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The map label for this gene is cvrA [H]

Identifier: 94984330

GI number: 94984330

Start: 205968

End: 207467

Strand: Reverse

Name: cvrA [H]

Synonym: Dgeo_0222

Alternate gene names: 94984330

Gene position: 207467-205968 (Counterclockwise)

Preceding gene: 94984334

Following gene: 94984329

Centisome position: 8.41

GC content: 66.07

Gene sequence:

>1500_bases
ATGGGTGAGGTTCACGCGGAAGTTTATCTGCTCGCGGCAGGCGTCCTGCTGCTGGCGAGCCTGGTGGTGAGCCGTCTGGG
TGGGCGGCTGGGCATTCCGGGGCTGCTGCTGTTTCTGGGGGTAGGGATGGCGGCAGGTTCAGACGGGCTGGGTATCCAGT
TCAGTGATTACCGCTTTGCCCAAGCACTCGGCACGGTTGCGCTGTGTTTTATCCTCTTTCAGGGCGGCCTGACCACCAAC
TGGCGCGAAACGCGGCCTGTCATTTGGCGTGGCCTGAGTTTGGCAACCCTGGGCGTGCTGCTGACTGCGGGCGTGATGGC
GGCCTTTGCGCACTTCCTGCTGGCGTGGCCTTGGCTGGCGGCCTGGATGCTGGGTGCCGTGGTGAGCAGCACCGACGCCA
GCGCGGTCTTTTCGGTGCTCAAGGAACGCGCGCTGGGCCTTAGGGGAGACATCGCTCCGCTGCTGGAGTTTGAGTCGGGC
GGCAACGACCCGATGGCGGTCTTTCTGACTGTCGGGATTCTCGAACTGATCGCCCACCCCGGCATGAGCGTGCTGGAGAT
CGTTCCGCTGTTTTTGCGGCAGATGCTGCTGGGGGCGCTGCTGGGTGCCGGACTGGGCCACGCGGCGCTGTGGGTGCTCA
ACCGGCTGCAACTCCAGTTCGAGGGGCTGTACTCGGTCCTCAGCCTGGCGCTGGCCCTCACCATCTTCAGCGCCACCGCT
GTCGCGGGGGGCAGCGGCTTTCTGGCGATCTACATCGCGGGGGTGATCCTGGGCAATGCGGACTTCATCCACAAGCGCAG
CCTGCTCGCCTTTCACGACGTCCTGGCTTGGTTGATGCAGGTGGTGATGTTCCTCACGCTGGGGTTGCTGGTCAATCCAC
ACGAACTGTGGCCGGTCGCCGGGCTGGGCCTATCCTTTGCGCTGGTGCTGGCGTTTGTGGCGCGGCCGCTGGCGGTGTAT
CTCGGCCTGGCGGGGTCCCCTATGCCGCTCAACCAGAAGACGATGGTGGCCTGGGTCGGCCTGCGCGGCGCGGTGCCGAT
CGTGCTGGCGACCTTTCCGCTGCTGGCGGGGGTGCCCCAGGCGCACACGCTGTTCAACGTGGTGTTCTTCATCGTCCTGA
CCAGCGTGCTGCTCCAGGGCACCACCCTGCCCCTGGTGGCAACCTGGCTGGGCGTGCGCGAGCCTCTGCCTCTGCCGGCG
GCCAACCCTATCAGCTACACCCCCACCGGGCATAGCCGCAACGCGCTGGTAGAGATCGAGGTCCAACAGGGCAGCGACGC
CGACGGACAGCGCATCGTGGACCTGCACCTGCCTCCGGACGCTCTGGTGATCCTGATTCACCGCGGCGGCGAGTTCCTGA
TTCCCAAGGGCGCGACCCGGCTGGAGGCCGGCGATAGCCTGCAGGTGCTGGCCCGTGAGGACGAGCTGCGCGAGGTGCGG
CGGCGACTGGAAGTGAAGGGCAACTTGGAACACCATAACGTGGAACACCGCACAGGGTGA

Upstream 100 bases:

>100_bases
GCGAAGGTGTACCGGCCCGGGGCGTCATGCCCTCCAGGGTAAAGGGCCAAGAAGGGGGGGTCAAGCCGGGTCGTCCCCCA
CTCTGTGAAACCATAGGCCG

Downstream 100 bases:

>100_bases
GGCGTTTCGCCCGCGCCCGTCCCCACTGCTGAGACAGCCCCCCTGCCGCCCCCCGGCGCGGGTGTTACCGTACCCCCATG
ACCACCGCCGAGCCATCCAA

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 499; Mature: 498

Protein sequence:

>499_residues
MGEVHAEVYLLAAGVLLLASLVVSRLGGRLGIPGLLLFLGVGMAAGSDGLGIQFSDYRFAQALGTVALCFILFQGGLTTN
WRETRPVIWRGLSLATLGVLLTAGVMAAFAHFLLAWPWLAAWMLGAVVSSTDASAVFSVLKERALGLRGDIAPLLEFESG
GNDPMAVFLTVGILELIAHPGMSVLEIVPLFLRQMLLGALLGAGLGHAALWVLNRLQLQFEGLYSVLSLALALTIFSATA
VAGGSGFLAIYIAGVILGNADFIHKRSLLAFHDVLAWLMQVVMFLTLGLLVNPHELWPVAGLGLSFALVLAFVARPLAVY
LGLAGSPMPLNQKTMVAWVGLRGAVPIVLATFPLLAGVPQAHTLFNVVFFIVLTSVLLQGTTLPLVATWLGVREPLPLPA
ANPISYTPTGHSRNALVEIEVQQGSDADGQRIVDLHLPPDALVILIHRGGEFLIPKGATRLEAGDSLQVLAREDELREVR
RRLEVKGNLEHHNVEHRTG

Sequences:

>Translated_499_residues
MGEVHAEVYLLAAGVLLLASLVVSRLGGRLGIPGLLLFLGVGMAAGSDGLGIQFSDYRFAQALGTVALCFILFQGGLTTN
WRETRPVIWRGLSLATLGVLLTAGVMAAFAHFLLAWPWLAAWMLGAVVSSTDASAVFSVLKERALGLRGDIAPLLEFESG
GNDPMAVFLTVGILELIAHPGMSVLEIVPLFLRQMLLGALLGAGLGHAALWVLNRLQLQFEGLYSVLSLALALTIFSATA
VAGGSGFLAIYIAGVILGNADFIHKRSLLAFHDVLAWLMQVVMFLTLGLLVNPHELWPVAGLGLSFALVLAFVARPLAVY
LGLAGSPMPLNQKTMVAWVGLRGAVPIVLATFPLLAGVPQAHTLFNVVFFIVLTSVLLQGTTLPLVATWLGVREPLPLPA
ANPISYTPTGHSRNALVEIEVQQGSDADGQRIVDLHLPPDALVILIHRGGEFLIPKGATRLEAGDSLQVLAREDELREVR
RRLEVKGNLEHHNVEHRTG
>Mature_498_residues
GEVHAEVYLLAAGVLLLASLVVSRLGGRLGIPGLLLFLGVGMAAGSDGLGIQFSDYRFAQALGTVALCFILFQGGLTTNW
RETRPVIWRGLSLATLGVLLTAGVMAAFAHFLLAWPWLAAWMLGAVVSSTDASAVFSVLKERALGLRGDIAPLLEFESGG
NDPMAVFLTVGILELIAHPGMSVLEIVPLFLRQMLLGALLGAGLGHAALWVLNRLQLQFEGLYSVLSLALALTIFSATAV
AGGSGFLAIYIAGVILGNADFIHKRSLLAFHDVLAWLMQVVMFLTLGLLVNPHELWPVAGLGLSFALVLAFVARPLAVYL
GLAGSPMPLNQKTMVAWVGLRGAVPIVLATFPLLAGVPQAHTLFNVVFFIVLTSVLLQGTTLPLVATWLGVREPLPLPAA
NPISYTPTGHSRNALVEIEVQQGSDADGQRIVDLHLPPDALVILIHRGGEFLIPKGATRLEAGDSLQVLAREDELREVRR
RLEVKGNLEHHNVEHRTG

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=452, Percent_Identity=41.8141592920354, Blast_Score=274, Evalue=8e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018421
- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 53193; Mature: 53061

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVHAEVYLLAAGVLLLASLVVSRLGGRLGIPGLLLFLGVGMAAGSDGLGIQFSDYRFA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCHHHH
QALGTVALCFILFQGGLTTNWRETRPVIWRGLSLATLGVLLTAGVMAAFAHFLLAWPWLA
HHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWMLGAVVSSTDASAVFSVLKERALGLRGDIAPLLEFESGGNDPMAVFLTVGILELIAHP
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHCC
GMSVLEIVPLFLRQMLLGALLGAGLGHAALWVLNRLQLQFEGLYSVLSLALALTIFSATA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGGSGFLAIYIAGVILGNADFIHKRSLLAFHDVLAWLMQVVMFLTLGLLVNPHELWPVA
HCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHH
GLGLSFALVLAFVARPLAVYLGLAGSPMPLNQKTMVAWVGLRGAVPIVLATFPLLAGVPQ
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCH
AHTLFNVVFFIVLTSVLLQGTTLPLVATWLGVREPLPLPAANPISYTPTGHSRNALVEIE
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEE
VQQGSDADGQRIVDLHLPPDALVILIHRGGEFLIPKGATRLEAGDSLQVLAREDELREVR
EECCCCCCCCEEEEEECCCCEEEEEEECCCCEEECCCCCCCCCCCCHHHHHCHHHHHHHH
RRLEVKGNLEHHNVEHRTG
HHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
GEVHAEVYLLAAGVLLLASLVVSRLGGRLGIPGLLLFLGVGMAAGSDGLGIQFSDYRFA
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCEEECCHHHH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HHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA