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The map label for this gene is serS [H]

Identifier: 94994938

GI number: 94994938

Start: 1475593

End: 1476870

Strand: Direct

Name: serS [H]

Synonym: MGAS10750_Spy1542

Alternate gene names: 94994938

Gene position: 1475593-1476870 (Clockwise)

Preceding gene: 94994937

Following gene: 94994970

Centisome position: 76.17

GC content: 41.94

Gene sequence:

>1278_bases
ATGCTAGATCTTAAACGTATCCGTACCGATTTTGACACTGTCGCTGCCAAATTAAAAAACCGTGGTGTTTCTGAAGACAC
CCTGACCCATCTTAAAGAACTTGATGAAAAACGTCGTACTCTATTAGTGCAATCAGAAGAATTAAAAGCAGAGCGTAATA
TTGCTTCTGCTGCCATCGCTCAAGCCAAACGTCAAAAAGAAGATGCCACTCAACAAATTGCTGATATGCAAAAAGTCTCT
GCAGATATCAAAACTATTGACAATCAACTAGTAGCTATCGACCAGCAAGTTACTGACATCATCACTGTTTTACCTAATAC
TCCTCACGATTCTGTCCCTGTTGGAGCTGACGAAGAAGACAATGTCGAAATTCGCCGTTGGGGAACGCCTCGTGACTTTG
ACTTCGAAGTTAAGGCTCATTGGGATCTAGGCGAAGATCTTGATATTTTAGACTGGGAACGTGGGGCAAAGGTAACTGGT
GCTCGTTTCTTATTCTATAAAAATCTTGGTGCTCGTTTGGAGCGTGCTCTTTATAACTTCATGCTGGATGAACATATCAA
AGAAGGTTATCAAGAAATCATCACACCTTACATGGTTAACCACGATTCCATGTTTGGTACAGGACAATATCCAAAATTCA
AAGAGGACACCTTTGAATTAGCAGATACCAACTTTGTCCTGATTCCAACTGCTGAAGTGCCTTTGACCAATTATTACCGT
GGGGAAATCCTAGACGGCAAAGAATTGCCAATTTACTTTACTGCAATGAGTCCATCTTTTCGTTCTGAAGCGGGTTCTGC
GGGTCGTGACACACGTGGCCTTATCCGCCTACACCAATTCCACAAAGTTGAAATGGTTAAATTTGCTAAACCAGAAGAAT
CTTACCAAGAACTAGAAAAAATGACTGCTAATGCTGAAAATATTCTTCAAAAACTTGGTTTGCCATATCGCGTCATTTCC
CTTTGTACTGGAGACATGGGCTTCTCAGCTGCTAAAACCTATGACCTTGAAGTCTGGATTCCTGCACAAAATACCTATCG
TGAAATTTCATCATGTTCAAATACAGAAGATTTCCAAGCACGACGTGCTCAAATCCGTTACCGTGATGAAGCTGACGGCA
AGGTCAAACTTCTTCACACCCTTAATGGGTCAGGACTTGCTGTCGGTCGTACCGTAGCAGCCATTTTAGAAAACTACCAA
AATGAAGATGGTTCTGTTACCATCCCTGAAGTACTCCGCCCTTACATGGGTGGCGAAACCGTCATTTCACCTAAATAA

Upstream 100 bases:

>100_bases
GCTGTGCTTTTTCTATCGTCAGAGAATCACAAGATCCAACTGTCTTACTTAGCCTTGTTTCACTGACAGCTACTAATAAC
TATCTTAAAGGAGCTTATGT

Downstream 100 bases:

>100_bases
TAAACTCACCCCAGAGATCATTAAAGTGATTTCTGGGGTTTACTATTTTAAAGAGCCACCACATCACTTGAAACTCACTA
CATTGCCCCTTTAACAACAC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQSEELKAERNIASAAIAQAKRQKEDATQQIADMQKVS
ADIKTIDNQLVAIDQQVTDIITVLPNTPHDSVPVGADEEDNVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTG
ARFLFYKNLGARLERALYNFMLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTFELADTNFVLIPTAEVPLTNYYR
GEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLGLPYRVIS
LCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEVLRPYMGGETVISPK

Sequences:

>Translated_425_residues
MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQSEELKAERNIASAAIAQAKRQKEDATQQIADMQKVS
ADIKTIDNQLVAIDQQVTDIITVLPNTPHDSVPVGADEEDNVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTG
ARFLFYKNLGARLERALYNFMLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTFELADTNFVLIPTAEVPLTNYYR
GEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLGLPYRVIS
LCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEVLRPYMGGETVISPK
>Mature_425_residues
MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQSEELKAERNIASAAIAQAKRQKEDATQQIADMQKVS
ADIKTIDNQLVAIDQQVTDIITVLPNTPHDSVPVGADEEDNVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTG
ARFLFYKNLGARLERALYNFMLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTFELADTNFVLIPTAEVPLTNYYR
GEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEKMTANAENILQKLGLPYRVIS
LCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQARRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQ
NEDGSVTIPEVLRPYMGGETVISPK

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=31.7697228144989, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI8923421, Length=414, Percent_Identity=32.1256038647343, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI225579074, Length=329, Percent_Identity=34.0425531914894, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1787120, Length=426, Percent_Identity=56.8075117370892, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786392, Length=171, Percent_Identity=26.9005847953216, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17539260, Length=429, Percent_Identity=32.1678321678322, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=325, Percent_Identity=29.5384615384615, Blast_Score=154, Evalue=9e-38,
Organism=Saccharomyces cerevisiae, GI6320226, Length=396, Percent_Identity=35.3535353535354, Blast_Score=240, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321799, Length=431, Percent_Identity=30.6264501160093, Blast_Score=223, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24581334, Length=330, Percent_Identity=36.0606060606061, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17737985, Length=347, Percent_Identity=31.4121037463977, Blast_Score=168, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48212; Mature: 48212

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQSEELKAERNIASAAIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHH
QAKRQKEDATQQIADMQKVSADIKTIDNQLVAIDQQVTDIITVLPNTPHDSVPVGADEED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTGARFLFYKNLGARLERALYNF
CEEEEECCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCEEEEEHHHHHHHHHHHHHHH
MLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTFELADTNFVLIPTAEVPLTNYYR
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCC
GEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEK
CCEECCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MTANAENILQKLGLPYRVISLCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQA
HHCCHHHHHHHCCCCCEEHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEVLRPYMGGET
HHHHEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCE
VISPK
EECCC
>Mature Secondary Structure
MLDLKRIRTDFDTVAAKLKNRGVSEDTLTHLKELDEKRRTLLVQSEELKAERNIASAAIA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHHH
QAKRQKEDATQQIADMQKVSADIKTIDNQLVAIDQQVTDIITVLPNTPHDSVPVGADEED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCCCCCCCCC
NVEIRRWGTPRDFDFEVKAHWDLGEDLDILDWERGAKVTGARFLFYKNLGARLERALYNF
CEEEEECCCCCCCCEEEEEECCCCCCCCCEECCCCCCCCCEEEEEHHHHHHHHHHHHHHH
MLDEHIKEGYQEIITPYMVNHDSMFGTGQYPKFKEDTFELADTNFVLIPTAEVPLTNYYR
HHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCCCCCHHHCCCCCEEEEECCCCCCCCCCC
GEILDGKELPIYFTAMSPSFRSEAGSAGRDTRGLIRLHQFHKVEMVKFAKPEESYQELEK
CCEECCCCCCEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
MTANAENILQKLGLPYRVISLCTGDMGFSAAKTYDLEVWIPAQNTYREISSCSNTEDFQA
HHCCHHHHHHHCCCCCEEHHHHCCCCCCCCCEEEEEEEEECCCHHHHHHHCCCCCHHHHH
RRAQIRYRDEADGKVKLLHTLNGSGLAVGRTVAAILENYQNEDGSVTIPEVLRPYMGGET
HHHHEEECCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCE
VISPK
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]