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The map label for this gene is arlS [H]

Identifier: 94985370

GI number: 94985370

Start: 1347211

End: 1348461

Strand: Reverse

Name: arlS [H]

Synonym: Dgeo_1269

Alternate gene names: 94985370

Gene position: 1348461-1347211 (Counterclockwise)

Preceding gene: 94985371

Following gene: 94985369

Centisome position: 54.66

GC content: 67.23

Gene sequence:

>1251_bases
ATGACCGGCCCGCAGCGTGCACTGCCCGAAGAGGGCCAGCCCCTGCGGATCCTGCATCTGGAGGACAACGAACTCGATCA
CGAGCTGGTGACCCTCAATCTCGAGGGCGAACTGCCCTGGCCGCTGGAGATCGAGCGGGTGGAGGACGAGGCGAGTTTTC
TGCGGGCGCTGGAAGAACACCGCCCGCACCTGGTCCTGAGCGACTACGCGCTGCCGGGCTACGACGGCCTCTCGGCCTTT
CGGGCTGCGCACCAGCGGGCACCTCAGCTGCCCTTTATCATCGTGACCGGCGCACTGGGTGAAGAAGTCGCGGTGGATAC
GCTGCGCCAGGGCGTCACAGACTACATCCTCAAGCAGCGCCTGGAACGGCTCGCGCCCAGCGTGAGGCGGGCACTGGCCG
AGGCCGACGCCCGCGACCGCCGCGAGCGCGCTGAGCAGGAGGTCCGTGAACTCAACCTCTCCCTGCAGGCCCGCCTGGAG
GAGGTCGAGCGGCTCCGCAGCATCGCGGAGGCTCAGCGTCAGCGCCTGGAGGAACAGGCCCAGCAGCTCGAGGAGGCCCT
CAACCTCCAGAAGACCTTTCTGGCCGAAACCAGCCACGAACTGCGCACGCCGCTGACGGCGCTCTTGGGCTATCTGCGCC
GCGCCGAGCGCGAGGTGGGCGGCTCCCAGACCCTGCAGGATGCGCAGCGCGTCGCGGAGAACATGACCCGGCTGGTGAAT
GACCTGCTGCAACTCTCGCGCGGCGAACTTGTGCAGGGCATCGAGATGCATTTTGTAAATCTGGGCAATCTGGTGCGCCA
GGTGGGACGCGACTACGGCGTGAAGGTCAAGGCCCCCGATCTAGAGATCATCGGCGATCCGGGACGGCTCACGCAGGTGT
TTGTGAATCTGGTGAGCAACGCGATTCGGGTGTGTGGCACGCCGGAACTGGTGAGCCTGGAAGTCTGGCAGGAGGGGCGG
CACGCCTGCGCCGCGGTGATCGACCACGGCCCGGGCATTCCCGACCACATCAAACCGCGCATCTTTGACAAGTTCTACCG
CGGCAAGGAGGCCGGATCCGCTGGGCTAGGCCTCACCATCGCGCAGCAGGTGGTCCACACCCACGGCGGCACCATCGAGG
TGCTCGACACGCCGGGCGGCGGCGCCACCTTCCGCGTCTGTCTGCCGATGCCCGACGAGGACGAGGAAGAGCTGGACGTG
GGTGCAGACGTAGACCTGTACGGTGTGGCCGAGGGTGGCCCGGCGGCCTGA

Upstream 100 bases:

>100_bases
TCCGCCGCATCGTGACCCGCCACGGGGGCCGCGTCCGGGCCGAAGCTGTGCCCGGCCAGGGCGCGGCCTTCTCCGTCACT
CTGCCGAAGGGAGGAGCGGC

Downstream 100 bases:

>100_bases
GGCGCGCTAGGCTGCCGCCATGAAAAAGACCCTGAAGGTCACCTGGCTGGGCGAGCAGCGGTATGTTGGCGTCAGCGAGA
GCGGACACCAGATCCTGATC

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTGPQRALPEEGQPLRILHLEDNELDHELVTLNLEGELPWPLEIERVEDEASFLRALEEHRPHLVLSDYALPGYDGLSAF
RAAHQRAPQLPFIIVTGALGEEVAVDTLRQGVTDYILKQRLERLAPSVRRALAEADARDRRERAEQEVRELNLSLQARLE
EVERLRSIAEAQRQRLEEQAQQLEEALNLQKTFLAETSHELRTPLTALLGYLRRAEREVGGSQTLQDAQRVAENMTRLVN
DLLQLSRGELVQGIEMHFVNLGNLVRQVGRDYGVKVKAPDLEIIGDPGRLTQVFVNLVSNAIRVCGTPELVSLEVWQEGR
HACAAVIDHGPGIPDHIKPRIFDKFYRGKEAGSAGLGLTIAQQVVHTHGGTIEVLDTPGGGATFRVCLPMPDEDEEELDV
GADVDLYGVAEGGPAA

Sequences:

>Translated_416_residues
MTGPQRALPEEGQPLRILHLEDNELDHELVTLNLEGELPWPLEIERVEDEASFLRALEEHRPHLVLSDYALPGYDGLSAF
RAAHQRAPQLPFIIVTGALGEEVAVDTLRQGVTDYILKQRLERLAPSVRRALAEADARDRRERAEQEVRELNLSLQARLE
EVERLRSIAEAQRQRLEEQAQQLEEALNLQKTFLAETSHELRTPLTALLGYLRRAEREVGGSQTLQDAQRVAENMTRLVN
DLLQLSRGELVQGIEMHFVNLGNLVRQVGRDYGVKVKAPDLEIIGDPGRLTQVFVNLVSNAIRVCGTPELVSLEVWQEGR
HACAAVIDHGPGIPDHIKPRIFDKFYRGKEAGSAGLGLTIAQQVVHTHGGTIEVLDTPGGGATFRVCLPMPDEDEEELDV
GADVDLYGVAEGGPAA
>Mature_415_residues
TGPQRALPEEGQPLRILHLEDNELDHELVTLNLEGELPWPLEIERVEDEASFLRALEEHRPHLVLSDYALPGYDGLSAFR
AAHQRAPQLPFIIVTGALGEEVAVDTLRQGVTDYILKQRLERLAPSVRRALAEADARDRRERAEQEVRELNLSLQARLEE
VERLRSIAEAQRQRLEEQAQQLEEALNLQKTFLAETSHELRTPLTALLGYLRRAEREVGGSQTLQDAQRVAENMTRLVND
LLQLSRGELVQGIEMHFVNLGNLVRQVGRDYGVKVKAPDLEIIGDPGRLTQVFVNLVSNAIRVCGTPELVSLEVWQEGRH
ACAAVIDHGPGIPDHIKPRIFDKFYRGKEAGSAGLGLTIAQQVVHTHGGTIEVLDTPGGGATFRVCLPMPDEDEEELDVG
ADVDLYGVAEGGPAA

Specific function: Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transf

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786912, Length=266, Percent_Identity=33.0827067669173, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790436, Length=233, Percent_Identity=31.7596566523605, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=235, Percent_Identity=30.2127659574468, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=29.4642857142857, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1789149, Length=244, Percent_Identity=30.327868852459, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI145693157, Length=238, Percent_Identity=31.9327731092437, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786600, Length=236, Percent_Identity=33.4745762711864, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=29.535864978903, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786783, Length=235, Percent_Identity=28.0851063829787, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI48994928, Length=253, Percent_Identity=28.0632411067194, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=331, Percent_Identity=25.6797583081571, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=228, Percent_Identity=31.140350877193, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082128, Length=245, Percent_Identity=26.530612244898, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=237, Percent_Identity=25.7383966244726, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=246, Percent_Identity=28.8617886178862, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=241, Percent_Identity=25.7261410788382, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1789403, Length=216, Percent_Identity=26.8518518518519, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 46151; Mature: 46020

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGPQRALPEEGQPLRILHLEDNELDHELVTLNLEGELPWPLEIERVEDEASFLRALEEH
CCCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHC
RPHLVLSDYALPGYDGLSAFRAAHQRAPQLPFIIVTGALGEEVAVDTLRQGVTDYILKQR
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LERLAPSVRRALAEADARDRRERAEQEVRELNLSLQARLEEVERLRSIAEAQRQRLEEQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLEEALNLQKTFLAETSHELRTPLTALLGYLRRAEREVGGSQTLQDAQRVAENMTRLVN
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DLLQLSRGELVQGIEMHFVNLGNLVRQVGRDYGVKVKAPDLEIIGDPGRLTQVFVNLVSN
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCHHHHHHHHHHHHH
AIRVCGTPELVSLEVWQEGRHACAAVIDHGPGIPDHIKPRIFDKFYRGKEAGSAGLGLTI
HHHHCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHH
AQQVVHTHGGTIEVLDTPGGGATFRVCLPMPDEDEEELDVGADVDLYGVAEGGPAA
HHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCC
>Mature Secondary Structure 
TGPQRALPEEGQPLRILHLEDNELDHELVTLNLEGELPWPLEIERVEDEASFLRALEEH
CCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHC
RPHLVLSDYALPGYDGLSAFRAAHQRAPQLPFIIVTGALGEEVAVDTLRQGVTDYILKQR
CCCEEEECCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
LERLAPSVRRALAEADARDRRERAEQEVRELNLSLQARLEEVERLRSIAEAQRQRLEEQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QQLEEALNLQKTFLAETSHELRTPLTALLGYLRRAEREVGGSQTLQDAQRVAENMTRLVN
HHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
DLLQLSRGELVQGIEMHFVNLGNLVRQVGRDYGVKVKAPDLEIIGDPGRLTQVFVNLVSN
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEECCCHHHHHHHHHHHHH
AIRVCGTPELVSLEVWQEGRHACAAVIDHGPGIPDHIKPRIFDKFYRGKEAGSAGLGLTI
HHHHCCCCCEEEHHHHHCCHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHH
AQQVVHTHGGTIEVLDTPGGGATFRVCLPMPDEDEEELDVGADVDLYGVAEGGPAA
HHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA