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The map label for this gene is hsdM [H]

Identifier: 94995074

GI number: 94995074

Start: 1620777

End: 1621568

Strand: Direct

Name: hsdM [H]

Synonym: MGAS10750_Spy1678

Alternate gene names: 94995074

Gene position: 1620777-1621568 (Clockwise)

Preceding gene: 94995073

Following gene: 94995075

Centisome position: 83.67

GC content: 35.86

Gene sequence:

>792_bases
ATGGCAGAGAAAACAACTTCACTCCGTCAAGCACTATGGCATTCGGCCGACCAATTACGTGGCCAAATGGATGCCAATGA
CTATAAAAACTATCTTCTTGGACTTATTTTTTACAAACACTTATCTGATAAATTACTCTTGGCTGTTTGTGATAATCTAG
AAAAACACTTCAATACCTTTACAGAGGCTCAAAAAATCTTTGAAGATGCTTATCAAGATGAAGGCCTAAAAGATGACCTC
ATTTCTGTTGTTACTGGTGATTTAGGTTACTTTATCGAACCAACACTGACCTTTGAAAAACTCATCCAAGATGTTTATCA
CAATACTTTCCAATTAGAATCATTAGCTCAAGGTTTTCGCGATATTGAACAAAGTGGTGAAGACTTTGAAAACTTATTTG
AAGATATTGACCTCTACTCTAAAAAATTAGGCTCTACTCCTCAAAAACAAAATCAAACCATTTCTAATGTCATGAAAACA
TTAAATGAAATTGACTTTGAGGCAGTAGATGGGGATACTTTAGGCGATGCTTATGAGTACTTGATTGGTGAATTTGCCAG
TGAGTCAGGAAAAAAAGCAGGTGAGTTCTATACCCCACAAGCTGTCTCTCACTTGATGACTCAGATTGTCTTTTTAGGTC
GTGAAGATCAAAAAGGAATGACCCTCTATGACCCTGCTATGGGGTTTCGTGTCATAATAGTGATAGAGGCAAATAGTTAT
GTAAATATAAGGAGTTCAAGACTTCTACCAAAGTTTAAAACTCAAAAAATAAATAGTTGGTGTGCTACTTAG

Upstream 100 bases:

>100_bases
CCTAGACCAACAAATGAGTCAAATCGAAGATAAATTAACAGAACTTAAAGCACTCAAACAAACATTACTCAATCGTTTAT
TCGTATAAGAAAGGACTCAC

Downstream 100 bases:

>100_bases
AATATCCATTTTAAGAATGGGTATTGTAAATAGCATACCAATGAAACTAAAGATTCTTTAAAGAGTCTTATTTTGTGATG
AAAATTTAATATGTAAATCT

Product: Type I restriction-modification system methylation subunit

Products: NA

Alternate protein names: M.EcoR124II [H]

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL
ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT
LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGFRVIIVIEANSY
VNIRSSRLLPKFKTQKINSWCAT

Sequences:

>Translated_263_residues
MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDL
ISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKT
LNEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGFRVIIVIEANSY
VNIRSSRLLPKFKTQKINSWCAT
>Mature_262_residues
AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTFTEAQKIFEDAYQDEGLKDDLI
SVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFRDIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTL
NEIDFEAVDGDTLGDAYEYLIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGFRVIIVIEANSYV
NIRSSRLLPKFKTQKINSWCAT

Specific function: Methylation of specific adenine residues; required for both restriction and modification activities. The EcoR124/3 I enzyme recognizes 5'-GAAN(7)RTCG-3' [H]

COG id: COG0286

COG function: function code V; Type I restriction-modification system methyltransferase subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N(4)/N(6)-methyltransferase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022749
- InterPro:   IPR003356
- InterPro:   IPR002052
- InterPro:   IPR002296
- InterPro:   IPR004546 [H]

Pfam domain/function: PF12161 HsdM_N; PF02384 N6_Mtase [H]

EC number: =2.1.1.72 [H]

Molecular weight: Translated: 30032; Mature: 29901

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFR
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNEIDFEAVDGDTLGDAYEY
HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHH
LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGFRVIIVIEANSY
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEEECCCE
VNIRSSRLLPKFKTQKINSWCAT
EEEHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
AEKTTSLRQALWHSADQLRGQMDANDYKNYLLGLIFYKHLSDKLLLAVCDNLEKHFNTF
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TEAQKIFEDAYQDEGLKDDLISVVTGDLGYFIEPTLTFEKLIQDVYHNTFQLESLAQGFR
HHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
DIEQSGEDFENLFEDIDLYSKKLGSTPQKQNQTISNVMKTLNEIDFEAVDGDTLGDAYEY
HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHH
LIGEFASESGKKAGEFYTPQAVSHLMTQIVFLGREDQKGMTLYDPAMGFRVIIVIEANSY
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEEEEEEECCCE
VNIRSSRLLPKFKTQKINSWCAT
EEEHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2784505 [H]