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The map label for this gene is tetA [H]

Identifier: 94984786

GI number: 94984786

Start: 737086

End: 738159

Strand: Reverse

Name: tetA [H]

Synonym: Dgeo_0679

Alternate gene names: 94984786

Gene position: 738159-737086 (Counterclockwise)

Preceding gene: 94984787

Following gene: 228964358

Centisome position: 29.92

GC content: 73.09

Gene sequence:

>1074_bases
GTGCCCGCCATGCAGGCCCATTTCGCTGGGCTGGCGAACGCCGACGTGCTGGTCCGGCTGACGGTGACGGTGGTGGGCCT
TGCCATCGCGGTCAGTGCGCCCGTCAGCGGATACCTCACCGACCGAATTGGGCGCCGACCCGTGCTGGTCGGCGCCATGC
TGCTGTATGCCCTGGCCGGATCGAGCGGCCTGTACGCCCCGACCCTGGGGACGCTGCTGCTGGGGCGGGTGCTGCTGGGG
CTGGCGGTGGGAGCCACCATGACGGCGGGCTCGGCACTGGTGGCGGACCTGTTCGCCGGGCAGGAACGGGCACGTTTCCT
GGGGCTGCAGAGCGCCTTTACCAGTCTGGGCGGCGTGATCTTCCTGCCGCTGGGGGGACTGCTGGCGGGCATCGGCTGGC
GGCTGCCCTTCGCGGTGTACCTGGCGGCCCTCCTGCTGGTGCCGCTGGCGCTGCGGCTGCCGCGCGGGGAGACGGCGGGG
GAGCGGCGGGCGGAGGTGGCGGCGGAGCGGATTCCGTGGCGCCCGGTCGCGCTGGCCTACGGGGTGGCGCTCTCGTACAT
GCTGGTCTACTACCTGATGCCCACCCAGATCCCCTACCGATTGGAGGGCCTCGGTGTGGCCCCGGCGCTGGTGGGGTTCG
TCATGGGCGTCAGCACACTTTCGGGCGCGCTCGCGGCGCTGTGGTTCTCCCGGCGCGGCGGCACCCGGACGCCCATCCGA
ATGGCAGGCCTCAGCTTGCTGGCGCTGGCGGTCGGGTGGACGGTGGTGAGCCTCGCGCCGGGGGCCGGGTGGGTGGTGCC
GGGCCTGATCATCGGCGGGGCGGGGGCCGGTCTGGTCACGCCCAACCTGAACACCTTCCTGGCCGCCCTGGCCCCGGCCC
ATGCCCGCGGACGGGTGATGAGCGGGCTGTCAGTCAGCATCTTTCTCGGGCAGTTCCTGTCGCCGCTGCTCGCGCGGCCC
TTCGTCCACGGCACCGACGTAAGCCGGACCTTCGCCGCCGCGGCGACCTTCGCGGTCCTGGTGGGGACGGCGCTGCTGCT
GCTGGGACGCAGGCGAGCGGCGCTGGCGGGCTAA

Upstream 100 bases:

>100_bases
ATGGAGTAAAGGTGCGCGAGGCGCAAGTTTCGCACACAGACTCCAACCTCGTAAGCCCCGCGTAGGGGAACCCCCGGTCT
TCAGGCCGGGGAGGATGTCA

Downstream 100 bases:

>100_bases
TCTTCCTTTACACTTGTTATCCCTATGCCAGCTCTACTTTTCACGTGCTACCTTCTTACCATGATTGTGGTGAAGGTGGG
CGGAAGCGCCGGAATCGATT

Product: major facilitator transporter

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MPAMQAHFAGLANADVLVRLTVTVVGLAIAVSAPVSGYLTDRIGRRPVLVGAMLLYALAGSSGLYAPTLGTLLLGRVLLG
LAVGATMTAGSALVADLFAGQERARFLGLQSAFTSLGGVIFLPLGGLLAGIGWRLPFAVYLAALLLVPLALRLPRGETAG
ERRAEVAAERIPWRPVALAYGVALSYMLVYYLMPTQIPYRLEGLGVAPALVGFVMGVSTLSGALAALWFSRRGGTRTPIR
MAGLSLLALAVGWTVVSLAPGAGWVVPGLIIGGAGAGLVTPNLNTFLAALAPAHARGRVMSGLSVSIFLGQFLSPLLARP
FVHGTDVSRTFAAAATFAVLVGTALLLLGRRRAALAG

Sequences:

>Translated_357_residues
MPAMQAHFAGLANADVLVRLTVTVVGLAIAVSAPVSGYLTDRIGRRPVLVGAMLLYALAGSSGLYAPTLGTLLLGRVLLG
LAVGATMTAGSALVADLFAGQERARFLGLQSAFTSLGGVIFLPLGGLLAGIGWRLPFAVYLAALLLVPLALRLPRGETAG
ERRAEVAAERIPWRPVALAYGVALSYMLVYYLMPTQIPYRLEGLGVAPALVGFVMGVSTLSGALAALWFSRRGGTRTPIR
MAGLSLLALAVGWTVVSLAPGAGWVVPGLIIGGAGAGLVTPNLNTFLAALAPAHARGRVMSGLSVSIFLGQFLSPLLARP
FVHGTDVSRTFAAAATFAVLVGTALLLLGRRRAALAG
>Mature_356_residues
PAMQAHFAGLANADVLVRLTVTVVGLAIAVSAPVSGYLTDRIGRRPVLVGAMLLYALAGSSGLYAPTLGTLLLGRVLLGL
AVGATMTAGSALVADLFAGQERARFLGLQSAFTSLGGVIFLPLGGLLAGIGWRLPFAVYLAALLLVPLALRLPRGETAGE
RRAEVAAERIPWRPVALAYGVALSYMLVYYLMPTQIPYRLEGLGVAPALVGFVMGVSTLSGALAALWFSRRGGTRTPIRM
AGLSLLALAVGWTVVSLAPGAGWVVPGLIIGGAGAGLVTPNLNTFLAALAPAHARGRVMSGLSVSIFLGQFLSPLLARPF
VHGTDVSRTFAAAATFAVLVGTALLLLGRRRAALAG

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6324264, Length=160, Percent_Identity=30, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 36656; Mature: 36525

Theoretical pI: Translated: 11.99; Mature: 11.99

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAMQAHFAGLANADVLVRLTVTVVGLAIAVSAPVSGYLTDRIGRRPVLVGAMLLYALAG
CCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHC
SSGLYAPTLGTLLLGRVLLGLAVGATMTAGSALVADLFAGQERARFLGLQSAFTSLGGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCEE
FLPLGGLLAGIGWRLPFAVYLAALLLVPLALRLPRGETAGERRAEVAAERIPWRPVALAY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
GVALSYMLVYYLMPTQIPYRLEGLGVAPALVGFVMGVSTLSGALAALWFSRRGGTRTPIR
HHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
MAGLSLLALAVGWTVVSLAPGAGWVVPGLIIGGAGAGLVTPNLNTFLAALAPAHARGRVM
HHHHHHHHHHHHHHHEEECCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHH
SGLSVSIFLGQFLSPLLARPFVHGTDVSRTFAAAATFAVLVGTALLLLGRRRAALAG
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC
>Mature Secondary Structure 
PAMQAHFAGLANADVLVRLTVTVVGLAIAVSAPVSGYLTDRIGRRPVLVGAMLLYALAG
CCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHHHC
SSGLYAPTLGTLLLGRVLLGLAVGATMTAGSALVADLFAGQERARFLGLQSAFTSLGGVI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCEE
FLPLGGLLAGIGWRLPFAVYLAALLLVPLALRLPRGETAGERRAEVAAERIPWRPVALAY
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHH
GVALSYMLVYYLMPTQIPYRLEGLGVAPALVGFVMGVSTLSGALAALWFSRRGGTRTPIR
HHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
MAGLSLLALAVGWTVVSLAPGAGWVVPGLIIGGAGAGLVTPNLNTFLAALAPAHARGRVM
HHHHHHHHHHHHHHHEEECCCCCCHHHHHEECCCCCCCCCCCHHHHHHHHCCHHHHHHHH
SGLSVSIFLGQFLSPLLARPFVHGTDVSRTFAAAATFAVLVGTALLLLGRRRAALAG
CCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]