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The map label for this gene is pntAA [H]

Identifier: 104779423

GI number: 104779423

Start: 109609

End: 110730

Strand: Reverse

Name: pntAA [H]

Synonym: PSEEN0116

Alternate gene names: 104779423

Gene position: 110730-109609 (Counterclockwise)

Preceding gene: 104779424

Following gene: 104779422

Centisome position: 1.88

GC content: 66.76

Gene sequence:

>1122_bases
GTGCACATTGGTGTTCCTCTCGAGACGCAGACGGGTGAGACAAGGGTCGCCGCGACCCCGGAAACCATCAAGAAACTGGT
AGGCCAGGGCCATCAGGTCACCGTGCAACGGGGGGCAGGGCTCAACGCCAGCATTCCGGACAGTGCCTATGAGGCCGTGG
GCGCCAAGCTAGGCGAAGCCACCGACGCATTCGGCGCGCAGCTGGTGCTCAAGGTGGTCGCGCCCAACGACCAGGAACTG
GCGCTGATCAACAGCGGCAGCCTGCTGGTGGGCATGCTCAACCCCTTCAACAGCGAACTGATCGGCAAGATGGCCGAACG
CGGCGTCACCGCCTTCGCCCTGGAAGCCGCGCCACGCACTTCACGGGCCCAGAGCCTTGACGTGCTGTCGTCCCAGGCCA
ACATCGCCGGCTACAAGGCCGTGCTGCTGGCCGCCCATCACTACCCGCGCTTCATGCCCATGCTGATGACTGCCGCTGGC
ACCGTGAAGGCCGCCCGCGTGCTGATCCTCGGCGCCGGCGTCGCCGGCCTGCAGGCCATCGCCACGGCCAAGCGCCTGGG
TGCGGTGATCGAAGCGTCGGATGTGCGCCCGGCGGTGAAGGAGCAGATCGAATCGCTGGGGGCCAAGTTCATCGACGTGC
CCTACGAGACCGATGAAGAGCGCGAATGCGCCGAAGGTGTCGGCGGTTATGCCCGACCCATGCCCGCCAGCTGGATGCAA
CGCCAGGCCCAGGCCGTGCACGAGCGCGCCAAGCAGGCCGATATCGTCATCACCACCGCGCTGATTCCCGGGCGCAAGGC
GCCGACCCTGCTCAGCGCAGAGACCGTGGCGCAAATGAAACCCGGCTCGGTGGTCATCGACCTCGCGGCGGCCCAGGGCG
GCAACTGCCCGCTGACCGTCGCTGACCAGGTGGTGCAAGCGAACGGCGTGATCATCGTCGGCCCGACCAACCTGCCGGCC
CAGGTCGGCGCCGACGCTTCGGCGCTGTATGCCCGCAACCTGCTGGACTTCATGAAGCTGCTGTTCGATAAGGACGGCAA
CCTGGTCATCAACCTCGAAGACGACATCGTCGCCGCGTGCCTGATGTGCCGCGACGGCCAGGTCGTGCGCAAGAACGGCT
GA

Upstream 100 bases:

>100_bases
CCGAATCAGGCGGAGTCGTGCTCTACGGCCGCCCAGCCGCACCACCCGAAGTGCGCTGGTTTCCATAAAGACAATAAAGG
TCACCGCAGGAGACATAGTC

Downstream 100 bases:

>100_bases
GGAGCACGACAATGGAAGACATGCTGATTTCCCACGGCATCTACAACCTGATCATCTTCGTGCTGGCCATCTACGTGGGC
TACCACGTGGTGTGGAACGT

Product: proton-translocating NAD(P) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MHIGVPLETQTGETRVAATPETIKKLVGQGHQVTVQRGAGLNASIPDSAYEAVGAKLGEATDAFGAQLVLKVVAPNDQEL
ALINSGSLLVGMLNPFNSELIGKMAERGVTAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHHYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFIDVPYETDEERECAEGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSAETVAQMKPGSVVIDLAAAQGGNCPLTVADQVVQANGVIIVGPTNLPA
QVGADASALYARNLLDFMKLLFDKDGNLVINLEDDIVAACLMCRDGQVVRKNG

Sequences:

>Translated_373_residues
MHIGVPLETQTGETRVAATPETIKKLVGQGHQVTVQRGAGLNASIPDSAYEAVGAKLGEATDAFGAQLVLKVVAPNDQEL
ALINSGSLLVGMLNPFNSELIGKMAERGVTAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHHYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFIDVPYETDEERECAEGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSAETVAQMKPGSVVIDLAAAQGGNCPLTVADQVVQANGVIIVGPTNLPA
QVGADASALYARNLLDFMKLLFDKDGNLVINLEDDIVAACLMCRDGQVVRKNG
>Mature_373_residues
MHIGVPLETQTGETRVAATPETIKKLVGQGHQVTVQRGAGLNASIPDSAYEAVGAKLGEATDAFGAQLVLKVVAPNDQEL
ALINSGSLLVGMLNPFNSELIGKMAERGVTAFALEAAPRTSRAQSLDVLSSQANIAGYKAVLLAAHHYPRFMPMLMTAAG
TVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFIDVPYETDEERECAEGVGGYARPMPASWMQ
RQAQAVHERAKQADIVITTALIPGRKAPTLLSAETVAQMKPGSVVIDLAAAQGGNCPLTVADQVVQANGVIIVGPTNLPA
QVGADASALYARNLLDFMKLLFDKDGNLVINLEDDIVAACLMCRDGQVVRKNG

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=384, Percent_Identity=38.28125, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI122939153, Length=384, Percent_Identity=38.28125, Blast_Score=258, Evalue=4e-69,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=45.822102425876, Blast_Score=321, Evalue=4e-89,
Organism=Caenorhabditis elegans, GI17550456, Length=369, Percent_Identity=40.9214092140921, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39003; Mature: 39003

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHIGVPLETQTGETRVAATPETIKKLVGQGHQVTVQRGAGLNASIPDSAYEAVGAKLGEA
CCCCCCCCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCH
TDAFGAQLVLKVVAPNDQELALINSGSLLVGMLNPFNSELIGKMAERGVTAFALEAAPRT
HHHHHHEEEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
SRAQSLDVLSSQANIAGYKAVLLAAHHYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFIDVPYETDEERECAEGVGGYARPMPASWMQ
HHHHHHHHHEECCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAQAVHERAKQADIVITTALIPGRKAPTLLSAETVAQMKPGSVVIDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCCEECHHHHHHCCCCCEEEEEEECCCCCCCCHH
ADQVVQANGVIIVGPTNLPAQVGADASALYARNLLDFMKLLFDKDGNLVINLEDDIVAAC
HHHHHHHCCEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LMCRDGQVVRKNG
HHCCCCEEEECCC
>Mature Secondary Structure
MHIGVPLETQTGETRVAATPETIKKLVGQGHQVTVQRGAGLNASIPDSAYEAVGAKLGEA
CCCCCCCCCCCCCEEEEECHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCH
TDAFGAQLVLKVVAPNDQELALINSGSLLVGMLNPFNSELIGKMAERGVTAFALEAAPRT
HHHHHHEEEEEEECCCCCEEEEEECCCEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCC
SRAQSLDVLSSQANIAGYKAVLLAAHHYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
CHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCHHHHEEEEEEECCHHHHHHH
ATAKRLGAVIEASDVRPAVKEQIESLGAKFIDVPYETDEERECAEGVGGYARPMPASWMQ
HHHHHHHHHEECCCCCHHHHHHHHHCCCEEEECCCCCCCHHHHHHCCCCCCCCCCHHHHH
RQAQAVHERAKQADIVITTALIPGRKAPTLLSAETVAQMKPGSVVIDLAAAQGGNCPLTV
HHHHHHHHHHHCCCEEEEEEECCCCCCCCEECHHHHHHCCCCCEEEEEEECCCCCCCCHH
ADQVVQANGVIIVGPTNLPAQVGADASALYARNLLDFMKLLFDKDGNLVINLEDDIVAAC
HHHHHHHCCEEEECCCCCCHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHH
LMCRDGQVVRKNG
HHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]