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The map label for this gene is ska [H]

Identifier: 94995174

GI number: 94995174

Start: 1729804

End: 1731126

Strand: Direct

Name: ska [H]

Synonym: MGAS10750_Spy1778

Alternate gene names: 94995174

Gene position: 1729804-1731126 (Clockwise)

Preceding gene: 94995170

Following gene: 94995178

Centisome position: 89.3

GC content: 40.67

Gene sequence:

>1323_bases
ATGAAAAATTACTTATCTTTTGGGATGTTTGCACTGCTGTTTGCATTAACATTTGGAACAGTCAAGCCTGTCCAAGCTAT
TGCTGGACCTGAATGGCTGCTAGACCGTCCATCTGTCAACAACATCCAATTAGTTGTTAGCGTTGCCGGTACTGTTGAGG
GGACGAATCAAGAAATTAGCCTTAAATTTTTTGAAATTGACCTAACATCAGGACCTGCTCAGGGAGGAAAGACAGAGCAA
GGCTTAAGTCCAAAATCAAAACCATTTGCTACAAATAAAGGCGCAATGCCACATAAACTTGAAAAAGCTGACTTATTAAA
GGCTATTCAAGAACAATTGATCGCTAACGTTCACAGTAACGACGGCTACTTTGAGGTCATTGATTTTGCAAGCGATGCAA
CCATTACTGATCGAAACGGCAAGGTCTACTTTGCTGACCGAGATGATTCGGTAACCTTGCCGACCCAACCTGTCCAAGAA
TTTTTGCTAAGCGGGCATGTGCGCGTTAGACCGTATCAACCTAAAGCCGTTCACAACTCAGCTGAACGCGTTAACGTCAA
CTATGAAGTGAGCTTTGTCTCCGAAACAGGAGATTTAGACTTTACACCGTTGTTAAGAAACCAATACCAATTGACCACAC
TGGCAGTTGGTGACTCTCTTTCATCACAAGAGTTAGCAGCGATTGCCCAATTTATCCTATCAAAAAAATATCCAGATTAT
ATCATTACAAAACGTGACTCCTCAATCGTCACTCATGACAATGACATTTTCCGTACGATTTTACCAATGGATCAAGAGTT
TACTTACCATATCAAAGACCGGGAACAAGCTTATAAGGCCAATTCTAAAACAGGTATTGTAGAAAAAACGAACAACACTG
ACCTTATCTCTGAGAAATATTACGTCCTTAAAAAAGGGGAAAAGCCGTATGATCCCTTTGATCGCAGTCACTTGAAACTG
TTCACCATCAATTACGTTGATGTCAACACCAACGAATTGCTAAAAAGCGAGCAGCTCTTAACAGCTAGCGAACGTAACTT
AGACTTCAGAGATTTATACGATCCTCGTGATAAGGCTAAACTACTCTACAACAATCTCGATGCTTTTGGTATTATGGACT
ATACCTTAACTGGAAAAGTAGAGGATAATCACAATGACACCAACCGTATCATAACCGTTTATATGGGCAAGCGACCCGAA
GGAGAGAATGCTAGCTATCATTTAGCTTATGATAAAGATCGTTATACCGAAGAAGAACGAGAAGTTTACAGCTACCTGCG
TTATACAGGGACACCTATACCTGATAACCCTAACGACAAATAA

Upstream 100 bases:

>100_bases
GATATCATTTAAAAACAATTATTAGGTTTTTGTTTGTATCTATAAAATTATTATGTTATTCTAATAATGGGGATTGAAAC
TTAACTTTTAGGAGGTTTCT

Downstream 100 bases:

>100_bases
CCACGATCTTCTAAAACGATGAGATTAACTGACAAAAAAAGCAAGCAACACGCTATCAACAGTTGCTTGCTTTTTTCTAA
CCTCTTAGTTGTAGAGACTA

Product: Streptokinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEISLKFFEIDLTSGPAQGGKTEQ
GLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQE
FLLSGHVRVRPYQPKAVHNSAERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY
IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKYYVLKKGEKPYDPFDRSHLKL
FTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPE
GENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK

Sequences:

>Translated_440_residues
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEISLKFFEIDLTSGPAQGGKTEQ
GLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQE
FLLSGHVRVRPYQPKAVHNSAERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY
IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKYYVLKKGEKPYDPFDRSHLKL
FTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPE
GENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK
>Mature_440_residues
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEISLKFFEIDLTSGPAQGGKTEQ
GLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSNDGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQE
FLLSGHVRVRPYQPKAVHNSAERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY
IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKYYVLKKGEKPYDPFDRSHLKL
FTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAKLLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPE
GENASYHLAYDKDRYTEEEREVYSYLRYTGTPIPDNPNDK

Specific function: This protein is not a protease, but it activates plasminogen by complexing with it. As a potential virulence factor, it is thought to prevent the formation of effective fibrin barriers around the site of infection, thereby contributing to the invasiveness

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004093
- InterPro:   IPR008124 [H]

Pfam domain/function: PF02821 Staphylokinase [H]

EC number: NA

Molecular weight: Translated: 49975; Mature: 49975

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEIS
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHEECCCCCCCEEEEEEEECEECCCCCEEE
LKFFEIDLTSGPAQGGKTEQGLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSN
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYQPKAVHNS
CCEEEEEEECCCCEEECCCCEEEEECCCCCEECCCHHHHHHHHCCCEEEECCCCHHHCCC
AERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY
CCEEEEEEEEEEEECCCCCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKY
EEEECCCEEEECCCCHHHHHCCCCCCEEEEECCHHHHHHCCCCCCEEEECCCCCEECCCE
YVLKKGEKPYDPFDRSHLKLFTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAK
EEEECCCCCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHH
LLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
HHHCCCCEEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEECCHHCCHHHH
EVYSYLRYTGTPIPDNPNDK
HHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MKNYLSFGMFALLFALTFGTVKPVQAIAGPEWLLDRPSVNNIQLVVSVAGTVEGTNQEIS
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCHHEECCCCCCCEEEEEEEECEECCCCCEEE
LKFFEIDLTSGPAQGGKTEQGLSPKSKPFATNKGAMPHKLEKADLLKAIQEQLIANVHSN
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
DGYFEVIDFASDATITDRNGKVYFADRDDSVTLPTQPVQEFLLSGHVRVRPYQPKAVHNS
CCEEEEEEECCCCEEECCCCEEEEECCCCCEECCCHHHHHHHHCCCEEEECCCCHHHCCC
AERVNVNYEVSFVSETGDLDFTPLLRNQYQLTTLAVGDSLSSQELAAIAQFILSKKYPDY
CCEEEEEEEEEEEECCCCCCCCHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCE
IITKRDSSIVTHDNDIFRTILPMDQEFTYHIKDREQAYKANSKTGIVEKTNNTDLISEKY
EEEECCCEEEECCCCHHHHHCCCCCCEEEEECCHHHHHHCCCCCCEEEECCCCCEECCCE
YVLKKGEKPYDPFDRSHLKLFTINYVDVNTNELLKSEQLLTASERNLDFRDLYDPRDKAK
EEEECCCCCCCCCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHH
LLYNNLDAFGIMDYTLTGKVEDNHNDTNRIITVYMGKRPEGENASYHLAYDKDRYTEEER
HHHCCCCEEEEEEEEEEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEEECCHHCCHHHH
EVYSYLRYTGTPIPDNPNDK
HHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8746458 [H]