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The map label for this gene is mprA [H]

Identifier: 94986415

GI number: 94986415

Start: 2438439

End: 2439116

Strand: Reverse

Name: mprA [H]

Synonym: Dgeo_2318

Alternate gene names: 94986415

Gene position: 2439116-2438439 (Counterclockwise)

Preceding gene: 94986416

Following gene: 94986414

Centisome position: 98.86

GC content: 63.13

Gene sequence:

>678_bases
ATGGAACGCAAGCCTCTGGTCCTCGTCATTGAGGATGAAAAAGATATTGCCCGCTTCATCGAACTGGAATTGGCTGCCGA
GGGCTATGCCACTGAGGTGGCCTTCGATGGCGTGACTGGCCTCAGCAAATTCCGTGAAGTGAACCCTGACCTGGTGATCC
TGGACCTGATGCTGCCGGTGCTGGACGGGTTGGAAGTGGCGCGGCGCATTCGCAAGACCAGCAACACGCCGATCATCATC
CTCACCGCCAAGGACGGCATCCAGGACAAGGTGGAGGGCCTGGATTCCGGCGCGGACGACTATCTGATCAAGCCGTTTTC
CATCGAGGAGCTGCTGGCCCGTGTCCGCGCCCACCTGCGCCGGGTGAACCCGGCCGTGACCGGGGAGGTGCGGGTGGCCG
ACCTGGTGATGAATCTGGATGGGCGCGAGATTTTCCGGGGTGGGCGCCGGGTGGAACTCAGTGCCAAGGAGTTCGAGCTG
CTCGAGTTGCTCGCGCGCAACCCCGGCAAGGTCTTTTCCCGCTTTGAGATCGAGGAGAAGGTCTGGCCGGAGTACACCGG
GGGCAGCAACGTGGTGGACGTGTATATCGGCTACCTGCGCCGCAAGCTGGAGGAGGGCGGGGAGCGCCGCCTGATCCACA
CGGTGCGCGGCGTGGGCTACGTGCTGCGTGAGGAGTAG

Upstream 100 bases:

>100_bases
GTGCTTACGGCCTGCTGCGCCCCAGTAGTCAGCAATCCGCATGAAAAGCAGTTAAGCGGCCGGGTCGCCTTCTCATGAGA
ACGGTCAATAGACTGGCCGT

Downstream 100 bases:

>100_bases
AGCGAGCCGGGCGGGCGTTAGACTGCGGGCGTGACCCGGTCGAACGTGCCCCGCCCCGCCTGTTTGGAGGGCCGCCGGTG
ACGCTGCGCTGGCGGCTCAC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MERKPLVLVIEDEKDIARFIELELAAEGYATEVAFDGVTGLSKFREVNPDLVILDLMLPVLDGLEVARRIRKTSNTPIII
LTAKDGIQDKVEGLDSGADDYLIKPFSIEELLARVRAHLRRVNPAVTGEVRVADLVMNLDGREIFRGGRRVELSAKEFEL
LELLARNPGKVFSRFEIEEKVWPEYTGGSNVVDVYIGYLRRKLEEGGERRLIHTVRGVGYVLREE

Sequences:

>Translated_225_residues
MERKPLVLVIEDEKDIARFIELELAAEGYATEVAFDGVTGLSKFREVNPDLVILDLMLPVLDGLEVARRIRKTSNTPIII
LTAKDGIQDKVEGLDSGADDYLIKPFSIEELLARVRAHLRRVNPAVTGEVRVADLVMNLDGREIFRGGRRVELSAKEFEL
LELLARNPGKVFSRFEIEEKVWPEYTGGSNVVDVYIGYLRRKLEEGGERRLIHTVRGVGYVLREE
>Mature_225_residues
MERKPLVLVIEDEKDIARFIELELAAEGYATEVAFDGVTGLSKFREVNPDLVILDLMLPVLDGLEVARRIRKTSNTPIII
LTAKDGIQDKVEGLDSGADDYLIKPFSIEELLARVRAHLRRVNPAVTGEVRVADLVMNLDGREIFRGGRRVELSAKEFEL
LELLARNPGKVFSRFEIEEKVWPEYTGGSNVVDVYIGYLRRKLEEGGERRLIHTVRGVGYVLREE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=40.6392694063927, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082012, Length=215, Percent_Identity=39.5348837209302, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1786911, Length=218, Percent_Identity=40.8256880733945, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=36.6071428571429, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=40.990990990991, Blast_Score=142, Evalue=1e-35,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=39.0134529147982, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=35.7798165137615, Blast_Score=132, Evalue=1e-32,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=38.5321100917431, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1790860, Length=228, Percent_Identity=37.280701754386, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=35.8407079646018, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=35.8407079646018, Blast_Score=110, Evalue=7e-26,
Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=33.1877729257642, Blast_Score=100, Evalue=7e-23,
Organism=Escherichia coli, GI1787229, Length=225, Percent_Identity=29.7777777777778, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788550, Length=142, Percent_Identity=29.5774647887324, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=27.8260869565217, Blast_Score=81, Evalue=6e-17,
Organism=Escherichia coli, GI1790437, Length=129, Percent_Identity=31.7829457364341, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790299, Length=114, Percent_Identity=31.5789473684211, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=31, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25461; Mature: 25461

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERKPLVLVIEDEKDIARFIELELAAEGYATEVAFDGVTGLSKFREVNPDLVILDLMLPV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEHHHHHHHH
LDGLEVARRIRKTSNTPIIILTAKDGIQDKVEGLDSGADDYLIKPFSIEELLARVRAHLR
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHH
RVNPAVTGEVRVADLVMNLDGREIFRGGRRVELSAKEFELLELLARNPGKVFSRFEIEEK
HCCCCCCCCEEEEHHHHCCCCHHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHEEHHHH
VWPEYTGGSNVVDVYIGYLRRKLEEGGERRLIHTVRGVGYVLREE
HCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEECC
>Mature Secondary Structure
MERKPLVLVIEDEKDIARFIELELAAEGYATEVAFDGVTGLSKFREVNPDLVILDLMLPV
CCCCCEEEEEECCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHCCCCEEHHHHHHHH
LDGLEVARRIRKTSNTPIIILTAKDGIQDKVEGLDSGADDYLIKPFSIEELLARVRAHLR
HHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHCCCCCCCCEECCCCHHHHHHHHHHHHH
RVNPAVTGEVRVADLVMNLDGREIFRGGRRVELSAKEFELLELLARNPGKVFSRFEIEEK
HCCCCCCCCEEEEHHHHCCCCHHHHCCCCEEEECHHHHHHHHHHHCCCCHHHHHEEHHHH
VWPEYTGGSNVVDVYIGYLRRKLEEGGERRLIHTVRGVGYVLREE
HCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA