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The map label for this gene is atpA [H]

Identifier: 94986146

GI number: 94986146

Start: 2154183

End: 2155931

Strand: Reverse

Name: atpA [H]

Synonym: Dgeo_2047

Alternate gene names: 94986146

Gene position: 2155931-2154183 (Counterclockwise)

Preceding gene: 94986147

Following gene: 94986145

Centisome position: 87.38

GC content: 64.49

Gene sequence:

>1749_bases
ATGACGCAACAGCAAAGAGGCGTCGTGCAAAGCATCGCTGGTCCCGCCGTGATTGCAAGCGGGATGTATGGTGCGAAGAT
GTACGACATCGTGCGCGTGGGCAAGGAGCGCCTGGTCGGTGAGATCATCCGGCTGGAGGGCAACACCGCCTTCGTGCAGG
TGTACGAAGATACCAGCGGCCTGACGGTGGGTGAACCCGTTGAGACGACCGGTTTGCCGCTCAGCGTGGAGCTGGGGCCG
GGGATGCTCAACGGCATCTACGACGGCATCCAGCGTCCGCTCGACAAGATCCGCGAGGCTTCCGGCGACTTCATCGCGCG
CGGCATCGAGGTGTCGAGCCTCGACCGCACCAAGAAGTGGGCCTTTACGCCGACCGTGCAGGCGGGTGACACCGTAGGCG
GCAGCTCGATTCTGGGGACCGTGCCGGAATTCAGCTTCACCCACAAGATTCTGACACCGCCGGACAAGGGGGGGCGGCTG
ACCTGGGTGGCCCCCGCAGGCGAATACACCATCGATGACACCATCGCCACCTTGGAAGACGGCACGAACCTGCGCCTGGC
CCACTACTGGCCGGTGCGGGCGCCGCGTCCGGTCGCGCAGAAGCTGGATCCCAGCCAGCCCTTCCTGACGGGCATGCGCA
TCCTCGACGTGCTGTTCCCGCTGGTGATGGGCGGTACAGCGGCGATTCCCGGTCCCTTCGGTTCGGGCAAAACGGTGACG
CAGCAGTCGGTTGCGAAGTACGGCAACGCCGATATCGTGGTGTACGTGGGCTGTGGCGAGCGCGGCAACGAGATGACCGA
TGTGCTCGTGGAGTTCCCGGAACTGGAAGACCCCAAGACCGGCGGGCCCCTGATGCACCGCACCATCCTGATCGCCAACA
CCTCCAACATGCCGGTGGCAGCGCGTGAAGCCTCGGTCTATACCGGCATCACATTGGCCGAGTACTTCCGCGACCAGGGC
TACAGCGTTTCGCTGATGGCCGACTCCACCAGCCGCTGGGCCGAGGCGCTGCGCGAGATCTCCTCCCGTCTGGAAGAGAT
GCCCGCCGAAGAGGGCTATCCGCCCTACCTGGGCGCCAAGCTGGCGGCCTTCTACGAGCGCGCGGGGGCCGTGAAGACCC
TGGCCGGGGAAGACGGCGCGGTTTCCGTGATCGGGGCGGTGTCCCCGGCGGGCGGCGACATGTCTGAACCCGTCACCCAG
GCGACGCTGCGCATCACCGGTGCCTTCTGGCGTCTGGATGCGGGTCTGGCCCGGCGCCGTCACTTCCCGGCGATCAACTG
GAACGGTTCCTACAGCCTGTTTACGCCGATTCTCGATTCCTGGTACCGCGAGAACGTGGGCCGGGACTTCCCCGAACTGC
GCCAGCGCATCAGCAACCTGCTTCAGCAGGAAGCGTCCCTCCAGGAAGTTGTGCAGCTCGTCGGCCCCGATGCGCTGCAG
GATCAGGAACGCCTGGTGATCGAGACGGGCCGTATGCTGCGGCAGGACTTCCTCCAGCAGAACGGCTTTGACCCGGTGGA
TGCCTCGGCGTCTATGCCCAAGAACTACGGCCTGATGAAGATGATGCTGAAGTTCTACGACGAGGCGGAGGCCGCGCTGC
GAAATGGCGTTGGCATCGATGAAATCATTCAGAACCCGGTGATCGAGAAACTCTCGCGCGCTCGCTACGTGCCTGAGGCC
GACTTCATGGCCTACGCCGAGAGCGTGATGGACGAACTCGACACCACCTTCAAAGGAGTGAAGGCGTGA

Upstream 100 bases:

