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The map label for this gene is galE [H]

Identifier: 99080124

GI number: 99080124

Start: 288006

End: 288905

Strand: Reverse

Name: galE [H]

Synonym: TM1040_0283

Alternate gene names: 99080124

Gene position: 288905-288006 (Counterclockwise)

Preceding gene: 99080126

Following gene: 99080123

Centisome position: 9.03

GC content: 59.33

Gene sequence:

>900_bases
ATGCGTATTCTGTTCACCGGAGGCTCTGGCAAAGCTGGACGCCATGTCATCGCCTATCTGCTGGCGCAGGGGCATCGGGT
CGTCAATGTGGATCTCACCCCGCTCGATCTGCCCGGTGTGGACAATCGCATCGCGGATATGACCGATGCGGGTCAGATGC
ATGACGTGATGCACGCCTGGGCCGGATATGACGAGATGGAGCAGCATCGGAGCCCGCCGCCCTTTGACGCGGTGGTGCAT
TTTGCAGCCATCCCGCGCCTGCTGATGCGGTCGGACAATGAGTGCTACCGGATCAACACCGTGGGCACCTACAATGTGAT
CGACGCCGCCCTGAAGGCGGGGGTGCGCAAGGTGATCTTTGCTTCGTCCGAGACCACCTATGGCATCTGTTTTGCCGGGG
GCGAGCGCAAGCCCGAGTATCTGCCGATCGACGAAGCACATCCGGTGGTGCCCGAAGACGCCTATGCAATGTCCAAGGTG
GCCAATGAACAGGCGGCGCTGAGCTTTCAACGCCGCAGTGGCGCCGACATCTATGGATTGCGCATCAACAACGTGATCGA
ACCCCATGAATACAAGGCGAACTTCCCAGCCTATATGGCCGATCCCGAACTCAGACGGCGCAATATCTTTGCCTATATCG
ACGCCCGCGACCTCGGCCAGATGGTGCAGCGCTGTCTGGACGCCGACGGGCTTGGCTATGAGATCTTCAACGTCGCCAAT
GAGGACCATTCGGTGAACCTCAGCACCTCGGAGATCATCAGCCACTACTATCGCGGCATCCCCAAGGCCGAGATGGGCGA
GACGGAGACCTTCTATTCCATCGAGAAAGCAAAGCGGATGTTGGGATTTGCGCCGGAGCACAATTGGCGAATGTACCTCA
ATGACCCGCGCGAGGCCTGA

Upstream 100 bases:

>100_bases
GCCGCCGGGGGGACTCGGCCGTGACGGCAAAGATCACGTAAGCGTGCACTGGACCACAGCGCCGTTACCGCTATCCTCGC
CGCAAGGAGAGGAGGCCATC

Downstream 100 bases:

>100_bases
TCACCGGGACGACCAGAGAATAGAACCTAGACTGAAATAACCCTGTGCGCGGCGCGCATGGGGCGCTAAAGACGGGACAT
GACAGATAGCTTGCCCCCCT

Product: NAD-dependent epimerase/dehydratase

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MRILFTGGSGKAGRHVIAYLLAQGHRVVNVDLTPLDLPGVDNRIADMTDAGQMHDVMHAWAGYDEMEQHRSPPPFDAVVH
FAAIPRLLMRSDNECYRINTVGTYNVIDAALKAGVRKVIFASSETTYGICFAGGERKPEYLPIDEAHPVVPEDAYAMSKV
ANEQAALSFQRRSGADIYGLRINNVIEPHEYKANFPAYMADPELRRRNIFAYIDARDLGQMVQRCLDADGLGYEIFNVAN
EDHSVNLSTSEIISHYYRGIPKAEMGETETFYSIEKAKRMLGFAPEHNWRMYLNDPREA

Sequences:

>Translated_299_residues
MRILFTGGSGKAGRHVIAYLLAQGHRVVNVDLTPLDLPGVDNRIADMTDAGQMHDVMHAWAGYDEMEQHRSPPPFDAVVH
FAAIPRLLMRSDNECYRINTVGTYNVIDAALKAGVRKVIFASSETTYGICFAGGERKPEYLPIDEAHPVVPEDAYAMSKV
ANEQAALSFQRRSGADIYGLRINNVIEPHEYKANFPAYMADPELRRRNIFAYIDARDLGQMVQRCLDADGLGYEIFNVAN
EDHSVNLSTSEIISHYYRGIPKAEMGETETFYSIEKAKRMLGFAPEHNWRMYLNDPREA
>Mature_299_residues
MRILFTGGSGKAGRHVIAYLLAQGHRVVNVDLTPLDLPGVDNRIADMTDAGQMHDVMHAWAGYDEMEQHRSPPPFDAVVH
FAAIPRLLMRSDNECYRINTVGTYNVIDAALKAGVRKVIFASSETTYGICFAGGERKPEYLPIDEAHPVVPEDAYAMSKV
ANEQAALSFQRRSGADIYGLRINNVIEPHEYKANFPAYMADPELRRRNIFAYIDARDLGQMVQRCLDADGLGYEIFNVAN
EDHSVNLSTSEIISHYYRGIPKAEMGETETFYSIEKAKRMLGFAPEHNWRMYLNDPREA

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI56237023, Length=159, Percent_Identity=28.9308176100629, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI56118217, Length=159, Percent_Identity=28.9308176100629, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI189083684, Length=159, Percent_Identity=28.9308176100629, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR005886
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 33648; Mature: 33648

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILFTGGSGKAGRHVIAYLLAQGHRVVNVDLTPLDLPGVDNRIADMTDAGQMHDVMHAW
CEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHH
AGYDEMEQHRSPPPFDAVVHFAAIPRLLMRSDNECYRINTVGTYNVIDAALKAGVRKVIF
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCHHEEEE
ASSETTYGICFAGGERKPEYLPIDEAHPVVPEDAYAMSKVANEQAALSFQRRSGADIYGL
ECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEE
RINNVIEPHEYKANFPAYMADPELRRRNIFAYIDARDLGQMVQRCLDADGLGYEIFNVAN
EECCCCCCCCCCCCCCCEECCHHHHHCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEECC
EDHSVNLSTSEIISHYYRGIPKAEMGETETFYSIEKAKRMLGFAPEHNWRMYLNDPREA
CCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC
>Mature Secondary Structure
MRILFTGGSGKAGRHVIAYLLAQGHRVVNVDLTPLDLPGVDNRIADMTDAGQMHDVMHAW
CEEEEECCCCCCHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHCCCCCHHHHHHHHHH
AGYDEMEQHRSPPPFDAVVHFAAIPRLLMRSDNECYRINTVGTYNVIDAALKAGVRKVIF
CCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHCHHEEEE
ASSETTYGICFAGGERKPEYLPIDEAHPVVPEDAYAMSKVANEQAALSFQRRSGADIYGL
ECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCEEEE
RINNVIEPHEYKANFPAYMADPELRRRNIFAYIDARDLGQMVQRCLDADGLGYEIFNVAN
EECCCCCCCCCCCCCCCEECCHHHHHCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEECC
EDHSVNLSTSEIISHYYRGIPKAEMGETETFYSIEKAKRMLGFAPEHNWRMYLNDPREA
CCCEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8921853; 12948626 [H]