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The map label for this gene is purC [H]

Identifier: 161899029

GI number: 161899029

Start: 1565595

End: 1566356

Strand: Reverse

Name: purC [H]

Synonym: TM1040_1465

Alternate gene names: 161899029

Gene position: 1566356-1565595 (Counterclockwise)

Preceding gene: 99081310

Following gene: 99081305

Centisome position: 48.93

GC content: 60.1

Gene sequence:

>762_bases
ATGGCGCGGCGCAAGAAGATTTACGAAGGCAAGGCAAAAACTCTGTATGAAGGGCCCGAACCGGGCACGATCGTCCAGTA
CTTCAAGGACGATGCCACAGCCTTCAATGCCGAAAAGCACGACGTGATCGAGGGCAAGGGTGTCCTGAACAACATCCTGA
GCGAATTCTTCATGCTGGGTCTGGGGCAGATCGGGGTGCCAACACACTTCCTGAAACGGCTGAACATGCGCGAACAACTC
GTGCGCTCTTGCGAGATCGTCCCGCTGGAGATCATCGTTCGCAACTATGCCGCCGGGTCGCTGTGCAAGCGTCTCGGGAT
GGACGAAGGCACTCAGTTGCCGCGTCCGATCGTGGAATATTGCTACAAGGACGACGCGCTGGGGGACCCGCTGGTCACCG
AAGAGCATATCGCCGCCTTTGGCTGGGCGAGCCAGCAGGACATGGATGATATCTTGTCGCTGGCGCTGCGGGTGAATGAC
TTCCTCTCTGGCGTGATGCTCGCCGTGGGGATCCGCCTCGTGGACTTCAAGATCGAGATCGGCCGGATCTACGACGGCGA
TTTCCAGCGTCTTGTGGTGGCCGATGAGATCAGCCCCGACAGCTGCCGTCTGTGGGACATCAAGACCGGGCAAAAGCTCG
ACAAGGATGTGTTCCGCCGCGACCTTGGCAGCCTCACGGATGCCTATACCGAGGTGGCCCGCCGTCTGGGCGTCATGCCC
AACAACCCACCCGCGCCGGGCAAGCCCCAGCTGGTGAACTAA

Upstream 100 bases:

>100_bases
GAGATCGCCCTGCGCTGTGCTTGCGGGATGAGGCCCCTTGCACTATGAGAGCGCTACGGATCGGGGCAGATTCCCGGTGG
TCCATACCGAAAGGCTCTCC

Downstream 100 bases:

>100_bases
GAGATTTCGCCCGCAAGCGCCGCTCCGTCGGTCTTGCGGGTTTTTCAATAGCGCAACAGGGCAGGGCGCTCATGCTCCCG
CCCGCAGGAACTTGAGGAAA

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKHDVIEGKGVLNNILSEFFMLGLGQIGVPTHFLKRLNMREQL
VRSCEIVPLEIIVRNYAAGSLCKRLGMDEGTQLPRPIVEYCYKDDALGDPLVTEEHIAAFGWASQQDMDDILSLALRVND
FLSGVMLAVGIRLVDFKIEIGRIYDGDFQRLVVADEISPDSCRLWDIKTGQKLDKDVFRRDLGSLTDAYTEVARRLGVMP
NNPPAPGKPQLVN

Sequences:

>Translated_253_residues
MARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKHDVIEGKGVLNNILSEFFMLGLGQIGVPTHFLKRLNMREQL
VRSCEIVPLEIIVRNYAAGSLCKRLGMDEGTQLPRPIVEYCYKDDALGDPLVTEEHIAAFGWASQQDMDDILSLALRVND
FLSGVMLAVGIRLVDFKIEIGRIYDGDFQRLVVADEISPDSCRLWDIKTGQKLDKDVFRRDLGSLTDAYTEVARRLGVMP
NNPPAPGKPQLVN
>Mature_252_residues
ARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKHDVIEGKGVLNNILSEFFMLGLGQIGVPTHFLKRLNMREQLV
RSCEIVPLEIIVRNYAAGSLCKRLGMDEGTQLPRPIVEYCYKDDALGDPLVTEEHIAAFGWASQQDMDDILSLALRVNDF
LSGVMLAVGIRLVDFKIEIGRIYDGDFQRLVVADEISPDSCRLWDIKTGQKLDKDVFRRDLGSLTDAYTEVARRLGVMPN
NPPAPGKPQLVN

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=231, Percent_Identity=35.9307359307359, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI5453539, Length=231, Percent_Identity=35.9307359307359, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI119220559, Length=238, Percent_Identity=35.7142857142857, Blast_Score=101, Evalue=8e-22,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=42.0168067226891, Blast_Score=196, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17531275, Length=236, Percent_Identity=30.9322033898305, Blast_Score=91, Evalue=7e-19,
Organism=Drosophila melanogaster, GI18860083, Length=242, Percent_Identity=33.4710743801653, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24583917, Length=242, Percent_Identity=28.099173553719, Blast_Score=85, Evalue=5e-17,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 28376; Mature: 28245

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKHDVIEGKGVLNNILSEFFMLG
CCCCCCHHCCCCHHCCCCCCCCHHHHHHHCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHC
LGQIGVPTHFLKRLNMREQLVRSCEIVPLEIIVRNYAAGSLCKRLGMDEGTQLPRPIVEY
CCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
CYKDDALGDPLVTEEHIAAFGWASQQDMDDILSLALRVNDFLSGVMLAVGIRLVDFKIEI
HHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
GRIYDGDFQRLVVADEISPDSCRLWDIKTGQKLDKDVFRRDLGSLTDAYTEVARRLGVMP
CEEECCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NNPPAPGKPQLVN
CCCCCCCCCCCCC
>Mature Secondary Structure 
ARRKKIYEGKAKTLYEGPEPGTIVQYFKDDATAFNAEKHDVIEGKGVLNNILSEFFMLG
CCCCCHHCCCCHHCCCCCCCCHHHHHHHCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHC
LGQIGVPTHFLKRLNMREQLVRSCEIVPLEIIVRNYAAGSLCKRLGMDEGTQLPRPIVEY
CCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
CYKDDALGDPLVTEEHIAAFGWASQQDMDDILSLALRVNDFLSGVMLAVGIRLVDFKIEI
HHCCCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEE
GRIYDGDFQRLVVADEISPDSCRLWDIKTGQKLDKDVFRRDLGSLTDAYTEVARRLGVMP
CEEECCCCEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
NNPPAPGKPQLVN
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA