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The map label for this gene is comEC [H]

Identifier: 94986191

GI number: 94986191

Start: 2201524

End: 2202519

Strand: Reverse

Name: comEC [H]

Synonym: Dgeo_2092

Alternate gene names: 94986191

Gene position: 2202519-2201524 (Counterclockwise)

Preceding gene: 94986192

Following gene: 94986190

Centisome position: 89.27

GC content: 66.37

Gene sequence:

>996_bases
ATGAGTCAGAAAAAGCCTCCCACCCGCAAGTCCCCGGCCCGCGCCGCGGCGGCGCGCAAAGCTCCGGCCCGCGCTCCTGC
CGCTCGCGCCAAGCCCGGCAAGCAAAACGAGCGGCGCAGCGGCCCCACACCTTCCGACCTGCTCGGTCTGCTGGTGTTGG
CGCTCACGGCGAGCCTGGCGGCCTGCGCCTTTGGCGGCGACAAGCAGGGCGGGGACGAGAAGCCGGGGCAGCCCGGCGGC
CAGGTCACGATCCGTTTTCTGGATGTGGGCCAGGGCGACGCGGTGCTGGTGCGCAGTCCAGAAGGCAAGACCCTGCTCTA
CGACGGCGGCCGCAGCGTCAGCCGCATGCAGGAAGACCTGCGCACCTACGGCATCGACAAGCTCGACCTCATGATCGCCA
GCCATGCCGATGCCGACCACATCACCGGGCTGATCCCGGCTGCCGAGCAGGCCAAGCCGACCCTCTTCATCAACAACGGT
CTGGCGGGCACCACCCGAACCTGGGACCGCCTGGTGACGGCGCTCAAGGACGCCGGGACCACCTTCCAAAAGGCGAACAA
CCAGGTCATTAACCTGGGCAGTGTGAAGGTCCGGGTGATCGCGCCTCCTGCGGGCATGGGCAGTGACCAGAACGACAACA
GCGTCGGCATTCGCATTGACTTCGGTGACTTCCACGCCCTGATGACCGGTGACAGCGAGACGCCCGAGACGACTGCCTGG
CTGGCCCAGGACCGTGCCGAGGTGCAGGGGCCTTTTCAGGTCTACAAGAGCATCCACCACGGCGCTGCCAACGGGGACAA
CCAGGCGTGGCTCGCGGTGGTCCGGCCGGAAAACGTCGTGATCAGCGTCGGGGAGAACAACTACGGCCACCCCACCCAGA
AGGCTCTGGACCTCTACAAGCAAAACGGGATCCGCATCTACCGCACCGACCAGCAGGGCACCATAACCTTTATGGGCCGT
GGCGACGGAACCTACACAGTGACGACAGACCGCTGA

Upstream 100 bases:

>100_bases
TGGAGCGGCTCCCCGCAGAGACGCGTGCCCGCCGCGAACGCGCCCAGCGCCGCCTGGACGCCCTGAACTCGGTCCCAGAG
GACGGTGAGGAGATCAATCG

Downstream 100 bases:

>100_bases
GATGACAGACCGCTGAGACGACAGATCGCCGAGGCGGTCAGGGACCGGGACCAGTGCCGGTTGCCCGCGCGCTGCGCTAG
ACTCCCCCGTTGATGTTTGG

Product: metallo-beta-lactamase superfamily hydrolase-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSQKKPPTRKSPARAAAARKAPARAPAARAKPGKQNERRSGPTPSDLLGLLVLALTASLAACAFGGDKQGGDEKPGQPGG
QVTIRFLDVGQGDAVLVRSPEGKTLLYDGGRSVSRMQEDLRTYGIDKLDLMIASHADADHITGLIPAAEQAKPTLFINNG
LAGTTRTWDRLVTALKDAGTTFQKANNQVINLGSVKVRVIAPPAGMGSDQNDNSVGIRIDFGDFHALMTGDSETPETTAW
LAQDRAEVQGPFQVYKSIHHGAANGDNQAWLAVVRPENVVISVGENNYGHPTQKALDLYKQNGIRIYRTDQQGTITFMGR
GDGTYTVTTDR

Sequences:

>Translated_331_residues
MSQKKPPTRKSPARAAAARKAPARAPAARAKPGKQNERRSGPTPSDLLGLLVLALTASLAACAFGGDKQGGDEKPGQPGG
QVTIRFLDVGQGDAVLVRSPEGKTLLYDGGRSVSRMQEDLRTYGIDKLDLMIASHADADHITGLIPAAEQAKPTLFINNG
LAGTTRTWDRLVTALKDAGTTFQKANNQVINLGSVKVRVIAPPAGMGSDQNDNSVGIRIDFGDFHALMTGDSETPETTAW
LAQDRAEVQGPFQVYKSIHHGAANGDNQAWLAVVRPENVVISVGENNYGHPTQKALDLYKQNGIRIYRTDQQGTITFMGR
GDGTYTVTTDR
>Mature_330_residues
SQKKPPTRKSPARAAAARKAPARAPAARAKPGKQNERRSGPTPSDLLGLLVLALTASLAACAFGGDKQGGDEKPGQPGGQ
VTIRFLDVGQGDAVLVRSPEGKTLLYDGGRSVSRMQEDLRTYGIDKLDLMIASHADADHITGLIPAAEQAKPTLFINNGL
AGTTRTWDRLVTALKDAGTTFQKANNQVINLGSVKVRVIAPPAGMGSDQNDNSVGIRIDFGDFHALMTGDSETPETTAWL
AQDRAEVQGPFQVYKSIHHGAANGDNQAWLAVVRPENVVISVGENNYGHPTQKALDLYKQNGIRIYRTDQQGTITFMGRG
DGTYTVTTDR

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 35354; Mature: 35223

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKKPPTRKSPARAAAARKAPARAPAARAKPGKQNERRSGPTPSDLLGLLVLALTASLA
CCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ACAFGGDKQGGDEKPGQPGGQVTIRFLDVGQGDAVLVRSPEGKTLLYDGGRSVSRMQEDL
HHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHH
RTYGIDKLDLMIASHADADHITGLIPAAEQAKPTLFINNGLAGTTRTWDRLVTALKDAGT
HHHCCCEEEEEEECCCCHHHHEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
TFQKANNQVINLGSVKVRVIAPPAGMGSDQNDNSVGIRIDFGDFHALMTGDSETPETTAW
HHHHCCCCEEEECCEEEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCHHHH
LAQDRAEVQGPFQVYKSIHHGAANGDNQAWLAVVRPENVVISVGENNYGHPTQKALDLYK
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHH
QNGIRIYRTDQQGTITFMGRGDGTYTVTTDR
HCCEEEEEECCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
SQKKPPTRKSPARAAAARKAPARAPAARAKPGKQNERRSGPTPSDLLGLLVLALTASLA
CCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
ACAFGGDKQGGDEKPGQPGGQVTIRFLDVGQGDAVLVRSPEGKTLLYDGGRSVSRMQEDL
HHHCCCCCCCCCCCCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEEECCCCHHHHHHHH
RTYGIDKLDLMIASHADADHITGLIPAAEQAKPTLFINNGLAGTTRTWDRLVTALKDAGT
HHHCCCEEEEEEECCCCHHHHEECCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCC
TFQKANNQVINLGSVKVRVIAPPAGMGSDQNDNSVGIRIDFGDFHALMTGDSETPETTAW
HHHHCCCCEEEECCEEEEEEECCCCCCCCCCCCEEEEEEECCCEEEEEECCCCCCCHHHH
LAQDRAEVQGPFQVYKSIHHGAANGDNQAWLAVVRPENVVISVGENNYGHPTQKALDLYK
HHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHH
QNGIRIYRTDQQGTITFMGRGDGTYTVTTDR
HCCEEEEEECCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]