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The map label for this gene is ilvC

Identifier: 94984707

GI number: 94984707

Start: 640964

End: 641974

Strand: Reverse

Name: ilvC

Synonym: Dgeo_0600

Alternate gene names: 94984707

Gene position: 641974-640964 (Counterclockwise)

Preceding gene: 94984708

Following gene: 94984706

Centisome position: 26.02

GC content: 63.3

Gene sequence:

>1011_bases
ATGGCTGCAACGATGTACTACGACCGCGACGTGAGCCTCTCACCCATCGAAGACAAGCTGATCGCCATCATCGGCTACGG
TTCTCAAGCGCACGCGCACGCGCAAAACCTGCGCGACAGCGGGTTGAACGTGGTGGTCGGCCTCCGCGAGGGCAGCCCCA
GCCGTCCCAAGGCCGAGCAGGCGGGCCTGCGCGTGACGAGCATCGAGGACGCGACCCGGGAAGCGGACGTGATCATGCTG
CTGATCCCCGACGAAACGCAGCCCAAGGTGTACGAGGAGAGCATCGCCCCGAACCTGACGGCGGGCAAGGCCCTCGCCTT
CGGGCACGGCTTCAACATCCACTTTGGGCGCATCAAGCCACCGGCCGACGTGGATGTGTTCCTGGTGGCGCCCAAGGGGC
CGGGCCACATGCTGCGCCGCGTGTACGTGGACGGTGCCGGAATGCCCAGCATCTTCGCGGTGGGGCAGGACGCGAGCGGC
AATGCCCGCGACCTCGCTCTCGCCTATGCGCGCGGCATCGGCGGCACCCGTGCGGGCGTGCTGGAAACGACCTTTAAGGA
GGAGACAGAAACGGACCTCTTCGGAGAGCAGTCCGTTCTCTGCGGCGGCGTGACGCACCTGATCCAGGCGGGCTTTGAGA
CGCTGGTGGAAGCCGGGTACCAGCCCGAGATCGCCTACTTCGAGACGCTGCACGAGGTCAAGCTAATTGTGGACCTGATC
TACGAGAAGGGCTTCGAGGGGATGCGCCACTCCATCTCCAACACCGCCGAATACGGCGACTATGTGACCGGGCCGCGCAT
CATCACAGACGAGACGAAAGCGACCATGAAGGACGTCCTGAGCGATATCCAAAGCGGCAAGTTCGCACGTGACTTCATTC
ATGAGGCCGAGAGCGGCTTCCCCTTTATGAAAGAGCAGCGCCAGAAGATGCGCCACCACACCCTAGAAGTGGTGGGCCGA
GAGTTGCGGAGCAAGATGCCCTTTATCAGCAAGCAGGAGCTGGAGGTTTAA

Upstream 100 bases:

>100_bases
GGCGCGAGGAGTGCCCAATCTGTTCTGAATCCGCCCAGCGCGGGCGTTCTCCCCTAGCTCACACTCTTCCCCAACTCACA
ATCTGTAGGAGAATTCTCCA

Downstream 100 bases:

>100_bases
CAAAGAGAGCCAGCGTGATGGCTTCACGGGGCGGCTTGCGCCTTGGGAGGCATCCTCCAGCCCCGGTTCTTCGAACGCCC
TCCACCCGTGTAGACGACTT

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MAATMYYDRDVSLSPIEDKLIAIIGYGSQAHAHAQNLRDSGLNVVVGLREGSPSRPKAEQAGLRVTSIEDATREADVIML
LIPDETQPKVYEESIAPNLTAGKALAFGHGFNIHFGRIKPPADVDVFLVAPKGPGHMLRRVYVDGAGMPSIFAVGQDASG
NARDLALAYARGIGGTRAGVLETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLI
YEKGFEGMRHSISNTAEYGDYVTGPRIITDETKATMKDVLSDIQSGKFARDFIHEAESGFPFMKEQRQKMRHHTLEVVGR
ELRSKMPFISKQELEV

