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The map label for this gene is fba [H]

Identifier: 94986182

GI number: 94986182

Start: 2194170

End: 2195096

Strand: Reverse

Name: fba [H]

Synonym: Dgeo_2083

Alternate gene names: 94986182

Gene position: 2195096-2194170 (Counterclockwise)

Preceding gene: 94986188

Following gene: 94986181

Centisome position: 88.97

GC content: 63.75

Gene sequence:

>927_bases
ATGCTCGTCACCGGTAATGACATCCTGATCCCCGCCCGCGCGGGCAAGTACGCCGTCGGCGCGTTCAACACCAACAACAT
GGAGATCACCCAGGCGATCATCCACACCGCGGAAAGGCTGCGTTCGCCCGTTATGGTGCAGATGAGCGAGGGCGCCATCA
AGTACGGTGGGCAGGATCTGGCCAACATCGTCCTGGACCTGGCCGAGCGGGCCAGCGTGCCGGTCGCGCTGCACCTTGAC
CACGGCTCCTCCTACGAGAGTGCCCTCAAGGCCATCAAGATGGGCTTTACGTCGGTGATGATCGACGCCTCGCACCATCC
CTTCGAGGAGAATGTCCATGAGACGCGCCGGGTGGTTGAGGCCGCCCATGCGATGGGGATTTCTGTCGAGGCCGAACTTG
GACGCTTGGGCGGCATCGAGGAACATGTCGTGGTGGATGAAAAGGATGCCTTCCTGACCGACCCTGAGGAAGCGGTGCGC
TTTGTCGAGCAGACCGGTACCGACTACCTCGCCATTGCCATCGGCACCAGCCACGGTGCCTACAAGGGCAAGGGGCGTCC
CTTCATCGATCTGGCGCGCATCCAACGCATCAGTGAGCTGGTGTCTATCCCCCTGGTTGCGCACGGTTCCAGCGGCGTGC
CCGCCGAATTGGTGCAGCGCTTCCGCGACGCGGGCGGCGAGATCGGGGACGCGGTGGGCATCGCGGACGAGGACCTGCAA
CAGGCCGCCCAGTACGGCATCGCCAAGGTGAATGTGGACACAGACCTGCGCCTGGCCATGACCACCGGCGTGCGCGAGGT
GCTGAAGAAAAACCCCAAGGAGTTCGACCCCCGCAAGATCTTTGGTCCTGCCCGCGAGCTGATGGGGCAGATTGTCGAAC
ACAAGCTGCGTGTGCTGGGGAGTGTTGGCCAGGCGCCCGGCTGCTGA

Upstream 100 bases:

>100_bases
CTCATCCTACTCCTGGCTCCCTCAACGGCCCTGAGCGCCGTTCGGGATAGCTGATCTCCCGCGGGCAGGGTAAAGTAAAG
CCCCGAAGGAGGCACAAGCC

Downstream 100 bases:

>100_bases
ACTCCTGTTGGAGGCCCCCCGCTCTGACCGCTCAACTTCCCCCTCTTGGATGGCCGGAGGATTGGGTGTCTGGCCGGGGG
CTTCCCTGTTCTCAGCCTCA

Product: fructose-1,6-bisphosphate aldolase, class II

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MLVTGNDILIPARAGKYAVGAFNTNNMEITQAIIHTAERLRSPVMVQMSEGAIKYGGQDLANIVLDLAERASVPVALHLD
HGSSYESALKAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVEAELGRLGGIEEHVVVDEKDAFLTDPEEAVR
FVEQTGTDYLAIAIGTSHGAYKGKGRPFIDLARIQRISELVSIPLVAHGSSGVPAELVQRFRDAGGEIGDAVGIADEDLQ
QAAQYGIAKVNVDTDLRLAMTTGVREVLKKNPKEFDPRKIFGPARELMGQIVEHKLRVLGSVGQAPGC

Sequences:

>Translated_308_residues
MLVTGNDILIPARAGKYAVGAFNTNNMEITQAIIHTAERLRSPVMVQMSEGAIKYGGQDLANIVLDLAERASVPVALHLD
HGSSYESALKAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVEAELGRLGGIEEHVVVDEKDAFLTDPEEAVR
FVEQTGTDYLAIAIGTSHGAYKGKGRPFIDLARIQRISELVSIPLVAHGSSGVPAELVQRFRDAGGEIGDAVGIADEDLQ
QAAQYGIAKVNVDTDLRLAMTTGVREVLKKNPKEFDPRKIFGPARELMGQIVEHKLRVLGSVGQAPGC
>Mature_308_residues
MLVTGNDILIPARAGKYAVGAFNTNNMEITQAIIHTAERLRSPVMVQMSEGAIKYGGQDLANIVLDLAERASVPVALHLD
HGSSYESALKAIKMGFTSVMIDASHHPFEENVHETRRVVEAAHAMGISVEAELGRLGGIEEHVVVDEKDAFLTDPEEAVR
FVEQTGTDYLAIAIGTSHGAYKGKGRPFIDLARIQRISELVSIPLVAHGSSGVPAELVQRFRDAGGEIGDAVGIADEDLQ
QAAQYGIAKVNVDTDLRLAMTTGVREVLKKNPKEFDPRKIFGPARELMGQIVEHKLRVLGSVGQAPGC

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=304, Percent_Identity=39.1447368421053, Blast_Score=214, Evalue=6e-57,
Organism=Escherichia coli, GI87082041, Length=305, Percent_Identity=36.3934426229508, Blast_Score=207, Evalue=9e-55,
Organism=Escherichia coli, GI1788072, Length=292, Percent_Identity=34.9315068493151, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1789293, Length=317, Percent_Identity=27.4447949526814, Blast_Score=85, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6322790, Length=356, Percent_Identity=25.561797752809, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 33164; Mature: 33164

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVTGNDILIPARAGKYAVGAFNTNNMEITQAIIHTAERLRSPVMVQMSEGAIKYGGQDL
CEEECCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHCCCHHH
ANIVLDLAERASVPVALHLDHGSSYESALKAIKMGFTSVMIDASHHPFEENVHETRRVVE
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCHHHHHHHHHHHH
AAHAMGISVEAELGRLGGIEEHVVVDEKDAFLTDPEEAVRFVEQTGTDYLAIAIGTSHGA
HHHHHCCEEEHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
YKGKGRPFIDLARIQRISELVSIPLVAHGSSGVPAELVQRFRDAGGEIGDAVGIADEDLQ
CCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
QAAQYGIAKVNVDTDLRLAMTTGVREVLKKNPKEFDPRKIFGPARELMGQIVEHKLRVLG
HHHHCCCEEEECCCCEEHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHH
SVGQAPGC
CCCCCCCC
>Mature Secondary Structure
MLVTGNDILIPARAGKYAVGAFNTNNMEITQAIIHTAERLRSPVMVQMSEGAIKYGGQDL
CEEECCCEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCEEEEECCCCHHCCCHHH
ANIVLDLAERASVPVALHLDHGSSYESALKAIKMGFTSVMIDASHHPFEENVHETRRVVE
HHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCHHHEEEECCCCCCHHHHHHHHHHHH
AAHAMGISVEAELGRLGGIEEHVVVDEKDAFLTDPEEAVRFVEQTGTDYLAIAIGTSHGA
HHHHHCCEEEHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCEEEEEEECCCCC
YKGKGRPFIDLARIQRISELVSIPLVAHGSSGVPAELVQRFRDAGGEIGDAVGIADEDLQ
CCCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHH
QAAQYGIAKVNVDTDLRLAMTTGVREVLKKNPKEFDPRKIFGPARELMGQIVEHKLRVLG
HHHHCCCEEEECCCCEEHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHH
SVGQAPGC
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA