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The map label for this gene is nuoD

Identifier: 99080585

GI number: 99080585

Start: 801379

End: 802590

Strand: Direct

Name: nuoD

Synonym: TM1040_0744

Alternate gene names: 99080585

Gene position: 801379-802590 (Clockwise)

Preceding gene: 99080584

Following gene: 99080586

Centisome position: 25.04

GC content: 59.65

Gene sequence:

>1212_bases
ATGGACGGCTCCAAATTCGACGACGCCCAGACGGGCGAACAGAAAATCCGTAACTTCAACATCAACTTCGGCCCGCAGCA
CCCTGCGGCGCACGGCGTGCTGCGTCTGGTGCTGGAACTGGATGGCGAGATCGTGGAACGCTGCGACCCGCACATCGGTC
TTCTGCACCGTGGCACCGAAAAGCTGATGGAAAGCCGCACCTACCTGCAGAACCTGCCGTATTTCGACCGCCTCGACTAT
GTGGCGCCGATGAACCAGGAGCACGCTTGGTGTCTGGCAATCGAAAAGCTGACTGGCGTGGAGGTCCCCCGCCGTGCGCA
GCTGATCCGAGTGCTCTATTCTGAGATCGGCCGTATCCTCAATCACCTCTTGAACATCACCACTCAGGCGATGGACGTGG
GCGCGCTGACGCCGCCGCTCTGGGGCTTTGAGGAACGCGAGAAGCTGATGATCTTCTACGAGCGGGCCTGTGGTGCACGC
TTGCACGCGGCCTACTTCCGCCCTGGTGGCGTGCATCAGGATCTGCCGGACGAGCTGCTGGATGATATCGACCTCTGGGC
GATGGAATTTCCGAAGGTCATGGACGACATCGACGGCCTCTTGACCGAGAACCGGATCTTCAAGCAGCGCAACTGCGACA
TTGGCGTAGTCACCGAGGATGACATCCAGAAGTATGGCTTCTCCGGTGTGATGGTGCGCGGGTCTGGCCTGGCTTGGGAT
TTGCGCCGCGCGCAGCCCTATGAATGCTACGACGAGTTCGATTTCCAGATCCCGGTCGGCAAGAACGGCGACTGCTACGA
TCGCTATCTGGTGCGGATGGAAGAGATGCGTCAGTCGCTCTCGATCATCCGTCAGGCTATCGCAAAATTGCGCGAGGCCA
CCGGTGACGTTCTGGCCCGTGGCAAGCTCACCCCGCCTAAGCGCGGCGATATGAAGACCTCGATGGAGAGCCTGATCCAC
CACTTCAAGCTCTACACCGAAGGCTTCCATGTTCCCGAGGGCGAGGTCTATGCCGCTGTCGAGGCGCCCAAAGGCGAATT
TGGCGTCTATCTCGTGGCGGATGGCAGCAACAAGCCCTACCGCGCCAAGCTGCGCGCACCGGGGTTCTTGCATCTTCAAG
CGATGGATTACGTCGCCAAGGGCCACCAGCTTGCGGATGTCGCTGCAATTATTGGAACCATGGACATCGTGTTTGGAGAG
ATTGACCGATGA

Upstream 100 bases:

>100_bases
TGCTTTCGGCTATCGGTGGTCTGGGCTGGCTTTGGGTGAAACTGGTTCGCTTAGTAGGGTTTTCTGCTTGTCGAATTATT
GCGAAAGGTGGGAAGTAGTG

Downstream 100 bases:

>100_bases
CACTACGCGCATTTATCGCAGGGGCCTCCCTGTGTCTGATCGGACAAACCGCACTGGCAGAAAAATCGCTGGCGGATCTC
GTTGCTGAATCCGTTGGATA

Product: NADH dehydrogenase subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D; NDH-1 subunit D

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MDGSKFDDAQTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTEKLMESRTYLQNLPYFDRLDY
VAPMNQEHAWCLAIEKLTGVEVPRRAQLIRVLYSEIGRILNHLLNITTQAMDVGALTPPLWGFEEREKLMIFYERACGAR
LHAAYFRPGGVHQDLPDELLDDIDLWAMEFPKVMDDIDGLLTENRIFKQRNCDIGVVTEDDIQKYGFSGVMVRGSGLAWD
LRRAQPYECYDEFDFQIPVGKNGDCYDRYLVRMEEMRQSLSIIRQAIAKLREATGDVLARGKLTPPKRGDMKTSMESLIH
HFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVADGSNKPYRAKLRAPGFLHLQAMDYVAKGHQLADVAAIIGTMDIVFGE
IDR

Sequences:

>Translated_403_residues
MDGSKFDDAQTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTEKLMESRTYLQNLPYFDRLDY
VAPMNQEHAWCLAIEKLTGVEVPRRAQLIRVLYSEIGRILNHLLNITTQAMDVGALTPPLWGFEEREKLMIFYERACGAR
LHAAYFRPGGVHQDLPDELLDDIDLWAMEFPKVMDDIDGLLTENRIFKQRNCDIGVVTEDDIQKYGFSGVMVRGSGLAWD
LRRAQPYECYDEFDFQIPVGKNGDCYDRYLVRMEEMRQSLSIIRQAIAKLREATGDVLARGKLTPPKRGDMKTSMESLIH
HFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVADGSNKPYRAKLRAPGFLHLQAMDYVAKGHQLADVAAIIGTMDIVFGE
IDR
>Mature_403_residues
MDGSKFDDAQTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTEKLMESRTYLQNLPYFDRLDY
VAPMNQEHAWCLAIEKLTGVEVPRRAQLIRVLYSEIGRILNHLLNITTQAMDVGALTPPLWGFEEREKLMIFYERACGAR
LHAAYFRPGGVHQDLPDELLDDIDLWAMEFPKVMDDIDGLLTENRIFKQRNCDIGVVTEDDIQKYGFSGVMVRGSGLAWD
LRRAQPYECYDEFDFQIPVGKNGDCYDRYLVRMEEMRQSLSIIRQAIAKLREATGDVLARGKLTPPKRGDMKTSMESLIH
HFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVADGSNKPYRAKLRAPGFLHLQAMDYVAKGHQLADVAAIIGTMDIVFGE
IDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=389, Percent_Identity=63.7532133676092, Blast_Score=521, Evalue=1e-148,
Organism=Homo sapiens, GI260898743, Length=383, Percent_Identity=63.1853785900783, Blast_Score=507, Evalue=1e-144,
Organism=Escherichia coli, GI145693162, Length=388, Percent_Identity=39.1752577319588, Blast_Score=285, Evalue=3e-78,
Organism=Escherichia coli, GI1789076, Length=389, Percent_Identity=26.7352185089974, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1788832, Length=386, Percent_Identity=26.6839378238342, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17555284, Length=392, Percent_Identity=59.6938775510204, Blast_Score=494, Evalue=1e-140,
Organism=Caenorhabditis elegans, GI17568379, Length=392, Percent_Identity=59.1836734693878, Blast_Score=493, Evalue=1e-140,
Organism=Drosophila melanogaster, GI24638644, Length=392, Percent_Identity=61.2244897959184, Blast_Score=516, Evalue=1e-146,
Organism=Drosophila melanogaster, GI221459469, Length=392, Percent_Identity=56.1224489795918, Blast_Score=461, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD_SILST (Q1GIN9)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612739.1
- ProteinModelPortal:   Q1GIN9
- SMR:   Q1GIN9
- STRING:   Q1GIN9
- GeneID:   4076153
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0744
- NMPDR:   fig|292414.1.peg.2847
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   IFYERAC
- PhylomeDB:   Q1GIN9
- ProtClustDB:   PRK06075
- BioCyc:   SSP292414:TM1040_0744-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45806; Mature: 45806

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGSKFDDAQTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTE
CCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHH
KLMESRTYLQNLPYFDRLDYVAPMNQEHAWCLAIEKLTGVEVPRRAQLIRVLYSEIGRIL
HHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHH
NHLLNITTQAMDVGALTPPLWGFEEREKLMIFYERACGARLHAAYFRPGGVHQDLPDELL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHCCCHHHHHEECCCCCCCCCHHHHH
DDIDLWAMEFPKVMDDIDGLLTENRIFKQRNCDIGVVTEDDIQKYGFSGVMVRGSGLAWD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCEEEEECCCCEEE
LRRAQPYECYDEFDFQIPVGKNGDCYDRYLVRMEEMRQSLSIIRQAIAKLREATGDVLAR
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKLTPPKRGDMKTSMESLIHHFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVADGSNKPY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCE
RAKLRAPGFLHLQAMDYVAKGHQLADVAAIIGTMDIVFGEIDR
EEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDGSKFDDAQTGEQKIRNFNINFGPQHPAAHGVLRLVLELDGEIVERCDPHIGLLHRGTE
CCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCHHHHHHCCCCHHHHHHHHH
KLMESRTYLQNLPYFDRLDYVAPMNQEHAWCLAIEKLTGVEVPRRAQLIRVLYSEIGRIL
HHHHHHHHHHHCCCHHHCCCCCCCCCCCEEEEEEHHHCCCCCCHHHHHHHHHHHHHHHHH
NHLLNITTQAMDVGALTPPLWGFEEREKLMIFYERACGARLHAAYFRPGGVHQDLPDELL
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEHHCCCHHHHHEECCCCCCCCCHHHHH
DDIDLWAMEFPKVMDDIDGLLTENRIFKQRNCDIGVVTEDDIQKYGFSGVMVRGSGLAWD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHCCCCEEEEECCCCEEE
LRRAQPYECYDEFDFQIPVGKNGDCYDRYLVRMEEMRQSLSIIRQAIAKLREATGDVLAR
CCCCCCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GKLTPPKRGDMKTSMESLIHHFKLYTEGFHVPEGEVYAAVEAPKGEFGVYLVADGSNKPY
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCE
RAKLRAPGFLHLQAMDYVAKGHQLADVAAIIGTMDIVFGEIDR
EEEECCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA