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The map label for this gene is hisD [H]

Identifier: 94984691

GI number: 94984691

Start: 621484

End: 622977

Strand: Reverse

Name: hisD [H]

Synonym: Dgeo_0584

Alternate gene names: 94984691

Gene position: 622977-621484 (Counterclockwise)

Preceding gene: 94984692

Following gene: 94984687

Centisome position: 25.25

GC content: 67.4

Gene sequence:

>1494_bases
ATGCCCATGCAAGTCCTTCAAGGTGACGCCGCCCGCGCGGCCCTGACCCGCTCCTTTGGTGAGATTCCTGTTCCAGAAAG
CGTTTTGGCCCGCATTGAGGCCACCTTTGGCGAACCCCTCACGCCGGAGGAGGTGGTGGCGCGCATCCTCGCAGACGTGA
GGGCACGCGGCGACGAGGCCCTGCTCGACTGGACCGAAAAGCTGGACGGCGCCCGTCCCGAGGCGCTTGAAGTGACGCGG
GAAGAGATCGAGGCGGCGCAGGTTGACCCCGCGTTGCATGACGCAATCCGCCTCGCCGCTGCGCGCGTCCGGGCCTTTTA
CGAGCAGCAGCCCGCCCACGGCTTTCTGGATCATGGTCCGGATGGAGCACTGGGCCAACTGGTGCGCCCGCTCTCGCGGG
TCGGCGTGTATGTGCCCGGCGGCCTGGCACCCCTCATCAGCACGCTGATTCACACGGTGGTTCCGGCACAGGTGGCAGGC
GTGCCAGAAATCATCGTGACGACGCCACCAGGACGGGACAGCCGGGTGAATCCGGCCATCCTGGTGGCGGCGCGGGAGGT
TGGGGTGAACCGCATCTTCCGAGTAGGCGGCGCCCAGGCCATTGGCGCCTTCGCCTACGGCACCGCCAGCGTCCCTGCTG
TGGATAAAATTGCCGGGCCGGGCAACCTCTTTGTGGTGATTGCCAAGCGAATGGTCTACGGCGCGGCGGGTATCGAGAGC
CTGCCCGGCCCGACCGAGACACTGGTGGTGGCAGACGACTCTGCCGACCCGCGCTTTGTGGCGGCGGACCTGCTGGCCCA
GGCCGAACACCTGGGGGCCGAACCTGTGTTGGTGTCCACCAGCCGCGACCTGCTGGTGGAGGTGCAAAACAAGCTGAACG
GACAACTGGAAGCGCTGCCCGAACCCAACCGGAGTTGGGCGCGTGACAGCGTGCTCAGCCGCATGAAGGTGGTGCTGGCC
GCCGACCTCGCGGAGGCCCTCGACCTCGCCAACCTCTACGCCCCCGAACACCTTTGCCTGCTGACCCGCGACCCCTGGAG
CCTGCTGGGGCAGGTGCGCCGAGCAGGCGGCGTCTTTGTGGGCGAGGCGAGCATGGAGGCTCTGGGCGACTATGTGGCCG
GCCCCAGCCACGTCATGCCCACCGGCGGCACCGCCCGCTTTATGAGTCCGGTCAATGTTCGCGACTTTCAGAACATCATC
AGTGTGGTCGGCGTGAACGAGGCAGCGCTGCGCCGCATCGGCCCTCCCGCCGCCCGCCTCGCCCGCGCCGAGGGCCTAGA
AGCTCACGCCCGCGCGATCGAAAGCCGCCTGACCCCAGAGGTGCCCGAGGCGCACCCGGAGGCAACACTGAAGGTGCTGG
AGGAGGCCGCACTGGATAAGGACGGAGGACAAGGCTTAGAGCAGGTCGAGCGGGTGCGGACAACTCCCCCGGTGGATCAG
CCCCTCTCTACCCAAACCCCGCCTTCCAAGACCCGAAGGCGTAACGACTCCTAA

Upstream 100 bases:

>100_bases
GTAAACTTCAAACGGCTCCACCCAGTCCGCGCCGCCGCCCTCGCCCTTTCGTCTGGTGTTCAGCACTCACAGCTCAGCGC
CACAGCGCCTTCCTCCGGAG

Downstream 100 bases:

>100_bases
TCTCTTCTTTTTACCCCTTCGCCGCCGGAGGCTGCGTTCCTCCATCTGCCAGTTGAATCAACCACGCCATCAGCTGCACC
AACGCGAGTGCCATCGCGGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MPMQVLQGDAARAALTRSFGEIPVPESVLARIEATFGEPLTPEEVVARILADVRARGDEALLDWTEKLDGARPEALEVTR
EEIEAAQVDPALHDAIRLAAARVRAFYEQQPAHGFLDHGPDGALGQLVRPLSRVGVYVPGGLAPLISTLIHTVVPAQVAG
VPEIIVTTPPGRDSRVNPAILVAAREVGVNRIFRVGGAQAIGAFAYGTASVPAVDKIAGPGNLFVVIAKRMVYGAAGIES
LPGPTETLVVADDSADPRFVAADLLAQAEHLGAEPVLVSTSRDLLVEVQNKLNGQLEALPEPNRSWARDSVLSRMKVVLA
ADLAEALDLANLYAPEHLCLLTRDPWSLLGQVRRAGGVFVGEASMEALGDYVAGPSHVMPTGGTARFMSPVNVRDFQNII
SVVGVNEAALRRIGPPAARLARAEGLEAHARAIESRLTPEVPEAHPEATLKVLEEAALDKDGGQGLEQVERVRTTPPVDQ
PLSTQTPPSKTRRRNDS

Sequences:

>Translated_497_residues
MPMQVLQGDAARAALTRSFGEIPVPESVLARIEATFGEPLTPEEVVARILADVRARGDEALLDWTEKLDGARPEALEVTR
EEIEAAQVDPALHDAIRLAAARVRAFYEQQPAHGFLDHGPDGALGQLVRPLSRVGVYVPGGLAPLISTLIHTVVPAQVAG
VPEIIVTTPPGRDSRVNPAILVAAREVGVNRIFRVGGAQAIGAFAYGTASVPAVDKIAGPGNLFVVIAKRMVYGAAGIES
LPGPTETLVVADDSADPRFVAADLLAQAEHLGAEPVLVSTSRDLLVEVQNKLNGQLEALPEPNRSWARDSVLSRMKVVLA
ADLAEALDLANLYAPEHLCLLTRDPWSLLGQVRRAGGVFVGEASMEALGDYVAGPSHVMPTGGTARFMSPVNVRDFQNII
SVVGVNEAALRRIGPPAARLARAEGLEAHARAIESRLTPEVPEAHPEATLKVLEEAALDKDGGQGLEQVERVRTTPPVDQ
PLSTQTPPSKTRRRNDS
>Mature_496_residues
PMQVLQGDAARAALTRSFGEIPVPESVLARIEATFGEPLTPEEVVARILADVRARGDEALLDWTEKLDGARPEALEVTRE
EIEAAQVDPALHDAIRLAAARVRAFYEQQPAHGFLDHGPDGALGQLVRPLSRVGVYVPGGLAPLISTLIHTVVPAQVAGV
PEIIVTTPPGRDSRVNPAILVAAREVGVNRIFRVGGAQAIGAFAYGTASVPAVDKIAGPGNLFVVIAKRMVYGAAGIESL
PGPTETLVVADDSADPRFVAADLLAQAEHLGAEPVLVSTSRDLLVEVQNKLNGQLEALPEPNRSWARDSVLSRMKVVLAA
DLAEALDLANLYAPEHLCLLTRDPWSLLGQVRRAGGVFVGEASMEALGDYVAGPSHVMPTGGTARFMSPVNVRDFQNIIS
VVGVNEAALRRIGPPAARLARAEGLEAHARAIESRLTPEVPEAHPEATLKVLEEAALDKDGGQGLEQVERVRTTPPVDQP
LSTQTPPSKTRRRNDS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=38.4615384615385, Blast_Score=255, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6319819, Length=411, Percent_Identity=37.2262773722628, Blast_Score=244, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 52779; Mature: 52648

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMQVLQGDAARAALTRSFGEIPVPESVLARIEATFGEPLTPEEVVARILADVRARGDEA
CCCHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
LLDWTEKLDGARPEALEVTREEIEAAQVDPALHDAIRLAAARVRAFYEQQPAHGFLDHGP
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DGALGQLVRPLSRVGVYVPGGLAPLISTLIHTVVPAQVAGVPEIIVTTPPGRDSRVNPAI
CCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEE
LVAAREVGVNRIFRVGGAQAIGAFAYGTASVPAVDKIAGPGNLFVVIAKRMVYGAAGIES
EEEHHHHCHHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCCCEEHHHHHHHHHHHCCCCC
LPGPTETLVVADDSADPRFVAADLLAQAEHLGAEPVLVSTSRDLLVEVQNKLNGQLEALP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCEECCC
EPNRSWARDSVLSRMKVVLAADLAEALDLANLYAPEHLCLLTRDPWSLLGQVRRAGGVFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEE
GEASMEALGDYVAGPSHVMPTGGTARFMSPVNVRDFQNIISVVGVNEAALRRIGPPAARL
ECHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHH
ARAEGLEAHARAIESRLTPEVPEAHPEATLKVLEEAALDKDGGQGLEQVERVRTTPPVDQ
HHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
PLSTQTPPSKTRRRNDS
CCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
PMQVLQGDAARAALTRSFGEIPVPESVLARIEATFGEPLTPEEVVARILADVRARGDEA
CCHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHH
LLDWTEKLDGARPEALEVTREEIEAAQVDPALHDAIRLAAARVRAFYEQQPAHGFLDHGP
HHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DGALGQLVRPLSRVGVYVPGGLAPLISTLIHTVVPAQVAGVPEIIVTTPPGRDSRVNPAI
CCHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCEE
LVAAREVGVNRIFRVGGAQAIGAFAYGTASVPAVDKIAGPGNLFVVIAKRMVYGAAGIES
EEEHHHHCHHHHHHHCCCHHHHHHHCCCCCCCCHHHCCCCCCEEHHHHHHHHHHHCCCCC
LPGPTETLVVADDSADPRFVAADLLAQAEHLGAEPVLVSTSRDLLVEVQNKLNGQLEALP
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCCCEECCC
EPNRSWARDSVLSRMKVVLAADLAEALDLANLYAPEHLCLLTRDPWSLLGQVRRAGGVFV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCEEE
GEASMEALGDYVAGPSHVMPTGGTARFMSPVNVRDFQNIISVVGVNEAALRRIGPPAARL
ECHHHHHHHHHHCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCHHHHHHCCCHHHHH
ARAEGLEAHARAIESRLTPEVPEAHPEATLKVLEEAALDKDGGQGLEQVERVRTTPPVDQ
HHHCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCC
PLSTQTPPSKTRRRNDS
CCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]