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The map label for this gene is luxQ [H]

Identifier: 99080183

GI number: 99080183

Start: 347255

End: 349738

Strand: Direct

Name: luxQ [H]

Synonym: TM1040_0342

Alternate gene names: 99080183

Gene position: 347255-349738 (Clockwise)

Preceding gene: 99080182

Following gene: 99080188

Centisome position: 10.85

GC content: 59.02

Gene sequence:

>2484_bases
GTGCGCGATTGGTTGCAGTCATTTTTTGTAGCTCTGGGGAACCGGACGTATCTGCCAACCTGGATCGCACTCTTTGTCGT
TGGCATCGCCTTTGCCTATGCAGAGAGACAGAACCAGATCATCAATGATCAGGAACTGCGCGCCGAGGTGCAGGCAGAAG
TCGGGCTGATCCGATCCCATCTCGAAGGCAAGCTGACAGCAGATGTGCAGCTGATCAAAGGTCTTGTCGGGGCGTTGATG
GCTGAACAGCTGATGACGCAGGAAACCTTTAACGAGGTGGCCTCTTACGCTGCCGGTGATCGGCATGAAATCCTGAACAT
CGCCATCGCGCCCGATCTGGTTGTCACCATGGTCTACCCCTACGAGCGCAACAAGGCGGTGCTCGGCCTTGATTACAACA
AGAACGAAGCCCAGCGAGAAGCCGTCATGCGCATGCGTGACAGTGGCGAGATCGTGTTGGCCGGTCCGGTGAACCTCGTG
CAAGGGGGCACGGGGTTTATCATTCGCTACCCGGTCTTTGCCGGTGAAGGCGCGGATCGCAGGTTCTGGGGTATGGTCGC
GGCCGTGATCGACGCCGATGCACTTTATGCGGAGGCGGGGCTCGCGGCAGAGGACCTGCCGATTGAAATCGCACTCAGTG
GCCGTGACGGGACAGGCCATCAGGGCGGTGTTTTCTACGGGGATCAGAACATTCACGACCATGATCCGATTGTGACGGAT
GTGTTTCTGCCAACCGGCACCTGGGAATTGGCGGCGATTCCGCGTGGCGGCTGGCCCAAACAGCCCGGGAACCTGCTAGA
ATTGAGGCTGGTCCTTTTGGCGGCCGGGATCTTGATCATTGTGCCGACGTTCATGGCATGCCGGCTCTCTGCGGTGCGGC
GGGCGACCATCAACACGCTGCGCAAACGTGAAACCGAGCTGGAGCGCAATCAGGCGGAGCTTGAACAGCTCTCGACCGTG
GCGCAGAACGCATCGGACAGCATCGTTCTGAGCGGTCCAGATCAGCGGATTTTCTGGGTCAACGAGGCGTTTTCGCGCAT
GACTGGCTACACGGTTGACGAGGCCGTCGGCAAACGTCCCGGCGAGCTGTTGAACGGACCTGAGACCGACCCGGCCACCA
TCCGCGAGATCAGCGAGTATATCTCGCGCGGGGAGCGGCTCCACCGCGAGATCCTGAATTACACCAAAAGCGGCAAGACG
ATTTGGGTCGATACCAATCTTGTGCCCGTGCTTGATGAGGACGGCGAGATAAACATGGTGATTGGCATCGAACGCGATGT
GACCTCGCAAAAGCAGAACGCGGCAGAACTGGCGGTGGCCAAGGTTGCGGCAGAGCAGGCAGATCGCACCAAGACGGAAT
TTCTCGCCAATATGAGCCATGAGATCCGCACCCCCATGAACGGCATCATCGGCATGGCGGATCTCCTGTCGGAGACGGAG
CTACACGAGGATCAGGAGCAATATGTCCAGATCATCCGCACCTCCTCGAAGGCGCTGTTGAAGATCATCAACGACATTCT
GGATCTCACCCGGATGGAGTCCGGCAAACTCTCGCTGGAGCCTGTCGATTTCGATCTTGAGAGCTGCATCGAGAATGCTG
TTGATATTCTGCGTCCCGTCGCCAGCGAAAAGGGGCTGGATCTGACCGTCAATTACGCCTCGGGGCTGCCAAGAACCGTA
CGGGCTGATGATGGACGCCTGCGACAGATCCTTGTGAACCTCGTGGGCAATGCAGTGAAATTCACGGCCTCCGGTCGCGT
GGACGTGCGCGTGCTCTGCGCATCAACCAACCCCTACCGGCTGACGATCGACGTGCAGGACACCGGGATCGGCATGACGT
CAGCACAGCTGCACAATATCTTTGATCGGTTTTCGCAGGCAGATGCGGCGACCACGCGCTCCTTTGGTGGCACCGGCCTC
GGGCTGACGATCTCGCGCTTGCTGGCAAAGCAGATGGACGGGGATATCACCGTGTATTCCGACCCGGGACGAGGCAGCTG
TTTCTCGCTGCATATCCAGTGCCAGGCGCCCCTTGGCCTGCCCGGGCATATTGACGCCGACGAAGCGCCGGATCTCGATC
TGATCTATGGCTGCAAGGTCCTGCTGGCCGAGGACAATCGCACCAACCGCCTGTTGATCCGCAAATACCTCTCGGATCTC
TCTGTCGATCTGATCGAAGCCAGCAATGGCCAAGAGGCGGTGGAACTCTGCGCGCATCATCGTCCGGATCTGATCCTGAT
GGATATGTCGATGCCGGAAATGGACGGGCTCACGGCGACCCGTCTGATCCGCATGCCGCAAAACCCGCACCAACCACCAA
TCGTGGCTTTGACGGCCAATGCCTTTGCAAGCGATCGGGAGGCTTGTCTGGCGGCCGGGATGAACGGCTTCTTGTCAAAG
CCCATCAACAAGCGCGAGCTCTTGCACGGAATGGCCGGTGTGCTTGATGACCCTGACAACCTCAGACGCGTTGCAAGCGG
CTGA

Upstream 100 bases:

>100_bases
GAATGATGAAACTGTGCTTGTTTAACGGCACGGGAAGGATTCTGATGGATACTGCCTGCTAGTGTTAACGAGGACCAAGT
ATGAAACGGAGACCGAAGCG

Downstream 100 bases:

>100_bases
TCGCGTGACCCTGAGGTGATCTGCAGGTCCAAGGTCAGAAGATCGGGCGTCATACCCAATCAGAAAACCCAAGGCCGCAA
ACACGGGCCTTGGGTTTTAT

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 827; Mature: 827

Protein sequence:

>827_residues
MRDWLQSFFVALGNRTYLPTWIALFVVGIAFAYAERQNQIINDQELRAEVQAEVGLIRSHLEGKLTADVQLIKGLVGALM
AEQLMTQETFNEVASYAAGDRHEILNIAIAPDLVVTMVYPYERNKAVLGLDYNKNEAQREAVMRMRDSGEIVLAGPVNLV
QGGTGFIIRYPVFAGEGADRRFWGMVAAVIDADALYAEAGLAAEDLPIEIALSGRDGTGHQGGVFYGDQNIHDHDPIVTD
VFLPTGTWELAAIPRGGWPKQPGNLLELRLVLLAAGILIIVPTFMACRLSAVRRATINTLRKRETELERNQAELEQLSTV
AQNASDSIVLSGPDQRIFWVNEAFSRMTGYTVDEAVGKRPGELLNGPETDPATIREISEYISRGERLHREILNYTKSGKT
IWVDTNLVPVLDEDGEINMVIGIERDVTSQKQNAAELAVAKVAAEQADRTKTEFLANMSHEIRTPMNGIIGMADLLSETE
LHEDQEQYVQIIRTSSKALLKIINDILDLTRMESGKLSLEPVDFDLESCIENAVDILRPVASEKGLDLTVNYASGLPRTV
RADDGRLRQILVNLVGNAVKFTASGRVDVRVLCASTNPYRLTIDVQDTGIGMTSAQLHNIFDRFSQADAATTRSFGGTGL
GLTISRLLAKQMDGDITVYSDPGRGSCFSLHIQCQAPLGLPGHIDADEAPDLDLIYGCKVLLAEDNRTNRLLIRKYLSDL
SVDLIEASNGQEAVELCAHHRPDLILMDMSMPEMDGLTATRLIRMPQNPHQPPIVALTANAFASDREACLAAGMNGFLSK
PINKRELLHGMAGVLDDPDNLRRVASG

Sequences:

>Translated_827_residues
MRDWLQSFFVALGNRTYLPTWIALFVVGIAFAYAERQNQIINDQELRAEVQAEVGLIRSHLEGKLTADVQLIKGLVGALM
AEQLMTQETFNEVASYAAGDRHEILNIAIAPDLVVTMVYPYERNKAVLGLDYNKNEAQREAVMRMRDSGEIVLAGPVNLV
QGGTGFIIRYPVFAGEGADRRFWGMVAAVIDADALYAEAGLAAEDLPIEIALSGRDGTGHQGGVFYGDQNIHDHDPIVTD
VFLPTGTWELAAIPRGGWPKQPGNLLELRLVLLAAGILIIVPTFMACRLSAVRRATINTLRKRETELERNQAELEQLSTV
AQNASDSIVLSGPDQRIFWVNEAFSRMTGYTVDEAVGKRPGELLNGPETDPATIREISEYISRGERLHREILNYTKSGKT
IWVDTNLVPVLDEDGEINMVIGIERDVTSQKQNAAELAVAKVAAEQADRTKTEFLANMSHEIRTPMNGIIGMADLLSETE
LHEDQEQYVQIIRTSSKALLKIINDILDLTRMESGKLSLEPVDFDLESCIENAVDILRPVASEKGLDLTVNYASGLPRTV
RADDGRLRQILVNLVGNAVKFTASGRVDVRVLCASTNPYRLTIDVQDTGIGMTSAQLHNIFDRFSQADAATTRSFGGTGL
GLTISRLLAKQMDGDITVYSDPGRGSCFSLHIQCQAPLGLPGHIDADEAPDLDLIYGCKVLLAEDNRTNRLLIRKYLSDL
SVDLIEASNGQEAVELCAHHRPDLILMDMSMPEMDGLTATRLIRMPQNPHQPPIVALTANAFASDREACLAAGMNGFLSK
PINKRELLHGMAGVLDDPDNLRRVASG
>Mature_827_residues
MRDWLQSFFVALGNRTYLPTWIALFVVGIAFAYAERQNQIINDQELRAEVQAEVGLIRSHLEGKLTADVQLIKGLVGALM
AEQLMTQETFNEVASYAAGDRHEILNIAIAPDLVVTMVYPYERNKAVLGLDYNKNEAQREAVMRMRDSGEIVLAGPVNLV
QGGTGFIIRYPVFAGEGADRRFWGMVAAVIDADALYAEAGLAAEDLPIEIALSGRDGTGHQGGVFYGDQNIHDHDPIVTD
VFLPTGTWELAAIPRGGWPKQPGNLLELRLVLLAAGILIIVPTFMACRLSAVRRATINTLRKRETELERNQAELEQLSTV
AQNASDSIVLSGPDQRIFWVNEAFSRMTGYTVDEAVGKRPGELLNGPETDPATIREISEYISRGERLHREILNYTKSGKT
IWVDTNLVPVLDEDGEINMVIGIERDVTSQKQNAAELAVAKVAAEQADRTKTEFLANMSHEIRTPMNGIIGMADLLSETE
LHEDQEQYVQIIRTSSKALLKIINDILDLTRMESGKLSLEPVDFDLESCIENAVDILRPVASEKGLDLTVNYASGLPRTV
RADDGRLRQILVNLVGNAVKFTASGRVDVRVLCASTNPYRLTIDVQDTGIGMTSAQLHNIFDRFSQADAATTRSFGGTGL
GLTISRLLAKQMDGDITVYSDPGRGSCFSLHIQCQAPLGLPGHIDADEAPDLDLIYGCKVLLAEDNRTNRLLIRKYLSDL
SVDLIEASNGQEAVELCAHHRPDLILMDMSMPEMDGLTATRLIRMPQNPHQPPIVALTANAFASDREACLAAGMNGFLSK
PINKRELLHGMAGVLDDPDNLRRVASG

Specific function: At low cell density, in absence of autoinducer has a kinase activity, and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is transferred to

COG id: COG3452

COG function: function code T; Predicted periplasmic ligand-binding sensor domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=524, Percent_Identity=35.3053435114504, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1789149, Length=239, Percent_Identity=46.8619246861925, Blast_Score=215, Evalue=1e-56,
Organism=Escherichia coli, GI1788713, Length=381, Percent_Identity=33.8582677165354, Blast_Score=197, Evalue=3e-51,
Organism=Escherichia coli, GI145693157, Length=255, Percent_Identity=39.6078431372549, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI87081816, Length=372, Percent_Identity=30.9139784946237, Blast_Score=166, Evalue=4e-42,
Organism=Escherichia coli, GI1786912, Length=243, Percent_Identity=30.8641975308642, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1786600, Length=369, Percent_Identity=25.4742547425474, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1788549, Length=356, Percent_Identity=23.5955056179775, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1790436, Length=216, Percent_Identity=30.5555555555556, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=24.7863247863248, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87082128, Length=226, Percent_Identity=27.8761061946903, Blast_Score=84, Evalue=5e-17,
Organism=Escherichia coli, GI1786783, Length=283, Percent_Identity=25.7950530035336, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=26.9387755102041, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI87081921, Length=145, Percent_Identity=28.2758620689655, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=117, Percent_Identity=42.7350427350427, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322000, Length=115, Percent_Identity=37.3913043478261, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 90745; Mature: 90745

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50839 CHASE ; PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDWLQSFFVALGNRTYLPTWIALFVVGIAFAYAERQNQIINDQELRAEVQAEVGLIRSH
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LEGKLTADVQLIKGLVGALMAEQLMTQETFNEVASYAAGDRHEILNIAIAPDLVVTMVYP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCEEEEEEEE
YERNKAVLGLDYNKNEAQREAVMRMRDSGEIVLAGPVNLVQGGTGFIIRYPVFAGEGADR
ECCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCEECCCCCEEEEEEEEECCCCCH
RFWGMVAAVIDADALYAEAGLAAEDLPIEIALSGRDGTGHQGGVFYGDQNIHDHDPIVTD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEE
VFLPTGTWELAAIPRGGWPKQPGNLLELRLVLLAAGILIIVPTFMACRLSAVRRATINTL
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRETELERNQAELEQLSTVAQNASDSIVLSGPDQRIFWVNEAFSRMTGYTVDEAVGKRP
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHCCCCHHHHHCCCC
GELLNGPETDPATIREISEYISRGERLHREILNYTKSGKTIWVDTNLVPVLDEDGEINMV
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCEEEE
IGIERDVTSQKQNAAELAVAKVAAEQADRTKTEFLANMSHEIRTPMNGIIGMADLLSETE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LHEDQEQYVQIIRTSSKALLKIINDILDLTRMESGKLSLEPVDFDLESCIENAVDILRPV
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHH
ASEKGLDLTVNYASGLPRTVRADDGRLRQILVNLVGNAVKFTASGRVDVRVLCASTNPYR
HCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCEE
LTIDVQDTGIGMTSAQLHNIFDRFSQADAATTRSFGGTGLGLTISRLLAKQMDGDITVYS
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEE
DPGRGSCFSLHIQCQAPLGLPGHIDADEAPDLDLIYGCKVLLAEDNRTNRLLIRKYLSDL
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHC
SVDLIEASNGQEAVELCAHHRPDLILMDMSMPEMDGLTATRLIRMPQNPHQPPIVALTAN
CEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHEECCCCCCCCCEEEEECC
AFASDREACLAAGMNGFLSKPINKRELLHGMAGVLDDPDNLRRVASG
CCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHHHCCC
>Mature Secondary Structure
MRDWLQSFFVALGNRTYLPTWIALFVVGIAFAYAERQNQIINDQELRAEVQAEVGLIRSH
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LEGKLTADVQLIKGLVGALMAEQLMTQETFNEVASYAAGDRHEILNIAIAPDLVVTMVYP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCCEEEEEEEE
YERNKAVLGLDYNKNEAQREAVMRMRDSGEIVLAGPVNLVQGGTGFIIRYPVFAGEGADR
ECCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEECCCCEECCCCCEEEEEEEEECCCCCH
RFWGMVAAVIDADALYAEAGLAAEDLPIEIALSGRDGTGHQGGVFYGDQNIHDHDPIVTD
HHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCCCCEEECCCCCCCCCCEEEE
VFLPTGTWELAAIPRGGWPKQPGNLLELRLVLLAAGILIIVPTFMACRLSAVRRATINTL
EEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKRETELERNQAELEQLSTVAQNASDSIVLSGPDQRIFWVNEAFSRMTGYTVDEAVGKRP
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHCCCCHHHHHCCCC
GELLNGPETDPATIREISEYISRGERLHREILNYTKSGKTIWVDTNLVPVLDEDGEINMV
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCCEEEE
IGIERDVTSQKQNAAELAVAKVAAEQADRTKTEFLANMSHEIRTPMNGIIGMADLLSETE
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
LHEDQEQYVQIIRTSSKALLKIINDILDLTRMESGKLSLEPVDFDLESCIENAVDILRPV
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHH
ASEKGLDLTVNYASGLPRTVRADDGRLRQILVNLVGNAVKFTASGRVDVRVLCASTNPYR
HCCCCCEEEEECCCCCCCEEECCCHHHHHHHHHHHCCCEEEEECCCEEEEEEEECCCCEE
LTIDVQDTGIGMTSAQLHNIFDRFSQADAATTRSFGGTGLGLTISRLLAKQMDGDITVYS
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEEE
DPGRGSCFSLHIQCQAPLGLPGHIDADEAPDLDLIYGCKVLLAEDNRTNRLLIRKYLSDL
CCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHC
SVDLIEASNGQEAVELCAHHRPDLILMDMSMPEMDGLTATRLIRMPQNPHQPPIVALTAN
CEEEEECCCCHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHEECCCCCCCCCEEEEECC
AFASDREACLAAGMNGFLSKPINKRELLHGMAGVLDDPDNLRRVASG
CCCCHHHHHHHHCCCHHHCCCCCHHHHHHHHHHCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA