Click here to switch to the map view.

The map label for this gene is hsdM [H]

Identifier: 94995116

GI number: 94995116

Start: 1670421

End: 1671224

Strand: Direct

Name: hsdM [H]

Synonym: MGAS10750_Spy1720

Alternate gene names: 94995116

Gene position: 1670421-1671224 (Clockwise)

Preceding gene: 94995115

Following gene: 94995117

Centisome position: 86.23

GC content: 37.69

Gene sequence:

>804_bases
TTGGCTCGTATGAACATGATGCTTCATGGCGTTGCCATCGAAAACCAACACTTAAGTAACGCTGATACCTTGGATGCAGA
CTGGCCAACAGATGAGCCAACCAACTTTGATGGGGTGTTGATGAACCCACCTTATTCTTTGAAATGGTCAGCGACTGCTG
GTTTCTTAACGGATCCACGTTTTTCAAGTTATGGTGTATTAGCACCAAAATCAAAAGCTGACTTTGCCTTTTTACTTCAT
GGTTTCTATCATTTAAAAAATACAGGAACTATGGCAATTGTCTTACCACATGGTGTTCTTTTCCGTGGAGCTGCAGAAGG
CAAGATTCGCCAAAAACTACTCGAACAAGGGGCTATCGATACCATTATCGGACTCCCATCAAATATCTTTTATAATACAA
GCATCCCTACGACTATTATCATATTAAAGAAGAACAGAACCAACAAAGATGTCTTCTTTATCGATGCTTCAAAAGAGTTT
GATAAAGGCAAAAATCAAAACACAATGACAGATAGCCATATCAAAAAGATCCTTGATGCTTATAAGAGTCGTGATAATTC
TGATAAGTTTTCATATTTAGCCTCATTTGATGAAATCATTGAAAATGACTATAACTTAAATATCCCACGCTATGTTGATA
CCTTTGAGGAAGTCCCAGTTAAACCACTGCCAGAATTAGCTAAACAGCTCAGTGACATTGATCAAGAAATTGCCAAAACA
AATGCCAAACTAGATCAACTCATGAAACAACTAGTCGGAACAACCAAAGAAGCACAAGACGAATTGGATACTTTTAGAAA
CTAA

Upstream 100 bases:

>100_bases
AGAGGGATCTGGATCACTCCTTTTAAATGCTAAGAAATATAGTAACCAATCCGATACCGTTTCTTACTATGGTCAAGAAA
TCAATACTTCTACTTATAAC

Downstream 100 bases:

>100_bases
AAGACAAAAAAACACCACAGTAGATGATTACTACTGTGGCGTTTTATTTAAAATTGAGTAGTGAACCTTTATTGAGTACT
TATCAAACAAGATTCTCCTT

Product: Type I restriction-modification system methylation subunit

Products: NA

Alternate protein names: M.EcoR124II [H]

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLH
GFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEF
DKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKT
NAKLDQLMKQLVGTTKEAQDELDTFRN

Sequences:

>Translated_267_residues
MARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLH
GFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEF
DKGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKT
NAKLDQLMKQLVGTTKEAQDELDTFRN
>Mature_266_residues
ARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPRFSSYGVLAPKSKADFAFLLHG
FYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAIDTIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFD
KGKNQNTMTDSHIKKILDAYKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKTN
AKLDQLMKQLVGTTKEAQDELDTFRN

Specific function: Methylation of specific adenine residues; required for both restriction and modification activities. The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3' [H]

COG id: COG0286

COG function: function code V; Type I restriction-modification system methyltransferase subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022749
- InterPro:   IPR003356
- InterPro:   IPR002052
- InterPro:   IPR002296
- InterPro:   IPR004546 [H]

Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 30115; Mature: 29983

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00092 N6_MTASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPR
CCCHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCC
FSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAID
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHCCCHH
TIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDA
HHHCCCCCEEECCCCCEEEEEEECCCCCCEEEEEECCCHHCCCCCCCCCCHHHHHHHHHH
YKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKT
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NAKLDQLMKQLVGTTKEAQDELDTFRN
HHHHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
ARMNMMLHGVAIENQHLSNADTLDADWPTDEPTNFDGVLMNPPYSLKWSATAGFLTDPR
CCHHEEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCEEECCCCCCCCCCC
FSSYGVLAPKSKADFAFLLHGFYHLKNTGTMAIVLPHGVLFRGAAEGKIRQKLLEQGAID
CCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHCCCHH
TIIGLPSNIFYNTSIPTTIIILKKNRTNKDVFFIDASKEFDKGKNQNTMTDSHIKKILDA
HHHCCCCCEEECCCCCEEEEEEECCCCCCEEEEEECCCHHCCCCCCCCCCHHHHHHHHHH
YKSRDNSDKFSYLASFDEIIENDYNLNIPRYVDTFEEVPVKPLPELAKQLSDIDQEIAKT
HHCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
NAKLDQLMKQLVGTTKEAQDELDTFRN
HHHHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2784505 [H]