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The map label for this gene is fkl [H]

Identifier: 104779453

GI number: 104779453

Start: 167406

End: 168071

Strand: Reverse

Name: fkl [H]

Synonym: PSEEN0160

Alternate gene names: 104779453

Gene position: 168071-167406 (Counterclockwise)

Preceding gene: 104779455

Following gene: 104779444

Centisome position: 2.85

GC content: 67.27

Gene sequence:

>666_bases
ATGCCTCGTTACCTGATTCTCGGCCTGTGCCTGGTGGCCCCACTGGCGCTGGCCAACCCCGAGTCCCCACCCGGCAACGA
CAGCGACCTGGCCTACAGCCTCGGCGCCAGCCTGGGCGAACGCCTGCGCCAGGAGGTACCTGGCCTGCAACTCGATGCCC
TGGTCGAAGGCCTGCGCCAGGCCTATCAGGGCCAGCCGCCACGGATCGCCAAGTCACAGATGGATGCGATCCTGCAGCAG
CATGAAGAGCAGGCCAACGCCGCCGCCGAACAGGCGCGCGTGGACACCCTGCTGAACGCGGAAAAGCGCTTCATGGCCAC
CGAGCGCGCACGCGCCGGCGTCCATGAGTTGCCCGAGGGCATCCTCTACAGCGAACTGGCCAGCGGCAACGGCGCGCAAC
CCAAGGCCACCGGCAGCGTGCAGGTGCGTTACGTGGGGAAACTGCCGGACGGCTCGGTGTTCGACCAGAGCCAGCAACCG
CAGTGGTTCAAGCTGGACTCGGTGATCGAAGGCTGGCAAGTGGCGCTGCCCAGGATGAAGGCGGGGTCGAAATGGCGGCT
GGTGATACCGTCGGCGCAAGCTTATGGCGCCGACGGCGCGGGCGACCTGATCGCGCCCTACACCCCGTTGGTGTTCGAGA
TCGAACTGCTGGCGGTGGCCGACTGA

Upstream 100 bases:

>100_bases
TGGAAGCAAGTGTAGTTGCCTGTTAATTCCTTGCCGACAATTGCACATCTTTCTTCGACAACGCTGGCATACTTCGCGCT
CTTTGCAGCAGGAGTCGACC

Downstream 100 bases:

>100_bases
GTCAGGCCTGCAGCGCGTCCTCTTCCTTGTGCGCGGTATGCAGCACTTCGATGAGGCAGTCCTCCAGCTCGAAGCGTTCG
CGCAACAGGCCGCCCAACTT

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPRYLILGLCLVAPLALANPESPPGNDSDLAYSLGASLGERLRQEVPGLQLDALVEGLRQAYQGQPPRIAKSQMDAILQQ
HEEQANAAAEQARVDTLLNAEKRFMATERARAGVHELPEGILYSELASGNGAQPKATGSVQVRYVGKLPDGSVFDQSQQP
QWFKLDSVIEGWQVALPRMKAGSKWRLVIPSAQAYGADGAGDLIAPYTPLVFEIELLAVAD

Sequences:

>Translated_221_residues
MPRYLILGLCLVAPLALANPESPPGNDSDLAYSLGASLGERLRQEVPGLQLDALVEGLRQAYQGQPPRIAKSQMDAILQQ
HEEQANAAAEQARVDTLLNAEKRFMATERARAGVHELPEGILYSELASGNGAQPKATGSVQVRYVGKLPDGSVFDQSQQP
QWFKLDSVIEGWQVALPRMKAGSKWRLVIPSAQAYGADGAGDLIAPYTPLVFEIELLAVAD
>Mature_220_residues
PRYLILGLCLVAPLALANPESPPGNDSDLAYSLGASLGERLRQEVPGLQLDALVEGLRQAYQGQPPRIAKSQMDAILQQH
EEQANAAAEQARVDTLLNAEKRFMATERARAGVHELPEGILYSELASGNGAQPKATGSVQVRYVGKLPDGSVFDQSQQPQ
WFKLDSVIEGWQVALPRMKAGSKWRLVIPSAQAYGADGAGDLIAPYTPLVFEIELLAVAD

Specific function: PPIases accelerate the folding of proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm And Periplasmic Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Escherichia coli, GI87082390, Length=197, Percent_Identity=35.5329949238579, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1789745, Length=208, Percent_Identity=33.6538461538462, Blast_Score=87, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324194, Length=113, Percent_Identity=38.0530973451327, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323566, Length=106, Percent_Identity=34.9056603773585, Blast_Score=64, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323482, Length=104, Percent_Identity=35.5769230769231, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 23829; Mature: 23698

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRYLILGLCLVAPLALANPESPPGNDSDLAYSLGASLGERLRQEVPGLQLDALVEGLRQ
CCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AYQGQPPRIAKSQMDAILQQHEEQANAAAEQARVDTLLNAEKRFMATERARAGVHELPEG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ILYSELASGNGAQPKATGSVQVRYVGKLPDGSVFDQSQQPQWFKLDSVIEGWQVALPRMK
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCC
AGSKWRLVIPSAQAYGADGAGDLIAPYTPLVFEIELLAVAD
CCCEEEEEECCHHHCCCCCCCCCCCCCCCEEEEEEEEEECC
>Mature Secondary Structure 
PRYLILGLCLVAPLALANPESPPGNDSDLAYSLGASLGERLRQEVPGLQLDALVEGLRQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AYQGQPPRIAKSQMDAILQQHEEQANAAAEQARVDTLLNAEKRFMATERARAGVHELPEG
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
ILYSELASGNGAQPKATGSVQVRYVGKLPDGSVFDQSQQPQWFKLDSVIEGWQVALPRMK
HHHHHHHCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHCCCCC
AGSKWRLVIPSAQAYGADGAGDLIAPYTPLVFEIELLAVAD
CCCEEEEEECCHHHCCCCCCCCCCCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2514124; 2110144; 10984043 [H]