Sequences:

>Translated_336_residues
MAATMYYDRDVSLSPIEDKLIAIIGYGSQAHAHAQNLRDSGLNVVVGLREGSPSRPKAEQAGLRVTSIEDATREADVIML
LIPDETQPKVYEESIAPNLTAGKALAFGHGFNIHFGRIKPPADVDVFLVAPKGPGHMLRRVYVDGAGMPSIFAVGQDASG
NARDLALAYARGIGGTRAGVLETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLI
YEKGFEGMRHSISNTAEYGDYVTGPRIITDETKATMKDVLSDIQSGKFARDFIHEAESGFPFMKEQRQKMRHHTLEVVGR
ELRSKMPFISKQELEV
>Mature_335_residues
AATMYYDRDVSLSPIEDKLIAIIGYGSQAHAHAQNLRDSGLNVVVGLREGSPSRPKAEQAGLRVTSIEDATREADVIMLL
IPDETQPKVYEESIAPNLTAGKALAFGHGFNIHFGRIKPPADVDVFLVAPKGPGHMLRRVYVDGAGMPSIFAVGQDASGN
ARDLALAYARGIGGTRAGVLETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLIY
EKGFEGMRHSISNTAEYGDYVTGPRIITDETKATMKDVLSDIQSGKFARDFIHEAESGFPFMKEQRQKMRHHTLEVVGRE
LRSKMPFISKQELEV

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=293, Percent_Identity=34.4709897610922, Blast_Score=134, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323387, Length=336, Percent_Identity=33.3333333333333, Blast_Score=153, Evalue=5e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_DEIGD (Q1J0T2)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_604071.1
- ProteinModelPortal:   Q1J0T2
- SMR:   Q1J0T2
- STRING:   Q1J0T2
- GeneID:   4058050
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0600
- NMPDR:   fig|68909.1.peg.903
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- PhylomeDB:   Q1J0T2
- ProtClustDB:   PRK05479
- BioCyc:   DGEO319795:DGEO_0600-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36901; Mature: 36770

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: NA

Important sites: ACT_SITE 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAATMYYDRDVSLSPIEDKLIAIIGYGSQAHAHAQNLRDSGLNVVVGLREGSPSRPKAEQ
CCCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
AGLRVTSIEDATREADVIMLLIPDETQPKVYEESIAPNLTAGKALAFGHGFNIHFGRIKP
HCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEECCCCC
PADVDVFLVAPKGPGHMLRRVYVDGAGMPSIFAVGQDASGNARDLALAYARGIGGTRAGV
CCCCEEEEECCCCHHHHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCH
LETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YEKGFEGMRHSISNTAEYGDYVTGPRIITDETKATMKDVLSDIQSGKFARDFIHEAESGF
HHHCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
PFMKEQRQKMRHHTLEVVGRELRSKMPFISKQELEV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AATMYYDRDVSLSPIEDKLIAIIGYGSQAHAHAQNLRDSGLNVVVGLREGSPSRPKAEQ
CCEEEECCCCCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHH
AGLRVTSIEDATREADVIMLLIPDETQPKVYEESIAPNLTAGKALAFGHGFNIHFGRIKP
HCCEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCCCCCCCEEEECCCCEEEECCCCC
PADVDVFLVAPKGPGHMLRRVYVDGAGMPSIFAVGQDASGNARDLALAYARGIGGTRAGV
CCCCEEEEECCCCHHHHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCH
LETTFKEETETDLFGEQSVLCGGVTHLIQAGFETLVEAGYQPEIAYFETLHEVKLIVDLI
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
YEKGFEGMRHSISNTAEYGDYVTGPRIITDETKATMKDVLSDIQSGKFARDFIHEAESGF
HHHCHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCC
PFMKEQRQKMRHHTLEVVGRELRSKMPFISKQELEV
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA