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The map label for this gene is glyA

Identifier: 94984329

GI number: 94984329

Start: 204652

End: 205890

Strand: Reverse

Name: glyA

Synonym: Dgeo_0221

Alternate gene names: 94984329

Gene position: 205890-204652 (Counterclockwise)

Preceding gene: 94984330

Following gene: 94984328

Centisome position: 8.35

GC content: 65.46

Gene sequence:

>1239_bases
ATGACCACCGCCGAGCCATCCAAGACCGTGCAGGCTGCCTTCCGGGACACGGCCATCTTCGACCTGATCGCGCAGGAGGC
AGAGCGCCAGCGCGTAGGGCTAGAGCTGATCGCCTCCGAAAACTTTTGTAGCGCCGAGGTGCGTGCCGCGCAGGGCAGCG
TCCTGACCAACAAGTATGCGGAGGGCTATCCCGGCAAGCGCTGGTACGGCGGCTGCGAGGTCGTGGACGAGGTGGAACGC
CTCGCCATCGAGCGGGTCAAGCAGCTCTTCGGCGCCGAGTGGGCCAACGTGCAGCCGCACTCCGGCTCGAGCGCCAATCT
GGCTGTCTACAACGCGCTGCTGGAACCCGGCGACACTGTGCTGGGCATGGACCTCGCACATGGCGGCCACCTGACCCACG
GCAGCCCGGTGAACTTTTCGGGCCTGCGTTACCGGGTGGTGGGCTACAAGGTCAACCCCGAGACGGAATTGATCGATATG
GAGGAGGTGCGCCGCCTCGCTCATGAACACCAACCGAAGATGATCATCGCGGGGGCGAGCGCCTACAGCCGCATCATCGA
CTTCGCGGCCTTCCGTGAGATCGCGGATGAGGTGGGCGCGCTGCTGTTTGCGGACATCGCCCATATCGCGGGCCTGATCG
CGGCGGGACTGCATCCCAATGCGCTGCCGCACGCGCACGTGGTCGCCAGCACCACCCACAAAACCCTGAGAGGCCCGCGC
GGCGGGGTCATCCTCAGCAATGATCCCGAAATCGGCGCGAAGATCGACCGGGCTGTTTTCCCCGGTTATCAGGGCGGACC
GCTCGAACACGTGATCGCCGCCAAAGCCGTCGCCTTTGGGGAAGCCCTCCAGCCCGAATTCAAGGACTATGCTGCGCAGA
TCATCCGGAATGCGCAGGCGCTCGCCGGAGCCTTCCAGAACCGCGGCTACCGCGTGGTCTCGGGCGGGACCGACAATCAC
CTCTTCGTGCTCGACCTGCGCCCGCAGGGGCTGAACGGGACCAAGGCCACTCGGCGCCTCGACGCCAACGACATCACCAT
CAGCAAGTCCACCCTCCCCTACGACACCGAAAAGATCCTGCACGGCGGCGGTATCCGCATCGGGACACCGGCGATCACCA
CCCGCGGAATGAAAGAGGCGGACATGGAACGGGTGGCGGACCTGATCGACCGCGCGCTCAAGGGTGAGGACGTCAAAGCC
GAGGTCCACGCCTTTGCGGGCAGCTTTCCTCTGCCCTGA

Upstream 100 bases:

>100_bases
ACGTGGAACACCGCACAGGGTGAGGCGTTTCGCCCGCGCCCGTCCCCACTGCTGAGACAGCCCCCCTGCCGCCCCCCGGC
GCGGGTGTTACCGTACCCCC

Downstream 100 bases:

>100_bases
GCGGGGCTGCCTTCCCACGCCGCCCCATGGGGCCTTGCGCTGCCAGAACTCTGTGAGGTTTCTCGCGTTAAGCTGCCCTT
AATGACCGCCATCTCCCGTG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTTAEPSKTVQAAFRDTAIFDLIAQEAERQRVGLELIASENFCSAEVRAAQGSVLTNKYAEGYPGKRWYGGCEVVDEVER
LAIERVKQLFGAEWANVQPHSGSSANLAVYNALLEPGDTVLGMDLAHGGHLTHGSPVNFSGLRYRVVGYKVNPETELIDM
EEVRRLAHEHQPKMIIAGASAYSRIIDFAAFREIADEVGALLFADIAHIAGLIAAGLHPNALPHAHVVASTTHKTLRGPR
GGVILSNDPEIGAKIDRAVFPGYQGGPLEHVIAAKAVAFGEALQPEFKDYAAQIIRNAQALAGAFQNRGYRVVSGGTDNH
LFVLDLRPQGLNGTKATRRLDANDITISKSTLPYDTEKILHGGGIRIGTPAITTRGMKEADMERVADLIDRALKGEDVKA
EVHAFAGSFPLP

Sequences:

>Translated_412_residues
MTTAEPSKTVQAAFRDTAIFDLIAQEAERQRVGLELIASENFCSAEVRAAQGSVLTNKYAEGYPGKRWYGGCEVVDEVER
LAIERVKQLFGAEWANVQPHSGSSANLAVYNALLEPGDTVLGMDLAHGGHLTHGSPVNFSGLRYRVVGYKVNPETELIDM
EEVRRLAHEHQPKMIIAGASAYSRIIDFAAFREIADEVGALLFADIAHIAGLIAAGLHPNALPHAHVVASTTHKTLRGPR
GGVILSNDPEIGAKIDRAVFPGYQGGPLEHVIAAKAVAFGEALQPEFKDYAAQIIRNAQALAGAFQNRGYRVVSGGTDNH
LFVLDLRPQGLNGTKATRRLDANDITISKSTLPYDTEKILHGGGIRIGTPAITTRGMKEADMERVADLIDRALKGEDVKA
EVHAFAGSFPLP
>Mature_411_residues
TTAEPSKTVQAAFRDTAIFDLIAQEAERQRVGLELIASENFCSAEVRAAQGSVLTNKYAEGYPGKRWYGGCEVVDEVERL
AIERVKQLFGAEWANVQPHSGSSANLAVYNALLEPGDTVLGMDLAHGGHLTHGSPVNFSGLRYRVVGYKVNPETELIDME
EVRRLAHEHQPKMIIAGASAYSRIIDFAAFREIADEVGALLFADIAHIAGLIAAGLHPNALPHAHVVASTTHKTLRGPRG
GVILSNDPEIGAKIDRAVFPGYQGGPLEHVIAAKAVAFGEALQPEFKDYAAQIIRNAQALAGAFQNRGYRVVSGGTDNHL
FVLDLRPQGLNGTKATRRLDANDITISKSTLPYDTEKILHGGGIRIGTPAITTRGMKEADMERVADLIDRALKGEDVKAE
VHAFAGSFPLP

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=411, Percent_Identity=49.3917274939173, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI261862352, Length=411, Percent_Identity=49.3917274939173, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI261862350, Length=411, Percent_Identity=49.3917274939173, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI261862348, Length=411, Percent_Identity=49.3917274939173, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI261862346, Length=411, Percent_Identity=48.1751824817518, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI22547186, Length=450, Percent_Identity=44.6666666666667, Blast_Score=347, Evalue=2e-95,
Organism=Homo sapiens, GI22547189, Length=436, Percent_Identity=42.6605504587156, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1788902, Length=405, Percent_Identity=57.037037037037, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI25144732, Length=396, Percent_Identity=46.2121212121212, Blast_Score=347, Evalue=5e-96,
Organism=Caenorhabditis elegans, GI25144729, Length=401, Percent_Identity=45.6359102244389, Blast_Score=347, Evalue=8e-96,
Organism=Saccharomyces cerevisiae, GI6319739, Length=409, Percent_Identity=44.0097799511002, Blast_Score=342, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=448, Percent_Identity=40.8482142857143, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI24640005, Length=415, Percent_Identity=47.2289156626506, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI221329721, Length=415, Percent_Identity=47.2289156626506, Blast_Score=370, Evalue=1e-102,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_DEIGD (Q1J1W0)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_603693.1
- ProteinModelPortal:   Q1J1W0
- SMR:   Q1J1W0
- STRING:   Q1J1W0
- GeneID:   4059129
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0221
- NMPDR:   fig|68909.1.peg.1166
- eggNOG:   COG0112
- HOGENOM:   HBG301263
- OMA:   RAVFPGY
- PhylomeDB:   Q1J1W0
- ProtClustDB:   PRK00011
- BioCyc:   DGEO319795:DGEO_0221-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 44368; Mature: 44237

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAEPSKTVQAAFRDTAIFDLIAQEAERQRVGLELIASENFCSAEVRAAQGSVLTNKYA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCCHHHHHHH
EGYPGKRWYGGCEVVDEVERLAIERVKQLFGAEWANVQPHSGSSANLAVYNALLEPGDTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
LGMDLAHGGHLTHGSPVNFSGLRYRVVGYKVNPETELIDMEEVRRLAHEHQPKMIIAGAS
EEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEECHHHHHHHHHHCCCCEEEECCH
AYSRIIDFAAFREIADEVGALLFADIAHIAGLIAAGLHPNALPHAHVVASTTHKTLRGPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHCCCC
GGVILSNDPEIGAKIDRAVFPGYQGGPLEHVIAAKAVAFGEALQPEFKDYAAQIIRNAQA
CCEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LAGAFQNRGYRVVSGGTDNHLFVLDLRPQGLNGTKATRRLDANDITISKSTLPYDTEKIL
HHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHEECCCCEEEECCCCCCCHHHHH
HGGGIRIGTPAITTRGMKEADMERVADLIDRALKGEDVKAEVHAFAGSFPLP
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC
>Mature Secondary Structure 
TTAEPSKTVQAAFRDTAIFDLIAQEAERQRVGLELIASENFCSAEVRAAQGSVLTNKYA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHCCCHHHHHHH
EGYPGKRWYGGCEVVDEVERLAIERVKQLFGAEWANVQPHSGSSANLAVYNALLEPGDTV
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHCCCCEE
LGMDLAHGGHLTHGSPVNFSGLRYRVVGYKVNPETELIDMEEVRRLAHEHQPKMIIAGAS
EEEEECCCCCCCCCCCCCCCCEEEEEEEEEECCCCCEECHHHHHHHHHHCCCCEEEECCH
AYSRIIDFAAFREIADEVGALLFADIAHIAGLIAAGLHPNALPHAHVVASTTHKTLRGPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHCCCC
GGVILSNDPEIGAKIDRAVFPGYQGGPLEHVIAAKAVAFGEALQPEFKDYAAQIIRNAQA
CCEEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
LAGAFQNRGYRVVSGGTDNHLFVLDLRPQGLNGTKATRRLDANDITISKSTLPYDTEKIL
HHHHHHCCCEEEEECCCCCEEEEEEECCCCCCCCHHHHEECCCCEEEECCCCCCCHHHHH
HGGGIRIGTPAITTRGMKEADMERVADLIDRALKGEDVKAEVHAFAGSFPLP
CCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA