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The map label for this gene is ermA1 [H]

Identifier: 94995100

GI number: 94995100

Start: 1652896

End: 1653627

Strand: Direct

Name: ermA1 [H]

Synonym: MGAS10750_Spy1703

Alternate gene names: 94995100

Gene position: 1652896-1653627 (Clockwise)

Preceding gene: 94995098

Following gene: 94995101

Centisome position: 85.33

GC content: 29.78

Gene sequence:

>732_bases
ATGAAACAGAAAAACCCGAAAAATACGCAAAATTTCATTACATCTAAAAAGCATGTAAAGGAAATATTAAAATATACGAA
TATCAATAAACAAGATAAAATAATAGAAATTGGGTCAGGAAAAGGACATTTTACCAAGGAACTTGTGGAAATGAGTCAAC
GGGTGAATGCTATAGAGATTGATGAAGGTTTATGTCATGCCACGAAAAAAGCAGTTGAACCTTTTCAGAATATAAAAGTT
ATTCATGAGGATATTTTGAAGTTTAGCTTTCCTAAAAATACAGACTATAAAATATTTGGTAATATTCCCTACAATATTAG
TACTGATATTGTAAAAAAGATTGCTTTTGATAGTCAAGCGAAATATAGCTACCTTATTGTAGAGAGGGGATTTGCTAAAA
GGTTGCAAAATACCCAACGAGCTTTAGGTTTGCTGTTAATGGTGGAAATGGATATAAAAATTCTTAAAAAAGTGCCACGA
GCATATTTTCACCCTAAGCCTAATGTAGATTCTGTATTGATTGTACTTGAAAGGCATAAACCATTTATTTTAAAGAAGGA
CTACAAAAAGTATAGATTTTTCGTTTATAAATGGGTAAACAGGGAATATCATGTTCTTTTTACTAAAAATCAATTAAGAC
AGGTGCTGAAGCATGCGAATGTTACTGATCTTGATAAATTATCCAATGAACAATTTTTGTCTGTTTTCAATAGTTACAAA
TTATTTCAATAA

Upstream 100 bases:

>100_bases
ATTTGTTATTGAGAGATTTCATTATCAACCAAACCAAAAATAATTGGTTATAATGAGCTCTTAAGATTAGTTCATTATAA
CCGGCAAGGAGAAGGTTATA

Downstream 100 bases:

>100_bases
ATTAAAAATAATTAAGCGTTCTCTAACTTTAAGAGAACGCTTAATCTTATTACATTGAAAAATGCATTCTATTATTTTCA
ATTATTATGATATAACATAA

Product: rRNA adenine N-6-methyltransferase

Products: NA

Alternate protein names: Erythromycin resistance protein; Macrolide-lincosamide-streptogramin B resistance protein [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEIDEGLCHATKKAVEPFQNIKV
IHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQAKYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPR
AYFHPKPNVDSVLIVLERHKPFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
LFQ

Sequences:

>Translated_243_residues
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEIDEGLCHATKKAVEPFQNIKV
IHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQAKYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPR
AYFHPKPNVDSVLIVLERHKPFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
LFQ
>Mature_243_residues
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEIDEGLCHATKKAVEPFQNIKV
IHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQAKYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPR
AYFHPKPNVDSVLIVLERHKPFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
LFQ

Specific function: This protein produces a dimethylation of the adenine residue at position 2085 in 23S rRNA, resulting in reduced affinity between ribosomes and macrolide-lincosamide-streptogramin B antibiotics [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1786236, Length=184, Percent_Identity=26.0869565217391, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146882, Length=191, Percent_Identity=28.7958115183246, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.184 [H]

Molecular weight: Translated: 28715; Mature: 28715

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEC
DEGLCHATKKAVEPFQNIKVIHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCC
KYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPRAYFHPKPNVDSVLIVLERHK
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
PFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
CEEECCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHC
LFQ
CCC
>Mature Secondary Structure
MKQKNPKNTQNFITSKKHVKEILKYTNINKQDKIIEIGSGKGHFTKELVEMSQRVNAIEI
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCEEEC
DEGLCHATKKAVEPFQNIKVIHEDILKFSFPKNTDYKIFGNIPYNISTDIVKKIAFDSQA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCC
KYSYLIVERGFAKRLQNTQRALGLLLMVEMDIKILKKVPRAYFHPKPNVDSVLIVLERHK
CEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCC
PFILKKDYKKYRFFVYKWVNREYHVLFTKNQLRQVLKHANVTDLDKLSNEQFLSVFNSYK
CEEECCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHC
LFQ
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]