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The map label for this gene is purQ

Identifier: 94984173

GI number: 94984173

Start: 64046

End: 64714

Strand: Reverse

Name: purQ

Synonym: Dgeo_0065

Alternate gene names: 94984173

Gene position: 64714-64046 (Counterclockwise)

Preceding gene: 94984174

Following gene: 94984172

Centisome position: 2.62

GC content: 66.67

Gene sequence:

>669_bases
GTGAGGACCGCCGTCATTCAGTTTCCTGGCTCCAACTGCGACGCCGACGCGCTGCATGCGGCCCGCCTCACCCTCGATCC
GGATGCAGGGTTTGTGTGGCACACCGAGACGGCGCTGCCCAGAGGCACCGAGCTGGTGTTCTTGCCGGGCGGCTTCTCCT
ACGGTGATCATCTCCGGAGCGGTGCCATTGCGGCCCGCAGCCCGATCATGGCGGCGGTGAAGGCGCATGCGGAGCGCGGC
GGCTTTGTGCTCGGCGTGTGCAACGGCTTTCAGGTGCTCACCGAAGCGGGGCTGCTGCCCGGAGCGCTGTCGCGCAACCG
CGACCTGCACTTTCGTTGCGCGCCCGTTCACCTGCGCGTGGAGAATGCCCAGACAGTCTTTACGCGGGCCTACCAGCCGG
GGCAGATCCTCGAAATCCCCATCGCACACGGCGAGGGCAACTACTACGCCGACCCGGAGACGATTGCGCGGTTAGAGGCG
GAAGGCCGGGTGGTCTTCCGTTACGTGGACAACCCCAACGGCTCCCTCAACGACATCGCCGGCATCGTGAATGAGCGCGG
CAATGTCCTTGGCATGATGCCCCACCCCGAACGGGCGGTCGAGGCGCTGCTGGGGAGCGAAGACGGGCGGGGCATCTTCG
AGAGCCTGAAAGGGGCGCTGGTCCAGTGA

Upstream 100 bases:

>100_bases
AGCGGACAGAGGTTGAAACCGAACTCGCCCACATCGTCGAGAACGTGCTGAGCAATCCCATTATGGAAAACGCCCGCTGG
GAACTGGAGGAGCGCCCCGC

Downstream 100 bases:

>100_bases
CACACACCGAGTCTCTCCGGCCCCAGGCCGCCACCTTTGGCCTCACCTCCGAAGAATTCGATCTGCTTGTCTCCAGGCTG
GGTCGCGAGCCGAATGCGCT

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MRTAVIQFPGSNCDADALHAARLTLDPDAGFVWHTETALPRGTELVFLPGGFSYGDHLRSGAIAARSPIMAAVKAHAERG
GFVLGVCNGFQVLTEAGLLPGALSRNRDLHFRCAPVHLRVENAQTVFTRAYQPGQILEIPIAHGEGNYYADPETIARLEA
EGRVVFRYVDNPNGSLNDIAGIVNERGNVLGMMPHPERAVEALLGSEDGRGIFESLKGALVQ

Sequences:

>Translated_222_residues
MRTAVIQFPGSNCDADALHAARLTLDPDAGFVWHTETALPRGTELVFLPGGFSYGDHLRSGAIAARSPIMAAVKAHAERG
GFVLGVCNGFQVLTEAGLLPGALSRNRDLHFRCAPVHLRVENAQTVFTRAYQPGQILEIPIAHGEGNYYADPETIARLEA
EGRVVFRYVDNPNGSLNDIAGIVNERGNVLGMMPHPERAVEALLGSEDGRGIFESLKGALVQ
>Mature_222_residues
MRTAVIQFPGSNCDADALHAARLTLDPDAGFVWHTETALPRGTELVFLPGGFSYGDHLRSGAIAARSPIMAAVKAHAERG
GFVLGVCNGFQVLTEAGLLPGALSRNRDLHFRCAPVHLRVENAQTVFTRAYQPGQILEIPIAHGEGNYYADPETIARLEA
EGRVVFRYVDNPNGSLNDIAGIVNERGNVLGMMPHPERAVEALLGSEDGRGIFESLKGALVQ

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI31657129, Length=253, Percent_Identity=32.8063241106719, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI48994899, Length=182, Percent_Identity=34.0659340659341, Blast_Score=76, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=201, Percent_Identity=33.8308457711443, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24582111, Length=184, Percent_Identity=31.5217391304348, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24582109, Length=184, Percent_Identity=31.5217391304348, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI17137292, Length=184, Percent_Identity=31.5217391304348, Blast_Score=80, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURQ_DEIGD (Q1J2B6)

Other databases:

- EMBL:   CP000359
- RefSeq:   YP_603537.1
- ProteinModelPortal:   Q1J2B6
- SMR:   Q1J2B6
- STRING:   Q1J2B6
- GeneID:   4058506
- GenomeReviews:   CP000359_GR
- KEGG:   dge:Dgeo_0065
- NMPDR:   fig|68909.1.peg.1518
- eggNOG:   COG0047
- HOGENOM:   HBG302712
- OMA:   FPGTNCD
- ProtClustDB:   PRK03619
- BioCyc:   DGEO319795:DGEO_0065-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00421
- InterPro:   IPR017926
- InterPro:   IPR011698
- InterPro:   IPR010075
- PIRSF:   PIRSF001586
- TIGRFAMs:   TIGR01737

Pfam domain/function: PF07685 GATase_3

EC number: =6.3.5.3

Molecular weight: Translated: 23853; Mature: 23853

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS51273 GATASE_TYPE_1

Important sites: ACT_SITE 87-87 ACT_SITE 195-195 ACT_SITE 197-197

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAVIQFPGSNCDADALHAARLTLDPDAGFVWHTETALPRGTELVFLPGGFSYGDHLRS
CCEEEEEECCCCCCHHHEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHC
GAIAARSPIMAAVKAHAERGGFVLGVCNGFQVLTEAGLLPGALSRNRDLHFRCAPVHLRV
CCHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEE
ENAQTVFTRAYQPGQILEIPIAHGEGNYYADPETIARLEAEGRVVFRYVDNPNGSLNDIA
CCCEEEEEECCCCCCEEEEEEEECCCCEEECHHHHEEEECCCEEEEEEECCCCCCHHHHH
GIVNERGNVLGMMPHPERAVEALLGSEDGRGIFESLKGALVQ
HHHCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MRTAVIQFPGSNCDADALHAARLTLDPDAGFVWHTETALPRGTELVFLPGGFSYGDHLRS
CCEEEEEECCCCCCHHHEEEEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCCHHHHHC
GAIAARSPIMAAVKAHAERGGFVLGVCNGFQVLTEAGLLPGALSRNRDLHFRCAPVHLRV
CCHHHCCHHHHHHHHHHCCCCEEEEECCCHHHHHHCCCCCCCCCCCCCEEEEEEEEEEEE
ENAQTVFTRAYQPGQILEIPIAHGEGNYYADPETIARLEAEGRVVFRYVDNPNGSLNDIA
CCCEEEEEECCCCCCEEEEEEEECCCCEEECHHHHEEEECCCEEEEEEECCCCCCHHHHH
GIVNERGNVLGMMPHPERAVEALLGSEDGRGIFESLKGALVQ
HHHCCCCCEEEECCCHHHHHHHHHCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA