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The map label for this gene is yfmO [H]

Identifier: 94986302

GI number: 94986302

Start: 2324380

End: 2325486

Strand: Reverse

Name: yfmO [H]

Synonym: Dgeo_2203

Alternate gene names: 94986302

Gene position: 2325486-2324380 (Counterclockwise)

Preceding gene: 94986303

Following gene: 94986301

Centisome position: 94.26

GC content: 68.02

Gene sequence:

>1107_bases
ATGGGGATTGGGGTGGTGGACCCGATTCTGCCCGAGATCGGGCACCAGCTGGGCGCGACGCCAACCCAGGTCGAACTGCT
CTTCACCGCCTACTTGGGTGTGATGGCCGTGATGACGCTGTTTGCAGGAAACATCGGCGCGCGGCTGGGACGCCGCCGGG
TGGCGGTGATCGGCCTAGCCCTGATCGCCCTGTTTGCGCTGGCCTGTGGGCTGAGCGGCAGTATTCCCGCGCTGGCGGTG
TTTCGAGGTGGCTGGGGGCTGGGCAGCGCTCTCTTCACGCCAACCGCGCTGGTGCTGTTGCTCGCGCTGATTGGCCACGC
TGAAAAAGCCATTATGCGCTACGAGGCTGCCATCGGTCTGGGCATGAGCATGGGGCCGTTGCTGGGCGGCGTGCTGGGCA
GTCACGGCTGGCGTTTTCCCTTTCTGGGCGCGGCCACACTGATGCTGCTGGCGCTGGTCGCGGTCGCCGCCTTCGTGCGC
GTGCCGGAGAGCCGGGAGCCGGTTCGTCCTGTGGGAGACGTGTTCCGCGCGTACCGCCACCCGGCCTTTCTGGCGGTGGG
TCTGACCGGGCTGCTGTACTACTTCGGCTTCTTCTTGTTGCTGGGCTACACGCCGCTCTTCCTGCACCTGGGTACCCTGG
GGCTGGGCCTGACCTTCTTCGGCTGGGGCGTGCTGCTGGGGTTGGGGAGCACCGTGCTGGTGGAACGCTTGCTGCGCCGT
CTGCGGGCCAGCTGGATCGTCATCCTGGCGCTGGCCGGACTGACCCTGCTGTTTGTGCTGCTGGGCTTCGCACCCCTGGC
GGGCGGCGTCAAGATCGCGCTGGTCGTCCTGAGCGGCACCCTCTTCGGCCTGATGAATGCCCTGCTGACCACGCTCAGCG
TGGAAGTCGCCCACCTGCCGCGCGCCACCGCCACGAGCGCCTACAACTTCCTGCGCTGGTTGGGGGCGACGGTGGCACCG
GTGGGGAGCGGCTTTGTGGCCGAACACCTCGGCGCCCCTGTGCCCTACGCGTTCGGGGCTGCGGCGGTGGCCCTGGCCGT
GCTGATCATGGCCTTTGCGGCCCGCTCCATCGATGCGGCACGAGCCAGCGATCCGCACGTCCACTAA

Upstream 100 bases:

>100_bases
TTCCCCGCGTACCTCCGCCGCGGCAGCTGGAACGGCAGCCCAGTCCACCCGGCAGAACGTGGCCGCCTGGGCGATCACGG
CGGCCTGTTTGATCGCCTTT

Downstream 100 bases:

>100_bases
ACTCTCGGTATGACGGATCCGGCTGCCCCCGACGACACCCCCCGCTACCGAGTGGGCGAGGTTGCCGCGCGGCTGGGCCT
CACACTGCGGACATTGAAGT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 367

Protein sequence:

>368_residues
MGIGVVDPILPEIGHQLGATPTQVELLFTAYLGVMAVMTLFAGNIGARLGRRRVAVIGLALIALFALACGLSGSIPALAV
FRGGWGLGSALFTPTALVLLLALIGHAEKAIMRYEAAIGLGMSMGPLLGGVLGSHGWRFPFLGAATLMLLALVAVAAFVR
VPESREPVRPVGDVFRAYRHPAFLAVGLTGLLYYFGFFLLLGYTPLFLHLGTLGLGLTFFGWGVLLGLGSTVLVERLLRR
LRASWIVILALAGLTLLFVLLGFAPLAGGVKIALVVLSGTLFGLMNALLTTLSVEVAHLPRATATSAYNFLRWLGATVAP
VGSGFVAEHLGAPVPYAFGAAAVALAVLIMAFAARSIDAARASDPHVH

Sequences:

>Translated_368_residues
MGIGVVDPILPEIGHQLGATPTQVELLFTAYLGVMAVMTLFAGNIGARLGRRRVAVIGLALIALFALACGLSGSIPALAV
FRGGWGLGSALFTPTALVLLLALIGHAEKAIMRYEAAIGLGMSMGPLLGGVLGSHGWRFPFLGAATLMLLALVAVAAFVR
VPESREPVRPVGDVFRAYRHPAFLAVGLTGLLYYFGFFLLLGYTPLFLHLGTLGLGLTFFGWGVLLGLGSTVLVERLLRR
LRASWIVILALAGLTLLFVLLGFAPLAGGVKIALVVLSGTLFGLMNALLTTLSVEVAHLPRATATSAYNFLRWLGATVAP
VGSGFVAEHLGAPVPYAFGAAAVALAVLIMAFAARSIDAARASDPHVH
>Mature_367_residues
GIGVVDPILPEIGHQLGATPTQVELLFTAYLGVMAVMTLFAGNIGARLGRRRVAVIGLALIALFALACGLSGSIPALAVF
RGGWGLGSALFTPTALVLLLALIGHAEKAIMRYEAAIGLGMSMGPLLGGVLGSHGWRFPFLGAATLMLLALVAVAAFVRV
PESREPVRPVGDVFRAYRHPAFLAVGLTGLLYYFGFFLLLGYTPLFLHLGTLGLGLTFFGWGVLLGLGSTVLVERLLRRL
RASWIVILALAGLTLLFVLLGFAPLAGGVKIALVVLSGTLFGLMNALLTTLSVEVAHLPRATATSAYNFLRWLGATVAPV
GSGFVAEHLGAPVPYAFGAAAVALAVLIMAFAARSIDAARASDPHVH

Specific function: Acts to efflux copper or a copper complex. It is possible that yfmO could contribute to copper resistance [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1790195, Length=141, Percent_Identity=34.7517730496454, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 38327; Mature: 38195

Theoretical pI: Translated: 10.58; Mature: 10.58

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIGVVDPILPEIGHQLGATPTQVELLFTAYLGVMAVMTLFAGNIGARLGRRRVAVIGLA
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIALFALACGLSGSIPALAVFRGGWGLGSALFTPTALVLLLALIGHAEKAIMRYEAAIGL
HHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GMSMGPLLGGVLGSHGWRFPFLGAATLMLLALVAVAAFVRVPESREPVRPVGDVFRAYRH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
PAFLAVGLTGLLYYFGFFLLLGYTPLFLHLGTLGLGLTFFGWGVLLGLGSTVLVERLLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LRASWIVILALAGLTLLFVLLGFAPLAGGVKIALVVLSGTLFGLMNALLTTLSVEVAHLP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RATATSAYNFLRWLGATVAPVGSGFVAEHLGAPVPYAFGAAAVALAVLIMAFAARSIDAA
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASDPHVH
CCCCCCCC
>Mature Secondary Structure 
GIGVVDPILPEIGHQLGATPTQVELLFTAYLGVMAVMTLFAGNIGARLGRRRVAVIGLA
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIALFALACGLSGSIPALAVFRGGWGLGSALFTPTALVLLLALIGHAEKAIMRYEAAIGL
HHHHHHHHHCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GMSMGPLLGGVLGSHGWRFPFLGAATLMLLALVAVAAFVRVPESREPVRPVGDVFRAYRH
CCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHC
PAFLAVGLTGLLYYFGFFLLLGYTPLFLHLGTLGLGLTFFGWGVLLGLGSTVLVERLLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
LRASWIVILALAGLTLLFVLLGFAPLAGGVKIALVVLSGTLFGLMNALLTTLSVEVAHLP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
RATATSAYNFLRWLGATVAPVGSGFVAEHLGAPVPYAFGAAAVALAVLIMAFAARSIDAA
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RASDPHVH
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]