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The map label for this gene is Hgd [H]

Identifier: 99080355

GI number: 99080355

Start: 540185

End: 541099

Strand: Direct

Name: Hgd [H]

Synonym: TM1040_0514

Alternate gene names: 99080355

Gene position: 540185-541099 (Clockwise)

Preceding gene: 99080354

Following gene: 99080356

Centisome position: 16.88

GC content: 63.93

Gene sequence:

>915_bases
ATGGTAGCAACACAGAACAAACGGGCCGGGGTGATCGGCCTCGGTGCAATGGGATTGGGCATGGCGCGCAGTCTCTTGAA
GGCGGGTTTTGCCGTGTCTGGATATGACCCGGCAGAGACCGCTCGCGAAAACGCGGCGGCGGCGGGTGTTTGGCTCACCG
CTGACACGGATGCTGTCTTTGCCGACTGCGATGTGATCGTGCTCTCCCTGCCGACCGCGCAGCATGTACTCGCTGTTGTG
CAAGCGGCTCAGGCTGCGGGACATTTGGCGCAGACTGGCGCTGCGCGGGTGATCGTGGACACCTCCACCTCCGAGGCCGC
GACGAGCCGGACTCTCGCCGCAGAGCTCTCAGCCCTAGGGCACGGCTTTCTGGACGCCCCTGTGAGCGGAGGTCCAGCCG
GGGCGGCCTCGGGACAGCTTTCGGTGATGCTCGGCGGCGAGACGCAGTGGCTTGAGGCCGCGCGCCCGGCGCTGGAGGCC
ATGGCTGCAAAGATCCTGCATGTCGGCCCGAGTGGGGCAGGCAACGTGGCCAAGCTCGTGAACAATATGTTGGTTGCAAA
TCATATGGTGACCACCCTTGAGGCGCTGCGTTTGGGCGAAGCGGCGGGTGTGGCCGCAAAAGAGATGCTCGAAGTGGTGA
ATTCCGCGACCGGACGCAGCGCGATTTCGGAGGTTCACTATCCCAACTGGGTGTTGCCGCGAAGCTTTGACAGCGGGTTC
TCTGCAGGGCTGATGCGCAAGGATCTTCGTCTCGCACGTGCGCTGGCGGCAGAGGTCTCTGTGGCGACCCCGATGGCTGA
CCGCGTCGCCGAGCTCTGGGCTGAAACCCAATCGGGCCTGAGCGATAGCGATGATTTTATGCGCATGGGGGACCCGCAAG
TCGATCGCCTGAGCGCCAAGGAGGAACAGGCATGA

Upstream 100 bases:

>100_bases
GCAACGCATTGTGCGCAAACGACCATCTTCCTGAGATCACCCTAGCTGCGGTTTCCTGATGTAAAGCGCCCAAGGTGGGG
CGGTGCAGCAGGGAACACAG

Downstream 100 bases:

>100_bases
CAAAAGAAATGATCGACATCACGGGCCGTGTGGCGACCCTGTTGCGCGACCTCACAGGCACGTCGGAGGTCCGCTCATAT
GTCGGGGGGGAACTGGTTCA

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 304; Mature: 304

Protein sequence:

>304_residues
MVATQNKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVFADCDVIVLSLPTAQHVLAVV
QAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALGHGFLDAPVSGGPAGAASGQLSVMLGGETQWLEAARPALEA
MAAKILHVGPSGAGNVAKLVNNMLVANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYPNWVLPRSFDSGF
SAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDFMRMGDPQVDRLSAKEEQA

Sequences:

>Translated_304_residues
MVATQNKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVFADCDVIVLSLPTAQHVLAVV
QAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALGHGFLDAPVSGGPAGAASGQLSVMLGGETQWLEAARPALEA
MAAKILHVGPSGAGNVAKLVNNMLVANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYPNWVLPRSFDSGF
SAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDFMRMGDPQVDRLSAKEEQA
>Mature_304_residues
MVATQNKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVFADCDVIVLSLPTAQHVLAVV
QAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALGHGFLDAPVSGGPAGAASGQLSVMLGGETQWLEAARPALEA
MAAKILHVGPSGAGNVAKLVNNMLVANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYPNWVLPRSFDSGF
SAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDFMRMGDPQVDRLSAKEEQA

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=253, Percent_Identity=34.7826086956522, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI40556376, Length=290, Percent_Identity=29.3103448275862, Blast_Score=97, Evalue=1e-20,
Organism=Escherichia coli, GI145693186, Length=266, Percent_Identity=34.5864661654135, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1786719, Length=266, Percent_Identity=30.4511278195489, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1789092, Length=281, Percent_Identity=28.8256227758007, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790315, Length=267, Percent_Identity=26.9662921348315, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17557316, Length=271, Percent_Identity=32.4723247232472, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24655230, Length=294, Percent_Identity=34.0136054421769, Blast_Score=146, Evalue=2e-35,
Organism=Drosophila melanogaster, GI19922568, Length=294, Percent_Identity=34.0136054421769, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 31158; Mature: 31158

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVATQNKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVF
CCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEE
ADCDVIVLSLPTAQHVLAVVQAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALG
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHC
HGFLDAPVSGGPAGAASGQLSVMLGGETQWLEAARPALEAMAAKILHVGPSGAGNVAKLV
CCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NNMLVANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYPNWVLPRSFDSGF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCH
SAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDFMRMGDPQVDRLSAK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCH
EEQA
HCCC
>Mature Secondary Structure
MVATQNKRAGVIGLGAMGLGMARSLLKAGFAVSGYDPAETARENAAAAGVWLTADTDAVF
CCCCCCCCCCEEEECHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEE
ADCDVIVLSLPTAQHVLAVVQAAQAAGHLAQTGAARVIVDTSTSEAATSRTLAAELSALG
ECCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHC
HGFLDAPVSGGPAGAASGQLSVMLGGETQWLEAARPALEAMAAKILHVGPSGAGNVAKLV
CCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
NNMLVANHMVTTLEALRLGEAAGVAAKEMLEVVNSATGRSAISEVHYPNWVLPRSFDSGF
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCH
SAGLMRKDLRLARALAAEVSVATPMADRVAELWAETQSGLSDSDDFMRMGDPQVDRLSAK
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCH
EEQA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA