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The map label for this gene is pdp [H]

Identifier: 94986279

GI number: 94986279

Start: 2298605

End: 2299912

Strand: Reverse

Name: pdp [H]

Synonym: Dgeo_2180

Alternate gene names: 94986279

Gene position: 2299912-2298605 (Counterclockwise)

Preceding gene: 94986281

Following gene: 94986278

Centisome position: 93.22

GC content: 68.35

Gene sequence:

>1308_bases
ATGGCTCCATTGCCTCAGATTCCCGACCTGATTCGCAAGAAACGTGACGGCTTCGAGCATTCCCGTGCCGAGCTCGAAGC
CTTGGTGCTGGGTTACACCCGCGGTGAAGTGCCCGACTACCAGATCAGCGCCTGGCTGATGGCCGTGTATCTGAAGGGCA
TGACGCTGCAGGAAACGGCCGACCTGACCCAGGTGATGGCGGAAAGCGGCGAGCAGCTTGACCTCTCCGGGCTGCCGCGC
ACGGTGGATAAGCACTCCACCGGTGGTGTGGGCGACAAAACCAGCCTGATCCTCACGCCGATGCTGGCGGCCCTTGGCCT
CACGGTCGCCAAGATGAGCGGGCGCGGCCTGGCACACACCGGCGGCACCATCGATAAGCTCGAAAGCTTCCCCGGTTGGA
CTCCTGAGCTGTCCGAGGCGCAGTTTCTGACCCAGGCCCACGAGATCGGCCTCGCGCTGGTGGGCCAATCGAAGGATCTG
GCCCCCGCCGACGGCAAGCTGTACGCGCTGCGCGATGTGACAGCCACGGTAGACTGCCTGCCCCTGATCGCCTCCTCGAT
CATGAGCAAGAAACTCGCGTCGGGTGCCCACACCGTCGTGCTCGACGTGAAGGTGGGGGCAGGGGCCTTCATGCGGACCT
TGGAGGACGGTCGTGCCCTGGCCCGCGCGATGGTGGATATCGGTACGCGGGCTGGGCGCCAGGTTCGGGCTGTGCTGACC
GATATGGACACGCCGCTGGGCCACATGGCCGGAAACAGCCTGGAAGTGCAAGAAGCCCTCGCCACCCTGCGTGGGGAAGG
CCCCGCCGATCTGACCGAGCTGTGTGTGGCGCTGGCGGTGGAGGCGCTGGCGGCCTACGGCGAGGAGCCGGCGCAAGCCG
AGGCCCGCGCCCAGGCGACCCTGAGGGACGGCTCGGCTCTGGCAAAATTCCGCGCCTTCATTGCGGCGCAGGGGGGAGAC
GCGGCGCTGGTGGACCATCCCGAACGGCTGGACCTGGCCCCCGGACGCGCCGAGGTGACGGCCCCGTCCTCCGGGTACGT
GGAACGGGTGGACGCCCTGGCGGTGGGTCGGGCTGTCCTCGCGCTGGGCGGTGGGCGCGAGCGCAAGGGCGAGGCGATTG
ACCACGGTGTCGGTGTGGAGCTGCTCAAGAAACCTGGCGAGGCGGTGCAGGCGGGTGAGGCGGTGCTCCGTCTCTACCAC
AGAGAGGGTCGGGGCTTGGAGGCCGCACGGGGACTGCTGGAAGCGGGCCTGCGGGTGGGCGACACGCCGCCCGCGCCCGA
GCCGCTGATTCTGGACCGCGTGAACTGA

Upstream 100 bases:

>100_bases
GGAGCCGCGCGGCAACCCCAGCAGCTTGCGCCGCCCGGTTAAGGCGGACGTGAAATGTGCGGGGACGCCCTCGCCTTGGC
GCCAGCCTGTACCTTGAGGC

Downstream 100 bases:

>100_bases
GAAGCTGGCTGGCCCCGCTAGAATGGCCCCGGCCGATGACCTCCCCTCCTGAACCTGCCCTGCCACCCGCCCTGGCCCAC
CTGCTGGACGCTGCGGCGGA

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MAPLPQIPDLIRKKRDGFEHSRAELEALVLGYTRGEVPDYQISAWLMAVYLKGMTLQETADLTQVMAESGEQLDLSGLPR
TVDKHSTGGVGDKTSLILTPMLAALGLTVAKMSGRGLAHTGGTIDKLESFPGWTPELSEAQFLTQAHEIGLALVGQSKDL
APADGKLYALRDVTATVDCLPLIASSIMSKKLASGAHTVVLDVKVGAGAFMRTLEDGRALARAMVDIGTRAGRQVRAVLT
DMDTPLGHMAGNSLEVQEALATLRGEGPADLTELCVALAVEALAAYGEEPAQAEARAQATLRDGSALAKFRAFIAAQGGD
AALVDHPERLDLAPGRAEVTAPSSGYVERVDALAVGRAVLALGGGRERKGEAIDHGVGVELLKKPGEAVQAGEAVLRLYH
REGRGLEAARGLLEAGLRVGDTPPAPEPLILDRVN

Sequences:

>Translated_435_residues
MAPLPQIPDLIRKKRDGFEHSRAELEALVLGYTRGEVPDYQISAWLMAVYLKGMTLQETADLTQVMAESGEQLDLSGLPR
TVDKHSTGGVGDKTSLILTPMLAALGLTVAKMSGRGLAHTGGTIDKLESFPGWTPELSEAQFLTQAHEIGLALVGQSKDL
APADGKLYALRDVTATVDCLPLIASSIMSKKLASGAHTVVLDVKVGAGAFMRTLEDGRALARAMVDIGTRAGRQVRAVLT
DMDTPLGHMAGNSLEVQEALATLRGEGPADLTELCVALAVEALAAYGEEPAQAEARAQATLRDGSALAKFRAFIAAQGGD
AALVDHPERLDLAPGRAEVTAPSSGYVERVDALAVGRAVLALGGGRERKGEAIDHGVGVELLKKPGEAVQAGEAVLRLYH
REGRGLEAARGLLEAGLRVGDTPPAPEPLILDRVN
>Mature_434_residues
APLPQIPDLIRKKRDGFEHSRAELEALVLGYTRGEVPDYQISAWLMAVYLKGMTLQETADLTQVMAESGEQLDLSGLPRT
VDKHSTGGVGDKTSLILTPMLAALGLTVAKMSGRGLAHTGGTIDKLESFPGWTPELSEAQFLTQAHEIGLALVGQSKDLA
PADGKLYALRDVTATVDCLPLIASSIMSKKLASGAHTVVLDVKVGAGAFMRTLEDGRALARAMVDIGTRAGRQVRAVLTD
MDTPLGHMAGNSLEVQEALATLRGEGPADLTELCVALAVEALAAYGEEPAQAEARAQATLRDGSALAKFRAFIAAQGGDA
ALVDHPERLDLAPGRAEVTAPSSGYVERVDALAVGRAVLALGGGRERKGEAIDHGVGVELLKKPGEAVQAGEAVLRLYHR
EGRGLEAARGLLEAGLRVGDTPPAPEPLILDRVN

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=441, Percent_Identity=46.7120181405896, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI4503445, Length=441, Percent_Identity=46.7120181405896, Blast_Score=305, Evalue=5e-83,
Organism=Homo sapiens, GI166158922, Length=441, Percent_Identity=46.7120181405896, Blast_Score=305, Evalue=5e-83,
Organism=Escherichia coli, GI1790842, Length=435, Percent_Identity=40.2298850574713, Blast_Score=285, Evalue=4e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 45655; Mature: 45524

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPLPQIPDLIRKKRDGFEHSRAELEALVLGYTRGEVPDYQISAWLMAVYLKGMTLQETA
CCCCCCCHHHHHHHHCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHH
DLTQVMAESGEQLDLSGLPRTVDKHSTGGVGDKTSLILTPMLAALGLTVAKMSGRGLAHT
HHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGTIDKLESFPGWTPELSEAQFLTQAHEIGLALVGQSKDLAPADGKLYALRDVTATVDCL
CCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHH
PLIASSIMSKKLASGAHTVVLDVKVGAGAFMRTLEDGRALARAMVDIGTRAGRQVRAVLT
HHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DMDTPLGHMAGNSLEVQEALATLRGEGPADLTELCVALAVEALAAYGEEPAQAEARAQAT
HCCCCHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LRDGSALAKFRAFIAAQGGDAALVDHPERLDLAPGRAEVTAPSSGYVERVDALAVGRAVL
HCCCHHHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ALGGGRERKGEAIDHGVGVELLKKPGEAVQAGEAVLRLYHREGRGLEAARGLLEAGLRVG
HCCCCCCCCCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
DTPPAPEPLILDRVN
CCCCCCCCEEEECCC
>Mature Secondary Structure 
APLPQIPDLIRKKRDGFEHSRAELEALVLGYTRGEVPDYQISAWLMAVYLKGMTLQETA
CCCCCCHHHHHHHHCCCHHHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHH
DLTQVMAESGEQLDLSGLPRTVDKHSTGGVGDKTSLILTPMLAALGLTVAKMSGRGLAHT
HHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
GGTIDKLESFPGWTPELSEAQFLTQAHEIGLALVGQSKDLAPADGKLYALRDVTATVDCL
CCCHHHHHHCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCCCCCCCEEEEEHHHHHHHHH
PLIASSIMSKKLASGAHTVVLDVKVGAGAFMRTLEDGRALARAMVDIGTRAGRQVRAVLT
HHHHHHHHHHHHCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
DMDTPLGHMAGNSLEVQEALATLRGEGPADLTELCVALAVEALAAYGEEPAQAEARAQAT
HCCCCHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LRDGSALAKFRAFIAAQGGDAALVDHPERLDLAPGRAEVTAPSSGYVERVDALAVGRAVL
HCCCHHHHHHHHHHHCCCCCEEECCCCHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHH
ALGGGRERKGEAIDHGVGVELLKKPGEAVQAGEAVLRLYHREGRGLEAARGLLEAGLRVG
HCCCCCCCCCCHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
DTPPAPEPLILDRVN
CCCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]