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The map label for this gene is rocF [H]

Identifier: 94984400

GI number: 94984400

Start: 284614

End: 285513

Strand: Reverse

Name: rocF [H]

Synonym: Dgeo_0292

Alternate gene names: 94984400

Gene position: 285513-284614 (Counterclockwise)

Preceding gene: 94984403

Following gene: 94984399

Centisome position: 11.57

GC content: 68.0

Gene sequence:

>900_bases
ATGAACGTGCATATTCTGGGGATTCCGATGGACCTGGGCGCTGGACGGCGCGGTGTCGATATGGGGCCGTCGGCCCTGCG
CAACGCGCACCTGGCCGCTCGGCTGCGTGAACTGGGACACACGGTCCACGACCGAGGAGACGTGGATGTGGCCCTGCCAG
AAACGCTGGACAAACATGCGAGCGCGGGGCTGGTGTTCCTCGAACCAATTCTGGAAGCCTGCCGCAGTGCAGCCGAACGC
CTTGCGGCGCTGCCGGGGGACGTGTTTCCCATCACGCTGGGCGGTGATCACTCGGTCAGCATGGGCACCGTTACCGGCAA
TGCGCGGCGCGGAAACTCGGCGGGCGAACGCACCGGCCTGATCTGGGTGGACGCCCACACCGACTACAACACGCCGGAGA
GTAGCCCCAGCGGCAACATTCACGGAATGCCGGTCGCGCACCTCACCGGCTTGGGCGACCCCGCGCTCGCCGGGCTGGGT
GACGGTTGGCATCTGCGGCCCGAGGACATCGTGATGATCGGCATCCGCAGCGTGGACGCCCGCGAGCGCGACCTGCTGCG
CGCGGCAGGGATCAAGGCATACACCATGAAGGAGGTGGACCAGCTCGGCATCACCCGCATCACCGAGGAGACGCTGGAGC
GCCTCGGCGACGTCACGCGGCTGCACGTCTCCTTCGACGCGGACGCCCTCGACCCCAGCGTGGCGCCCGGCGTGGGCACC
CCGGTTCCCGGCGGTCTGACCTACCGCGAGGGGCACCTGCTGATGGAGCTGCTGAGCGAGTCGGGCCGGGTGACCAGCCT
TGATATCGTGGAGGTGAATCCCGTCCTGGACACCCGCAACCAGACCGCCGAGGTGATGGTGGGCATGGCCGCGAGCCTGC
TGGGACAGCGGATTCTGTAG

Upstream 100 bases:

>100_bases
ATATTCAGCTGTATAACAGCCCAGCGTGCCCTCCGCCGGAGACAGGTCATATTCTTGCAAGGCTGAGGCATAGGGGCTTT
TCAGCCCTACGCTGGGGAGC

Downstream 100 bases:

>100_bases
GCCCTGAGCCATCCCAAACGCGGTGCGGCTTCAGGACACCGGTCCGCAAGGACGCGGAGGAGCAGCCAGCAGCGCCCCGG
CAGATGCGTCGCTGCTTTCA

Product: arginase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNVHILGIPMDLGAGRRGVDMGPSALRNAHLAARLRELGHTVHDRGDVDVALPETLDKHASAGLVFLEPILEACRSAAER
LAALPGDVFPITLGGDHSVSMGTVTGNARRGNSAGERTGLIWVDAHTDYNTPESSPSGNIHGMPVAHLTGLGDPALAGLG
DGWHLRPEDIVMIGIRSVDARERDLLRAAGIKAYTMKEVDQLGITRITEETLERLGDVTRLHVSFDADALDPSVAPGVGT
PVPGGLTYREGHLLMELLSESGRVTSLDIVEVNPVLDTRNQTAEVMVGMAASLLGQRIL

Sequences:

>Translated_299_residues
MNVHILGIPMDLGAGRRGVDMGPSALRNAHLAARLRELGHTVHDRGDVDVALPETLDKHASAGLVFLEPILEACRSAAER
LAALPGDVFPITLGGDHSVSMGTVTGNARRGNSAGERTGLIWVDAHTDYNTPESSPSGNIHGMPVAHLTGLGDPALAGLG
DGWHLRPEDIVMIGIRSVDARERDLLRAAGIKAYTMKEVDQLGITRITEETLERLGDVTRLHVSFDADALDPSVAPGVGT
PVPGGLTYREGHLLMELLSESGRVTSLDIVEVNPVLDTRNQTAEVMVGMAASLLGQRIL
>Mature_299_residues
MNVHILGIPMDLGAGRRGVDMGPSALRNAHLAARLRELGHTVHDRGDVDVALPETLDKHASAGLVFLEPILEACRSAAER
LAALPGDVFPITLGGDHSVSMGTVTGNARRGNSAGERTGLIWVDAHTDYNTPESSPSGNIHGMPVAHLTGLGDPALAGLG
DGWHLRPEDIVMIGIRSVDARERDLLRAAGIKAYTMKEVDQLGITRITEETLERLGDVTRLHVSFDADALDPSVAPGVGT
PVPGGLTYREGHLLMELLSESGRVTSLDIVEVNPVLDTRNQTAEVMVGMAASLLGQRIL

Specific function: Controls arginine catabolism [H]

COG id: COG0010

COG function: function code E; Arginase/agmatinase/formimionoglutamate hydrolase, arginase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arginase family [H]

Homologues:

Organism=Homo sapiens, GI4502215, Length=307, Percent_Identity=39.413680781759, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI10947139, Length=303, Percent_Identity=39.9339933993399, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI37537722, Length=312, Percent_Identity=27.5641025641026, Blast_Score=78, Evalue=1e-14,
Organism=Escherichia coli, GI1789306, Length=278, Percent_Identity=26.978417266187, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71996843, Length=237, Percent_Identity=37.5527426160338, Blast_Score=135, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6325146, Length=317, Percent_Identity=34.7003154574132, Blast_Score=162, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24638886, Length=315, Percent_Identity=34.2857142857143, Blast_Score=163, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014033
- InterPro:   IPR006035
- InterPro:   IPR020855 [H]

Pfam domain/function: PF00491 Arginase [H]

EC number: =3.5.3.1 [H]

Molecular weight: Translated: 31689; Mature: 31689

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00147 ARGINASE_1 ; PS00148 ARGINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVHILGIPMDLGAGRRGVDMGPSALRNAHLAARLRELGHTVHDRGDVDVALPETLDKHA
CEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
SAGLVFLEPILEACRSAAERLAALPGDVFPITLGGDHSVSMGTVTGNARRGNSAGERTGL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCE
IWVDAHTDYNTPESSPSGNIHGMPVAHLTGLGDPALAGLGDGWHLRPEDIVMIGIRSVDA
EEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCC
RERDLLRAAGIKAYTMKEVDQLGITRITEETLERLGDVTRLHVSFDADALDPSVAPGVGT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCC
PVPGGLTYREGHLLMELLSESGRVTSLDIVEVNPVLDTRNQTAEVMVGMAASLLGQRIL
CCCCCCEEECHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNVHILGIPMDLGAGRRGVDMGPSALRNAHLAARLRELGHTVHDRGDVDVALPETLDKHA
CEEEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHH
SAGLVFLEPILEACRSAAERLAALPGDVFPITLGGDHSVSMGTVTGNARRGNSAGERTGL
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCE
IWVDAHTDYNTPESSPSGNIHGMPVAHLTGLGDPALAGLGDGWHLRPEDIVMIGIRSVDA
EEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHCCCCCCCCCCCCEEEEEEECCCC
RERDLLRAAGIKAYTMKEVDQLGITRITEETLERLGDVTRLHVSFDADALDPSVAPGVGT
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCCCCCCCCC
PVPGGLTYREGHLLMELLSESGRVTSLDIVEVNPVLDTRNQTAEVMVGMAASLLGQRIL
CCCCCCEEECHHHHHHHHHCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8647285; 10196128 [H]