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The map label for this gene is ywrD [H]

Identifier: 94985243

GI number: 94985243

Start: 1212264

End: 1213859

Strand: Reverse

Name: ywrD [H]

Synonym: Dgeo_1141

Alternate gene names: 94985243

Gene position: 1213859-1212264 (Counterclockwise)

Preceding gene: 94985244

Following gene: 94985234

Centisome position: 49.2

GC content: 70.11

Gene sequence:

>1596_bases
GTGACCTACCAGCCCGAGACTCCAGTTATTCGGCAAGCGGTGTACGCGCAGCGCGGCATGGTTGCCACCAGCCAGCCCCT
TGCCGCCCAAGCCGGGCTCAGCATCCTGCAGCAGGGCGGCAACGCCGTCGACGCGGCCATCGCCACCGCCGCCGCGCTGA
CGGTCGTTGAACCCACCAGCAACGGGCTGGGCGGCGACCTCTTCGCCCTGGTGTGGGCAAGGGGCGAGCTGCACGGCCTG
AATGCCAGCGGCGCCGCCCCCGCTGCCTTGACCCGCGACGTGTTGGCCGGCGGTGACATGCCCAGACATGGCTGGACCCC
CGTCACCGTCCCCGGCGCGGTCCGCGGTTGGGCCGACCTGCACGCCCGCTTTGGCCGCCTCCCCTTCGCCGACGTCCTGC
TCCCCGCCATCCGCTATGCCCGCGAGGGCTACCCCCTCTCGCCGGTCCTCGCCGCACACTGGACACGCGCCATCCGCAGC
TACCGGGGCCTGCAGCTCCCCATCCTGGAGGAGTGGTTCCGGGTCTTCGCCCCAGACGGTTTCACCCCTGCCCCCGGGGC
ACTCTGGCGCAGCGAAGACCACGCCCGCACCCTAGAGGCCATTGCCCGGACAGCAGGCGCGGACTTCTACGAGGGCAAGC
TTGCCCAGCAGATCGACGCCCACGCCCGCGAGACGGGCGGTCTGCTTCGCGCCGCCGACCTCGCCGCCCACCGCTCCGAG
TGGGTGAACCCCATCTACACCCGCTTCCTTGACCACCTCGTCTATGAGATCCCACCCAACGGGCAGGGCATCGCTGCACT
GATCGCCCTGAACATCCTGGACGAACTCGACCTCCCCGACCGCCGCGACGATCCCCGGGGGCTGCACCTCCAGATCGAGG
CGATGAAACGCGGCTTCCACGACGCCCACACCTTTGTCGGTGACCCGCGCCATGTGCCGGTGGATGTGGAAGGGCTCCTC
TCCGCCGAAAACGCCGCCACCCACCGCACCTTCCTGGGTGAGCTGGCCCACGACCCCGCCACCCGCGCCCCCAGCAGTGG
CGGCACCGTCTACCTCGCCACCGCCGACGGCGAGGGAGGAATGGTCAGCCTCATCCAGAGCAACTACATGGGCTTTGGCA
GCGGCGTGGTCGTGCCCGGCACCGGCATCGCCCTCCACAACCGCGGCCACAACTTCCACCTCGACCCCGCCCACCCCAAC
GCCCTCGCGCCCGGCAAACGGCCCTACCACACCATCATCCCCGGCTTCCTGTCACGCGCAGACGGCACCCCGCTCGGCCC
CTTCGGGGTGATGGGCGGCTTCATGCAACCGCAGGGCCATGTTCAGGTCGTGCTGAACACCCTCCGCTACGGCTTGAATC
CCCAGCAGGCCCTCGATGCCCCGCGCTGGCAGTGGCTCCAGGGCAAGGCTGTAGACCTTGAACCCGCCCTCGGCGCACAG
TTGGCACGGGCCCTCGCCGCCCGTGGGCATGACGTGCGCCTCCAGCTCGACTCCAGCGCCTTTGGCCGCGGCCAGATCAT
CTGGCGCAACCCCCACACCGGCGTGCTGGAAGGCGGCACAGAAAGCCGCACGGACGGACACATCGCCGTGTGGTAA

Upstream 100 bases:

>100_bases
CCGAATATATACAAACCCCCCTGAGTTCTCCTCGAGGAAAGGGAATATATACAAAAAAAGCAAGAGGACACACCTCCTCA
ACCGTACTAGCCTATCCCAC

Downstream 100 bases:

>100_bases
AAAGCTCACCCCCCCACGTACGCCTCGCTCAGCGCCCATAGCCGCGCCGCTGCCCGGTCGTCGCGGGCCTGGGGCGCCTC
CTTCGCCACCCGCTCGGCGC

Product: gamma-glutamyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 531; Mature: 530

Protein sequence:

>531_residues
MTYQPETPVIRQAVYAQRGMVATSQPLAAQAGLSILQQGGNAVDAAIATAAALTVVEPTSNGLGGDLFALVWARGELHGL
NASGAAPAALTRDVLAGGDMPRHGWTPVTVPGAVRGWADLHARFGRLPFADVLLPAIRYAREGYPLSPVLAAHWTRAIRS
YRGLQLPILEEWFRVFAPDGFTPAPGALWRSEDHARTLEAIARTAGADFYEGKLAQQIDAHARETGGLLRAADLAAHRSE
WVNPIYTRFLDHLVYEIPPNGQGIAALIALNILDELDLPDRRDDPRGLHLQIEAMKRGFHDAHTFVGDPRHVPVDVEGLL
SAENAATHRTFLGELAHDPATRAPSSGGTVYLATADGEGGMVSLIQSNYMGFGSGVVVPGTGIALHNRGHNFHLDPAHPN
ALAPGKRPYHTIIPGFLSRADGTPLGPFGVMGGFMQPQGHVQVVLNTLRYGLNPQQALDAPRWQWLQGKAVDLEPALGAQ
LARALAARGHDVRLQLDSSAFGRGQIIWRNPHTGVLEGGTESRTDGHIAVW

Sequences:

>Translated_531_residues
MTYQPETPVIRQAVYAQRGMVATSQPLAAQAGLSILQQGGNAVDAAIATAAALTVVEPTSNGLGGDLFALVWARGELHGL
NASGAAPAALTRDVLAGGDMPRHGWTPVTVPGAVRGWADLHARFGRLPFADVLLPAIRYAREGYPLSPVLAAHWTRAIRS
YRGLQLPILEEWFRVFAPDGFTPAPGALWRSEDHARTLEAIARTAGADFYEGKLAQQIDAHARETGGLLRAADLAAHRSE
WVNPIYTRFLDHLVYEIPPNGQGIAALIALNILDELDLPDRRDDPRGLHLQIEAMKRGFHDAHTFVGDPRHVPVDVEGLL
SAENAATHRTFLGELAHDPATRAPSSGGTVYLATADGEGGMVSLIQSNYMGFGSGVVVPGTGIALHNRGHNFHLDPAHPN
ALAPGKRPYHTIIPGFLSRADGTPLGPFGVMGGFMQPQGHVQVVLNTLRYGLNPQQALDAPRWQWLQGKAVDLEPALGAQ
LARALAARGHDVRLQLDSSAFGRGQIIWRNPHTGVLEGGTESRTDGHIAVW
>Mature_530_residues
TYQPETPVIRQAVYAQRGMVATSQPLAAQAGLSILQQGGNAVDAAIATAAALTVVEPTSNGLGGDLFALVWARGELHGLN
ASGAAPAALTRDVLAGGDMPRHGWTPVTVPGAVRGWADLHARFGRLPFADVLLPAIRYAREGYPLSPVLAAHWTRAIRSY
RGLQLPILEEWFRVFAPDGFTPAPGALWRSEDHARTLEAIARTAGADFYEGKLAQQIDAHARETGGLLRAADLAAHRSEW
VNPIYTRFLDHLVYEIPPNGQGIAALIALNILDELDLPDRRDDPRGLHLQIEAMKRGFHDAHTFVGDPRHVPVDVEGLLS
AENAATHRTFLGELAHDPATRAPSSGGTVYLATADGEGGMVSLIQSNYMGFGSGVVVPGTGIALHNRGHNFHLDPAHPNA
LAPGKRPYHTIIPGFLSRADGTPLGPFGVMGGFMQPQGHVQVVLNTLRYGLNPQQALDAPRWQWLQGKAVDLEPALGAQL
ARALAARGHDVRLQLDSSAFGRGQIIWRNPHTGVLEGGTESRTDGHIAVW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=521, Percent_Identity=27.831094049904, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI73915090, Length=521, Percent_Identity=27.831094049904, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI73915096, Length=521, Percent_Identity=27.831094049904, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI73915094, Length=521, Percent_Identity=27.831094049904, Blast_Score=152, Evalue=8e-37,
Organism=Homo sapiens, GI113429324, Length=529, Percent_Identity=27.2211720226843, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI113429326, Length=531, Percent_Identity=26.9303201506591, Blast_Score=142, Evalue=9e-34,
Organism=Homo sapiens, GI109148539, Length=507, Percent_Identity=30.1775147928994, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI153266885, Length=519, Percent_Identity=27.1676300578035, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI153266901, Length=520, Percent_Identity=27.5, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI153266907, Length=514, Percent_Identity=26.4591439688716, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1789856, Length=542, Percent_Identity=29.7047970479705, Blast_Score=201, Evalue=1e-52,
Organism=Caenorhabditis elegans, GI17506189, Length=513, Percent_Identity=27.8752436647173, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI72000294, Length=434, Percent_Identity=26.9585253456221, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI212646519, Length=482, Percent_Identity=25.9336099585062, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI193208245, Length=526, Percent_Identity=24.9049429657795, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI193208247, Length=504, Percent_Identity=25.1984126984127, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=526, Percent_Identity=23.384030418251, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323330, Length=523, Percent_Identity=21.6061185468451, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161077878, Length=513, Percent_Identity=27.4853801169591, Blast_Score=142, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24642670, Length=513, Percent_Identity=27.4853801169591, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24642666, Length=513, Percent_Identity=27.4853801169591, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI45551474, Length=513, Percent_Identity=27.4853801169591, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI161077880, Length=513, Percent_Identity=27.4853801169591, Blast_Score=142, Evalue=8e-34,
Organism=Drosophila melanogaster, GI161077496, Length=514, Percent_Identity=26.6536964980545, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859741, Length=511, Percent_Identity=26.4187866927593, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18859893, Length=527, Percent_Identity=25.426944971537, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 56911; Mature: 56780

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYQPETPVIRQAVYAQRGMVATSQPLAAQAGLSILQQGGNAVDAAIATAAALTVVEPTS
CCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCC
NGLGGDLFALVWARGELHGLNASGAAPAALTRDVLAGGDMPRHGWTPVTVPGAVRGWADL
CCCCHHHHHHEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHH
HARFGRLPFADVLLPAIRYAREGYPLSPVLAAHWTRAIRSYRGLQLPILEEWFRVFAPDG
HHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
FTPAPGALWRSEDHARTLEAIARTAGADFYEGKLAQQIDAHARETGGLLRAADLAAHRSE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WVNPIYTRFLDHLVYEIPPNGQGIAALIALNILDELDLPDRRDDPRGLHLQIEAMKRGFH
HCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCH
DAHTFVGDPRHVPVDVEGLLSAENAATHRTFLGELAHDPATRAPSSGGTVYLATADGEGG
HHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC
MVSLIQSNYMGFGSGVVVPGTGIALHNRGHNFHLDPAHPNALAPGKRPYHTIIPGFLSRA
EEEEEHHCCCCCCCCEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
DGTPLGPFGVMGGFMQPQGHVQVVLNTLRYGLNPQQALDAPRWQWLQGKAVDLEPALGAQ
CCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCEECCCCCCCCCHHHHHH
LARALAARGHDVRLQLDSSAFGRGQIIWRNPHTGVLEGGTESRTDGHIAVW
HHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEC
>Mature Secondary Structure 
TYQPETPVIRQAVYAQRGMVATSQPLAAQAGLSILQQGGNAVDAAIATAAALTVVEPTS
CCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHEEEEECCCC
NGLGGDLFALVWARGELHGLNASGAAPAALTRDVLAGGDMPRHGWTPVTVPGAVRGWADL
CCCCHHHHHHEECCCCEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCEECCCHHHHHHHH
HARFGRLPFADVLLPAIRYAREGYPLSPVLAAHWTRAIRSYRGLQLPILEEWFRVFAPDG
HHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCC
FTPAPGALWRSEDHARTLEAIARTAGADFYEGKLAQQIDAHARETGGLLRAADLAAHRSE
CCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
WVNPIYTRFLDHLVYEIPPNGQGIAALIALNILDELDLPDRRDDPRGLHLQIEAMKRGFH
HCCHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHCCCH
DAHTFVGDPRHVPVDVEGLLSAENAATHRTFLGELAHDPATRAPSSGGTVYLATADGEGG
HHHHHCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCC
MVSLIQSNYMGFGSGVVVPGTGIALHNRGHNFHLDPAHPNALAPGKRPYHTIIPGFLSRA
EEEEEHHCCCCCCCCEEECCCCEEEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHC
DGTPLGPFGVMGGFMQPQGHVQVVLNTLRYGLNPQQALDAPRWQWLQGKAVDLEPALGAQ
CCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHHHCCCCCEECCCCCCCCCHHHHHH
LARALAARGHDVRLQLDSSAFGRGQIIWRNPHTGVLEGGTESRTDGHIAVW
HHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]