>100_bases
TTCGATATCAAGCTTTAAGGTGTTGGGGAGTCGGTTGGGGGTGTTGGGATTTTCCTCAGCCCTGACACCTCATCCCTCCC
CCCTCTCCCAAGGAGACACA

Downstream 100 bases:

>100_bases
CCACCCTCCTGAAAAAGGAATACAACGACGTCTCGTACATCTCTGGGCCGCTGCTGTTCGTGAATGCGGCCTCCGACCTG
GCGTACGGTGCGATCGTCGA

Product: V-type ATP synthase subunit A

Products: NA

Alternate protein names: V-ATPase subunit A [H]

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MTQQQRGVVQSIAGPAVIASGMYGAKMYDIVRVGKERLVGEIIRLEGNTAFVQVYEDTSGLTVGEPVETTGLPLSVELGP
GMLNGIYDGIQRPLDKIREASGDFIARGIEVSSLDRTKKWAFTPTVQAGDTVGGSSILGTVPEFSFTHKILTPPDKGGRL
TWVAPAGEYTIDDTIATLEDGTNLRLAHYWPVRAPRPVAQKLDPSQPFLTGMRILDVLFPLVMGGTAAIPGPFGSGKTVT
QQSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVAAREASVYTGITLAEYFRDQG
YSVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAKLAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQ
ATLRITGAFWRLDAGLARRRHFPAINWNGSYSLFTPILDSWYRENVGRDFPELRQRISNLLQQEASLQEVVQLVGPDALQ
DQERLVIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMMLKFYDEAEAALRNGVGIDEIIQNPVIEKLSRARYVPEA
DFMAYAESVMDELDTTFKGVKA

Sequences:

>Translated_582_residues
MTQQQRGVVQSIAGPAVIASGMYGAKMYDIVRVGKERLVGEIIRLEGNTAFVQVYEDTSGLTVGEPVETTGLPLSVELGP
GMLNGIYDGIQRPLDKIREASGDFIARGIEVSSLDRTKKWAFTPTVQAGDTVGGSSILGTVPEFSFTHKILTPPDKGGRL
TWVAPAGEYTIDDTIATLEDGTNLRLAHYWPVRAPRPVAQKLDPSQPFLTGMRILDVLFPLVMGGTAAIPGPFGSGKTVT
QQSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVAAREASVYTGITLAEYFRDQG
YSVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAKLAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQ
ATLRITGAFWRLDAGLARRRHFPAINWNGSYSLFTPILDSWYRENVGRDFPELRQRISNLLQQEASLQEVVQLVGPDALQ
DQERLVIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMMLKFYDEAEAALRNGVGIDEIIQNPVIEKLSRARYVPEA
DFMAYAESVMDELDTTFKGVKA
>Mature_581_residues
TQQQRGVVQSIAGPAVIASGMYGAKMYDIVRVGKERLVGEIIRLEGNTAFVQVYEDTSGLTVGEPVETTGLPLSVELGPG
MLNGIYDGIQRPLDKIREASGDFIARGIEVSSLDRTKKWAFTPTVQAGDTVGGSSILGTVPEFSFTHKILTPPDKGGRLT
WVAPAGEYTIDDTIATLEDGTNLRLAHYWPVRAPRPVAQKLDPSQPFLTGMRILDVLFPLVMGGTAAIPGPFGSGKTVTQ
QSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVAAREASVYTGITLAEYFRDQGY
SVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAKLAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQA
TLRITGAFWRLDAGLARRRHFPAINWNGSYSLFTPILDSWYRENVGRDFPELRQRISNLLQQEASLQEVVQLVGPDALQD
QERLVIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMMLKFYDEAEAALRNGVGIDEIIQNPVIEKLSRARYVPEAD
FMAYAESVMDELDTTFKGVKA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit [H]

COG id: COG1155

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913424, Length=555, Percent_Identity=52.7927927927928, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI32189394, Length=332, Percent_Identity=29.8192771084337, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913426, Length=243, Percent_Identity=26.3374485596708, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI19913428, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI50345984, Length=245, Percent_Identity=25.3061224489796, Blast_Score=66, Evalue=1e-10,
Organism=Homo sapiens, GI4757810, Length=245, Percent_Identity=25.3061224489796, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1790170, Length=322, Percent_Identity=28.5714285714286, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1788251, Length=257, Percent_Identity=31.1284046692607, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1790172, Length=254, Percent_Identity=26.3779527559055, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17565854, Length=580, Percent_Identity=50.5172413793103, Blast_Score=572, Evalue=1e-163,
Organism=Caenorhabditis elegans, GI25144756, Length=324, Percent_Identity=29.0123456790123, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=240, Percent_Identity=27.9166666666667, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17570191, Length=336, Percent_Identity=23.8095238095238, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71988080, Length=254, Percent_Identity=25.5905511811024, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71988063, Length=254, Percent_Identity=25.5905511811024, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71988074, Length=254, Percent_Identity=25.5905511811024, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320016, Length=305, Percent_Identity=54.7540983606557, Blast_Score=336, Evalue=6e-93,
Organism=Saccharomyces cerevisiae, GI6322581, Length=316, Percent_Identity=30.0632911392405, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=244, Percent_Identity=26.6393442622951, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319370, Length=326, Percent_Identity=26.0736196319018, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129479, Length=598, Percent_Identity=49.4983277591973, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI24583988, Length=583, Percent_Identity=50.4288164665523, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24583986, Length=583, Percent_Identity=50.4288164665523, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24583984, Length=583, Percent_Identity=50.4288164665523, Blast_Score=571, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24583992, Length=580, Percent_Identity=49.4827586206897, Blast_Score=562, Evalue=1e-160,
Organism=Drosophila melanogaster, GI28574560, Length=303, Percent_Identity=31.3531353135314, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24638766, Length=307, Percent_Identity=30.2931596091205, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361666, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24646341, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17136796, Length=243, Percent_Identity=25.9259259259259, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: 10836 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 8,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022878 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 63440; Mature: 63309

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQQRGVVQSIAGPAVIASGMYGAKMYDIVRVGKERLVGEIIRLEGNTAFVQVYEDTSG
CCCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCC
LTVGEPVETTGLPLSVELGPGMLNGIYDGIQRPLDKIREASGDFIARGIEVSSLDRTKKW
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCE
AFTPTVQAGDTVGGSSILGTVPEFSFTHKILTPPDKGGRLTWVAPAGEYTIDDTIATLED
EECCCCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEECCHHHHHCC
GTNLRLAHYWPVRAPRPVAQKLDPSQPFLTGMRILDVLFPLVMGGTAAIPGPFGSGKTVT
CCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
QQSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVA
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEE
AREASVYTGITLAEYFRDQGYSVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAK
ECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQATLRITGAFWRLDAGLARRR
HHHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHEEEHHHHHHHHHHHHHH
HFPAINWNGSYSLFTPILDSWYRENVGRDFPELRQRISNLLQQEASLQEVVQLVGPDALQ
CCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DQERLVIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMMLKFYDEAEAALRNGVGID
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
EIIQNPVIEKLSRARYVPEADFMAYAESVMDELDTTFKGVKA
HHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TQQQRGVVQSIAGPAVIASGMYGAKMYDIVRVGKERLVGEIIRLEGNTAFVQVYEDTSG
CCHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCC
LTVGEPVETTGLPLSVELGPGMLNGIYDGIQRPLDKIREASGDFIARGIEVSSLDRTKKW
CCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCEECCCCCCCCE
AFTPTVQAGDTVGGSSILGTVPEFSFTHKILTPPDKGGRLTWVAPAGEYTIDDTIATLED
EECCCCCCCCCCCCCCHHCCCCCCCCCCEEECCCCCCCEEEEEECCCCCEECCHHHHHCC
GTNLRLAHYWPVRAPRPVAQKLDPSQPFLTGMRILDVLFPLVMGGTAAIPGPFGSGKTVT
CCCEEEEEECCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHH
QQSVAKYGNADIVVYVGCGERGNEMTDVLVEFPELEDPKTGGPLMHRTILIANTSNMPVA
HHHHHHCCCCCEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEEEECCCCCEE
AREASVYTGITLAEYFRDQGYSVSLMADSTSRWAEALREISSRLEEMPAEEGYPPYLGAK
ECCCHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHH
LAAFYERAGAVKTLAGEDGAVSVIGAVSPAGGDMSEPVTQATLRITGAFWRLDAGLARRR
HHHHHHHHCCEEEECCCCCCEEEEEECCCCCCCCCCCHHHHHHEEEHHHHHHHHHHHHHH
HFPAINWNGSYSLFTPILDSWYRENVGRDFPELRQRISNLLQQEASLQEVVQLVGPDALQ
CCCEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DQERLVIETGRMLRQDFLQQNGFDPVDASASMPKNYGLMKMMLKFYDEAEAALRNGVGID
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHH
EIIQNPVIEKLSRARYVPEADFMAYAESVMDELDTTFKGVKA
HHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA