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The map label for this gene is icd [H]

Identifier: 94985268

GI number: 94985268

Start: 1238230

End: 1239492

Strand: Reverse

Name: icd [H]

Synonym: Dgeo_1166

Alternate gene names: 94985268

Gene position: 1239492-1238230 (Counterclockwise)

Preceding gene: 94985280

Following gene: 94985267

Centisome position: 50.24

GC content: 63.26

Gene sequence:

>1263_bases
ATGACCCAGCTCACTGACCAGCACATCAAGGTGCCCACCCAGGGCGAGAAGATTCGGATGGAGGGGGGCAAACTCGTGGT
GCCGAGCCGCCCCATCATCCCCTTCGTGGAGGGCGACGGCACCGGCCCCGACATTTGGCGCGCCTCTGTGCGTGTGTTTG
ACGCTGCCGTCGAGCATGCCTACGGCGGCGAGAAGAAAATCGAGTGGATGGAGGTCTACGCGGGCGAAAAGGCCACCCAG
GTCTACGGCGAGGGCGAGTGGCTGCCCCAGGGCACCCTGGACGCCTTCAACGAGTACCTCTTCGGCATCAAGGGACCGCT
GACCACGCCCGTCGGCGGCGGCATTCGCTCCATCAACGTGGCGCTGCGTCAGATGCTTGACCTCTACGCCTGCGTGCGCC
CCGTTCAGTACTTCCCCGGCGTGCCCAGCCCGGTGAGGCGTCCAGAAGACGTCAACATGGTGATCTTCCGTGAAAACACC
GAAGACATCTATGCCGGGATCGAGTACAAGGCGGGCACGCCCGAGGCAAACAAGCTGCGTGACTTCCTGGTGAATGAGCT
GGGCGTCAACAAGATCCGCTTCCCCGAAACGTCCTCACTGGGTGTCAAGCCCGTGTCGCAAGAAGGCAGTGAGCGCCTGA
TCCGGGCCGCGATCGAGTACGCCATCCAGAACGGGCGCAAGAGCGTGACCCTGGTCCACAAGGGCAACATCATGAAGTTC
ACGGAGGGCGGCTTCCGCGACTGGGGGTATGACCTCGCCAAGCGCGAATTCGGCGGCGTAGAGATTGATGGCGGCCCCTG
GCTCCAGCTGCCGAACGGCATCGTGATCAAGGACGTGATCGCGGACAACTTCCTGCAACAGATCCTGCTGCGCCCGCGCG
AGTATGACGTGATCGCCACCACCAACCTCAACGGCGACTACATCTCCGACGCGCTCGCCGCGCAGGTCGGCGGCATCGGC
ATTGCGCCCGGCGCCAACATCAACTATCAGACCGGCCACGCCATCTTCGAGGCCACCCACGGCACCGCGCCCAAGTACGC
CGGGAAGGACGTGATCAACCCCTCTTCCGTCATCCTCTCGGGCGAGATGATGCTGCGCTACATGGGCTGGGTCGAGGCCG
CCGACCTGATCCTGAAGGGCCTGGAACAGACCATCGCGCAGAAGGTCGTCACCTACGACTTTGCCCGCAACATGGAGGGT
GCCACCGAGGTGAAGACCAGCCAATTCGGGGACAAGATCATCGAAAACATGCGCCGGATGTAG

Upstream 100 bases:

>100_bases
AGCCTTGAAGCGCACCAGAATGTTGAACTGCGTGTACACCTTTCGGGTAACAGTGACACCAATTCCCCGTCAGGCTGCGC
GGCGCTAGAGTTGGACCGTC

Downstream 100 bases:

>100_bases
GCGCGGCAAGCGGCAAAGGGCAGAGAGCAGGAGCCTCTGCCCGTTTTTCATGTCTGGTCCCGGCCGGACTTGTGATGCCC
ATGTCGCACCGCGCACAATG

Product: isocitrate/isopropylmalate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTQLTDQHIKVPTQGEKIRMEGGKLVVPSRPIIPFVEGDGTGPDIWRASVRVFDAAVEHAYGGEKKIEWMEVYAGEKATQ
VYGEGEWLPQGTLDAFNEYLFGIKGPLTTPVGGGIRSINVALRQMLDLYACVRPVQYFPGVPSPVRRPEDVNMVIFRENT
EDIYAGIEYKAGTPEANKLRDFLVNELGVNKIRFPETSSLGVKPVSQEGSERLIRAAIEYAIQNGRKSVTLVHKGNIMKF
TEGGFRDWGYDLAKREFGGVEIDGGPWLQLPNGIVIKDVIADNFLQQILLRPREYDVIATTNLNGDYISDALAAQVGGIG
IAPGANINYQTGHAIFEATHGTAPKYAGKDVINPSSVILSGEMMLRYMGWVEAADLILKGLEQTIAQKVVTYDFARNMEG
ATEVKTSQFGDKIIENMRRM

Sequences:

>Translated_420_residues
MTQLTDQHIKVPTQGEKIRMEGGKLVVPSRPIIPFVEGDGTGPDIWRASVRVFDAAVEHAYGGEKKIEWMEVYAGEKATQ
VYGEGEWLPQGTLDAFNEYLFGIKGPLTTPVGGGIRSINVALRQMLDLYACVRPVQYFPGVPSPVRRPEDVNMVIFRENT
EDIYAGIEYKAGTPEANKLRDFLVNELGVNKIRFPETSSLGVKPVSQEGSERLIRAAIEYAIQNGRKSVTLVHKGNIMKF
TEGGFRDWGYDLAKREFGGVEIDGGPWLQLPNGIVIKDVIADNFLQQILLRPREYDVIATTNLNGDYISDALAAQVGGIG
IAPGANINYQTGHAIFEATHGTAPKYAGKDVINPSSVILSGEMMLRYMGWVEAADLILKGLEQTIAQKVVTYDFARNMEG
ATEVKTSQFGDKIIENMRRM
>Mature_419_residues
TQLTDQHIKVPTQGEKIRMEGGKLVVPSRPIIPFVEGDGTGPDIWRASVRVFDAAVEHAYGGEKKIEWMEVYAGEKATQV
YGEGEWLPQGTLDAFNEYLFGIKGPLTTPVGGGIRSINVALRQMLDLYACVRPVQYFPGVPSPVRRPEDVNMVIFRENTE
DIYAGIEYKAGTPEANKLRDFLVNELGVNKIRFPETSSLGVKPVSQEGSERLIRAAIEYAIQNGRKSVTLVHKGNIMKFT
EGGFRDWGYDLAKREFGGVEIDGGPWLQLPNGIVIKDVIADNFLQQILLRPREYDVIATTNLNGDYISDALAAQVGGIGI
APGANINYQTGHAIFEATHGTAPKYAGKDVINPSSVILSGEMMLRYMGWVEAADLILKGLEQTIAQKVVTYDFARNMEGA
TEVKTSQFGDKIIENMRRM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=391, Percent_Identity=32.9923273657289, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI28178816, Length=366, Percent_Identity=29.7814207650273, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI28178821, Length=366, Percent_Identity=29.7814207650273, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI4758582, Length=357, Percent_Identity=29.1316526610644, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI28178838, Length=368, Percent_Identity=28.5326086956522, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI28178819, Length=178, Percent_Identity=32.0224719101124, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=67.8657074340528, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1788101, Length=399, Percent_Identity=28.8220551378446, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI87081683, Length=399, Percent_Identity=27.0676691729323, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71986051, Length=376, Percent_Identity=34.3085106382979, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI25144293, Length=361, Percent_Identity=30.7479224376731, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17505779, Length=306, Percent_Identity=31.6993464052288, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17550882, Length=309, Percent_Identity=27.831715210356, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324709, Length=389, Percent_Identity=31.8766066838046, Blast_Score=172, Evalue=8e-44,
Organism=Saccharomyces cerevisiae, GI6324291, Length=397, Percent_Identity=27.9596977329975, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6322097, Length=364, Percent_Identity=29.3956043956044, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24643268, Length=388, Percent_Identity=35.0515463917526, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24643270, Length=388, Percent_Identity=35.0515463917526, Blast_Score=196, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24661184, Length=387, Percent_Identity=32.5581395348837, Blast_Score=192, Evalue=3e-49,
Organism=Drosophila melanogaster, GI161078635, Length=277, Percent_Identity=32.8519855595668, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI161078637, Length=277, Percent_Identity=32.8519855595668, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161078639, Length=277, Percent_Identity=32.8519855595668, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI161078633, Length=277, Percent_Identity=32.8519855595668, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24650122, Length=277, Percent_Identity=32.8519855595668, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI281362242, Length=396, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648872, Length=396, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130355, Length=345, Percent_Identity=24.6376811594203, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 46376; Mature: 46244

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQLTDQHIKVPTQGEKIRMEGGKLVVPSRPIIPFVEGDGTGPDIWRASVRVFDAAVEHA
CCCCCCCCEECCCCCCEEEECCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
YGGEKKIEWMEVYAGEKATQVYGEGEWLPQGTLDAFNEYLFGIKGPLTTPVGGGIRSINV
CCCCCCEEEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
ALRQMLDLYACVRPVQYFPGVPSPVRRPEDVNMVIFRENTEDIYAGIEYKAGTPEANKLR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEECEEECCCCCCHHHHH
DFLVNELGVNKIRFPETSSLGVKPVSQEGSERLIRAAIEYAIQNGRKSVTLVHKGNIMKF
HHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEE
TEGGFRDWGYDLAKREFGGVEIDGGPWLQLPNGIVIKDVIADNFLQQILLRPREYDVIAT
CCCCCCHHCHHHHHHCCCCEEECCCCCEECCCCEEEHHHHHHHHHHHHHCCCCCCCEEEE
TNLNGDYISDALAAQVGGIGIAPGANINYQTGHAIFEATHGTAPKYAGKDVINPSSVILS
ECCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEE
GEMMLRYMGWVEAADLILKGLEQTIAQKVVTYDFARNMEGATEVKTSQFGDKIIENMRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQLTDQHIKVPTQGEKIRMEGGKLVVPSRPIIPFVEGDGTGPDIWRASVRVFDAAVEHA
CCCCCCCEECCCCCCEEEECCCEEEECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
YGGEKKIEWMEVYAGEKATQVYGEGEWLPQGTLDAFNEYLFGIKGPLTTPVGGGIRSINV
CCCCCCEEEEEECCCCHHEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
ALRQMLDLYACVRPVQYFPGVPSPVRRPEDVNMVIFRENTEDIYAGIEYKAGTPEANKLR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCEEECEEECCCCCCHHHHH
DFLVNELGVNKIRFPETSSLGVKPVSQEGSERLIRAAIEYAIQNGRKSVTLVHKGNIMKF
HHHHHHHCCCEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCEEEE
TEGGFRDWGYDLAKREFGGVEIDGGPWLQLPNGIVIKDVIADNFLQQILLRPREYDVIAT
CCCCCCHHCHHHHHHCCCCEEECCCCCEECCCCEEEHHHHHHHHHHHHHCCCCCCCEEEE
TNLNGDYISDALAAQVGGIGIAPGANINYQTGHAIFEATHGTAPKYAGKDVINPSSVILS
ECCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEE
GEMMLRYMGWVEAADLILKGLEQTIAQKVVTYDFARNMEGATEVKTSQFGDKIIENMRRM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]