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The map label for this gene is accC [H]

Identifier: 94984574

GI number: 94984574

Start: 480682

End: 482019

Strand: Reverse

Name: accC [H]

Synonym: Dgeo_0466

Alternate gene names: 94984574

Gene position: 482019-480682 (Counterclockwise)

Preceding gene: 94984575

Following gene: 94984571

Centisome position: 19.54

GC content: 63.23

Gene sequence:

>1338_bases
GTGTTCAAGAAAATCCTGATCGCCAACCGGGGTGAGATCGCCCTGCGCGTGATTCGCACGGCACGCGAGATGGGCGTGAA
GACGGTGGTGGTGTACTCCACCGCCGACGAGAAAAGCTTGCCGGTGCTGCTGGCCGACGAATCGGTGTGTGTGGGGCCGC
CCGCCAGCAATGCCAGTTATTTGAATATTCCCAACATCCTCTCGGCGGCGCTGATGACCGGAGCAGAGGCGATTCACCCC
GGCTACGGCTTCCTGGCCGAGAACCCCAACTTTGCCGAGATGTGCCGCGAACACGGCCTGGTCTTCATTGGGCCGACACC
GGAATCGATGCACGCGCTGGGCTCGAAGGCAGGCGGGCGCGCGATCGCCGCGCAGAGCAACGTGCCGGTGGTCCCCGGCA
CCGGCGTGCTGGAGGACGTGGATGCCGCGCTGCTGGCCGCCAAGCAGATCGGCTATCCGGTGCTGCTCAAGGCGTCGGCA
GGGGGTGGCGGGCGCGGCCAGAAGGTGGTTCGCACCCAAGAGGAGCTGCGCAGCGCCTTCGGGCAGGCGCAGGAGGAAGC
GCGGCTGTACTTCGGTGACCCCGCCATCATCATGGAGAAGTTCCTGGAAGAGTTCCGGCACGTCGAGGTCCAGGTGATGG
GCGACGGCCAGGGCCACGTGATCCACATTGGGGAGCGCGACTGCTCGATCCAGCGCCGCAACCAGAAGCTGATCGAAGAG
GCCCCCTCTACCCTGCCCGAGTCGCTGCGGCAAGAGATCCTGGCGGCGGGCGTGCGCCTTGCCAAGCACGTCCACTACGC
CGGAGCGGGCACGCTGGAATTCATCGTGGACCGCGACGGGAACTACTACTTCATGGAGATGAACACCCGCATCCAGGTCG
AGCACTGCGTCAGCGAGATGATCTCTGGCCTGGACTTCGTGAAGCTGCAACTCCAGATTGCGGCGGGTGAGGGACTCCAT
CTCCAGCAGGAGGACATCAAGCTGCGCGGGCACGCCATCGAGTGCCGCATCAACGCCGAAGATCCCGACAAGGATTTCCG
CCCAGCAGCAGGCAAAATCGACGACGTACATTTCGCAGGTGGACCCGGCGTGCGCGTGGATTCGCATGCCTACAGTGGCT
ACGTCATTCCGCCGCACTACGACTCCCTGATCGGCAAATTGATCGTCCATCACGACACCCGTGAGGAGGCCATCGCCCGG
ATGAAGCGGGCACTGGAAGAAACCGTGATTCAGGGGCCAAAAACGACCATCCCGCTCTATATCCGGATCATGGACAATCC
CTTCTACAAGCGTGGTGCCGTGCTGACCAACTTCCTCAAAACCCGGCTGGAAGTCTGA

Upstream 100 bases:

>100_bases
TCATCATCGAATGAGCCGTCAGCCTTCAGTGGTCAGCGCTGAGCAGCAAAAGCTGCGGTGACCGCTGGGGGTGACAGCTG
AAAGCTGAGGACTGAGAGCT

Downstream 100 bases:

>100_bases
CACTTAAGCCGGCCCAAGATGACCCTCTGCAGCTGGGCGTAGAGGGAACTTGAGCGGACAGAGCGCGGTTGGTGACGCGA
GCCGCCGCGGGTCTAGCCCA

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MFKKILIANRGEIALRVIRTAREMGVKTVVVYSTADEKSLPVLLADESVCVGPPASNASYLNIPNILSAALMTGAEAIHP
GYGFLAENPNFAEMCREHGLVFIGPTPESMHALGSKAGGRAIAAQSNVPVVPGTGVLEDVDAALLAAKQIGYPVLLKASA
GGGGRGQKVVRTQEELRSAFGQAQEEARLYFGDPAIIMEKFLEEFRHVEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE
APSTLPESLRQEILAAGVRLAKHVHYAGAGTLEFIVDRDGNYYFMEMNTRIQVEHCVSEMISGLDFVKLQLQIAAGEGLH
LQQEDIKLRGHAIECRINAEDPDKDFRPAAGKIDDVHFAGGPGVRVDSHAYSGYVIPPHYDSLIGKLIVHHDTREEAIAR
MKRALEETVIQGPKTTIPLYIRIMDNPFYKRGAVLTNFLKTRLEV

Sequences:

>Translated_445_residues
MFKKILIANRGEIALRVIRTAREMGVKTVVVYSTADEKSLPVLLADESVCVGPPASNASYLNIPNILSAALMTGAEAIHP
GYGFLAENPNFAEMCREHGLVFIGPTPESMHALGSKAGGRAIAAQSNVPVVPGTGVLEDVDAALLAAKQIGYPVLLKASA
GGGGRGQKVVRTQEELRSAFGQAQEEARLYFGDPAIIMEKFLEEFRHVEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE
APSTLPESLRQEILAAGVRLAKHVHYAGAGTLEFIVDRDGNYYFMEMNTRIQVEHCVSEMISGLDFVKLQLQIAAGEGLH
LQQEDIKLRGHAIECRINAEDPDKDFRPAAGKIDDVHFAGGPGVRVDSHAYSGYVIPPHYDSLIGKLIVHHDTREEAIAR
MKRALEETVIQGPKTTIPLYIRIMDNPFYKRGAVLTNFLKTRLEV
>Mature_445_residues
MFKKILIANRGEIALRVIRTAREMGVKTVVVYSTADEKSLPVLLADESVCVGPPASNASYLNIPNILSAALMTGAEAIHP
GYGFLAENPNFAEMCREHGLVFIGPTPESMHALGSKAGGRAIAAQSNVPVVPGTGVLEDVDAALLAAKQIGYPVLLKASA
GGGGRGQKVVRTQEELRSAFGQAQEEARLYFGDPAIIMEKFLEEFRHVEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE
APSTLPESLRQEILAAGVRLAKHVHYAGAGTLEFIVDRDGNYYFMEMNTRIQVEHCVSEMISGLDFVKLQLQIAAGEGLH
LQQEDIKLRGHAIECRINAEDPDKDFRPAAGKIDDVHFAGGPGVRVDSHAYSGYVIPPHYDSLIGKLIVHHDTREEAIAR
MKRALEETVIQGPKTTIPLYIRIMDNPFYKRGAVLTNFLKTRLEV

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=441, Percent_Identity=46.2585034013605, Blast_Score=406, Evalue=1e-113,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=46.0674157303371, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI295821183, Length=445, Percent_Identity=46.0674157303371, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI65506442, Length=445, Percent_Identity=46.0674157303371, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049528, Length=450, Percent_Identity=43.5555555555556, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049295, Length=450, Percent_Identity=43.5555555555556, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI106049292, Length=450, Percent_Identity=43.5555555555556, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI38679960, Length=502, Percent_Identity=31.4741035856574, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI38679971, Length=502, Percent_Identity=31.4741035856574, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI38679974, Length=502, Percent_Identity=31.4741035856574, Blast_Score=255, Evalue=7e-68,
Organism=Homo sapiens, GI38679977, Length=502, Percent_Identity=31.4741035856574, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI38679967, Length=502, Percent_Identity=31.4741035856574, Blast_Score=254, Evalue=9e-68,
Organism=Homo sapiens, GI134142062, Length=503, Percent_Identity=32.0079522862823, Blast_Score=254, Evalue=2e-67,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=52.7964205816555, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17562816, Length=453, Percent_Identity=46.3576158940397, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI71987519, Length=440, Percent_Identity=46.8181818181818, Blast_Score=382, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=45.9276018099548, Blast_Score=370, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI71997168, Length=511, Percent_Identity=30.1369863013699, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71997163, Length=511, Percent_Identity=30.1369863013699, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI133931226, Length=492, Percent_Identity=31.3008130081301, Blast_Score=204, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.7607223476298, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=44.6188340807175, Blast_Score=359, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=45.7399103139013, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6323863, Length=485, Percent_Identity=32.9896907216495, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=510, Percent_Identity=31.7647058823529, Blast_Score=226, Evalue=7e-60,
Organism=Drosophila melanogaster, GI24651757, Length=449, Percent_Identity=44.988864142539, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI281363050, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652224, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652222, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652220, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652218, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652212, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652210, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652214, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI19921944, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24652216, Length=446, Percent_Identity=44.6188340807175, Blast_Score=368, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=42.7872860635697, Blast_Score=325, Evalue=4e-89,
Organism=Drosophila melanogaster, GI161076409, Length=498, Percent_Identity=32.3293172690763, Blast_Score=247, Evalue=9e-66,
Organism=Drosophila melanogaster, GI24586458, Length=498, Percent_Identity=32.3293172690763, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI161076407, Length=498, Percent_Identity=32.3293172690763, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI24586460, Length=498, Percent_Identity=32.3293172690763, Blast_Score=247, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 48702; Mature: 48702

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKILIANRGEIALRVIRTAREMGVKTVVVYSTADEKSLPVLLADESVCVGPPASNASY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCEEECCCCCCCCE
LNIPNILSAALMTGAEAIHPGYGFLAENPNFAEMCREHGLVFIGPTPESMHALGSKAGGR
ECCHHHHHHHHHHCHHHCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHHCCCCCCC
AIAAQSNVPVVPGTGVLEDVDAALLAAKQIGYPVLLKASAGGGGRGQKVVRTQEELRSAF
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
GQAQEEARLYFGDPAIIMEKFLEEFRHVEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE
CCCHHCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHH
APSTLPESLRQEILAAGVRLAKHVHYAGAGTLEFIVDRDGNYYFMEMNTRIQVEHCVSEM
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEHHHHHHHH
ISGLDFVKLQLQIAAGEGLHLQQEDIKLRGHAIECRINAEDPDKDFRPAAGKIDDVHFAG
HCCCEEEEEEEEEECCCCCEEECCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCEEECC
GPGVRVDSHAYSGYVIPPHYDSLIGKLIVHHDTREEAIARMKRALEETVIQGPKTTIPLY
CCCCEECCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
IRIMDNPFYKRGAVLTNFLKTRLEV
EEEECCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFKKILIANRGEIALRVIRTAREMGVKTVVVYSTADEKSLPVLLADESVCVGPPASNASY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCEEECCCCCCCCE
LNIPNILSAALMTGAEAIHPGYGFLAENPNFAEMCREHGLVFIGPTPESMHALGSKAGGR
ECCHHHHHHHHHHCHHHCCCCCCEECCCCCHHHHHHHCCEEEECCCCHHHHHHCCCCCCC
AIAAQSNVPVVPGTGVLEDVDAALLAAKQIGYPVLLKASAGGGGRGQKVVRTQEELRSAF
EEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHH
GQAQEEARLYFGDPAIIMEKFLEEFRHVEVQVMGDGQGHVIHIGERDCSIQRRNQKLIEE
CCCHHCCEEEECCHHHHHHHHHHHHCCEEEEEEECCCCCEEEECCCCCCHHHHHHHHHHH
APSTLPESLRQEILAAGVRLAKHVHYAGAGTLEFIVDRDGNYYFMEMNTRIQVEHCVSEM
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCEEEHHHHHHHH
ISGLDFVKLQLQIAAGEGLHLQQEDIKLRGHAIECRINAEDPDKDFRPAAGKIDDVHFAG
HCCCEEEEEEEEEECCCCCEEECCCCEEECEEEEEEECCCCCCCCCCCCCCCCCCEEECC
GPGVRVDSHAYSGYVIPPHYDSLIGKLIVHHDTREEAIARMKRALEETVIQGPKTTIPLY
CCCCEECCCCCCCEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEE
IRIMDNPFYKRGAVLTNFLKTRLEV
EEEECCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]