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The map label for this gene is Hgd [H]

Identifier: 94985185

GI number: 94985185

Start: 1150666

End: 1151553

Strand: Reverse

Name: Hgd [H]

Synonym: Dgeo_1081

Alternate gene names: 94985185

Gene position: 1151553-1150666 (Counterclockwise)

Preceding gene: 94985189

Following gene: 94985184

Centisome position: 46.67

GC content: 70.72

Gene sequence:

>888_bases
ATGAGCAGAACTCTGGCATTCCTGGGCCTGGGCGCGATGGGCTGGCCGATGGCCGCGCAGCTCGCCCGGCACACCAACGC
AACAGGTGGGCGCACCCTGGTCTGGAACCGCACTCCGGCGAAAGCGGAGGCCCACGCCCGCGAGTTCGGCAGCGAGGCCG
TCACACTGCCCGAGGTGGCCGCTGCCGACGTGATCTTTTCCTGTCTGCCCACAAGCGCGGAGGTGGACGAGGTGCTGGAG
GCGCTGGGGGGACAACTGCGCGCGGGGACGATCTGGGTGGACTGCACCAGCGGGCAGCCAGAGGCCGCGCGGCGGCAGGC
GGCAGCACTGGCGGAGCGCGGGGTGGCGTTTCTGGACGCGCCCGTCAGCGGCGGGCCGATGGGCGCGCAGGCCGGAACGC
TGGCCGTGATGGTGGGCGGGGACCCAGCGGTGCTGGAGAGGGTACGGGGTGACCTCGCCTTTGCAGGCACGGTCGTGCAC
GTGGGGGGGGCCGGCACGGGCTTTGCGGTGAAGGCGATCAACAACACGCTGATGGCCGTGAATATGTGGGCGGCGGGCGA
GGGGCTGGCGGCACTGGTGCGCAGCGGGGTGGACCCCCACGCGGCGCTGGAGGTGATCAACGCGGGGAGCGGGCGCTCCT
ATCCCACCGAGACGCTGATCCCCCAGCGAGTGCTGACGCGCGAGTTTCCGGTCACCTTTCAGCTTGGCCTGCTTGCCAAG
GACACGGGCATTGCGGTGGACGTGGTGCAGGACGCCAGGGCAAGCGCGCCCGTGCTGCTGCAGGTGGCGGCACTTTACCG
GGCAGCGGCGCACCGCGTCGGAGCAGAGGCCGATTACAGCGCCGCACTGAAACTGGTGGAGCAGCTGAACGGCGTGGAGA
TCGCGTGA

Upstream 100 bases:

>100_bases
TGAGGAGGGCCGGAAACATAGGTGGCAGGATACCCATCCATATTTCTGGACTCGGTTCAGAGTTGACCGCGAACGGGCAG
AGGAAGCCTAGCCTGACACC

Downstream 100 bases:

>100_bases
CCGCTTCCTTGTTCGCAGTTGCCACAGACGGCGGCCTGGATGCCTTCGCAGAGCTGAAGAATGCTGTTCCGGTCGCGCCC
TTCAGTCTGAACTTCGGCTC

Product: 6-phosphogluconate dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSRTLAFLGLGAMGWPMAAQLARHTNATGGRTLVWNRTPAKAEAHAREFGSEAVTLPEVAAADVIFSCLPTSAEVDEVLE
ALGGQLRAGTIWVDCTSGQPEAARRQAAALAERGVAFLDAPVSGGPMGAQAGTLAVMVGGDPAVLERVRGDLAFAGTVVH
VGGAGTGFAVKAINNTLMAVNMWAAGEGLAALVRSGVDPHAALEVINAGSGRSYPTETLIPQRVLTREFPVTFQLGLLAK
DTGIAVDVVQDARASAPVLLQVAALYRAAAHRVGAEADYSAALKLVEQLNGVEIA

Sequences:

>Translated_295_residues
MSRTLAFLGLGAMGWPMAAQLARHTNATGGRTLVWNRTPAKAEAHAREFGSEAVTLPEVAAADVIFSCLPTSAEVDEVLE
ALGGQLRAGTIWVDCTSGQPEAARRQAAALAERGVAFLDAPVSGGPMGAQAGTLAVMVGGDPAVLERVRGDLAFAGTVVH
VGGAGTGFAVKAINNTLMAVNMWAAGEGLAALVRSGVDPHAALEVINAGSGRSYPTETLIPQRVLTREFPVTFQLGLLAK
DTGIAVDVVQDARASAPVLLQVAALYRAAAHRVGAEADYSAALKLVEQLNGVEIA
>Mature_294_residues
SRTLAFLGLGAMGWPMAAQLARHTNATGGRTLVWNRTPAKAEAHAREFGSEAVTLPEVAAADVIFSCLPTSAEVDEVLEA
LGGQLRAGTIWVDCTSGQPEAARRQAAALAERGVAFLDAPVSGGPMGAQAGTLAVMVGGDPAVLERVRGDLAFAGTVVHV
GGAGTGFAVKAINNTLMAVNMWAAGEGLAALVRSGVDPHAALEVINAGSGRSYPTETLIPQRVLTREFPVTFQLGLLAKD
TGIAVDVVQDARASAPVLLQVAALYRAAAHRVGAEADYSAALKLVEQLNGVEIA

Specific function: Catalyzes the conversion of 2-formylglutarate to (S)-2- hydroxymethylglutarate. Has very low activity with (S)-3- hydroxyisobutyrate [H]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=302, Percent_Identity=31.1258278145695, Blast_Score=124, Evalue=9e-29,
Organism=Homo sapiens, GI40556376, Length=288, Percent_Identity=25, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI145693186, Length=296, Percent_Identity=35.1351351351351, Blast_Score=131, Evalue=5e-32,
Organism=Escherichia coli, GI1786719, Length=287, Percent_Identity=33.4494773519164, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=29.3103448275862, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789092, Length=284, Percent_Identity=27.8169014084507, Blast_Score=65, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557316, Length=307, Percent_Identity=28.3387622149837, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24655230, Length=295, Percent_Identity=27.1186440677966, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI19922568, Length=295, Percent_Identity=27.1186440677966, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI28574115, Length=288, Percent_Identity=23.9583333333333, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.291 [H]

Molecular weight: Translated: 30283; Mature: 30152

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRTLAFLGLGAMGWPMAAQLARHTNATGGRTLVWNRTPAKAEAHAREFGSEAVTLPEVA
CCCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHH
AADVIFSCLPTSAEVDEVLEALGGQLRAGTIWVDCTSGQPEAARRQAAALAERGVAFLDA
HHHHHHHHCCCCCCHHHHHHHCCCCEEECEEEEEECCCCCHHHHHHHHHHHHCCCEEEEC
PVSGGPMGAQAGTLAVMVGGDPAVLERVRGDLAFAGTVVHVGGAGTGFAVKAINNTLMAV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHCCEEEEEEEEEECCCCCCEEEEECCCEEEEE
NMWAAGEGLAALVRSGVDPHAALEVINAGSGRSYPTETLIPQRVLTREFPVTFQLGLLAK
EEEECCCHHHHHHHCCCCHHHHHHEEECCCCCCCCCHHHCHHHHHHHCCCCEEEEEEEEC
DTGIAVDVVQDARASAPVLLQVAALYRAAAHRVGAEADYSAALKLVEQLNGVEIA
CCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SRTLAFLGLGAMGWPMAAQLARHTNATGGRTLVWNRTPAKAEAHAREFGSEAVTLPEVA
CCEEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHH
AADVIFSCLPTSAEVDEVLEALGGQLRAGTIWVDCTSGQPEAARRQAAALAERGVAFLDA
HHHHHHHHCCCCCCHHHHHHHCCCCEEECEEEEEECCCCCHHHHHHHHHHHHCCCEEEEC
PVSGGPMGAQAGTLAVMVGGDPAVLERVRGDLAFAGTVVHVGGAGTGFAVKAINNTLMAV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHCCEEEEEEEEEECCCCCCEEEEECCCEEEEE
NMWAAGEGLAALVRSGVDPHAALEVINAGSGRSYPTETLIPQRVLTREFPVTFQLGLLAK
EEEECCCHHHHHHHCCCCHHHHHHEEECCCCCCCCCHHHCHHHHHHHCCCCEEEEEEEEC
DTGIAVDVVQDARASAPVLLQVAALYRAAAHRVGAEADYSAALKLVEQLNGVEIA
CCCCEEEEEHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA