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The map label for this gene is pgi

Identifier: 99080219

GI number: 99080219

Start: 388010

End: 389620

Strand: Reverse

Name: pgi

Synonym: TM1040_0378

Alternate gene names: 99080219

Gene position: 389620-388010 (Counterclockwise)

Preceding gene: 99080220

Following gene: 99080218

Centisome position: 12.17

GC content: 61.82

Gene sequence:

>1611_bases
ATGAGTGACATTTGGCAGCAACTCTCAGCCCATCGCGCCGCGACCGAGGCCACCCCGCTCACCGACTACTTTGCTCAGGA
CGCCGACAGGTTCGCGCGCTACTCCGCCTCTGCCGGTGAGATGTTGCTGGACTATTCCAAGACCGCGCTGGACGATACCG
CGCGCGACCTTTTGGTCCAACTGGCCGAAAGCGTGGATCTGAAGTCGAGGATCGCGGCGATGATGTCGGGTGCCAAGATC
AATTCAACCGAGAACCGCGCCGTGCTGCACACGGCCCTGCGTGCGCCAAAGGATGCAGTCATTGAGGTGGACGGCGAAAA
CGTCGTCCCTGGCATCCAAAAGGTCCTGGCGCAGATGGGCGCCTTTGCCACCGCCCTGCGGGAGGGCAGCTACCAGACCA
AGACCGGCACGGCCTTCACCGATGTTGTGAACATCGGCATCGGCGGCTCTGACCTTGGCCCGGTGATGGCCACGCTGGCG
CTTGCCCCCTATCACGACGGGCCCGCCTGTCATTTTGTGTCCAACGTGGATGGCGCGCATATCCATGACGTGCTGGCCGG
TCTGAACCCGGAAACCACTCTGGTCGTGATCGCCTCCAAAACCTTTACCACCATCGAGACGATGACCAACGCCGAGACCG
CTATCCAGTGGCTCAAAGGTGCGCTGGGTGAGGATGTTTCGACCCATCTGGCGGCCGTGTCGACAGCACTGGACAAAACG
GCCGCGATGGGCATCCCAGACGCCCGTGTCTTTGGCTTTGCCGATTGGGTGGGCGGACGCTACTCCATGTGGGGACCGAT
CGGTCTGCCGATCATGATTGCCGTGGGGCCGGAGTCCTTTGGCGAATTCCTCGCAGGCGCTGCCGCGATGGATCAGCATT
TCCGTGATGCGCCGCTGATGGAAAACCTGCCTGCGCTGCTCGGGCTCATTGGCGTCTGGCACAACAACATCTGCGGTTAT
GGTTCGCGCGCGGTTCTGCCCTATGATCAGCGTCTGTCCCGCCTGCCCGCCTATCTTCAGCAGCTTGATATGGAGAGCAA
CGGCAAATCCGTCGCGCTCGATGGCAGCCCCCTGCCCCGCGCCTCCGGTCCCGTGGTTTGGGGCGAGCCCGGCACCAACG
GCCAGCACGCGTTTTACCAGTTGTTGCATCAGGGTACGCAGGTGATCCCCACCGAGTTCCTGATTGCCGCAACGGGTCAC
GAGCCCGAGCTGGCCCATCAGCACAATCTTCTGAAAGCCAACTGCCTTGCTCAATCCGAAGCGCTGATGCTGGGGCGATC
CTGGGATGAGGCGCGCGAGATTGCCATCGCGCGCGGATTTGACGGGGTGGATGCCGACCGTATGGCCGGGCATCTGAGCT
TTCCCGGCAACCGTCCCTCGGTGACCCTCGCCTACCCCAAACTGACGCCATTCGTATTTGGTCAGATCGTTGCTCTCTAC
GAACATCGTGTGTTCACCGAAGGCGTGATCTGGGGGATCAACTCCTTTGATCAATGGGGGGTTGAGCTGGGCAAAGAACT
GGCGACCCGCCTTCTGCCGATGGTCGAAGGGGCAGATGCATCCCAAAAAGACGCCTCCACCCGCGGCCTGCTCGCCAAAC
TCTCCACCTGA

Upstream 100 bases:

>100_bases
AGCATTGTTAGCGCTAACTTGGCATATAGGCCGCGAACCGGATCTCGCAGGCGCGCCACCAGCGCCGCCTATTCGATGCG
AATAACGAGGAGCCCACTTG

Downstream 100 bases:

>100_bases
CCGTCAACCAAGAGGAAGACACCCATGGTATCCCGCGTCATCCCCGTCGACAGTTTCGACTTCGTCTTGTTCGGCGCCAC
CGGCGACCTTGCCCGACGCA

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQLAESVDLKSRIAAMMSGAKI
NSTENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMGAFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLA
LAPYHDGPACHFVSNVDGAHIHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKT
AAMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLMENLPALLGLIGVWHNNICGY
GSRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPRASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGH
EPELAHQHNLLKANCLAQSEALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALY
EHRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST

Sequences:

>Translated_536_residues
MSDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQLAESVDLKSRIAAMMSGAKI
NSTENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMGAFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLA
LAPYHDGPACHFVSNVDGAHIHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKT
AAMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLMENLPALLGLIGVWHNNICGY
GSRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPRASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGH
EPELAHQHNLLKANCLAQSEALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALY
EHRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST
>Mature_535_residues
SDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQLAESVDLKSRIAAMMSGAKIN
STENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMGAFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLAL
APYHDGPACHFVSNVDGAHIHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKTA
AMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLMENLPALLGLIGVWHNNICGYG
SRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPRASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGHE
PELAHQHNLLKANCLAQSEALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALYE
HRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=530, Percent_Identity=49.4339622641509, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI296080693, Length=530, Percent_Identity=46.4150943396226, Blast_Score=464, Evalue=1e-131,
Organism=Escherichia coli, GI1790457, Length=533, Percent_Identity=48.968105065666, Blast_Score=522, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI71996708, Length=535, Percent_Identity=46.7289719626168, Blast_Score=489, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI71996703, Length=535, Percent_Identity=46.7289719626168, Blast_Score=488, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319673, Length=541, Percent_Identity=44.547134935305, Blast_Score=461, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24651916, Length=521, Percent_Identity=48.9443378119002, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24651914, Length=521, Percent_Identity=48.9443378119002, Blast_Score=509, Evalue=1e-144,
Organism=Drosophila melanogaster, GI17737445, Length=521, Percent_Identity=48.9443378119002, Blast_Score=509, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_SILST (Q1GJQ5)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612373.1
- ProteinModelPortal:   Q1GJQ5
- SMR:   Q1GJQ5
- STRING:   Q1GJQ5
- GeneID:   4078611
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0378
- NMPDR:   fig|292414.1.peg.2445
- eggNOG:   COG0166
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- PhylomeDB:   Q1GJQ5
- BioCyc:   SSP292414:TM1040_0378-MONOMER
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 57392; Mature: 57261

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 345-345 ACT_SITE 376-376 ACT_SITE 505-505

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQ
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LAESVDLKSRIAAMMSGAKINSTENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMG
HHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHH
AFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLALAPYHDGPACHFVSNVDGAH
HHHHHHHCCCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHH
IHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLM
HHCCCCCHHHEEHHHHCCCCEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
ENLPALLGLIGVWHNNICGYGSRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPR
HHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
ASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGHEPELAHQHNLLKANCLAQSE
CCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHH
ALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALY
HHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
EHRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST
HHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
SDIWQQLSAHRAATEATPLTDYFAQDADRFARYSASAGEMLLDYSKTALDDTARDLLVQ
CHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
LAESVDLKSRIAAMMSGAKINSTENRAVLHTALRAPKDAVIEVDGENVVPGIQKVLAQMG
HHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHH
AFATALREGSYQTKTGTAFTDVVNIGIGGSDLGPVMATLALAPYHDGPACHFVSNVDGAH
HHHHHHHCCCCCCCCCCHHHHHEEECCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHH
IHDVLAGLNPETTLVVIASKTFTTIETMTNAETAIQWLKGALGEDVSTHLAAVSTALDKT
HHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
AAMGIPDARVFGFADWVGGRYSMWGPIGLPIMIAVGPESFGEFLAGAAAMDQHFRDAPLM
HHCCCCCHHHEEHHHHCCCCEECCCCCCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCHH
ENLPALLGLIGVWHNNICGYGSRAVLPYDQRLSRLPAYLQQLDMESNGKSVALDGSPLPR
HHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCC
ASGPVVWGEPGTNGQHAFYQLLHQGTQVIPTEFLIAATGHEPELAHQHNLLKANCLAQSE
CCCCEEECCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHCCHHHHHHHHHH
ALMLGRSWDEAREIAIARGFDGVDADRMAGHLSFPGNRPSVTLAYPKLTPFVFGQIVALY
HHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHH
EHRVFTEGVIWGINSFDQWGVELGKELATRLLPMVEGADASQKDASTRGLLAKLST
HHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA