLLTPWVGKDGVV
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCE
AGRAAADPTPPAPERPQPAAKQAETAKKKAPAKPAVKKSDAATPAQPEAAAAKVTEPKAD
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHH
LEEQAPETLTAAREGGADDLKLLKGVGPKLEQTLNELGFFHFDQIAKWTEAEVAWVDARL
HHHHCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
KFKGRIERDGWIEQAKQLAAGEETEFAKSAKKDGRYKD
EECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLRRLHHEQPDSFAFTPANQAWAEAQMTKYPEGRQASAVIPILWRAQEQEGWISKPAIEY
CCCCCCCCCCCCEEECCCHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCCCCCCHHHHH
VADMLGMAYIRVLEVASFYFMFQLQPTGSVAHIQICGTTSCMICGAEDLVAICKDKISAK
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCEEEEECHHHHHHHHHHHHCCC
PHTLSEDGKFSWEEVECLGSCANAPMAQIGKDYYEDLTAASFTKLLDDLAAGKPVVPGPQ
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NGRYAAEPKAGLTSLTEYEAGKPQYNASAELATEIGDGVKRIQGDEVPLLTPWVGKDGVV
CCCCCCCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCE
AGRAAADPTPPAPERPQPAAKQAETAKKKAPAKPAVKKSDAATPAQPEAAAAKVTEPKAD
ECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHH
LEEQAPETLTAAREGGADDLKLLKGVGPKLEQTLNELGFFHFDQIAKWTEAEVAWVDARL
HHHHCHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEE
KFKGRIERDGWIEQAKQLAAGEETEFAKSAKKDGRYKD
EECCCCCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1909571 [H]